Amifostine trihydrate (BioDeep_00000817492)
代谢物信息卡片
Amifostine trihydrate
化学式: C5H21N2O6PS (268.0857896)
中文名称: 三水氨磷汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CN)CNCCSP(=O)(O)O.O.O.O
InChI: 3*1H2
描述信息
C26170 - Protective Agent > C2459 - Chemoprotective Agent > C2080 - Cytoprotective Agent
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D00226
- PubChem: 148139
- MeSH: Amifostine
- CAS: 112901-68-5
- medchemexpress: HY-B0639A
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Sunmin Park, Suhyun Kim, Soonil Koun, Hae-Chul Park, Won Sup Yoon, Chai Hong Rim. Radioprotective effect of mistletoe extract on intestinal toxicity: in vivo study using adult zebrafish.
International journal of radiation biology.
2022 Nov; ?(?):1-8. doi:
10.1080/09553002.2023.2142982. [PMID: 36318746] - Lu Wang, Yu Cao, Xiaoyi Zhang, Chang Liu, Jia Yin, Liangju Kuang, Weiwei He, Daoben Hua. Reactive oxygen species-responsive nanodrug of natural crocin-i with prolonged circulation for effective radioprotection.
Colloids and surfaces. B, Biointerfaces.
2022 May; 213(?):112441. doi:
10.1016/j.colsurfb.2022.112441. [PMID: 35272253] - Alexandra Crook, Aline De Lima Leite, Thomas Payne, Fatema Bhinderwala, Jade Woods, Vijay K Singh, Robert Powers. Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine.
Scientific reports.
2021 07; 11(1):14004. doi:
10.1038/s41598-021-93401-7. [PMID: 34234212] - Junling Zhang, Kui Li, Qianru Zhang, Zhimei Zhu, Gongchao Huang, Hongqi Tian. Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice.
Cell death & disease.
2021 02; 12(2):195. doi:
10.1038/s41419-021-03479-0. [PMID: 33602915] - Saad A Alkahtani. Silver nanoparticles conjugated MnFe-based Prussian blue analogue for voltammetric and impedimetric bioaptasensing of amifostine (ethyol).
Mikrochimica acta.
2020 09; 187(10):576. doi:
10.1007/s00604-020-04557-4. [PMID: 32975672] - Ching-Bin Ke, Te-Ling Lu, Jian-Lian Chen. Fluorometric determination of amifostine and alkaline phosphatase on amphiprotic molecularly imprinted silica crosslinked with binary functional silanes and carbon dots.
Biosensors & bioelectronics.
2020 Mar; 151(?):111965. doi:
10.1016/j.bios.2019.111965. [PMID: 31868611] - Liang Zhang, Bo Huang, Haiyang Tang, Xingchen Ye, Yang Yao, Ping Gong, Hua Tang. Amifostine inhibited the differentiation of RAW264.7 cells into osteoclasts by reducing the production of ROS under 2 Gy radiation.
Journal of cellular biochemistry.
2020 01; 121(1):497-507. doi:
10.1002/jcb.29247. [PMID: 31267572] - Till Markowiak, Nadine Kerner, Reiner Neu, Tobias Potzger, Christian Großer, Florian Zeman, Hans-Stefan Hofmann, Michael Ried. Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy.
Journal of surgical oncology.
2019 Dec; 120(7):1220-1226. doi:
10.1002/jso.25726. [PMID: 31602673] - Chai Hong Rim, Soonil Koun, Hae-Chul Park, Suk Lee, Chul Yong Kim. Radioprotective effects of mistletoe extract in zebrafish embryos in vivo.
International journal of radiation biology.
2019 08; 95(8):1150-1159. doi:
10.1080/09553002.2019.1590661. [PMID: 30836032] - Gulgun Cakmak Arslan, Feride Severcan. The effects of radioprotectant and potential antioxidant agent amifostine on the structure and dynamics of DPPC and DPPG liposomes.
Biochimica et biophysica acta. Biomembranes.
2019 06; 1861(6):1240-1251. doi:
10.1016/j.bbamem.2019.04.009. [PMID: 31028720] - Pamela Sinha, Kantha D Arunachalam, Sathesh Kumar Annamalai. Radio-protective dosimetry of Pangasius sutchi as a biomarker, against gamma radiation dosages perceived by genotoxic assays.
Ecotoxicology and environmental safety.
2018 Nov; 164(?):629-640. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2018 09; 391(9):915-931. doi:
10.1007/s00210-018-1514-4. [PMID: 29860655] - Vesna Jaćević, Viktorija Dragojević-Simić, Željka Tatomirović, Silva Dobrić, Dubravko Bokonjić, Aleksandra Kovačević, Eugenie Nepovimova, Martin Vališ, Kamil Kuča. The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats.
