Levobupivacaine hydrochloride (BioDeep_00000816777)
代谢物信息卡片
Levobupivacaine hydrochloride
化学式: C18H29ClN2O (324.1968294)
中文名称: 盐酸左布比卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
InChI: /m0./s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31772
- KEGGdrug: D01287
- PubChem: 117965
- ChEMBL: CHEMBL1200749
- MeSH: Levobupivacaine
- CAS: 27262-48-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Justina Jermolajevaite, Ilona Razlevice, Vaidotas Gurskis, Dovile Evalda Grinkeviciute, Laura Lukosiene, Andrius Macas. Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report.
Medicina (Kaunas, Lithuania).
2023 May; 59(5):. doi:
10.3390/medicina59050981. [PMID: 37241213] - Manuel Á Gómez-Ríos, Pastora Codesido-Barreiro, Carmen Seco-Vilariño, Marta Calvín-Lamas, Federico Curt-Nuño, Laura Nieto-Serradilla, María T Rabuñal-Álvarez, Fernando Fernández-Rodríguez, Javier Peteiro-Cartelle, Ramón Pensado-Boo, Germán Bou, Alberto Pensado-Castiñeiras, Rubén Casans-Francés. Wound Infusion of 0.35\% Levobupivacaine Reduces Mechanical Secondary Hyperalgesia and Opioid Consumption After Cesarean Delivery: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Trial.
Anesthesia and analgesia.
2022 04; 134(4):791-801. doi:
10.1213/ane.0000000000005917. [PMID: 35086112] - Hiroe Shigeta, Rie Yasumura, Yoshifumi Kotake. Comparison of plasma levobupivacaine concentrations with and without epinephrine following erector spinae plane block for breast cancer surgery: a randomized controlled trial.
BMC anesthesiology.
2022 03; 22(1):86. doi:
10.1186/s12871-022-01632-6. [PMID: 35350983] - Seong-Ho Ok, Dawon Kang, Soo Hee Lee, Hyun-Jin Kim, Seung Hyun Ahn, Ju-Tae Sohn. Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065978. doi:
10.1177/09603271211065978. [PMID: 35135371] - Akinori Yamazaki, Keisuke Fujii, Yuichi Aratani, Toshiyuki Kuriyama, Tomoyuki Kawamata. Comparison of plasma concentrations of levobupivacaine with and without epinephrine for thoracic paravertebral block: A randomised trial.
Anaesthesia, critical care & pain medicine.
2021 10; 40(5):100952. doi:
10.1016/j.accpm.2021.100952. [PMID: 34560315] - Hirotsugu Miyoshi, Takahiro Kato, Ryuji Nakamura, Noboru Saeki, Yuko Noda, Satoshi Kamiya, Atsushi Morio, Yasuo M Tsutsumi. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats.
Journal of anesthesia.
2021 04; 35(2):168-174. doi:
10.1007/s00540-020-02883-8. [PMID: 33386432] - Ana Rosa Brissant de Andrade, Rafaela de Siqueira Ferraz-Carvalho, Victor Passos Gibson, Juliana Kishishita, Mariane Cajuba de Britto Lira Nogueira, Nereide Stela Santos-Magalhães, Leila Bastos Leal, Davi Pereira de Santana. Levobupivacaine-Loaded Liposome Associated with Thermogel for Prolonged Analgesia.
AAPS PharmSciTech.
2021 Mar; 22(3):104. doi:
10.1208/s12249-021-01942-x. [PMID: 33718986] - Abdelghafour Elkoundi, Hicham Balkhi, Mustapha Bensghir, Abdelouahed Baite. Levobupivacaine plasma level between erector spinae plane block and thoracic paravertebral block.
Regional anesthesia and pain medicine.
2021 01; 46(1):90-91. doi:
10.1136/rapm-2020-101406. [PMID: 32273310] - Min Li, Shuo Feng, Huaixin Xing, Yingui Sun. Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid-polymer hybrid nanoparticles, which performed better for local anesthetic therapy?.
Drug delivery.
2020 Dec; 27(1):1452-1460. doi:
10.1080/10717544.2020.1831105. [PMID: 33100057] - Yanhong Cui. Binding of levobupivacaine-loaded gold nanoparticles to human serum albumin: a simulated physiological study.
Luminescence : the journal of biological and chemical luminescence.
2020 Dec; 35(8):1269-1276. doi:
10.1002/bio.3888. [PMID: 32608125] - Changcheng Jiang, Wenji Xie, Huijuan Xie, Wenqin Xie, Zhenming Kang, Naizhen Liu. Nalbuphine Exhibited a Better Adjuvant Than Dexmedetomidine in Supraclavicular Brachial Plexus Block in Youths.
Clinical neuropharmacology.
