Melanotan II (BioDeep_00000816170)

   


代谢物信息卡片


Melanotan II

化学式: C50H69N15O9 (1023.5402424)
中文名称: 美拉诺坦 II
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
InChI: InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

描述信息

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

同义名列表

2 个代谢物同义名

Melanotan II; Melanotan (MT)-II



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Patricia René, Damien Lanfray, Denis Richard, Michel Bouvier. Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity. JCI insight. 2021 02; 6(4):. doi: 10.1172/jci.insight.132778. [PMID: 33434184]
  • Thecla Rae McMillan, Maeghan A M Forster, Landon I Short, Alexander P Rudecki, Daemon L Cline, Sarah L Gray. Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice. Experimental physiology. 2021 02; 106(2):427-437. doi: 10.1113/ep088838. [PMID: 33332767]
  • Hui Yu, Kavaljit H Chhabra, Zoe Thompson, Graham L Jones, Sylee Kiran, Gary Shangguan, Malcolm J Low. Hypothalamic POMC deficiency increases circulating adiponectin despite obesity. Molecular metabolism. 2020 05; 35(?):100957. doi: 10.1016/j.molmet.2020.01.021. [PMID: 32244188]
  • Björn Peters, Henrik Hadimeri, Rebecka Wahlberg, Henri Afghahi. Melanotan II: a possible cause of renal infarction: review of the literature and case report. CEN case reports. 2020 05; 9(2):159-161. doi: 10.1007/s13730-020-00447-z. [PMID: 31953620]
  • Shalini Jain, Anna Panyutin, Naili Liu, Cuiying Xiao, Ramón A Piñol, Priyanka Pundir, Clémence Girardet, Andrew A Butler, Xinzhong Dong, Oksana Gavrilova, Marc L Reitman. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. American journal of physiology. Endocrinology and metabolism. 2018 09; 315(3):E357-E366. doi: 10.1152/ajpendo.00024.2018. [PMID: 29812984]
  • Kavaljit H Chhabra, Jessica M Adams, Brian Fagel, Daniel D Lam, Nathan Qi, Marcelo Rubinstein, Malcolm J Low. Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria. Diabetes. 2016 Mar; 65(3):660-72. doi: 10.2337/db15-0804. [PMID: 26467632]
  • Yuanzhong Xu, Eun Ran Kim, Shengjie Fan, Yan Xia, Yong Xu, Cheng Huang, Qingchun Tong. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochemical and biophysical research communications. 2014 Aug; 451(2):184-9. doi: 10.1016/j.bbrc.2014.07.079. [PMID: 25065745]
  • Petteri Rinne, Johanna M U Silvola, Sanna Hellberg, Mia Ståhle, Heidi Liljenbäck, Henriikka Salomäki, Emilia Koskinen, Salla Nuutinen, Pekka Saukko, Juhani Knuuti, Antti Saraste, Anne Roivainen, Eriika Savontaus. Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice. Arteriosclerosis, thrombosis, and vascular biology. 2014 Jul; 34(7):1346-54. doi: 10.1161/atvbaha.113.302963. [PMID: 24790139]
  • Peng Li, Bai-Ping Cui, Ling-Li Zhang, Hai-Jian Sun, Tong-Yan Liu, Guo-Qing Zhu. Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure. Experimental physiology. 2013 Feb; 98(2):435-43. doi: 10.1113/expphysiol.2012.067256. [PMID: 22872662]
  • Mamoru Tanida, Naoki Yamamoto, Toshishige Shibamoto, Kamal Rahmouni. Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation. PloS one. 2013; 8(2):e56660. doi: 10.1371/journal.pone.0056660. [PMID: 23418591]
  • Michael E Nelson, Sean M Bryant, Steven E Aks. Melanotan II injection resulting in systemic toxicity and rhabdomyolysis. Clinical toxicology (Philadelphia, Pa.). 2012 Dec; 50(10):1169-73. doi: 10.3109/15563650.2012.740637. [PMID: 23121206]
  • C Kay Song, Cheryl H Vaughan, Erin Keen-Rhinehart, Ruth B S Harris, Denis Richard, Timothy J Bartness. Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Aug; 295(2):R417-28. doi: 10.1152/ajpregu.00174.2008. [PMID: 18550869]
  • Márcia N Brito, Nilton A Brito, Deborah J Baro, C Kay Song, Timothy J Bartness. Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation. Endocrinology. 2007 Nov; 148(11):5339-47. doi: 10.1210/en.2007-0621. [PMID: 17702843]