International journal of molecular sciences.
2018 Aug; 19(8):. doi:
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Pharmaceutical research.
2018 Mar; 35(5):99. doi:
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Anticancer research.
2018 01; 38(1):227-238. doi:
10.21873/anticanres.12212. [PMID: 29277777] - Philip Riley, Anne-Marie Glenny, Fang Hua, Helen V Worthington. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
The Cochrane database of systematic reviews.
2017 07; 7(?):CD012744. doi:
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International journal of radiation biology.
2016 12; 92(12):837-848. doi:
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Acta cirurgica brasileira.
2016 Mar; 31(3):156-60. doi:
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European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
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Drug and chemical toxicology.
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Health physics.
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Journal of radiation research.
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Indian journal of pharmacology.
2015 Mar; 47(2):185-9. doi:
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Luminescence : the journal of biological and chemical luminescence.
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Bone marrow transplantation.
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Oncotarget.
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World journal of gastroenterology.
2014 Aug; 20(29):10158-65. doi:
10.3748/wjg.v20.i29.10158. [PMID: 25110444] - Z Chang, H L Wang, H Du. Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats.
Genetics and molecular research : GMR.
2014 Jul; 13(3):5276-84. doi:
10.4238/2014.july.24.6. [PMID: 25078583] - Gogsen Onalan, Cagri Gulumser, Barıs Mulayim, Atilla Dagdeviren, Hulusi Zeyneloglu. Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial.
Archives of gynecology and obstetrics.
2014 Jan; 289(1):193-200. doi:
10.1007/s00404-013-2963-0. [PMID: 23880890] - Abdol-Mohammad Kajbafzadeh, Nastaran Sabetkish, Shabnam Sabetkish, Niloufar Javan-Farazmand, Sara Harsini, Seyyed-Mohammad Tavangar. The ameliorative effect of various antioxidants on Adriamycin-induced fetal renal abnormalities.
Journal of pediatric urology.
2013 Dec; 9(6 Pt B):1084-92. doi:
10.1016/j.jpurol.2013.03.010. [PMID: 23665376] - Shekhar D Sawale, Pratul D Ambhore, Pallavi P Pawar, Uma Pathak, Utsab Deb, Ravindra M Satpute. Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammation.
Toxicology mechanisms and methods.
2013 Nov; 23(9):702-10. doi:
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Chemistry & biodiversity.
2013 Oct; 10(10):1791-803. doi:
10.1002/cbdv.201300054. [PMID: 24130023] - Viktorija Dragojević-Simić, Silva Dobrić, Vesna Jaćević, Dubravko Bokonjić, Ivica Milosavljević, Aleksandra Kovacević, Dragan Mikić. Efficacy of amifostine in protection against doxorubicin-induced acute cardiotoxic effects in rats.
Vojnosanitetski pregled.
2013 Jan; 70(1):38-45. doi:
10.2298/vsp110905041d. [PMID: 23401928] - Wenlong Lv, Mei Zhang, Zhenhuan Zhang, Luqiang Huang, Shanmin Yang, Liangjie Yin, Jinsheng Hong, Deping Han, Chun Chen, Sadasivan Vidyasagar, Paul Okunieff, Lurong Zhang. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines.
Advances in experimental medicine and biology.
2013; 789(?):195-201. doi:
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Medical oncology (Northwood, London, England).
2012 Sep; 29(3):2220. doi:
10.1007/s12032-011-0052-4. [PMID: 21874566] - Rusen Cosar, Vuslat Yurut-Caloglu, Sevgi Eskiocak, Alaattin Ozen, Semsi Altaner, Kamuran Ibis, Nesrin Turan, Bengu Denizli, Cem Uzal, Mert Saynak, Sule Parlar, Murat Caloglu, Burcu Uregen, Zafer Kocak. Radiation-induced chronic oxidative renal damage can be reduced by amifostine.
Medical oncology (Northwood, London, England).
2012 Jun; 29(2):768-75. doi:
10.1007/s12032-011-9870-7. [PMID: 21347716] - Marleen Melis, Roelf Valkema, Eric P Krenning, Marion de Jong. Reduction of renal uptake of radiolabeled octreotate by amifostine coadministration.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 May; 53(5):749-53. doi:
10.2967/jnumed.111.098665. [PMID: 22496587] - Gulgun Cakmak, Lisa M Miller, Faruk Zorlu, Feride Severcan. Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: an FTIR microspectroscopic imaging study.
Archives of biochemistry and biophysics.
2012 Apr; 520(2):67-73. doi:
10.1016/j.abb.2012.02.012. [PMID: 22402174] - Jini Joseph, Sudheesh Narayana Panicker, Kainoor Krishnankutty Janardhanan. Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress.
