Tamsulosin hydrochloride (BioDeep_00000815430)
代谢物信息卡片
Tamsulosin hydrochloride
化学式: C20H29ClN2O5S (444.14856140000006)
中文名称: 盐酸坦索罗辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl
InChI: /m1./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:9399
- KEGGdrug: D01024
- PubChem: 5362376
- ChEMBL: CHEMBL1200914
- MeSH: Tamsulosin
- CAS: 128332-25-2
- CAS: 106463-17-6
- medchemexpress: HY-B0661A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hong-Ping Shen, Jing-Xian Xu, Li Wang, Zhi-Bo Zheng, Yi Yu, Ke-Qi Zhu, Xue-Qin Chen. [Simiaotongzhuo Decoction for the treatment of type III prostatitis: A clinical observation].
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2020 05; 125(5):718-724. doi:
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American journal of men's health.
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Medical science monitor : international medical journal of experimental and clinical research.
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Medicine.
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American journal of men's health.
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Medicine.
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Urologia internationalis.
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Indian journal of pharmacology.
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Advances in therapy.
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American journal of men's health.
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European urology.
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BJU international.
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Current medical research and opinion.
2018 10; 34(10):1793-1801. doi:
10.1080/03007995.2018.1447451. [PMID: 29490509] - Shohei Yoshida, Takahisa Noma, Kazuhisa Miyoshi, Hiroshi Tsukihara, Naoki Orimoto, Atsushi Hakozaki, Eiji Sasaki. Therapeutic effect of TAC-302, a cyclohexenoic fatty alcohol derivative, on bladder denervation-related storage and voiding dysfunctions in rats.
Neurourology and urodynamics.
2018 09; 37(7):2106-2113. doi:
10.1002/nau.23571. [PMID: 29635706] - Andrew J Portis, Matthew F Bultitude. Re: Zhangqun Ye, Guohua Zeng, Huan Yang, et al. Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. Eur Urol 2018;73:385-91.
European urology.
2018 08; 74(2):e37-e39. doi:
10.1016/j.eururo.2018.02.009. [PMID: 29472142] - Güven Erbay, Ahmet Yalcın, Mehmet Hamza Gultekin. Predictor Role of Pretreatment Resistive and Pulsatile Indexes in the Success of Medical Expulsive Therapy of Ureteral Stones.
Urology.
2018 Aug; 118(?):47-51. doi:
10.1016/j.urology.2018.04.020. [PMID: 29729361] - Andrew C Meltzer, Pamela Katzen Burrows, Allan B Wolfson, Judd E Hollander, Michael Kurz, Ziya Kirkali, John W Kusek, Patrick Mufarrij, Stephen V Jackman, Jeremy Brown. Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial.
JAMA internal medicine.
2018 08; 178(8):1051-1057. doi:
10.1001/jamainternmed.2018.2259. [PMID: 29913020] - Andrew J Portis, Matthew F Bultitude. Reply to the Reply to Andrew J. Portis and Matthew F. Bultitude's Letter to the Editor re: Zhangqun Ye, Guohua Zeng, Huan Yang, et al. Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. Eur Urol 2018;73:385-91.
European urology.
2018 08; 74(2):e42. doi:
10.1016/j.eururo.2018.04.013. [PMID: 29724501] - Cheol-Hee Cho, Jin-Hong Min, Kyu-Mok Hwang, Eun-Seok Park. Development of sustained-release microparticles containing tamsulosin HCl for orally disintegrating tablet using melt-adsorption method.
Drug delivery and translational research.
2018 06; 8(3):552-564. doi:
10.1007/s13346-018-0477-9. [PMID: 29359246] - Kamaljot S Kaler, Egor Parkhomenko, Zhamshid Okunohov, Roshan M Patel, Jaime Landman, Ralph V Clayman, Carlos A Uribe. Ureteroscopic holmium laser-assisted retrograde nephrostomy access: a novel approach to percutaneous stone removal.
World journal of urology.