2020 Sep; 43(5):134-138. doi:
10.1097/wnf.0000000000000410. [PMID: 32947423] - Chantal A A Heppolette, Derek Brunnen, Sohail Bampoe, Peter M Odor. Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.
Clinical pharmacokinetics.
2020 06; 59(6):715-745. doi:
10.1007/s40262-020-00868-0. [PMID: 32034727] - Nunzia Palomba, Enzo Vettorato, Chiara De Gennaro, Federico Corletto. Peripheral nerve block versus systemic analgesia in dogs undergoing tibial plateau levelling osteotomy: Analgesic efficacy and pharmacoeconomics comparison.
Veterinary anaesthesia and analgesia.
2020 Jan; 47(1):119-128. doi:
10.1016/j.vaa.2019.08.046. [PMID: 31806432] - Peter M Odor, Alison G Cavalier, Neal D Reynolds, King S Ang, Simon J Parrington, Hua Xu, Atholl Johnston, Frederic J Sage. Safety and Pharmacokinetics of Levobupivacaine Following Fascia Iliaca Compartment Block in Elderly Patients.
Drugs & aging.
2019 06; 36(6):541-548. doi:
10.1007/s40266-019-00652-1. [PMID: 30924096] - Livija Šakić, Dinko Tonković, Kata Šakić. DEXAMETHASONE - INTRATHECAL MINIMISER OF SIMPLE HAEMATHOLOGIC STRESS BIOMARKERS IN HIP FRACTURE.
Acta clinica Croatica.
2019 Jun; 58(Suppl 1):9-17. doi:
10.20471/acc.2019.58.s1.01. [PMID: 31741553] - Yasuko Taketa, Yumi Irisawa, Taro Fujitani. Programmed intermittent bolus infusion versus continuous infusion of 0.2\% levobupivacaine after ultrasound-guided thoracic paravertebral block for video-assisted thoracoscopic surgery: A randomised controlled trial.
European journal of anaesthesiology.
2019 04; 36(4):272-278. doi:
10.1097/eja.0000000000000945. [PMID: 30664012] - Rita Vashisht, Anju A Bendon, Ijeoma Okonkwo, Davandra Patel, Catherine Fullwood, Kayode Ogungbenro, Leon Aarons, Adam S Darwich. A study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months.
Paediatric anaesthesia.
2019 Feb; 29(2):161-168. doi:
10.1111/pan.13548. [PMID: 30447167] - Ying Chen, Jian Zhang, Zhe Chen, Quanguang Wang, Bing Li, Rujing Lai, Xuzhong Xu, Zhifang Cao, Lizhen Yu. Lipid Emulsion Pretreatment Decreased the Maximum Total and Free Plasma Concentration of Levobupivacaine for Femoral and Sciatic Nerve Block in Below-Knee Fracture Surgery.
Regional anesthesia and pain medicine.
2018 Nov; 43(8):838-843. doi:
10.1097/aap.0000000000000834. [PMID: 29923955] - H J Lacassie, A Rolle, L I Cortínez, S Solari, M A Corvetto, F R Altermatt. Pharmacokinetics of levobupivacaine with epinephrine in transversus abdominis plane block for postoperative analgesia after Caesarean section.
British journal of anaesthesia.
2018 Aug; 121(2):469-475. doi:
10.1016/j.bja.2018.02.070. [PMID: 30032887] - Qiuxia Wan, Wengang Ding, Xiaoguang Cui, Xianzhang Zeng. CONSORT-epidural dexmedetomidine improves gastrointestinal motility after laparoscopic colonic resection compared with morphine.
Medicine.
2018 Jun; 97(25):e11218. doi:
10.1097/md.0000000000011218. [PMID: 29924051] - Martin Purdy, Mari Kinnunen, Merja Kokki, Maarit Anttila, Matti Eskelinen, Heidi Hautajärvi, Marko Lehtonen, Hannu Kokki. A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy.
Medicine.
2018 Feb; 97(7):e9968. doi:
10.1097/md.0000000000009968. [PMID: 29443788] - Masashi Yoshimoto, Takashi Horiguchi, Tetsu Kimura, Toshiaki Nishikawa. Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects.
Anesthesia and analgesia.
2017 11; 125(5):1496-1502. doi:
10.1213/ane.0000000000002435. [PMID: 28877036] - Zongwen Gao, Feng Cui, Xuemei Cao, Dejun Wang, Xiao Li, Tianzuo Li. Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle-controlled, and preclinical study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Aug; 92(?):459-467. doi:
10.1016/j.biopha.2017.05.038. [PMID: 28570980] - Martin Purdy, Jari Kärkkäinen, Merja Kokki, Maarit Anttila, Samuli Aspinen, Petri Juvonen, Hannu Kokki, Kari Pulkki, Tuomo Rantanen, Matti Eskelinen. Does Rectus Sheath Block Analgesia Alter Levels of the Oxidative Stress Biomarker Glutathione Peroxidase: A Randomised Trial of Patients with Cancer and Benign Disease.
