Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) (BioDeep_00000817387)
代谢物信息卡片
N-(1-{[1-({[1-(1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid
化学式: C40H55N7O11S (841.368)
中文名称: Senktide
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O
InChI: InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)
描述信息
Senktide is a tachykinin NK3 receptor agonist.
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代谢反应
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
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文献列表
- Rebecka Amodei, Kyle Gribbin, Wen He, Isa Lindgren, Keely R Corder, Sonnet S Jonker, Charles T Estill, Lique M Coolen, Michael N Lehman, William Whitler, Fred Stormshak, Charles E Roselli. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep.
Endocrinology.
2020 04; 161(4):. doi:
10.1210/endocr/bqaa013. [PMID: 32005991] - Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara. Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents.
Endocrine journal.
2018 Apr; 65(4):485-492. doi:
10.1507/endocrj.ej17-0136. [PMID: 29479004] - Ryosuke Misu, Shinya Oishi, Ai Yamada, Takashi Yamamura, Fuko Matsuda, Koki Yamamoto, Taro Noguchi, Hiroaki Ohno, Hiroaki Okamura, Satoshi Ohkura, Nobutaka Fujii. Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.
Journal of medicinal chemistry.
2014 Oct; 57(20):8646-51. doi:
10.1021/jm500771w. [PMID: 25247671] - F Ruiz-Pino, V M Navarro, A H Bentsen, D Garcia-Galiano, M A Sanchez-Garrido, P Ciofi, R A Steiner, J D Mikkelsen, L Pinilla, M Tena-Sempere. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.
Endocrinology.
2012 Oct; 153(10):4818-29. doi:
10.1210/en.2012-1287. [PMID: 22822161] - D P Poole, S Amadesi, E Rozengurt, M Thacker, N W Bunnett, J B Furness. Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.
American journal of physiology. Gastrointestinal and liver physiology.
2008 May; 294(5):G1245-56. doi:
10.1152/ajpgi.00521.2007. [PMID: 18308856] - Daniel P Poole, Hayato Matsuyama, Trung V Nguyen, Emily M Y Eriksson, Christopher J Fowler, John B Furness. Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.
Gastroenterology.
2007 Oct; 133(4):1229-39. doi:
10.1053/j.gastro.2007.07.002. [PMID: 17765238] - Tatiana Sandoval-Guzmán, Naomi E Rance. Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus.
Brain research.
2004 Nov; 1026(2):307-12. doi:
10.1016/j.brainres.2004.08.026. [PMID: 15488494] - Steven L Bealer, Francis W Flynn. Central neurokinin 3 receptors increase systemic oxytocin release: interaction with norepinephrine.
Experimental neurology.
2003 Dec; 184(2):1027-33. doi:
10.1016/j.expneurol.2003.08.012. [PMID: 14769397] - Douglas W P Hay, Giuseppe A M Giardina, Don E Griswold, David C Underwood, Charles J Kotzer, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J Foley, Dulcie B Schmidt, Lenox D Martin, David Kilian, Jeffrey J Legos, Frank C Barone, Mark A Luttmann, Mario Grugni, Luca F Raveglia, Henry M Sarau. Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
The Journal of pharmacology and experimental therapeutics.
2002 Jan; 300(1):314-23. doi:
10.1124/jpet.300.1.314. [PMID: 11752131] - W L Rumsey, D Aharony, R A Bialecki, B M Abbott, H G Barthlow, R Caccese, S Ghanekar, D Lengel, M McCarthy, B Wenrich, B Undem, C Ohnmacht, A Shenvi, J S Albert, F Brown, P R Bernstein, K Russell. Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
The Journal of pharmacology and experimental therapeutics.
2001 Jul; 298(1):307-15. doi:
NULL. [PMID: 11408556] - H M Sarau, D E Griswold, B Bush, W Potts, P Sandhu, D Lundberg, J J Foley, D B Schmidt, E F Webb, L D Martin, J J Legos, R G Whitmore, F C Barone, A D Medhurst, M A Luttmann, G A Giardina, D W Hay. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
2000 Oct; 295(1):373-81. doi:
NULL. [PMID: 10992004] - F Y Chang, S D Lee, G H Yeh, P S Wang. Rat gastrointestinal motor responses mediated via activation of neurokinin receptors.
Journal of gastroenterology and hepatology.
1999 Jan; 14(1):39-45. doi:
10.1046/j.1440-1746.1999.01808.x. [PMID: 10029276] - G A Sarosi, B C Kimball, D C Barnhart, W Zhang, M W Mulholland. Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons.
Peptides.
1998; 19(1):75-84. doi:
10.1016/s0196-9781(97)00271-4. [PMID: 9437739] - T Eguchi, Y Takano, T Hatae, R Saito, Y Nakayama, Y Shigeyoshi, H Okamura, J E Krause, H Kamiya. Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus.
Brain research.
1996 Dec; 743(1-2):49-55. doi:
10.1016/s0006-8993(96)01020-7. [PMID: 9017229] - A Saigo, Y Takano, T Matsumoto, M Tran, Y Nakayama, R Saito, K Yamada, H Kamiya. Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats.
Neuroscience letters.
1993 Sep; 159(1-2):187-90. doi:
10.1016/0304-3940(93)90830-e. [PMID: 7505413] - R M Hagan, S J Ireland, C C Jordan, I J Beresford, M J Deal, P Ward. Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
Neuropeptides.
1991 Jun; 19(2):127-35. doi:
10.1016/0143-4179(91)90142-6. [PMID: 1719445] - J M Paris, H Mitsushio, S A Lorens. Intra-midbrain raphe injections of the neurokinin-3 agonist senktide inhibit food and water intake in the rat.
Pharmacology, biochemistry, and behavior.
1991 Jan; 38(1):223-6. doi:
10.1016/0091-3057(91)90616-a. [PMID: 1708148] - Y Takano, A Nagashima, T Hagio, K Tateishi, H Kamiya. Role of central tachykinin peptides in cardiovascular regulation in rats.
Brain research.
1990 Oct; 528(2):231-7. doi:
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