2018 Jun; 36(6):963-969. doi:
10.1007/s00345-018-2223-9. [PMID: 29423876] - Olivia Burns, John Zhu, Michael J Manyak, Ramiya Ravindranath, Fariba Koosha, Nazneen Haque, Sally Chung. Relative Bioavailability of Fixed-Dose Combinations of Tamsulosin and Dutasteride: Results From 2 Randomized Trials in Healthy Male Volunteers.
Clinical pharmacology in drug development.
2018 05; 7(4):422-434. doi:
10.1002/cpdd.380. [PMID: 28800206] - Hamidreza Baghani Aval, Zeinab Ameli, Mojtaba Ameli. Effectiveness of the addition of tadalafil to tamsulosin in the treatment of acute urinary retention in patients with benign prostatic hyperplasia: A randomized clinical trial.
Urologia.
2018 May; 85(2):51-54. doi:
10.1177/0391560317749427. [PMID: 30043714] - D V Ergakov, A G Martov. [Combination therapy in the management of urinary disorders after transurethral resection of the prostate].
Urologiia (Moscow, Russia : 1999).
2018 Mar; ?(1):62-70. doi:
NULL. [PMID: 29634136] - Bo Ram Choi, Hye Kyung Kim, Kiran Kumar Soni, Keshab Kumar Karna, Sung Won Lee, Insuk So, Jong Kwan Park. Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model.
Drug design, development and therapy.
2018; 12(?):1855-1863. doi:
10.2147/dddt.s164049. [PMID: 29970959] - Lisette Haddad, Stéphanie Corriveau, Eric Rousseau, Simon Blouin, Jean-Charles Pasquier, Yves Ponsot, Marie-Ève Roy-Lacroix. Impact of tamsulosin and nifedipine on contractility of pregnant rat ureters in vitro.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2018 Jan; 31(2):191-196. doi:
10.1080/14767058.2017.1280017. [PMID: 28068846] - Oscar Luis Farelo-Trejos, Nahuel Eduardo Paesano, Juan José Serna-Hurtado, Mauro Fabián García, Juan Ignacio Monzó-Gardiner. [Prognostic factors predicting failure of the trial without catheter after tamsulosin in patients with acute urinary retention.].
Archivos espanoles de urologia.
2017 Nov; 70(9):759-765. doi:
NULL. [PMID: 29099378] - B U Shalekenov, Y A Kuandykov, S B Shalekenov. [Effectiveness of Omnic and Omnic Ocas in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (multi-center observing program)].
Urologiia (Moscow, Russia : 1999).
2017 Oct; ?(5):42-47. doi:
10.18565/urology.2017.5.42-47. [PMID: 29135141] - Jonathan S Ellison, Paul A Merguerian, Benjamin C Fu, Sarah K Holt, Thomas S Lendvay, John L Gore, Margarett Shnorhavorian. Use of medical expulsive therapy in children: An assessment of nationwide practice patterns and outcomes.
Journal of pediatric urology.
2017 Oct; 13(5):509.e1-509.e7. doi:
10.1016/j.jpurol.2017.03.022. [PMID: 28483465] - Renee Kurczewski, Chet Bowen, David Collins, John Zhu, Gulyeter Serbest, Michael Manyak. Bioequivalence Studies of a Reformulated Dutasteride and Tamsulosin Hydrochloride Combination Capsule and a Commercially Available Formulation.
Clinical pharmacology in drug development.
2017 Sep; 6(5):508-516. doi:
10.1002/cpdd.334. [PMID: 28127948] - A V Govorov, A O Vasilyev, D Yu Pushkar. [Efficacy of tamsulosin for treating lower urinary tract symptoms in patients with advanced prostate cancer].
Urologiia (Moscow, Russia : 1999).
2017 Sep; ?(4):37-41. doi:
. [PMID: 28952690] - Miao Yan, Peng Xue, Kunpeng Wang, Guojun Gao, Wei Zhang, Fanghu Sun. Does combination therapy with tamsulosin and trospium chloride improve lower urinary tract symptoms after SEEDS brachytherapy for prostate cancer compared with tamsulosin alone? : A prospective, randomized, controlled trial.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
2017 Sep; 193(9):714-721. doi:
10.1007/s00066-017-1162-5. [PMID: 28612083] - Xiang Fei, Wei Jin, Shengyu Hua, Yan Song. Prospective Study on Association of Prostatic Calcifications with Clinical Symptoms and Results of Treatment in Men with type III prostatitis.