Anticancer research.
2017 02; 37(2):897-902. doi:
10.21873/anticanres.11396. [PMID: 28179349] - F Gobbi, G Sales, P Bretto, P P Donadio, L Brazzi. Low-dose Spinal Block With Continuous Epidural Infusion for Renal Transplantation in a Patient With Alport Syndrome: A Case Report.
Transplantation proceedings.
2016 Nov; 48(9):3067-3069. doi:
10.1016/j.transproceed.2016.04.006. [PMID: 27932148] - Pauline Dureau, Beny Charbit, Nathalie Nicolas, Dan Benhamou, Jean-Xavier Mazoit. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study.
Anesthesiology.
2016 09; 125(3):474-83. doi:
10.1097/aln.0000000000001230. [PMID: 27404223] - Ramón Eizaga Rebollar, María V García Palacios, Javier Morales Guerrero, Luis M Torres Morera. Lipid rescue in children: The prompt decision.
Journal of clinical anesthesia.
2016 Aug; 32(?):248-52. doi:
10.1016/j.jclinane.2016.03.018. [PMID: 27290983] - Geoff Frawley, Ben Hallett, Tony Velkov, Andrew Bjorksten. Pharmacokinetics of levobupivacaine following infant spinal anesthesia.
Paediatric anaesthesia.
2016 Jun; 26(6):575-81. doi:
10.1111/pan.12899. [PMID: 27061607] - R Yasumura, Y Kobayashi, R Ochiai. A comparison of plasma levobupivacaine concentrations following transversus abdominis plane block and rectus sheath block.
Anaesthesia.
2016 May; 71(5):544-9. doi:
10.1111/anae.13414. [PMID: 26945692] - T Hamada, M Tsuchiya, K Mizutani, R Takahashi, K Muguruma, K Maeda, W Ueda, K Nishikawa. Levobupivacaine-dextran mixture for transversus abdominis plane block and rectus sheath block in patients undergoing laparoscopic colectomy: a randomised controlled trial.
Anaesthesia.
2016 Apr; 71(4):411-6. doi:
10.1111/anae.13408. [PMID: 26919568] - J A Heinonen, M B Skrifvars, J Haasio, J T Backman, P H Rosenberg, E Litonius. Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.
Anaesthesia and intensive care.
2016 Mar; 44(2):270-7. doi:
10.1177/0310057x1604400214. [PMID: 27029660] - Xian-Zhang Zeng, Zhi-Fang Lu, Xiang-Qi Lv, Yue-Ping Guo, Xiao-Guang Cui. Epidural Co-Administration of Dexmedetomidine and Levobupivacaine Improves the Gastrointestinal Motility Function after Colonic Resection in Comparison to Co-Administration of Morphine and Levobupivacaine.
PloS one.
2016; 11(1):e0146215. doi:
10.1371/journal.pone.0146215. [PMID: 26751791] - Seong-Ho Ok, Won Ho Kim, Jongsun Yu, Youngju Lee, Mun-Jeoung Choi, Dong Hoon Lim, Yeran Hwang, Yeon A Kim, Ju-Tae Sohn. Effects of Acidification and Alkalinization on the Lipid Emulsion-Mediated Reversal of Toxic Dose Levobupivacaine-Induced Vasodilation in the Isolated Rat Aorta.
International journal of medical sciences.
2016; 13(1):68-76. doi:
10.7150/ijms.13016. [PMID: 26917987] - Juhong Ran, Yanping Wang, Fangkun Li, Wei Zhang, Minyu Ma. Pharmacodynamics and Pharmacokinetics of Levobupivacaine Used for Epidural Anesthesia in Patients with Liver Dysfunction.
Cell biochemistry and biophysics.
2015 Dec; 73(3):717-21. doi:
10.1007/s12013-015-0677-6. [PMID: 27259315] - Joachim Krylborn, Marie E Anell-Olofsson, Catarina Bitkover, Stefan Lundeberg, Marco Bartocci, Carl-Olav Stiller, Bjorn A Larsson. Plasma levels of levobupivacaine during continuous infusion via a wound catheter after major surgery in newborn infants: An observational study.
European journal of anaesthesiology.
2015 Dec; 32(12):851-6. doi:
10.1097/eja.0000000000000317. [PMID: 26241764] - Francesco Paolo Busardò, Luigi Tritapepe, Angelo Montana, Francesca Indorato, Simona Zaami, Guido Romano. A fatal accidental subarachnoid injection of lidocaine and levobupivacaine during a lumbar paravertebral block.
