Isoxazole (BioDeep_00000816781)
Volatile Flavor Compounds
代谢物信息卡片
Isoxazole
化学式: C3H3NO (69.0214628)
中文名称: 异噁唑, 异恶唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CON=C1
InChI: InChI=1S/C3H3NO/c1-2-4-5-3-1/h1-3H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- G N Yatoo, Basharat A Bhat, Zubaid-Ul-Khazir, Mohammad Asif, Sajad A Bhat, Farhana Gulzar, Fehmida Rashied, Abdul Haleem Wani, Ishfaq Ahmed, Sajad Majeed Zargar, Mushtaq A Mir, Javid A Banday. Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer.
Fitoterapia.
2024 Jun; 175(?):105927. doi:
10.1016/j.fitote.2024.105927. [PMID: 38548028] - Kotaro Takano, Scott Carver, Yolandi Vermaak, Katja Fischer, Robert J Harvey, Kate E Mounsey. Assessment of the in vitro acaricidal activity of Bravecto® (fluralaner) and a proposed orange oil-based formulation vehicle for the treatment of Sarcoptes scabiei.
Parasites & vectors.
2024 Apr; 17(1):194. doi:
10.1186/s13071-024-06275-9. [PMID: 38664829] - Dan Yan, Yueying Yang, Hanxiao Shen, Zhen Liu, Kun Yao, Qing Liu. 3D-QSAR and Molecular Dynamics Study of Isoxazole Derivatives to Identify the Structural Requirements for Farnesoid X Receptor (FXR) Agonists.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061210. [PMID: 38542850] - Harish Kumar Shah, Vaishnavi Srinivasan, Shakila Venkatesan, Vijayakumar Balakrishnan, Sadanandane Candasamy, Nisha Mathew, Ashwani Kumar, Vijesh Sreedhar Kuttiatt. Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control.
Scientific reports.
2024 03; 14(1):5628. doi:
10.1038/s41598-024-56053-x. [PMID: 38454095] - Leyi Shao, Wei Wang, Xin Gong, Yinghao Yu, Junao Xue, Xinnian Zeng, Jiali Liu. The Toxicity Differences of Fluralaner against the Red Imported Fire Ant (Solenopsis invicta) at Different Developmental Stages.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
10.3390/ijms242115627. [PMID: 37958611] - Maria A González-Morales, Andrea E Thomson, James Yeatts, Hiroko Enomoto, Ahmed Haija, Richard G Santangelo, Olivia A Petritz, Rocio Crespo, Coby Schal, Ronald Baynes. Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities.
Parasites & vectors.
2023 Sep; 16(1):333. doi:
10.1186/s13071-023-05962-3. [PMID: 37735689] - Le Chen, Baixin Sun, Yang Zhao, Ze-Yan Miao. Molecular Mechanisms and Biological Characteristics of Botrytis cinerea Field Isolate Resistance to Pyrisoxazole in Liaoning Province.
Plant disease.
2023 Sep; ?(?):. doi:
10.1094/pdis-04-23-0743-re. [PMID: 37682225] - Guangzheng Tian, Mingtong Ji, Fan Wu, Guan Wang, Changwu Zheng, Xiaoyu Wu. Copper-Catalyzed Asymmetric Propargylic Substitution of 2,2,2-Trifluoroethyl-isoxazoles with Propargylic Alcohol Derivatives.
Organic letters.
2023 Jun; 25(25):4666-4671. doi:
10.1021/acs.orglett.3c01521. [PMID: 37345932] - Evgeniy V Kondrashov, Lyudmila A Belovezhets, Nina S Shatokhina, Alexandra N Shilova, Yana A Kostyro, Yulia A Markova, Marina K Borovskaya, Gennadii B Borovskii. Design of novel water-soluble isoxazole-based antimicrobial agents and evaluation of their cytotoxicity and acute toxicity.
Bioorganic chemistry.
2023 Jun; 138(?):106644. doi:
10.1016/j.bioorg.2023.106644. [PMID: 37302315] - Dongchen Yang, Yan-En Wang, Miaomiao Chen, Haiyan Liu, Jingqian Huo, Jinlin Zhang. Discovery of Bis-5-cyclopropylisoxazole-4-carboxamides as Novel Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.
Journal of agricultural and food chemistry.
2023 Apr; 71(13):5136-5142. doi:
10.1021/acs.jafc.2c08912. [PMID: 36972477] - Jing Jing Zhang, Yujia Niu, Cong Ma, Te Zhao, Hongwei Wang, Zishuo Yan, Lin Zhou, Xiangyang Liu, Fengzhi Piao, Nanshan Du. Accumulation and metabolism of pyroxasulfone in tomato seedlings.
