Romurtide (BioDeep_00000816774)

   


代谢物信息卡片


2-[[4-[2-[2-[3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoylamino]-5-amino-5-oxopentanoyl]amino]-6-(octadecanoylamino)hexanoic acid

化学式: C43H78N6O13 (886.5626578)
中文名称: 罗莫肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C
InChI: InChI=1S/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)

描述信息

D007155 - Immunologic Factors

同义名列表

3 个代谢物同义名

Muroctasin; Romurtide; 2-[[4-[2-[2-[3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoylamino]-5-amino-5-oxopentanoyl]amino]-6-(octadecanoylamino)hexanoic acid



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Neil Cartwright, Oliver Murch, Shaun K McMaster, Mark J Paul-Clark, David A van Heel, Bernhard Ryffel, Valerie F J Quesniaux, Timothy W Evans, Christoph Thiemermann, Jane A Mitchell. Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. American journal of respiratory and critical care medicine. 2007 Mar; 175(6):595-603. doi: 10.1164/rccm.200608-1103oc. [PMID: 17234906]
  • K Namba, E Yamamura, H Nitanai, T Otani, I Azuma. Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression. Vaccine. 1997 Mar; 15(4):405-13. doi: 10.1016/s0264-410x(96)00193-4. [PMID: 9141212]
  • K Namba, R Nakajima, T Otani, I Azuma. Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice. Vaccine. 1996 Aug; 14(12):1149-53. doi: 10.1016/0264-410x(96)00015-1. [PMID: 8911012]
  • K Namba, T Otani, Y Osada. Enhancement of platelet recovery in X-irradiated guinea pigs by romurtide, a synthetic muramyl dipeptide derivative. Blood. 1994 May; 83(9):2480-8. doi: NULL. [PMID: 8167336]
  • T Sugawara, M Kato, K Furuhama, S Takada, S Takayama. Pharmacological aspects of arthritis induced by a muramyl dipeptide analogue in rats. European journal of pharmacology. 1992 Sep; 228(2-3):147-53. doi: 10.1016/0926-6917(92)90024-7. [PMID: 1446719]
  • Y Eizuru, N Nakagawa, R Hamasuna, Y Minamishima. Protective effect of MDP-Lys(L18), a synthetic derivative of muramyldipeptide, on murine cytomegalovirus infection. Natural immunity. 1992 Jul; 11(4):225-36. doi: NULL. [PMID: 1384831]
  • T Sugawara, M Kato, S Takayama. Arthritis and hematological changes induced by an analogue of muramyl dipeptide in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1992 Apr; 18(3):395-404. doi: 10.1016/0272-0590(92)90138-8. [PMID: 1597264]
  • I Azuma. Synthetic immunoadjuvants: application to non-specific host stimulation and potentiation of vaccine immunogenicity. Vaccine. 1992; 10(14):1000-6. doi: 10.1016/0264-410x(92)90108-v. [PMID: 1471423]
  • H Shimauchi. [Studies on the induction of the humoral immune responses to Bacteroides gingivalis fimbrial antigen in mice]. [Osaka Daigaku shigaku zasshi] The journal of Osaka University Dental Society. 1990 Jun; 35(1):60-77. doi: NULL. [PMID: 1983739]
  • N Sagara, K Furuhama, T Onodera. Characterization of lymphocyte subpopulations in the blood of the cynomolgus monkey using flow cytometry. Journal of applied toxicology : JAT. 1990 Jun; 10(3):211-5. doi: 10.1002/jat.2550100312. [PMID: 2116470]
  • N Endo, T Okuda, Y Osada, H Zen-yoji. Elevation by muroctasin of the serum level of the complement subcomponent C1q in mice and of its biosynthesis by cultured mouse peritoneal macrophages. Arzneimittel-Forschung. 1990 Jan; 40(1):58-61. doi: NULL. [PMID: 2340001]