Forensic science international.
2015 Nov; 256(?):17-20. doi:
10.1016/j.forsciint.2015.07.017. [PMID: 26332046] - Zahida Mamou, Jacques Descotes, Philippe Chevalier, Bernard Bui-Xuan, Caroline Romestaing, Quadiri Timour. Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?.
Fundamental & clinical pharmacology.
2015 Oct; 29(5):439-49. doi:
10.1111/fcp.12131. [PMID: 26118736] - Luciano Perotti, Maria Cusato, Pablo Ingelmo, Thekla Larissa Niebel, Marta Somaini, Francesca Riva, Carmine Tinelli, José De Andrés, Guido Fanelli, Antonio Braschi, Mario Regazzi, Massimo Allegri. A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial.
Anesthesia and analgesia.
2015 Aug; 121(2):348-56. doi:
10.1213/ane.0000000000000775. [PMID: 25977992] - Takashi Ishida, Akiyuki Sakamoto, Hidenori Tanaka, Susumu Ide, Kumiko Ishida, Satoshi Tanaka, Teruyo Mori, Mikito Kawamata. Transversus abdominis plane block with 0.25 \% levobupivacaine: a prospective, randomized, double-blinded clinical study.
Journal of anesthesia.
2015 Aug; 29(4):557-61. doi:
10.1007/s00540-015-1993-0. [PMID: 25725780] - Marie Anell-Olofsson, Per-Arne Lönnqvist, Catarina Bitkover, Stefan Lundeberg, Björn A Larsson, Staffan Eksborg, Marco Bartocci. Plasma concentrations of levobupivacaine associated with two different intermittent wound infusion regimens following surgical ductus ligation in preterm infants.
Paediatric anaesthesia.
2015 Jul; 25(7):711-8. doi:
10.1111/pan.12634. [PMID: 25752903] - Altug Tuncel, Melih Balci, Aysun Postaci, Yilmaz Aslan, Ali Atan. Comparıson of different postoperative paın managements in patients submitted to transperitoneal laparoscopic renal and adrenal surgery.
International braz j urol : official journal of the Brazilian Society of Urology.
2015 Jul; 41(4):669-75. doi:
10.1590/s1677-5538.ibju.2013.0238. [PMID: 26401858] - Florent Moriceau, Benoni Geffard, Frédéric Duflo. Levobupivacaine for continuous femoral nerve block in paediatric patients: A plasma concentration analysis report on safety.
Anaesthesia, critical care & pain medicine.
2015 Jun; 34(3):183. doi:
10.1016/j.accpm.2015.03.007. [PMID: 26004879] - X Li, M Cai. The effect of L-bupivacaine on BIS levels in the maintenance doses of propofol and fentanyl during general anesthesia in Chinese people.
Drug research.
2014 Dec; 64(12):675-9. doi:
10.1055/s-0034-1368716. [PMID: 24599541] - Hasan Ozkaya, Tuba Berra Sarıtaş, Zulfıkar Kadır Sarıtaş, Musa Korkmaz, Alper Sevımlı, Idris Mehmetoglu, Şeref Otelcıoglu. Investigation of effects of levobupivacaine injection to rabbit knee joint on histopathologic changes of joint cartilage tissue and changes of serum biochemical parameters.
Fundamental & clinical pharmacology.
2014 Dec; 28(6):627-32. doi:
10.1111/fcp.12062. [PMID: 24341591] - Marzena Górniak, Johannes H Proost, Marc Veckeneer, Verena C Mulder, René J Wubbels. Clonidine as an adjuvant to prolong local analgesia in conventional scleral buckle surgery.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2014 Nov; 30(9):777-82. doi:
10.1089/jop.2013.0243. [PMID: 25188774] - E Bolat, A Bestas, M K Bayar, S Ozcan, O L Erhan, B Ustundag. Evaluation of levobupivacaine passage to breast milk following epidural anesthesia for cesarean delivery.
International journal of obstetric anesthesia.
2014 Aug; 23(3):217-21. doi:
10.1016/j.ijoa.2014.03.005. [PMID: 24953218] - Emre Tüzel, Günes Kızıltepe, Bülent Akdoğan. The effect of local anesthetic infiltration around nephrostomy tract on postoperative pain control after percutaneous nephrolithotomy.
Urolithiasis.
2014 Aug; 42(4):353-8. doi:
10.1007/s00240-014-0680-1. [PMID: 24990067] - Sumithra Krishnan, Raymond G Morris, Peter J Hewett, John Field, Alex Karatassas, Samson Tou, Ian S Westley, Fiona A Wicks, Julie A Tonkin. A randomized double-blind clinical trial of a continuous 96-hour levobupivacaine infiltration after open or laparoscopic colorectal surgery for postoperative pain management--including clinically important changes in protein binding.