Ecotoxicology and environmental safety.
2023 Apr; 254(?):114765. doi:
10.1016/j.ecoenv.2023.114765. [PMID: 36907092] - María Salomé Gastaldi, Iván Felsztyna, Virginia Miguel, Mariela E Sánchez-Borzone, Daniel A García. Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes.
Journal of agricultural and food chemistry.
2023 Feb; 71(4):2134-2142. doi:
10.1021/acs.jafc.2c06811. [PMID: 36688903] - Emily Puumala, Olga Zaslaver, Amy Chen, Dustin Duncan, Meea Fogal, Rebecca S Shapiro, Mohammad T Mazhab-Jafari, Luke Whitesell, J Rafael Montenegro-Burke, Nicole Robbins, Leah E Cowen. The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis.
mBio.
2022 12; 13(6):e0273022. doi:
10.1128/mbio.02730-22. [PMID: 36300931] - Yuxuan Zhuang, Colleen M Noviello, Ryan E Hibbs, Rebecca J Howard, Erik Lindahl. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators.
Proceedings of the National Academy of Sciences of the United States of America.
2022 10; 119(43):e2208081119. doi:
10.1073/pnas.2208081119. [PMID: 36251999] - Qiuhui Wang, Haocheng Wang, Yingxin Zhang, Jing Chen, Archana Upadhyay, Biswajit Bhowmick, Jiayu Hang, Shaoying Wu, Chenghong Liao, Qian Han. Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti.
Pest management science.
2022 Oct; 78(10):4173-4182. doi:
10.1002/ps.7035. [PMID: 35690922] - Ting Xiong, Si-Quan Ling, Jia-Li Liu, Xin-Nian Zeng. Insecticidal and P450 mediate metabolism of fluralaner against red imported fire ant, Solenopsis invicta (Hymenoptera: Formicidae).
Pesticide biochemistry and physiology.
2022 Oct; 187(?):105184. doi:
10.1016/j.pestbp.2022.105184. [PMID: 36127046] - Sidra Razzaq, Amber Mahmood Minhas, Neelum Gul Qazi, Humaira Nadeem, Arif-Ullah Khan, Fawad Ali, Syed Shams Ul Hassan, Simona Bungau. Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H+/K+-ATPase Pump, Oxidative Stress and Inflammatory Pathways.
Molecules (Basel, Switzerland).
2022 Aug; 27(16):. doi:
10.3390/molecules27165065. [PMID: 36014311] - Vishal Kumar Gupta, Ajay Kumar. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response.
Apoptosis : an international journal on programmed cell death.
2022 06; 27(5-6):382-400. doi:
10.1007/s10495-022-01723-2. [PMID: 35366141] - Nan Xu, Ke Pang, Sihua Qi, Hongmei Wang. Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis.
BMC anesthesiology.
2022 05; 22(1):155. doi:
10.1186/s12871-022-01688-4. [PMID: 35596129] - Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang. Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor.
ACS infectious diseases.
2022 05; 8(5):1022-1030. doi:
10.1021/acsinfecdis.1c00629. [PMID: 35404564] - Seung Yeon Park, Wonjun Cho, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung. Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress.
Biochemical pharmacology.
2022 05; 199(?):115022. doi:
10.1016/j.bcp.2022.115022. [PMID: 35358477] - Yuanyuan Guo, Bin Wu, Qibin Chen, Su Min. Parecoxib ameliorates renal toxicity and injury in sepsis-induced mouse model and LPS-induced HK-2 cells.
Drug development research.
2022 May; 83(3):659-668. doi:
10.1002/ddr.21897. [PMID: 34813666] - Dwayne R J Moore, Colleen D Priest, Ben H Brayden, John P Hanzas, Meghan R Arpino, Leif Richardson, Jody Stryker, Chris Banman, Sara I Rodney, Andrew Chapple, Tilghman Hall, Rena Isemer, Lisa Ortego, Ismael Rodea-Palomares, Jane Tang, Mengyuan Wang, Tianbo Xu, Yaning Yang. A field spray drift study to determine the downwind effects of isoxaflutole herbicide to nontarget plants.
Integrated environmental assessment and management.
2022 May; 18(3):757-769. doi:
10.1002/ieam.4508. [PMID: 34383375] - Jin Chen, Jessie Gu, Bharti Shah, Rowan Stringer, Leonel Reis da Silva Torrao, Melissa Hackling, Prasanna Kumar Nidamarthy, William T Prince, Ralph Woessner. Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment.