  • Sophia Hatziieremia, Nikolaos Kostomitsopoulos, Vagelis Balafas, Constantin Tamvakopoulos. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice. Rapid communications in mass spectrometry : RCM. 2007; 21(15):2431-8. doi: 10.1002/rcm.3106. [PMID: 17610239]
  • Gertjan van Dijk, Koert de Vries, Csaba Nyakas, Bauke Buwalda, Tiziana Adage, Folkert Kuipers, Martien J H Kas, Roger A H Adan, Charles W Wilkinson, Todd E Thiele, Anton J W Scheurink. Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. Endocrinology. 2005 Dec; 146(12):5247-56. doi: 10.1210/en.2005-0472. [PMID: 16166222]
  • A C Heijboer, A M van den Hoek, H Pijl, P J Voshol, L M Havekes, J A Romijn, E P M Corssmit. Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Diabetologia. 2005 Aug; 48(8):1621-6. doi: 10.1007/s00125-005-1838-8. [PMID: 15971058]
  • G Li, Y Zhang, J T Wilsey, P J Scarpace. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. The Journal of endocrinology. 2004 Jul; 182(1):123-32. doi: 10.1677/joe.0.1820123. [PMID: 15225137]
  • Philip J Scarpace, Michael Matheny, Sergei Zolotukhin, Nihal Tümer, Yi Zhang. Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology. 2003 Aug; 45(2):211-9. doi: 10.1016/s0028-3908(03)00158-8. [PMID: 12842127]
  • Prashant Trivedi, Michael Jiang, Constantin C Tamvakopoulos, Xiaolan Shen, Hong Yu, Steven Mock, Judy Fenyk-Melody, Lex H T Van der Ploeg, Xiao-Ming Guan. Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats. Brain research. 2003 Jul; 977(2):221-30. doi: 10.1016/s0006-8993(03)02683-0. [PMID: 12834882]
  • Yang-Ho Choi, ChangLong Li, Diane L Hartzell, Ji Lin, Mary Anne Della-Fera, Clifton A Baile. MTII administered peripherally reduces fat without invoking apoptosis in rats. Physiology & behavior. 2003 Jul; 79(2):331-7. doi: 10.1016/s0031-9384(03)00118-5. [PMID: 12834806]
  • Philippe Cettour-Rose, Françoise Rohner-Jeanrenaud. The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats. Endocrinology. 2002 Jun; 143(6):2277-83. doi: 10.1210/endo.143.6.8871. [PMID: 12021192]
  • Douglas J MacNeil, Andrew D Howard, Xiaoming Guan, Tung M Fong, Ravi P Nargund, Maria A Bednarek, Mark T Goulet, David H Weinberg, Alison M Strack, Donald J Marsh, Howard Y Chen, Chun-Pyn Shen, Airu S Chen, Charles I Rosenblum, Tanya MacNeil, Michael Tota, Euan D MacIntyre, Lex H T Van der Ploeg. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. European journal of pharmacology. 2002 Apr; 440(2-3):141-57. doi: 10.1016/s0014-2999(02)01425-5. [PMID: 12007532]
  • S Mock, X Shen, C Tamvakopoulos. Determination of melanotan-II in rat plasma by liquid chromatography/tandem mass spectrometry: determination of pharmacokinetic parameters in rat following intravenous administration. Rapid communications in mass spectrometry : RCM. 2002; 16(22):2142-7. doi: 10.1002/rcm.847. [PMID: 12415547]
  • A E Walters, P B Myrdal, S Pinsuwan, A M Manka, S H Yalkowsky. Determination of melanotan II in rabbit urine using solid-phase extraction sample preparation followed by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1997 Mar; 690(1-2):99-103. doi: 10.1016/s0378-4347(96)00389-1. [PMID: 9106033]
  • S Pinsuwan, P B Myrdal, S H Yalkowsky. Systemic delivery of melanotan II through the ocular route in rabbits. Journal of pharmaceutical sciences. 1997 Mar; 86(3):396-7. doi: 10.1021/js9604265. [PMID: 9050812]
  • S O Ugwu, J Blanchard, L D Nguyen, M E Hadley, R T Dorr. A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: application to a pharmacokinetic study in rats. Biopharmaceutics & drug disposition. 1994 Jul; 15(5):383-90. doi: 10.1002/bdd.2510150505. [PMID: 7981427]
  • S O Ugwu, J Blanchard. High-performance liquid chromatographic assay for the alpha-melanotropin[4,10] fragment analogue (Melanotan-II) in rat plasma. Journal of chromatography. 1992 Dec; 584(2):175-80. doi: 10.1016/0378-4347(92)80573-9. [PMID: 1336500]