Therapeutic drug monitoring.
2014 Apr; 36(2):202-10. doi:
10.1097/ftd.0b013e3182a3772e. [PMID: 24089075] - M de Queiroz Siqueira, D Chassard, H Musard, A Heilporn, J-C Cejka, O Leveneur, B Allaouchiche, O Rhondali. Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets.
British journal of anaesthesia.
2014 Apr; 112(4):729-34. doi:
10.1093/bja/aet327. [PMID: 24091473] - M Harvey, G Cave. Lipid rescue: does the sink hold water? And other controversies.
British journal of anaesthesia.
2014 Apr; 112(4):622-5. doi:
10.1093/bja/aeu010. [PMID: 24535605] - Yunus Baydilek, Bülent Serhan Yurtlu, Volkan Hanci, Hilal Ayoğlu, Rahşan Dilek Okyay, Gulay Erdoğan Kayhan, Hüsnü Tokgöz, Görkem Mungan, Işıl Ozkoçak. The comparison of levobupivacaine in continuous or single dose spinal anesthesia for transurethral resection of prostate surgery.
Brazilian journal of anesthesiology (Elsevier).
2014 Mar; 64(2):89-97. doi:
10.1016/j.bjane.2013.03.007. [PMID: 24794450] - Mohana Raj Thanapal, Mahadevan D Tata, Ann J Tan, Thiruselvi Subramaniam, Jenny M G Tong, Kandasami Palayan, Sanjay Rampal, Ramesh Gurunathan. Pre-emptive intraperitoneal local anaesthesia: an effective method in immediate post-operative pain management and metabolic stress response in laparoscopic appendicectomy, a randomized, double-blinded, placebo-controlled study.
ANZ journal of surgery.
2014 Jan; 84(1-2):47-51. doi:
10.1111/j.1445-2197.2012.06210.x. [PMID: 23057502] - Murat Karcioğlu, Kasim Tuzcu, Fatih Sefil, Işil Davarci, Suzan Aydin, Ali Sari, Akin Aydoğan, Raif Özden. Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model.
Turkish journal of medical sciences.
2014; 44(2):330-6. doi:
10.3906/sag-1302-25. [PMID: 25536745] - Seong-Ho Ok, Chang-Shin Park, Hye Jung Kim, Soo Hee Lee, Bo-Hwa Choi, So Young Eun, Kyung-Nam Kim, Seong Min Yang, Il-Woo Shin, Mun-Jeoung Choi, Ju-Tae Sohn. Effect of two lipid emulsions on reversing high-dose levobupivacaine-induced reduced vasoconstriction in the rat aortas.
Cardiovascular toxicology.
2013 Dec; 13(4):370-80. doi:
10.1007/s12012-013-9218-y. [PMID: 23877627] - Soo Hee Lee, Hui-Jin Sung, Seong-Ho Ok, Jongsun Yu, Mun-Jeoung Choi, Jin Soo Lim, Ju-Tae Sohn. Lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic doses.
Yonsei medical journal.
2013 Nov; 54(6):1524-32. doi:
10.3349/ymj.2013.54.6.1524. [PMID: 24142661] - Yutaka Oda, Yuko Ikeda. Effect of lipid emulsion on the central nervous system and cardiac toxicity of bupivacaine and levobupivacaine in awake rats.
Journal of anesthesia.
2013 Aug; 27(4):500-4. doi:
10.1007/s00540-013-1581-0. [PMID: 23494675] - Marcia A Corvetto, Ghislaine C Echevarría, Natalia De La Fuente, Loreto Mosqueira, Sandra Solari, Fernando R Altermatt. Comparison of plasma concentrations of levobupivacaine with and without epinephrine for transversus abdominis plane block.
Regional anesthesia and pain medicine.
2012 Nov; 37(6):633-7. doi:
10.1097/aap.0b013e31826c330a. [PMID: 23038415] - Jiin-Tarng Liou, Chih-Chieh Mao, Fu-Chao Liu, Huan-Tang Lin, Li-Man Hung, Chang-Hui Liao, Yuan-Ji Day. Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists.
2012 Sep; 50(3):112-21. doi:
10.1016/j.aat.2012.07.001. [PMID: 23026170] - M Mercieri, R A De Blasi, S Palmisani, S Forte, P Cardelli, R Romano, G Pinto, R Arcioni. Changes in cerebrospinal fluid magnesium levels in patients undergoing spinal anaesthesia for hip arthroplasty: does intravenous infusion of magnesium sulphate make any difference? A prospective, randomized, controlled study.
British journal of anaesthesia.