Journal of clinical pharmacology.
2022 04; 62(4):520-531. doi:
10.1002/jcph.1996. [PMID: 34738233] - Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito. Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 04; 36(4):e22236. doi:
10.1096/fj.202101678r. [PMID: 35218596] - Xian-Zhang Liao, Man Liu, Lin Dong. An Approach to Vinylidenequinazolines from Isoxazoles and Dioxazolones.
The Journal of organic chemistry.
2022 03; 87(5):3741-3750. doi:
10.1021/acs.joc.1c02746. [PMID: 35089015] - Teruhisa Manome, Yasumasa Hara, Firoj Ahmed, Samir K Sadhu, Masami Ishibashi. Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica.
Journal of natural medicines.
2022 Mar; 76(2):482-489. doi:
10.1007/s11418-021-01593-z. [PMID: 35040087] - Agnieszka Pyrczak-Felczykowska, Tristan A Reekie, Marcin Jąkalski, Aleksandra Hać, Marcelina Malinowska, Anna Pawlik, Kamil Ryś, Beata Guzow-Krzemińska, Anna Herman-Antosiewicz. The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death.
International journal of molecular sciences.
2022 Feb; 23(3):. doi:
10.3390/ijms23031802. [PMID: 35163724] - Fabian Szepanowski, Maximilian Winkelhausen, Rebecca D Steubing, Anne K Mausberg, Christoph Kleinschnitz, Mark Stettner. LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis.
Journal of neuroinflammation.
2021 Dec; 18(1):293. doi:
10.1186/s12974-021-02350-5. [PMID: 34920725] - Surabhi Talele, Wenjuan Zhang, Danielle M Burgenske, Minjee Kim, Afroz S Mohammad, Sonja Dragojevic, Shiv K Gupta, Ranjit S Bindra, Jann N Sarkaria, William F Elmquist. Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma.
The Journal of pharmacology and experimental therapeutics.
2021 12; 379(3):343-357. doi:
10.1124/jpet.121.000845. [PMID: 34556535] - Mei Li, Zhi Zheng. Protective effect of parecoxib sodium against ischemia reperfusion‑induced intestinal injury.
Molecular medicine reports.
2021 Nov; 24(5):. doi:
10.3892/mmr.2021.12416. [PMID: 34498709] - Amr El-Demerdash, Afnan Hassan, Tarek Mohamed Abd El-Aziz, James D Stockand, Reem K Arafa. Marine Brominated Tyrosine Alkaloids as Promising Inhibitors of SARS-CoV-2.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206171. [PMID: 34684755] - Faisal K Algethami, Maher Cherif, Salma Jlizi, Naoufel Ben Hamadi, Anis Romdhane, Mohamed R Elamin, Mashael A Alghamdi, Hichem Ben Jannet. Design, Microwave-Assisted Synthesis and In Silico Prediction Study of Novel Isoxazole Linked Pyranopyrimidinone Conjugates as New Targets for Searching Potential Anti-SARS-CoV-2 Agents.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206103. [PMID: 34684683] - Nikhil Baliram Gaikwad, Sapana Bansod, Alekhya Mara, Ramana Garise, Nanduri Srinivas, Chandraiah Godugu, Venkata Madhavi Yaddanapudi. Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo[5,4-d]pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents.
Bioorganic & medicinal chemistry letters.
2021 10; 49(?):128294. doi:
10.1016/j.bmcl.2021.128294. [PMID: 34333139] - Xingdong Lin, Yan Li, Weiqiang Zhong, Tian Hong, Lihuang Li, Shaoyun Song, Daohang He. Synthesis, Bioactivity, and QSAR Study of 3,4-Dichlorophenyl Isoxazole-Substituted Stilbene Derivatives against the Phytopathogenic Fungus Botrytis cinerea.
Journal of agricultural and food chemistry.
2021 Aug; 69(33):9520-9528. doi:
10.1021/acs.jafc.1c01816. [PMID: 34382783] - Yong-Zhong Tang, Pingping Zeng, Yan Liao, Zheng Qin, Hao Zhang, Bo Li, Wen Ouyang, Dan Li. Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing non-cardiac surgery: a retrospective cohort analysis.
BMJ open.
2021 08; 11(8):e047840. doi:
10.1136/bmjopen-2020-047840. [PMID: 34433595] - Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Shi. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.
Neuropharmacology.
