Falecalcitriol (BioDeep_00000816291)
代谢物信息卡片
Falecalcitriol
化学式: C27H38F6O3 (524.2724989999999)
中文名称: 氟骨三醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCC(C(F)(F)F)(C(F)(F)F)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
InChI: InChI=1S/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1
描述信息
D018977 - Micronutrients > D014815 - Vitamins > D004100 - Dihydroxycholecalciferols
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D003879 - Dermatologic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kumi Futawaka, Tetsuya Tagami, Yuki Fukuda, Rie Koyama, Ayaka Nushida, Shoko Nezu, Hironori Yamamoto, Miyuki Imamoto, Masato Kasahara, Kenji Moriyama. Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs.
Journal of molecular endocrinology.
2016 07; 57(1):23-32. doi:
10.1530/jme-16-0048. [PMID: 27154546] - Motoko Tanaka, Kazuki Yoshida, Shingo Fukuma, Kazuko Ito, Kazutaka Matsushita, Masafumi Fukagawa, Shunichi Fukuhara, Tadao Akizawa. Effects of Secondary Hyperparathyroidism Treatment on Improvement in Anemia: Results from the MBD-5D Study.
PloS one.
2016; 11(10):e0164865. doi:
10.1371/journal.pone.0164865. [PMID: 27764168] - H Ito, H Ogata, M Yamamoto, K Takahashi, K Shishido, J Takahashi, S Taguchi, E Kinugasa. Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial.
Clinical nephrology.
2009 Jun; 71(6):660-8. doi:
10.5414/cnp71660. [PMID: 19473635] - M Tokunaga, M Tamura, N Kabashima, R Serino, T Shibata, M Matsumoto, T Miyamoto, M Miyazaki, Y Furuno, M Takeuchi, H Abe, M Okazaki, Y Otsuji. Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient.
Clinical nephrology.
2008 May; 69(5):393-4. doi:
10.5414/cnp69393. [PMID: 18538106] - Yoko Iwao, Yuki Yamaguchi, Kumiko Fujii, Yoshikazu Toba, Masahiro Asada, Naomi Nagano, Hitomi Yamamoto, Kazunori Hyoma, Sachiko Yamada, Hiroko Hirano, Yoshinori Tone, Haruhisa Ohtani, Yasushi Saika, Ryoichi Fujii. [Long-term suppressive effect of falecalcitriol on parathyroid hormone secretion in secondary hyperparathyroidism in hemodialysis patients].
Clinical calcium.
2006 May; 16(5):847-51. doi:
clica0605847851. [PMID: 16679628] - Hirotoshi Morii. [Falecalcitriol as a new therapeutic agent for secondary hyperparathyroidism].
Clinical calcium.
2005 Jan; 15(1):29-33. doi:
clica05012933. [PMID: 15632470] - Naoko Miwa, Takashi Akiba. [The trend in the development of the active vitamin D3 and its analogues].
Nihon rinsho. Japanese journal of clinical medicine.
2004 May; 62 Suppl 5(?):364-7. doi:
NULL. [PMID: 15197946] - Setsuko Komuro, Masayuki Sato, Hiroshi Kanamaru. Disposition and metabolism of F6-1alpha,25(OH)2 vitamin D3 and 1alpha,25(OH)2 vitamin D3 in the parathyroid glands of rats dosed with tritium-labeled compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Aug; 31(8):973-8. doi:
10.1124/dmd.31.8.973. [PMID: 12867483] - Noboru Ohtsuka, Koji Urayama. [Pharmacological action and clinical effects of falecalcitriol, a highly potent derivative of active vitamin D3].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2002 Dec; 120(6):427-36. doi:
10.1254/fpj.120.427. [PMID: 12528474] - S Komuro, M Sato, H Kanamaru, H Kaneko, I Nakatsuka, A Yoshitake. In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels.
Xenobiotica; the fate of foreign compounds in biological systems.
1999 Jun; 29(6):603-13. doi:
10.1080/004982599238425. [PMID: 10426559] - T Miyahara, M Harada, A Kozakai, M Matsumoto, K Hashimoto, H Inoue, K Yoda, T Nakatsu, S Kajita, R Yamazaki, S Higuchi, H Kozuka, N Nemoto. Comparison of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3 on the resorption of bone explants ex vivo.