2012 Aug; 109(2):208-15. doi:
10.1093/bja/aes146. [PMID: 22661752] - R Rikalainen-Salmi, J G Förster, K Mäkelä, P Virolainen, K A Leino, M T Pitkänen, P J Neuvonen, K S Kuusniemi. Local infiltration analgesia with levobupivacaine compared with intrathecal morphine in total hip arthroplasty patients.
Acta anaesthesiologica Scandinavica.
2012 Jul; 56(6):695-705. doi:
10.1111/j.1399-6576.2012.02667.x. [PMID: 22404241] - J Diaz, M Bernasinski, J-M Malinovsky. [Reversal of neurologic symptoms related to lidocaine toxicity with a lipid emulsion administration].
Annales francaises d'anesthesie et de reanimation.
2012 Jul; 31(7-8):647. doi:
10.1016/j.annfar.2012.05.001. [PMID: 22749556] - Z Milan, S Das, M Kocarev, V Rawari. Is single-shot epidural analgesia more effective than morphine patient-controlled analgesia for donor nephrectomy?.
Transplantation proceedings.
2011 Dec; 43(10):3588-92. doi:
10.1016/j.transproceed.2011.08.116. [PMID: 22172810] - Anne-Eva Lauprecht, Frank A Wenger, Osama El Fadil, Martin K Walz, Harald Groeben. Levobupivacaine plasma concentrations following major liver resection.
Journal of anesthesia.
2011 Jun; 25(3):369-75. doi:
10.1007/s00540-011-1107-6. [PMID: 21365353] - Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami. Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes.
Bioorganic & medicinal chemistry.
2011 Jun; 19(11):3410-5. doi:
10.1016/j.bmc.2011.04.030. [PMID: 21550810] - Seong-Ho Ok, Ju-Tae Sohn, Ji-Seok Baik, Jae-Gak Kim, Sang-Seung Park, Hui-Jin Sung, Mi-Kyung Shin, Yong-Hyun Kwon, Chang-Shin Park, Il-Woo Shin, Heon-Keun Lee, Young-Kyun Chung. Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels.
Anesthesiology.
2011 Feb; 114(2):293-301. doi:
10.1097/aln.0b013e3182054d22. [PMID: 21239969] - Catherine A Deegan, David Murray, Peter Doran, Denis C Moriarty, Daniel I Sessler, Ed Mascha, Brian P Kavanagh, Donal J Buggy. Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery.
Regional anesthesia and pain medicine.
2010 Nov; 35(6):490-5. doi:
10.1097/aap.0b013e3181ef4d05. [PMID: 20975461] - Yu-Tse Wu, Yi-Lin Kao, Lie-Chwen Lin, Tung-Hu Tsai. Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats.
International journal of pharmaceutics.
2010 Aug; 396(1-2):127-33. doi:
10.1016/j.ijpharm.2010.06.038. [PMID: 20600721] - Yuko Ikeda, Yutaka Oda, Taketo Nakamura, Ryota Takahashi, Wakako Miyake, Ichiro Hase, Akira Asada. Pharmacokinetics of lidocaine, bupivacaine, and levobupivacaine in plasma and brain in awake rats.
Anesthesiology.
2010 Jun; 112(6):1396-403. doi:
10.1097/aln.0b013e3181d9cc54. [PMID: 20460991] - M Allegri, T Niebel, C Baldi, S Bettinelli, M Cusato, A Braschi, M Regazzi. Plasma concentrations of levobupivacaine increase under continuous infusion after a major surgery.
Acta anaesthesiologica Scandinavica.
2010 May; 54(5):654-5. doi:
10.1111/j.1399-6576.2009.02176.x. [PMID: 20415948] - Derek Dillane, Brendan T Finucane. Local anesthetic systemic toxicity.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2010 Apr; 57(4):368-80. doi:
10.1007/s12630-010-9275-7. [PMID: 20151342] - A Malvasi, A Tinelli, M Stark, G Pontrelli, A Brizzi, R G Wetzl, D Benhamou. Low-dose sequential combined spinal-epidural anaesthesia in elective Stark caesarean section: a preliminary cohort study.
European review for medical and pharmacological sciences.
2010 Mar; 14(3):215-21. doi:
NULL. [PMID: 20391961] - Marcel A de Leeuw, Pierre M Bet, Abraham J Wilhelm, Rene M Vos, Martijn Hoeksema, Jaap J de Lange, Wouter Wa Zuurmond, Roberto Sgm Perez. Total plasma concentrations of bupivacaine, levobupivacaine and ropivacaine after combined psoas compartment-sciatic nerve block.
European journal of anaesthesiology.