2021 08; 194(?):108627. doi:
10.1016/j.neuropharm.2021.108627. [PMID: 34089729] - Przemysław J Danek, Wojciech Kuban, Władysława A Daniel. The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168447. [PMID: 34445153] - Alex Zaufel, Sandra M W van de Wiel, Lu Yin, Günter Fauler, Daphne Chien, Xinzhong Dong, John F Gilmer, Jennifer K Truong, Paul A Dawson, Stan F J van de Graaf, Peter Fickert, Tarek Moustafa. Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Biochimica et biophysica acta. Molecular basis of disease.
2021 08; 1867(8):166153. doi:
10.1016/j.bbadis.2021.166153. [PMID: 33895309] - Hui Xu, Kong Zhang, Min Lv, Meng Hao. Construction of Cholesterol Oxime Ether Derivatives Containing Isoxazoline/Isoxazole Fragments and Their Agricultural Bioactive Properties/Control Efficiency.
Journal of agricultural and food chemistry.
2021 Jul; 69(29):8098-8109. doi:
10.1021/acs.jafc.1c01884. [PMID: 34278787] - Yu-Chen Wang, Wei-Zhong Yu. [Prospective study on the effect of parecoxib sodium analgesia on pain and stress response after surgery in elderly patients with hip fracture].
Zhongguo gu shang = China journal of orthopaedics and traumatology.
2021 Jul; 34(7):612-6. doi:
10.12200/j.issn.1003-0034.2021.07.005. [PMID: 34318635] - Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Jessie Gu, Elizabeth McNamara, Markus Walles, Ralph Woessner, Gian Camenisch, Heidi J Einolf, Jin Chen. Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2021 07; 49(7):548-562. doi:
10.1124/dmd.120.000349. [PMID: 33952610] - Yanyan Liu, Yanna Liu, Qiaofang Wang, Yaodong Song, Sanyang Chen, Bo Cheng, Yan Zhang, Zongchao Cui, Zhongwei Wu, Changju Zhu. MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.
International immunopharmacology.
2021 Jul; 96(?):107555. doi:
10.1016/j.intimp.2021.107555. [PMID: 33823428] - Yang Liu, Yongtao Xiao, Shanshan Chen, Xinbei Tian, Weipeng Wang, Ying Wang, Wei Cai. The Farnesoid X Receptor Agonist Tropifexor Prevents Liver Damage in Parenteral Nutrition-fed Neonatal Piglets.
Journal of pediatric gastroenterology and nutrition.
2021 07; 73(1):e11-e19. doi:
10.1097/mpg.0000000000003135. [PMID: 33783400] - Bochra Tourki, Laurence M Black, Vasundhara Kain, Ganesh V Halade. Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111574. doi:
10.1016/j.biopha.2021.111574. [PMID: 33862495] - Yang Zhang, Haixia Gong, Biming Zhan, Shibiao Chen. Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study.
BMC anesthesiology.
2021 06; 21(1):175. doi:
10.1186/s12871-021-01391-w. [PMID: 34157970] - Tae Jin Kim, Hyun Jung Lee, Do Hyeon Pyun, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung. Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress.
Biochemical pharmacology.
2021 06; 188(?):114557. doi:
10.1016/j.bcp.2021.114557. [PMID: 33844985] - Chao Gong, Yu Qi, Yang Xu, Xiruo Tang, Feng Liang, Lianhua Chen. Parecoxib improves atherosclerotic plaque stability by suppressing inflammation and inhibiting matrix metalloproteinases production.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111423. doi:
10.1016/j.biopha.2021.111423. [PMID: 33740522] - Lori W E van der Schoor, Henkjan J Verkade, Anna Bertolini, Sanne de Wit, Elvira Mennillo, Eva Rettenmeier, André A Weber, Rick Havinga, Petra Valášková, Jana Jašprová, Dicky Struik, Vincent W Bloks, Shujuan Chen, Andrea B Schreuder, Libor Vítek, Robert H Tukey, Johan W Jonker. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
Scientific reports.
2021 05; 11(1):11107. doi:
10.1038/s41598-021-90687-5. [PMID: 34045606] - Lili Rong, Xiaohu Wu, Jun Xu, Fengshou Dong, Xingang Liu, Hanqing Xu, Junli Cao, Yongquan Zheng. Clomazone improves the interactions between soil microbes and affects C and N cycling functions.
The Science of the total environment.
2021 May; 770(?):144730. doi:
10.1016/j.scitotenv.2020.144730. [PMID: 33736380] - Marija Stevanović, Dragica Brkić, Tanja Tomić, Varja Mihajlović, Tijana Đorđević, Slavica Gašić. Effects of the technical ingredient clomazone and its two formulated products on aquatic macrophytes.
Environmental pollution (Barking, Essex : 1987).