Scientific reports.
2017 07; 7(1):5234. doi:
10.1038/s41598-017-05550-3. [PMID: 28701725] - Ruwen Zheng, Hui Hu. [Impacts of electroacupuncture on benign prostatic hyperplasia and the levels of estrogen and androgen in patients].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Jun; 37(6):599-602. doi:
10.13703/j.0255-2930.2017.06.007. [PMID: 29231500] - John Roger Bell, Kristina L Penniston, Sara L Best, Stephen Y Nakada. A survey of patient preferences regarding medical expulsive therapy following the SUSPEND trial.
The Canadian journal of urology.
2017 Jun; 24(3):8827-8831. doi:
NULL. [PMID: 28646938] - Yaser Pashaei, Fatemeh Ghorbani-Bidkorbeh, Maryam Shekarchi. Superparamagnetic graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of tamsulosin hydrochloride in human plasma by high performance liquid chromatography-ultraviolet detection.
Journal of chromatography. A.
2017 May; 1499(?):21-29. doi:
10.1016/j.chroma.2017.03.038. [PMID: 28410800] - M Kennedy Hall, Mathew Sorenson, Jonathan Harper. Should Kidney Stone Patients With Diagnosis by Ultrasonography Be Prescribed Tamsulosin?.
Annals of emergency medicine.
2017 04; 69(4):523-524. doi:
10.1016/j.annemergmed.2016.11.044. [PMID: 28335927] - Da-Lin Sun, Bin Cai, Bao-Fang Jin, Guo-Shou Xia, Zhi-An Tang, Wen-Tao Yang, Qiang Zou, Guo-Hong Song, Jian-Guo Liu, Hong-le Zhao, Ning Dai, Jia-Hui Wang, Ya-Long Gu, Ya-Lin Zhai. [Bushen Daozhuo Granules for type Ⅲ prostatitis: A multicenter randomized controlled clinical trial].
Zhonghua nan ke xue = National journal of andrology.
2017 Feb; 23(2):164-168. doi:
". [PMID: 29658256] - Fen Wei, Sicen Wang, Nan Lv, Yusi Bu, Xiaoyu Xie. Characterization the affinity of α1A adrenoreceptor by cell membrane chromatography with frontal analysis and stoichiometric displacement model.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jan; 1040(?):273-281. doi:
10.1016/j.jchromb.2016.11.002. [PMID: 27836488] - Pamela K Burrows, Judd E Hollander, Allan B Wolfson, Michael C Kurz, Lorna Richards, Sara DiFiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W Kusek, Chloe Michel, Andrew C Meltzer. Design and challenges of a randomized clinical trial of medical expulsive therapy (tamsulosin) for urolithiasis in the emergency department.
Contemporary clinical trials.
2017 01; 52(?):91-94. doi:
10.1016/j.cct.2016.11.010. [PMID: 27890522] - A G Martov, D V Ergakov. [Age-related androgen deficiency and benign prostatic hyperplasia: how to improve the rehabilitation of patients after transurethral surgery?].
Urologiia (Moscow, Russia : 1999).
2016 Dec; ?(6):110-117. doi:
NULL. [PMID: 28248054] - Naoki Wada, Hiromichi Iuchi, Masafumi Kita, Kazumi Hashizume, Seiji Matsumoto, Hidehiro Kakizaki. Urodynamic Efficacy and Safety of Mirabegron Add-on Treatment with Tamsulosin for Japanese Male Patients with Overactive Bladder.
Lower urinary tract symptoms.
2016 Sep; 8(3):171-6. doi:
10.1111/luts.12091. [PMID: 27619782] - Steven A Kaplan. Re: Comparison of Tamsulosin plus Serenoa repens with Tamsulosin in the Treatment of Benign Prostatic Hyperplasia in Korean Men: 1-Year Randomized Open Label Study.
The Journal of urology.
