Pirenzepine hydrochloride (BioDeep_00000815437)

   


代谢物信息卡片


Pirenzepine, Dihydrochloride

化学式: C19H23Cl2N5O2 (423.1229)
中文名称: 盐酸哌仑西平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.Cl.Cl
InChI: 2*1H

描述信息

C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells[1][2].

同义名列表

6 个代谢物同义名

Pirenzepine, Dihydrochloride; Pirenzepine hydrochloride; LS 519; Pirenzepin (dihydrochloride); Gastrozepin (dihydrochloride); Pirenzepine (dihydrochloride)



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Takahiro Suzuki, Tomohiro Higuchi, Takuma Kagami, Takahiro Uotani, Mihoko Yamade, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Takahisa Furuta. Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia. European journal of clinical pharmacology. 2021 Jul; 77(7):971-978. doi: 10.1007/s00228-021-03162-5. [PMID: 34059932]
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  • Yusra Rahman, Shumaila Afrin, Mohammad Tabish. Interaction of pirenzepine with bovine serum albumin and effect of β-cyclodextrin on binding: A biophysical and molecular docking approach. Archives of biochemistry and biophysics. 2018 08; 652(?):27-37. doi: 10.1016/j.abb.2018.06.005. [PMID: 29908138]
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  • Yuhki Sato, Shin Inoue, Fumihiko Katagiri, Hiroki Itoh, Masaharu Takeyama. Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans. Biological & pharmaceutical bulletin. 2006 Jan; 29(1):166-71. doi: 10.1248/bpb.29.166. [PMID: 16394532]
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  • Takeshi Aihara, Yusuke Nakamura, Makoto M Taketo, Minoru Matsui, Susumu Okabe. Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice. American journal of physiology. Gastrointestinal and liver physiology. 2005 Jun; 288(6):G1199-207. doi: 10.1152/ajpgi.00514.2004. [PMID: 15691866]
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  • Ali Abdel-Rahman, Anjelika M Dechkovskaia, Heena Mehta-Simmons, Jazmine M Sutton, Xiangrong Guan, Wasiuddin A Khan, Mohamed B Abou-Donia. Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Archives of toxicology. 2004 Aug; 78(8):467-76. doi: 10.1007/s00204-004-0560-5. [PMID: 15045467]
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