2021 May; 277(?):116753. doi:
10.1016/j.envpol.2021.116753. [PMID: 33640824] - Shuai-Jiang Liu, Qian Zhao, Cheng Peng, Qing Mao, Fengbo Wu, Feng-Hua Zhang, Quan-Sheng Feng, Gu He, Bo Han. Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation.
European journal of medicinal chemistry.
2021 May; 217(?):113359. doi:
10.1016/j.ejmech.2021.113359. [PMID: 33725632] - Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules.
Journal of physiology and biochemistry.
2021 May; 77(2):321-329. doi:
10.1007/s13105-021-00800-5. [PMID: 33704695] - Feng Guo, Masaki Endo, Takuya Yamaguchi, Akira Uchino, Yukari Sunohara, Hiroshi Matsumoto, Satoshi Iwakami. Investigation of clomazone-tolerance mechanism in a long-grain cultivar of rice.
Pest management science.
2021 May; 77(5):2454-2461. doi:
10.1002/ps.6274. [PMID: 33432689] - Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia, Changtao Jiang, Wei Jia. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Cell metabolism.
2021 04; 33(4):791-803.e7. doi:
10.1016/j.cmet.2020.11.017. [PMID: 33338411] - Gustavo Garcia, Arun Sharma, Arunachalam Ramaiah, Chandani Sen, Arunima Purkayastha, Donald B Kohn, Mark S Parcells, Sebastian Beck, Heeyoung Kim, Malina A Bakowski, Melanie G Kirkpatrick, Laura Riva, Karen C Wolff, Brandon Han, Constance Yuen, David Ulmert, Prabhat K Purbey, Philip Scumpia, Nathan Beutler, Thomas F Rogers, Arnab K Chatterjee, Gülsah Gabriel, Ralf Bartenschlager, Brigitte Gomperts, Clive N Svendsen, Ulrich A K Betz, Robert D Damoiseaux, Vaithilingaraja Arumugaswami. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Cell reports.
2021 04; 35(1):108940. doi:
10.1016/j.celrep.2021.108940. [PMID: 33784499] - Arjun Narala, Dinesh Suram, Kishan Veerabrahma. Pharmacokinetic and pharmacodynamic studies of iloperidone-loaded lipid nanoemulsions via oral route of administration.
Drug development and industrial pharmacy.
2021 Apr; 47(4):618-625. doi:
10.1080/03639045.2021.1908332. [PMID: 33784221] - Sang Youb Han, Hye Kyoung Song, Jin Joo Cha, Jee Young Han, Young Sun Kang, Dae Ryong Cha. Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.
Acta diabetologica.
2021 Apr; 58(4):495-503. doi:
10.1007/s00592-020-01652-z. [PMID: 33399988] - Richard Court, Chad M Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron. Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Apr; 105(?):688-694. doi:
10.1016/j.ijid.2021.03.001. [PMID: 33684562] - Ivo Petersen, Katharina Johannhörster, Eric Pagot, Damian Escribano, Eva Zschiesche, Déborah Temple, Emmanuel Thomas. Assessment of fluralaner as a treatment in controlling Dermanyssus gallinae infestation on commercial layer farms and the potential for resulting benefits of improved bird welfare and productivity.
Parasites & vectors.
2021 Mar; 14(1):181. doi:
10.1186/s13071-021-04685-7. [PMID: 33789728] - Yeong Kwang Ji, Seon Min Lee, Na-Hyun Kim, Nguyen Van Tu, Yun Na Kim, Jeong Doo Heo, Eun Ju Jeong, Jung-Rae Rho. Stereochemical Determination of Fistularins Isolated from the Marine Sponge Ecionemia acervus and Their Regulatory Effect on Intestinal Inflammation.
Marine drugs.
2021 Mar; 19(3):. doi:
10.3390/md19030170. [PMID: 33809895] - Chao Wan, Jian-Yu Pang, Wei Jiang, Xiao-Wei Zhang, Xiang-Guo Hu. Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib.
The Journal of organic chemistry.
2021 03; 86(6):4557-4566. doi:
10.1021/acs.joc.0c02980. [PMID: 33586981] - Abdullatif Al-Terki, Jaffar Hussain, Ahmed R El-Nahas, Abdullatif Aloumi, Monira Al-Asfoor, Abbas Amt Altamimi, Usama Abdelhamid, Majd Alkabbani, Tariq F Al-Shaiji. Parecoxib Vs Paracetamol for Treatment of Acute Renal Colic Due to Ureteric Calculi: A Randomized Controlled Trial.
Urology.
