Saralasin (BioDeep_00000817377)
代谢物信息卡片
(Sar1,Val5,Ala8)-Angiotensin II
化学式: C42H65N13O10 (911.4977110000001)
中文名称: 沙拉新
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
InChI: InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1
描述信息
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135894
- PubChem: 6324663
- DrugBank: DB06763
- ChEMBL: CHEMBL938
- MeSH: Saralasin
- CAS: 34273-10-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiandong Zhang, Jie Wu, Chunyan Gu, Nancy A Noble, Wayne A Border, Yufeng Huang. Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-β1 and PAI-1 expression in renal mesangial cells.
American journal of physiology. Renal physiology.
2012 Jul; 303(1):F11-20. doi:
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BMC gastroenterology.
2012 Mar; 12(?):26. doi:
10.1186/1471-230x-12-26. [PMID: 22453061] - Tony B Xu, Gabriela A Eppel, Geoffrey A Head, Roger G Evans. Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits.
Frontiers in physiology.
2011; 2(?):40. doi:
10.3389/fphys.2011.00040. [PMID: 21811470] - Melpomeni Peppa, Maria Krania, Sotirios A Raptis. Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review.
Integrated blood pressure control.
2011; 4(?):7-16. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2011; 28(3):513-20. doi:
10.1159/000335112. [PMID: 22116365] - Emma Felixsson, Ingrid A-L Persson, Andreas C Eriksson, Karin Persson. Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.
Phytotherapy research : PTR.
2010 Sep; 24(9):1297-301. doi:
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Heart rhythm.
2010 Jul; 7(7):964-70. doi:
10.1016/j.hrthm.2010.03.024. [PMID: 20346417] - Maria V Varoni, Domenico Palomba, Nicolò P Macciotta, Elisabetta Antuofermo, Graziella Deiana, Elena Baralla, Vittorio Anania, Maria P Demontis. Brain renin-angiotensin system modifies the blood pressure response to intracerebroventricular cadmium in rats.
Drug and chemical toxicology.
2010 Jul; 33(3):302-9. doi:
10.3109/01480540903418496. [PMID: 20429803] - Jai-Nien Tung, Yaw-Dong Lang, Leng-Fang Wang, Chung-Ming Chen. Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts.
Toxicology in vitro : an international journal published in association with BIBRA.
2010 Apr; 24(3):803-8. doi:
10.1016/j.tiv.2009.12.015. [PMID: 20035857] - Elisa Acosta, Oscar Peña, Frederick Naftolin, Julio Avila, Angela Palumbo. Angiotensin II induces apoptosis in human mural granulosa-lutein cells, but not in cumulus cells.
Fertility and sterility.
2009 May; 91(5 Suppl):1984-9. doi:
10.1016/j.fertnstert.2008.04.026. [PMID: 18684452] - Jiandong Zhang, Nancy A Noble, Wayne A Border, Rick T Owens, Yufeng Huang. Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells.
American journal of physiology. Endocrinology and metabolism.
2008 Oct; 295(4):E810-9. doi:
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2008 Aug; 146(2):172-5. doi:
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2008 Jun; 78(6):361-8. doi:
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Advances in urology.
2008; ?(?):102461. doi:
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Vascular health and risk management.
2008; 4(3):597-604. doi:
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2007 Dec; 41(6):465-75. doi:
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Metabolism: clinical and experimental.
2007 Oct; 56(10):1372-6. doi:
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Veterinary research communications.
2007 Aug; 31 Suppl 1(?):343-6. doi:
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American journal of physiology. Renal physiology.
2007 Jul; 293(1):F110-20. doi:
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Current pharmaceutical design.
2007; 13(12):1247-56. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2005 Jun; 28(6):545-52. doi:
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Critical care (London, England).
2004 Aug; 8(4):R163-71. doi:
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Nephron. Experimental nephrology.
2004; 96(1):e23-30. doi:
10.1159/000075573. [PMID: 14752245] - Wilson Abrão Saad, Luiz Antonio de Arruda Camargo. Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area.
Arquivos brasileiros de cardiologia.
2003 Apr; 80(4):396-405. doi:
10.1590/s0066-782x2003000400004. [PMID: 12754560] - Paul Chan, Kar-Lok Wong, I-Min Liu, Thing-Fong Tzeng, Tzu-Lin Yang, Juei-Tang Cheng. Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats.
Journal of hypertension.
2003 Apr; 21(4):761-9. doi:
10.1097/00004872-200304000-00020. [PMID: 12658023] - Siu Po Ip, Siu Wai Tsang, Tung Po Wong, Chun Tao Che, Po Sing Leung. Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis.
Pancreas.
2003 Apr; 26(3):224-9. doi:
10.1097/00006676-200304000-00003. [PMID: 12657946] - Siu Wai Tsang, Siu Po Ip, Tung Po Wong, Chun Tao Che, Po Sing Leung. Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis.
Regulatory peptides.