2009 Dec; 26(12):1083-5. doi:
10.1097/eja.0b013e3283308e07. [PMID: 19652603] - Zorica B Jankovic, Stephen G Pollard, Meyyappan M Nachiappan. Continuous transversus abdominis plane block for renal transplant recipients.
Anesthesia and analgesia.
2009 Nov; 109(5):1710-1. doi:
10.1213/ane.0b013e3181ba75d1. [PMID: 19843821] - Christopher F Tirotta, Hamish M Munro, Jane Salvaggio, Danielle Madril, Donald E Felix, Lynda Rusinowski, Cristi Tyler, William Decampli, Robert L Hannan, Redmond P Burke. Continuous incisional infusion of local anesthetic in pediatric patients following open heart surgery.
Paediatric anaesthesia.
2009 Jun; 19(6):571-6. doi:
10.1111/j.1460-9592.2009.03009.x. [PMID: 19645974] - M Sorbello, A Paratore, G Morello, M Tindaro Sidoti, D Rinzivillo, C Molino, C Di Tommaso, L Parrinello, P Veroux, D Corona, G Giuffrida, D Zerbo, M Veroux. Wound levobupivacaine continuous infusion for postoperative analgesia in living kidney donors: case-control study.
Transplantation proceedings.
2009 May; 41(4):1128-31. doi:
10.1016/j.transproceed.2009.03.013. [PMID: 19460497] - Andrea Perniola, Anil Gupta, Kristina Crafoord, Bijan Darvish, Anders Magnuson, Kjell Axelsson. Intraabdominal local anaesthetics for postoperative pain relief following abdominal hysterectomy: a randomized, double-blind, dose-finding study.
European journal of anaesthesiology.
2009 May; 26(5):421-9. doi:
10.1097/eja.0b013e3283261b53. [PMID: 19521298] - Surhan Ozer Cnar, Ulkü Kum, Nuri Cevizci, Semra Kayaoglu, Sibel Oba. Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair.
European journal of anaesthesiology.
2009 May; 26(5):430-4. doi:
10.1097/eja.0b013e32832974fc. [PMID: 19352187] - Luis I Cortínez, Ricardo Fuentes, Sandra Solari, Paola Ostermann, Miguel Vega, Hernán R Muñoz. Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years.
Anesthesia and analgesia.
2008 Oct; 107(4):1182-4. doi:
10.1213/ane.0b013e318181bb4d. [PMID: 18806025] - Rebecca A Fanning, Deirdre P Campion, Colm B Collins, Simon Keely, Liam P Briggs, John J O'Connor, Michael F Carey. A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility.
Anesthesia and analgesia.
2008 Oct; 107(4):1303-7. doi:
10.1213/ane.0b013e3181804245. [PMID: 18806044] - Tatjana Stopar Pintaric, Gordana Kozelj, Lovro Stanovnik, Andrea Casati, Marko Hocevar, Vesna Novak Jankovic. Pharmacokinetics of levobupivacaine 0.5\% after superficial or combined (deep and superficial) cervical plexus block in patients undergoing minimally invasive parathyroidectomy.
Journal of clinical anesthesia.
2008 Aug; 20(5):333-337. doi:
10.1016/j.jclinane.2008.01.007. [PMID: 18761239] - Emil Berta, Jiri Spanhel, Oldrich Smakal, Vratislav Smolka, Tomas Gabrhelik, Per-Arne Lönnqvist. Single injection paravertebral block for renal surgery in children.
Paediatric anaesthesia.
2008 Jul; 18(7):593-7. doi:
10.1111/j.1460-9592.2008.02592.x. [PMID: 18482238] - D H Bremerich, S Kuschel, N Fetsch, B Zwissler, C Byhahn, D Meininger. [Levobupivacaine for parturients undergoing elective caesarean delivery. A dose-finding investigation].
Der Anaesthesist.
2007 Aug; 56(8):772-9. doi:
10.1007/s00101-007-1201-1. [PMID: 17508190] - Kyaw Lin Tu, Stephen B Kaye, Gediminas Sidaras, William Taylor, Alan Shenkin. Effect of intraocular surgery and ketamine on aqueous and serum cytokines.
Molecular vision.
2007 Jul; 13(?):1130-7. doi:
NULL. [PMID: 17653058] - G Foxall, R McCahon, J Lamb, J G Hardman, N M Bedforth. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid.
Anaesthesia.
2007 May; 62(5):516-8. doi:
10.1111/j.1365-2044.2007.05065.x. [PMID: 17448066] - Crina L Burlacu, Henry P Frizelle, Denis C Moriarty, Donal J Buggy. Pharmacokinetics of levobupivacaine, fentanyl, and clonidine after administration in thoracic paravertebral analgesia.
Regional anesthesia and pain medicine.