2021 03; 149(?):76-80. doi:
10.1016/j.urology.2020.12.017. [PMID: 33373701] - Jinjun Lu, Ye Yang, Jian Lu, Zuqing Wang, Yiping He, Yeliang Yan, Kai Fu, Wenjuan Jiang, Yunqing Xu, Renrong Wu, Wenqing Liu, Jingping Zhao. Effect of CYP2D6 polymorphisms on plasma concentration and therapeutic effect of risperidone.
BMC psychiatry.
2021 02; 21(1):70. doi:
10.1186/s12888-020-03034-9. [PMID: 33535976] - Nadia Terranova, Mendel Jansen, Martin Falk, Bart S Hendriks. Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Cancer chemotherapy and pharmacology.
2021 02; 87(2):185-196. doi:
10.1007/s00280-020-04184-z. [PMID: 33145616] - Takashi Hirata, Stanley V Smith, Teisuke Takahashi, Noriyuki Miyata, Richard J Roman. Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
The Journal of pharmacology and experimental therapeutics.
2021 02; 376(2):240-249. doi:
10.1124/jpet.120.000353. [PMID: 33277348] - Vicky Wilkinson, Kotaro Takano, David Nichols, Alynn Martin, Roz Holme, David Phalen, Kate Mounsey, Michael Charleston, Alexandre Kreiss, Ruth Pye, Elizabeth Browne, Christina Næsborg-Nielsen, Shane A Richards, Scott Carver. Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use.
Parasites & vectors.
2021 Jan; 14(1):18. doi:
10.1186/s13071-020-04500-9. [PMID: 33407820] - Fangyong Wu, Wei Wang, Yingying Duan, Jia Guo, Guanhua Li, Tao Ma. Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Jan; 27(?):e928205. doi:
10.12659/msm.928205. [PMID: 33395402] - Guoshun Luo, Xin Lin, Zhenbang Li, Maoxu Xiao, Xinyu Li, Dayong Zhang, Hua Xiang. Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.
European journal of medicinal chemistry.
2021 Jan; 209(?):112910. doi:
10.1016/j.ejmech.2020.112910. [PMID: 33049605] - Yan Deng, Jia-Chun Hu, Shu-Hua He, Bin Lou, Ting-Bo Ding, Jin-Tong Yang, Ming-Guang Mo, De-Yong Ye, Lu Zhou, Xian-Cheng Jiang, Ker Yu, Ji-Bin Dong. Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.
Acta pharmacologica Sinica.
2021 Jan; 42(1):149-159. doi:
10.1038/s41401-020-0419-1. [PMID: 32451413] - Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, Min Chen. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 80(?):153378. doi:
10.1016/j.phymed.2020.153378. [PMID: 33113499] - Longying Jiang, Desheng Xiao, Yubin Li, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Hudie Wei, Yongheng Chen. Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor.
Biochemical and biophysical research communications.
2021 01; 534(?):1047-1052. doi:
10.1016/j.bbrc.2020.10.039. [PMID: 33121679] - Xin-Lin Sun, Zhen-Meng Ji, Shao-Peng Wei, Zhi-Qin Ji. Design, Synthesis, and Herbicidal Activity of N-Benzyl-5-cyclopropyl-isoxazole-4-carboxamides.
Journal of agricultural and food chemistry.
2020 Dec; 68(51):15107-15114. doi:
10.1021/acs.jafc.0c03582. [PMID: 33301336] - Ming Zhou, Ning Wang, Gang Wang, Zishan Jia, Xiaolei Qi. Parecoxib alleviates the inflammatory effect of leukocyte-rich platelet-rich plasma in normal rabbit tendons.
BMC musculoskeletal disorders.
2020 Dec; 21(1):831. doi:
10.1186/s12891-020-03793-2. [PMID: 33302906] - Srilakshmi Tirupathamma Reddy, Jolly Janette Mendonza, Venkata Krishna Kanth Makani, Manika Pal Bhadra, Venkata Mallavadhani Uppuluri. Synthesis of some novel methyl β-orsellinate based 3, 5-disubstituted isoxazoles and their anti-proliferative activity: Identification of potent leads active against MCF-7 breast cancer cell.
Bioorganic chemistry.
2020 12; 105(?):104374. doi:
10.1016/j.bioorg.2020.104374. [PMID: 33130349] - Wajima Safi, Andre Kraus, Steffen Grampp, Johannes Schödel, Bjoern Buchholz. Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner.
Journal of molecular medicine (Berlin, Germany).