2003 Mar; 111(1-3):47-53. doi:
10.1016/s0167-0115(02)00226-4. [PMID: 12609748] - Brian C Wilkes, Laurent Masaro, Peter W Schiller, Katharine A Carpenter. Angiotensin II vs its type I antagonists: conformational requirements for receptor binding assessed from NMR spectroscopic and receptor docking experiments.
Journal of medicinal chemistry.
2002 Sep; 45(20):4410-8. doi:
10.1021/jm0103155. [PMID: 12238921] - Jippe C Balt, Marie-Jeanne Mathy, Alex Nap, Martin Pfaffendorf, Pieter A van Zwieten. Involvement of the AT(2)-receptor in angiotensin II-induced facilitation of sympathetic neurotransmission.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2002 Sep; 3(3):181-7. doi:
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Regulatory peptides.
2002 Jan; 103(1):17-22. doi:
10.1016/s0167-0115(01)00322-6. [PMID: 11738244] - Magdalena Golos, Barbara Lewko, Ewa Bryl, Jacek M Witkowski, Anna Dubaniewicz, Agnieszka Olszewska, Elzbieta Latawiec, Stefan Angielski, Jan Stepinski. Effect of angiotensin II on ANP-dependent guanylyl cyclase activity in cultured mouse and rat podocytes.
Kidney & blood pressure research.
2002; 25(5):296-302. doi:
10.1159/000066790. [PMID: 12435875] - H Licea, Marian R Walters, L Gabriel Navar. Renal nuclear angiotensin II receptors in normal and hypertensive rats.
Acta physiologica Hungarica.
2002; 89(4):427-38. doi:
10.1556/aphysiol.89.2002.4.3. [PMID: 12489752] - Bozena Badzyńska, Monika Grzelec-Mojzesowicz, Leszek Dobrowolski, Janusz Sadowski. Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats.
The Journal of physiology.
2002 Jan; 538(Pt 1):159-66. doi:
10.1113/jphysiol.2001.012921. [PMID: 11773324] - M A El-Haddad, C R Chao, A A Sayed, H El-Haddad, M G Ross. Effects of central angiotensin II receptor antagonism on fetal swallowing and cardiovascular activity.
American journal of obstetrics and gynecology.
2001 Oct; 185(4):828-33. doi:
10.1067/mob.2001.117310. [PMID: 11641660] - L Lin, Y F Zheng, J H Qu, G H Bao. [The cellular mechanism of angiotensin II inhibition on BKCa of ECV304 cell and the protective effect of gingko leaf extract].
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2001 Oct; 23(5):467-71. doi:
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Canadian journal of physiology and pharmacology.
2001 Sep; 79(9):825-30. doi:
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Canadian journal of physiology and pharmacology.
2001 Sep; 79(9):768-78. doi:
10.1139/y01-056. [PMID: 11599777] - N L Wong, J K Tsui. Angiotensin regulates endothelin-B receptor in rat inner medullary collecting duct.
Metabolism: clinical and experimental.
2001 Jun; 50(6):661-6. doi:
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Journal of cellular physiology.
2000 Nov; 185(2):253-9. doi:
10.1002/1097-4652(200011)185:2<253::aid-jcp10>3.0.co;2-#. [PMID: 11025447] - J Ibrahim, A D Hughes, P S Sever. Action of angiotensin II on DNA synthesis by human saphenous vein in organ culture.
Hypertension (Dallas, Tex. : 1979).
2000 Nov; 36(5):917-21. doi:
10.1161/01.hyp.36.5.917. [PMID: 11082167] - L A de Arruda Camargo, W A Saad. Renal effects of angiotensin II receptor subtype 1 and 2-selective ligands injected into the paraventricular nucleus of conscious rats.
Regulatory peptides.
1999 Oct; 84(1-3):91-6. doi:
10.1016/s0167-0115(99)00075-0. [PMID: 10535413] - L M Smith, M Ikegami, G C Calvario, J Surdilla, M G Ervin. Renal responses to angiotensin II receptor blockade in ventilated preterm newborn lambs.
Reproduction, fertility, and development.
1999; 11(7-8):419-24. doi:
10.1071/rd00009. [PMID: 11101278] - S J Heitman, D B Jennings. Angiotensin II modulates respiratory and acid-base responses to prolonged hypoxia in conscious dogs.
The American journal of physiology.
1998 08; 275(2):R390-9. doi:
10.1152/ajpregu.1998.275.2.r390. [PMID: 9688673] - J J Cui. [Involvement of habenula nucleus in the pathogenesis of stress induced hypertension and the underlying mechanisms].
Sheng li ke xue jin zhan [Progress in physiology].
1998 Jul; 29(3):231-4. doi:
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Journal of hypertension.
1998 Mar; 16(3):311-20. doi:
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Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1998 Mar; 19(2):136-40. doi:
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The Journal of clinical investigation.
1998 Feb; 101(4):755-60. doi:
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Pediatrics.