2007 Mar; 32(2):136-45. doi:
10.1016/j.rapm.2006.11.011. [PMID: 17350525] - Ken Karashima, Toshiharu Kasaba, Masahiko Taniguchi, Mitsuru Irikura, Tetsumi Irie, Mayumi Takasaki. [Plasma levobupivacaine concentrations following epidural administration of levobupivacaine conjugated with or without maltosyl-beta-cyclodextrin].
Masui. The Japanese journal of anesthesiology.
2006 Nov; 55(11):1382-6. doi:
NULL. [PMID: 17131890] - P O Ranta, T I Ala-Kokko, J E Kukkonen, P P Ohtonen, T H Raudaskoski, P K Reponen, N Rawal. Incisional and epidural analgesia after caesarean delivery: a prospective, placebo-controlled, randomised clinical study.
International journal of obstetric anesthesia.
2006 Jul; 15(3):189-94. doi:
10.1016/j.ijoa.2006.02.003. [PMID: 16798442] - Fernando Altermatt, Luis I Cortínez, Hernán Muñoz. Plasma levels of levobupivacaine after combined posterior lumbar plexus and sciatic nerve blocks.
Anesthesia and analgesia.
2006 May; 102(5):1597. doi:
10.1213/01.ane.0000215120.90857.55. [PMID: 16632866] - Rong-zong Liao, Jian-hong Peng, Yao-xiong Chen, Jin-yan Ou, Yu-ping Liang, Shu Zhou, Yu-wu Shi. [Comparison of the block characteristics of levobupivacaine vs bupivacaine for unilateral spinal block].
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA.
2005 Dec; 25(12):1563-4, 1567. doi:
". [PMID: 16361166] - G A Chalkiadis, B J Anderson, M Tay, A Bjorksten, J J Kelly. Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age.
British journal of anaesthesia.
2005 Oct; 95(4):524-9. doi:
10.1093/bja/aei218. [PMID: 16100236] - Concetta Marganella, Valeria Bruno, Francesco Matrisciano, Carlo Reale, Ferdinando Nicoletti, Daniela Melchiorri. Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice.
European journal of pharmacology.
2005 Aug; 518(2-3):111-5. doi:
10.1016/j.ejphar.2005.06.022. [PMID: 16043171] - Gianluca Cappelleri, Giorgio Aldegheri, Giorgio Danelli, Chiara Marchetti, Massimiliano Nuzzi, Gabriella Iannandrea, Andrea Casati. Spinal anesthesia with hyperbaric levobupivacaine and ropivacaine for outpatient knee arthroscopy: a prospective, randomized, double-blind study.
Anesthesia and analgesia.
2005 Jul; 101(1):77-82, table of contents. doi:
10.1213/01.ane.0000155265.79673.56. [PMID: 15976210] - T G Costello, J R Cormack, L E Mather, B LaFerlita, M A Murphy, K Harris. Plasma levobupivacaine concentrations following scalp block in patients undergoing awake craniotomy.
British journal of anaesthesia.
2005 Jun; 94(6):848-51. doi:
10.1093/bja/aei135. [PMID: 15817709] - Katsuaki Tanaka, Yutaka Oda, Tomoharu Funao, Ryota Takahashi, Naoya Hamaoka, Akira Asada. Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions.
Anesthesia and analgesia.
2005 Mar; 100(3):687-696. doi:
10.1213/01.ane.0000144420.87770.fe. [PMID: 15728053] - T I Ala-Kokko, E Räihä, J Karinen, K Kiviluoma, S Alahuhta. Pharmacokinetics of 0.5\% levobupivacaine following ilioinguinal-iliohypogastric nerve blockade in children.
Acta anaesthesiologica Scandinavica.
2005 Mar; 49(3):397-400. doi:
10.1111/j.1399-6576.2005.00635.x. [PMID: 15752408] - M J G Simon, B T Veering, R Stienstra, J W van Kleef, A G L Burm. Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration.
British journal of anaesthesia.
2004 Oct; 93(4):512-20. doi:
10.1093/bja/aeh241. [PMID: 15321929] - M J G Simon, B T Veering, R Stienstra, J W van Kleef, S G P Williams, G M McGuire, A G L Burm. The systemic absorption and disposition of levobupivacaine 0.5\% after epidural administration in surgical patients: a stable-isotope study.
European journal of anaesthesiology.
2004 Jun; 21(6):460-70. doi:
10.1017/s0265021504006088. [PMID: 15248626] - G A Chalkiadis, R L Eyres, N Cranswick, R H Taylor, S Austin. Pharmacokinetics of levobupivacaine 0.25\% following caudal administration in children under 2 years of age.
British journal of anaesthesia.
2004 Feb; 92(2):218-22. doi:
10.1093/bja/aeh051. [PMID: 14722171]