2020 11; 98(11):1547-1559. doi:
10.1007/s00109-020-01964-1. [PMID: 32885302] - Peach Van Wick, Mark G Papich, Brie Hashem, Ernesto Dominguez-Villegas. PHARMACOKINETICS OF A SINGLE DOSE OF FLURALANER ADMINISTERED ORALLY TO AMERICAN BLACK BEARS (URSUS AMERICANUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Nov; 51(3):691-695. doi:
10.1638/2019-0200. [PMID: 33480547] - Takahiro Kyoya, Lora L Arnold, Karen L Pennington, Satoko Kakiuchi-Kiyota, Megumi Terada, Koichi Abe, Samuel M Cohen. Urinary crystal formation and urothelial effects of pyroxasulfone administered to male rats.
Toxicology mechanisms and methods.
2020 Nov; 30(9):656-671. doi:
10.1080/15376516.2020.1805666. [PMID: 32746684] - Maxwell T Chirehwa, Richard Court, Mariana de Kock, Lubbe Wiesner, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Rob Warren, Paolo Denti, Helen McIlleron. Population Pharmacokinetics of Cycloserine and Pharmacokinetic/Pharmacodynamic Target Attainment in Multidrug-Resistant Tuberculosis Patients Dosed with Terizidone.
Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.01381-20. [PMID: 32816738] - Ying Chen, Chen-Yang Wang, Liang Zhao, Yu-Pu Hong, Xiao-Yi Zhang, Fang-Chao Mei, Yu Zhou, Wen-Yi Guo, Qiao Shi, Kai-Liang Zhao, Chen Chen, Jia Yu, Wei-Xing Wang. Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis.
International immunopharmacology.
2020 Oct; 87(?):106771. doi:
10.1016/j.intimp.2020.106771. [PMID: 32683302] - Michael Camilleri, Priya Vijayvargiya. The Role of Bile Acids in Chronic Diarrhea.
The American journal of gastroenterology.
2020 10; 115(10):1596-1603. doi:
10.14309/ajg.0000000000000696. [PMID: 32558690] - Ke-Liang Guo, Li-Xia Zhao, Zi-Wei Wang, Ying-Chao Gao, Juan-Juan Li, Shuang Gao, Ying Fu, Fei Ye. Design, Synthesis, and Bioevaluation of Substituted Phenyl Isoxazole Analogues as Herbicide Safeners.
Journal of agricultural and food chemistry.
2020 Sep; 68(39):10550-10559. doi:
10.1021/acs.jafc.0c01867. [PMID: 32886503] - Maiken Cavling Arendrup, Anuradha Chowdhary, Karin Meinike Jørgensen, Joseph Meletiadis. Manogepix (APX001A) In Vitro Activity against Candida auris: Head-to-Head Comparison of EUCAST and CLSI MICs.
Antimicrobial agents and chemotherapy.
2020 09; 64(10):. doi:
10.1128/aac.00656-20. [PMID: 32660998] - Michael Camilleri, Sara Linker Nord, Duane Burton, Ibironke Oduyebo, Yiming Zhang, Jin Chen, Koeun Im, Prafulla Bhad, Michael K Badman, David S Sanders, Julian R F Walters. Randomised clinical trial: significant biochemical and colonic transit effects of the farnesoid X receptor agonist tropifexor in patients with primary bile acid diarrhoea.
Alimentary pharmacology & therapeutics.
2020 09; 52(5):808-820. doi:
10.1111/apt.15967. [PMID: 32702169] - Teerasak Wongwan, Varanuj Chatsudthipong, Sunhapas Soodvilai. Farnesoid X Receptor Activation Stimulates Organic Cations Transport in Human Renal Proximal Tubular Cells.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176078. [PMID: 32846898] - Katrina M Mirabito Colafella, Karla B Neves, Augusto C Montezano, Ingrid M Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Hans J Baelde, Anton H van den Meiracker, Rhian M Touyz, A H Jan Danser, Jorie Versmissen. Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats.
Cardiovascular research.
2020 08; 116(10):1779-1790. doi:
10.1093/cvr/cvz260. [PMID: 31593221] - Karin Meinike Jørgensen, Karen M T Astvad, Maiken Cavling Arendrup. In Vitro Activity of Manogepix (APX001A) and Comparators against Contemporary Molds: MEC Comparison and Preliminary Experience with Colorimetric MIC Determination.
Antimicrobial agents and chemotherapy.
2020 07; 64(8):. doi:
10.1128/aac.00730-20. [PMID: 32513793] - Aihua Zhao, Shouli Wang, Wenlian Chen, Xiaojiao Zheng, Fengjie Huang, Xiaolong Han, Kun Ge, Cynthia Rajani, Yanxia Huang, Herbert Yu, Jinshui Zhu, Wei Jia. Increased levels of conjugated bile acids are associated with human bile reflux gastritis.