1998 Jan; 101(1 Pt 1):48-56. doi:
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1998; 192(4):607-18. doi:
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Journal of reproduction and fertility.
1997 Sep; 111(1):71-9. doi:
10.1530/jrf.0.1110071. [PMID: 9370970] - Y Sahin, O Kontaş, I I Müderris, M Cankurtaran. Effects of angiotensin converting enzyme inhibitor cilazapril and angiotensin II antagonist saralasin in ovarian hyperstimulation syndrome in the rabbit.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
1997 Aug; 11(4):231-6. doi:
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Genes and function.
1997 Jun; 1(3):215-26. doi:
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The American journal of physiology.
1997 Jan; 272(1 Pt 2):R26-33. doi:
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General and comparative endocrinology.
1997 Jan; 105(1):18-30. doi:
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1997 Jan; 29(1 Pt 2):401-7. doi:
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General and comparative endocrinology.
1993 Oct; 92(1):123-31. doi:
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
1993 Sep; 12(5):851-5. doi:
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The American journal of physiology.
1993 Aug; 265(2 Pt 2):F195-203. doi:
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Brain research.
1993 Jun; 614(1-2):1-9. doi:
10.1016/0006-8993(93)91010-p. [PMID: 8348307] - Z A Abassi, H Klein, E Golomb, H R Keiser. Regulation of the urinary excretion of endothelin in the rat.
American journal of hypertension.
1993 Jun; 6(6 Pt 1):453-7. doi:
10.1093/ajh/6.6.453. [PMID: 8343226] - H G Cryer, I T Bloom, L S Unger, R N Garrison. Factors affecting renal microvascular blood flow in rat hyperdynamic bacteremia.
The American journal of physiology.
1993 Jun; 264(6 Pt 2):H1988-97. doi:
10.1152/ajpheart.1993.264.6.h1988. [PMID: 8322929] - P Dagenais, E Escher. Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model.
Regulatory peptides.
1993 Mar; 44(2):239-47. doi:
10.1016/0167-0115(93)90248-7. [PMID: 8385792] - D T Dudley, R M Summerfelt. Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells.
Regulatory peptides.
1993 Mar; 44(2):199-206. doi:
10.1016/0167-0115(93)90243-2. [PMID: 8469774] - R C Vari, F G Boineau, J E Lewy. Angiotensin or thromboxane receptor antagonism in rats with congenital hydronephrosis.
Journal of the American Society of Nephrology : JASN.
1993 Feb; 3(8):1522-9. doi:
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Advances in nephrology from the Necker Hospital.
1993; 22(?):305-27. doi:
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Experimental and clinical endocrinology.
1993; 101(6):350-5. doi:
10.1055/s-0029-1211256. [PMID: 8157090] - C M Peterson, C Zhu, T Mukaida, T A Butler, J F Woessner, W J LeMaire. The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary.
American journal of obstetrics and gynecology.
1993 Jan; 168(1 Pt 1):242-5. doi:
10.1016/s0002-9378(12)90920-5. [PMID: 8420334] - M Levy, P Cernacek. Modification of the renal response to endopeptidase inhibition and atrial natriuretic peptide infusion in normal dogs.
Canadian journal of physiology and pharmacology.
1992 Dec; 70(12):1563-70. doi:
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The American journal of physiology.
1992 Oct; 263(4 Pt 2):R756-61. doi:
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Clinical science (London, England : 1979).
1992 Oct; 83(4):477-82. doi:
10.1042/cs0830477. [PMID: 1385031] - W Robberecht, M Andries, C Denef. Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release.
Neuroendocrinology.
1992 Oct; 56(4):550-60. doi:
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The American journal of physiology.
1992 Oct; 263(4 Pt 2):R762-9. doi:
10.1152/ajpregu.1992.263.4.r762. [PMID: 1329565] - J A Keiser, F A Bjork, J C Hodges, D G Taylor. Renal hemodynamic and excretory responses to PD 123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands.
The Journal of pharmacology and experimental therapeutics.
1992 Sep; 262(3):1154-60. doi:
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Neuroendocrinology.
1992 Aug; 56(2):185-94. doi:
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European journal of clinical investigation.
1992 Aug; 22(8):516-22. doi:
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Kidney international.
1992 Aug; 42(2):417-23. doi:
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The Journal of clinical investigation.
1992 Aug; 90(2):604-11. doi:
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General pharmacology.
1992 Jul; 23(4):595-9. doi:
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Journal of developmental physiology.
1992 Jul; 18(1):25-33. doi:
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Hypertension (Dallas, Tex. : 1979).
1992 Jun; 19(6 Pt 1):575-81. doi:
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The Journal of clinical investigation.
1992 May; 89(5):1636-42. doi:
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The Journal of clinical investigation.
1992 Apr; 89(4):1248-56. doi:
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The Journal of clinical investigation.
1992 Mar; 89(3):925-31. doi:
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