Journal of nutritional science and vitaminology.
1999 Jun; 45(3):239-49. doi:
10.3177/jnsv.45.239. [PMID: 10524344] - T Yoshimura, S Itoh, K Tsujikawa, E Yamada, T Ishii, O Iemura, Y Kameda, T Mimura, Y Kohama. Effect of 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice.
Pharmacology.
1998 Dec; 57(6):286-94. doi:
10.1159/000028254. [PMID: 9792969] - T Akiba, F Marumo, A Owada, S Kurihara, A Inoue, Y Chida, R Ando, T Shinoda, Y Ishida, Y Ohashi. Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1998 Aug; 32(2):238-46. doi:
10.1053/ajkd.1998.v32.pm9708607. [PMID: 9708607] - K Hayashi, M Akiyoshi-Shibata, T Sakaki, Y Yabusaki. Rat CYP24 catalyses 23S-hydroxylation of 26,26,26,27,27,27-hexafluorocalcitriol in vitro.
Xenobiotica; the fate of foreign compounds in biological systems.
1998 May; 28(5):457-63. doi:
10.1080/004982598239380. [PMID: 9622848] - Y Fujisawa, K Kida. Effect of growth hormone (GH) therapy on parathyroid hormone metabolism in a girl with GH deficient short stature and chronic renal failure.
Journal of pediatric endocrinology & metabolism : JPEM.
1996 Sep; 9(5):555-8. doi:
10.1515/jpem.1996.9.5.555. [PMID: 8961134] - Y Miyamoto, T Shinki, Y Ohyama, T Kasama, H Iwasaki. Regulation of vitamin D-responsive gene expression by fluorinated analogs of calcitriol in rat osteoblastic ROB-C26 cells.
Journal of biochemistry.
1995 Nov; 118(5):1068-76. doi:
10.1093/jb/118.5.1068. [PMID: 8749328] - S Okuno, M Inaba, Y Nishizawa, H Morii. Biological activities of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 on human promyelocytic leukemic HL-60 cells: effects of fetal bovine serum and of incubation time.
Mineral and electrolyte metabolism.
1995; 21(1-3):211-6. doi:
NULL. [PMID: 7565452] - S Komuro, I Nakatsuka, A Yoshitake, K Iba. Quantitative determination of F6-1,25(OH)2 vitamin D3 in human serum by gas chromatography/mass spectrometry with high-resolution selected ion monitoring.
Biological mass spectrometry.
1994 Jan; 23(1):33-8. doi:
10.1002/bms.1200230107. [PMID: 8155746] - A Honda, N Nakashima, Y Mori, T Katsumata, S Ishizuka. Effects of vitamin D-binding proteins on HL-60 cell differentiation induced by 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D.
The Journal of steroid biochemistry and molecular biology.
1992 Jan; 41(1):109-12. doi:
10.1016/0960-0760(92)90231-7. [PMID: 1310414] - Y Nishizawa, H Morii, Y Ogura, H F De Luca. Clinical trial of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 in uremic patients on hemodialysis: preliminary report.
Contributions to nephrology.
1991; 90(?):196-203. doi:
10.1159/000420143. [PMID: 1659967] - S Okamoto, E Ejima, T Kiriyama, M Izumi, A Komori, H Suzuki, T Katsumata, A Nagata. Mechanism of action of newly developed vitamin D analogue.
Contributions to nephrology.
1991; 91(?):146-8. doi:
10.1159/000420171. [PMID: 1666031] - T Kiriyama, S Okamoto, H Suzuki, A Nagata, M Izumi, H Morii, S Nagataki. Biological activity of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 in the chick.
Acta endocrinologica.
1989 Oct; 121(4):520-4. doi:
10.1530/acta.0.1210520. [PMID: 2800926] - Y Tanaka, H F DeLuca, Y Kobayashi, N Ikekawa. 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3: a highly potent, long-lasting analog of 1,25-dihydroxyvitamin D3.
Archives of biochemistry and biophysics.
1984 Feb; 229(1):348-54. doi:
10.1016/0003-9861(84)90161-9. [PMID: 6322691]