Scientific reports.
2020 07; 10(1):11601. doi:
10.1038/s41598-020-68393-5. [PMID: 32665615] - Xiaoxia Gu, Xiujuan Tan, Jinxian Chen, Jingjing Wang, Yue Lu, Liangqing Zhang. The clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial.
BMC anesthesiology.
2020 07; 20(1):166. doi:
10.1186/s12871-020-01080-0. [PMID: 32631301] - Zhaoxian Zhang, Liangliang Zhou, Yingying Gao, Jing Zhang, Beibei Gao, Haiyan Shi, Minghua Wang. Enantioselective Detection, Bioactivity, and Metabolism of the Novel Chiral Insecticide Fluralaner.
Journal of agricultural and food chemistry.
2020 Jun; 68(25):6802-6810. doi:
10.1021/acs.jafc.9b07907. [PMID: 32323985] - Maiken Cavling Arendrup, Karin Meinike Jørgensen. Manogepix (APX001A) Displays Potent In Vitro Activity against Human Pathogenic Yeast, but with an Unexpected Correlation to Fluconazole MICs.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00429-20. [PMID: 32366708] - Shinichi Tebayashi, Ruri Moriyama, Ryo Arakawa, Masashi Sato. Induction of 2-cyanoethyl-isoxazolin-5-one as an antifeedant against the tobacco cutworm (Spodoptera litura) by jasmonic acid in sweet pea leaf.
Bioscience, biotechnology, and biochemistry.
2020 Jun; 84(6):1105-1112. doi:
10.1080/09168451.2020.1724072. [PMID: 32013735] - Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P Wiederhold, Karen Joy Shaw, Thomas F Patterson, Scott G Filler, Ashraf S Ibrahim. Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus.
Antimicrobial agents and chemotherapy.
2020 05; 64(6):. doi:
10.1128/aac.00178-20. [PMID: 32205345] - Blerina Shkodra-Pula, Christian Kretzer, Paul M Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz, Ulrich S Schubert. Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
Journal of nanobiotechnology.
2020 May; 18(1):73. doi:
10.1186/s12951-020-00620-7. [PMID: 32408877] - Lucia Ferrazzano, Dario Corbisiero, Eleonora Potenza, Monica Baiula, Samantha Deianira Dattoli, Santi Spampinato, Laura Belvisi, Monica Civera, Alessandra Tolomelli. Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems.
Scientific reports.
2020 05; 10(1):7410. doi:
10.1038/s41598-020-64396-4. [PMID: 32366988] - Chong Geng, Xiao Li, Yanni Li, Shuailing Song, Chunhui Wang. Nonsteroidal anti-inflammatory drugs alleviate severity of post-endoscopic retrograde cholangiopancreatography pancreatitis by inhibiting inflammation and reducing apoptosis.
Journal of gastroenterology and hepatology.
2020 May; 35(5):896-904. doi:
10.1111/jgh.15012. [PMID: 32064683] - Donatella Chianelli, Paul V Rucker, Jason Roland, David C Tully, John Nelson, Xiaodong Liu, Badry Bursulaya, Eloy D Hernandez, Jane Wu, Mahavir Prashad, Thierry Schlama, Yugang Liu, Alan Chu, James Schmeits, David J Huang, Robert Hill, Dingjiu Bao, Jocelyn Zoll, Young Kim, Todd Groessl, Peter McNamara, Bo Liu, Wendy Richmond, Ignacio Sancho-Martinez, Andrew Phimister, H Martin Seidel, Michael K Badman, Sean B Joseph, Bryan Laffitte, Valentina Molteni. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Journal of medicinal chemistry.
2020 04; 63(8):3868-3880. doi:
10.1021/acs.jmedchem.9b01621. [PMID: 31940200] - Mengchun Chen, Wei Sun, Zhe Wang, Chengke Huang, Guoxin Hu, Yijie Chen, Ledan Wang. Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies.
BMC pharmacology & toxicology.
2020 04; 21(1):27. doi:
10.1186/s40360-020-00406-5. [PMID: 32264977] - Michael K Badman, Jin Chen, Sachin Desai, Soniya Vaidya, Srikanth Neelakantham, Jie Zhang, Lu Gan, Kate Danis, Bryan Laffitte, Lloyd B Klickstein. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers.
Clinical pharmacology in drug development.
2020 04; 9(3):395-410. doi:
10.1002/cpdd.762. [PMID: 31823525]