  • H Ishida, I Saiki, S Saito, A Hasegawa, M Kiso, I Azuma. Regression of line-10 hepatocellular carcinoma by a less toxic cord factor analogue combined with L18-MDP or synthetic lipid A analogues. Vaccine. 1988 Oct; 6(5):440-4. doi: 10.1016/0264-410x(88)90146-6. [PMID: 3195200]
  • K Matsubayashi, T Takegoshi. Biotransformation of muroctasin in mice. Arzneimittel-Forschung. 1988 Jul; 38(7A):1015-8. doi: . [PMID: 3190793]
  • N Endo, T Okuda, Y Osada, H Zen-Yoji. Stimulation of plasma fibronectin production in mice by muroctasin. Arzneimittel-Forschung. 1988 Jul; 38(7A):997-8. doi: NULL. [PMID: 3190806]
  • N Ichihara, R Kanazawa, S Sasaki, K Ono, T Otani, F Yamaguchi, T Une. Phase I study and clinical pharmacological study of muroctasin. Arzneimittel-Forschung. 1988 Jul; 38(7A):1043-69. doi: NULL. [PMID: 3263868]
  • N Endo. In vitro and in vivo augmentation by muroctasin of the production of the third component of complement by murine macrophages. Arzneimittel-Forschung. 1988 Jul; 38(7A):993-6. doi: NULL. [PMID: 3190805]
  • F Yamaguchi, M Akasaki, W Tsukada. Induction of colony-stimulating factor and stimulation of stem cell proliferation by injection of muroctasin. Arzneimittel-Forschung. 1988 Jul; 38(7A):980-3. doi: NULL. [PMID: 3263869]
  • K Ono, H Masayasu, F Hashimoto, M Yamada, T Takegoshi. Metabolic disposition of 14C-muroctasin in laboratory animals. Arzneimittel-Forschung. 1988 Jul; 38(7A):1009-14. doi: NULL. [PMID: 3190792]
  • C Ishihara, N Mizukoshi, J Iida, K Kato, K Yamamoto, I Azuma. Suppression of Sendai virus growth by treatment with N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine in mice. Vaccine. 1987 Dec; 5(4):295-301. doi: 10.1016/0264-410x(87)90155-1. [PMID: 2448969]
  • T Ogawa, S Kotani, H Shimauchi. Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramylpeptides and bacterial lipopolysaccharides with bovine serum albumin. Methods and findings in experimental and clinical pharmacology. 1986 Jan; 8(1):19-26. doi: NULL. [PMID: 3702542]
  • S Ikeda, Y Matsuda, C Nishimura. Enhancement by muramyldipeptides of the activities of early-type inducers of interferon. Antiviral research. 1985 Dec; 5(6):345-53. doi: 10.1016/0166-3542(85)90004-x. [PMID: 2418780]
  • C Ishihara, K Yamamoto, N Hamada, I Azuma. Effect of stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine on host resistance to Corynebacterium kutscheri infection in cortisone-treated mice. Vaccine. 1984 Dec; 2(4):261-4. doi: 10.1016/0264-410x(84)90041-0. [PMID: 6531965]
  • N Endo, T Okuda, Y Osada, H Zen-Yoji. Stimulation of complement production in mice by N alpha-(N-acetylmuramyl-L-alanyl-D-isoglutamine)-N epsilon-stearoyl-L-lysine. Infection and immunity. 1983 Nov; 42(2):618-22. doi: 10.1128/iai.42.2.618-622.1983. [PMID: 6642645]
  • K Matsumoto, T Otani, T Une, Y Osada, H Ogawa, I Azuma. Stimulation of nonspecific resistance to infection induced by muramyl dipeptide analogs substituted in the gamma-carboxyl group and evaluation of N alpha-muramyl dipeptide-N epsilon-stearoyllysine. Infection and immunity. 1983 Mar; 39(3):1029-40. doi: 10.1128/iai.39.3.1029-1040.1983. [PMID: 6341226]