Redox report : communications in free radical research.
2012; 17(1):22-7. doi:
10.1179/1351000211y.0000000018. [PMID: 22340512] - Lebana J Joseph, Uma S Bhartiya, Yogita S Raut, Rohini W Hawaldar, Yogendra Nayak, Yogita P Pawar, Nirmala A Jambhekar, M G R Rajan. Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure.
Cancer biotherapy & radiopharmaceuticals.
2011 Dec; 26(6):737-43. doi:
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Medical oncology (Northwood, London, England).
2011 Dec; 28 Suppl 1(?):S690-6. doi:
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Dento maxillo facial radiology.
2011 Jul; 40(5):310-4. doi:
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American journal of clinical oncology.
2011 Jun; 34(3):281-5. doi:
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Analytical chemistry.
2011 Apr; 83(7):2438-44. doi:
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In vivo (Athens, Greece).
2011 Jan; 25(1):77-85. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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The Journal of pharmacy and pharmacology.
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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Cancer.
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Journal of cardiothoracic surgery.
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Shock (Augusta, Ga.).
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Clinical and experimental pharmacology & physiology.
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Acta medica Okayama.
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International journal of radiation oncology, biology, physics.
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Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
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Pediatric nephrology (Berlin, Germany).
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Journal of pediatric hematology/oncology.
2008 Mar; 30(3):204-9. doi:
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Cancer letters.
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Experimental biology and medicine (Maywood, N.J.).
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Pediatric hematology and oncology.
2007 Sep; 24(6):403-8. doi:
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Colloids and surfaces. B, Biointerfaces.
2007 Jul; 58(1):39-43. doi:
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International journal of toxicology.
2007 Jul; 26(4):315-23. doi:
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European journal of nuclear medicine and molecular imaging.
2007 May; 34(5):763-771. doi:
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Pediatric nephrology (Berlin, Germany).
2007 Mar; 22(3):358-65. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2007 Mar; 3(1):1-6. doi:
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Current opinion in oncology.
2006 May; 18(3):266-70. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2006 Apr; 44(4):517-21. doi:
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Advances in therapy.
2006 Mar; 23(2):332-41. doi:
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Zhonghua zhong liu za zhi [Chinese journal of oncology].
2006 Jan; 28(1):8-12. doi:
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The Tohoku journal of experimental medicine.
2005 Dec; 207(4):249-53. doi:
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Cancer.
2005 Oct; 104(7):1418-27. doi:
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Basic & clinical pharmacology & toxicology.
2005 Sep; 97(3):168-73. doi:
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Pediatric hematology and oncology.
2005 Jul; 22(5):441-5. doi:
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Chemotherapy.
2005 Jul; 51(4):200-5. doi:
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Life sciences.
2005 Mar; 76(16):1825-34. doi:
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International journal of radiation oncology, biology, physics.
2005 Mar; 61(3):901-7. doi:
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Clinical toxicology (Philadelphia, Pa.).
2005; 43(4):261-7. doi:
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Pediatric blood & cancer.
2004 Dec; 43(7):780-4. doi:
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The journal of supportive oncology.
2004 Nov; 2(6 Suppl 3):13-7. doi:
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The Laryngoscope.
2004 Sep; 114(9):1660-7. doi:
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International journal of radiation oncology, biology, physics.
2004 Jul; 59(4):1148-56. doi:
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Bone marrow transplantation.
2004 Jul; 34(1):51-6. doi:
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Bone marrow transplantation.
2004 Apr; 33(8):793-8. doi:
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International journal of radiation oncology, biology, physics.
2004 Mar; 58(4):1228-34. doi:
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Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
2004 Feb; 180(2):109-16. doi:
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Cancer chemotherapy and pharmacology.
2004 Jan; 53(1):8-14. doi:
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Oncology.
2004; 67(3-4):187-93. doi:
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Seminars in oncology.
2003 Dec; 30(6 Suppl 18):31-9. doi:
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Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.
2003 Nov; 7 Suppl 1(?):49s-54s. doi:
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Medical and pediatric oncology.
2003 Sep; 41(3):186-9. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2003 Aug; 17(4):397-402. doi:
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Pediatric hematology and oncology.
2003 Apr; 20(3):253-6. doi:
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Journal of radiation research.
2003 Mar; 44(1):59-67. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Feb; 9(2):703-10. doi:
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Medical oncology (Northwood, London, England).
2003; 20(2):169-74. doi:
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Seminars in oncology.
2002 Dec; 29(6 Suppl 19):22-8. doi:
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Seminars in oncology.
2002 Dec; 29(6 Suppl 19):2-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2002 Dec; 30(12):1425-30. doi:
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Experimental lung research.
2002 Oct; 28(7):577-90. doi:
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