2016 08; 196(2):503. doi:
10.1016/j.juro.2016.05.021. [PMID: 27479407] - Noriaki Utsunomiya, Keiyu Matsumoto, Hiroyuki Tsunemori, Koei Muguruma, Mutsushi Kawakita, Yuki Kamiyama, Sojun Kanamaru, Noriyuki Ito, Hideki Tsukazaki, Toshiaki Shirahase, Takeshi Takahashi. [A Crossover Comparison Study on Lower Urinary Tract Symptoms with Overactive Bladder Secondary to Benign Prostatic Hyperplasia: Naftopidil versus Tamsulosin with Solifenacin].
Hinyokika kiyo. Acta urologica Japonica.
2016 Jul; 62(7):341-7. doi:
10.14989/actauroljap_62_7_341. [PMID: 27569351] - Cosimo De Nunzio, Aldo Brassetti, Mariangela Bellangino, Alberto Trucchi, Stefano Petta, Fabrizio Presicce, Andrea Tubaro. Tamsulosin or Silodosin Adjuvant Treatment Is Ineffective in Improving Shockwave Lithotripsy Outcome: A Short-Term Follow-Up Randomized, Placebo-Controlled Study.
Journal of endourology.
2016 07; 30(7):817-21. doi:
10.1089/end.2016.0113. [PMID: 27080916] - Antonio Alcaraz, Joaquín Carballido-Rodríguez, Miguel Unda-Urzaiz, Rafael Medina-López, José L Ruiz-Cerdá, Federico Rodríguez-Rubio, Darío García-Rojo, Francisco J Brenes-Bermúdez, José M Cózar-Olmo, Víctor Baena-González, José Manasanch. Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment--the QUALIPROST study.
International urology and nephrology.
2016 May; 48(5):645-56. doi:
10.1007/s11255-015-1206-7. [PMID: 26810324] - Robert Chan, Alvaro Munoz, Evan P Wenker, Melissa Whipple, Brian Miles, Timothy B Boone. Solifenacin and Tamsulosin Combination Therapy Decreases Urine Nerve Growth Factor/Creatinine Levels in Men.
Urology.
2016 05; 91(?):150-3. doi:
10.1016/j.urology.2016.01.020. [PMID: 26829718] - Ahmed Shahat, Ahmad Elderwy, Ahmed S Safwat, Islam F Abdelkawi, Ahmed Reda, Yasser Abdelsalam, Mohamed Sayed, Hisham Hammouda. Is Tamsulosin Effective after Shock Wave Lithotripsy for Pediatric Renal Stones? A Randomized, Controlled Study.
The Journal of urology.
2016 Apr; 195(4 Pt 2):1284-8. doi:
10.1016/j.juro.2015.11.021. [PMID: 26926538] - Glenn M Preminger, John Roger Bell, Stephen Y Nakada. Medical Expulsive Therapy is Useful for Urinary Calculi.
The Journal of urology.
2016 Mar; 195(3):554-6. doi:
10.1016/j.juro.2015.12.066. [PMID: 26690572] - Bo Ram Choi, Kiran Kumar Soni, Li Tao Zhang, Sung Won Lee, Insuk So, Hye Kyung Kim, Jong Kwan Park. Effect of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid on the intraurethral pressure in a rat model of benign prostatic hyperplasia.
International journal of urology : official journal of the Japanese Urological Association.
2016 Mar; 23(3):259-65. doi:
10.1111/iju.13018. [PMID: 26646436] - Abul-Fotouh Ahmed. Sonographic Parameters Predicting the Outcome of Patients With Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Treated With Alpha1-Adrenoreceptor Antagonist.
Urology.
2016 Feb; 88(?):143-8. doi:
10.1016/j.urology.2015.11.017. [PMID: 26607685] - Sri Sivalingam, Necole M Streeper, Priyanka D Sehgal, Brian C Sninsky, Sara L Best, Stephen Y Nakada. Does Combination Therapy with Tamsulosin and Tolterodine Improve Ureteral Stent Discomfort Compared with Tamsulosin Alone? A Double-Blind, Randomized, Controlled Trial.
The Journal of urology.
2016 Feb; 195(2):385-90. doi:
10.1016/j.juro.2015.08.104. [PMID: 26393904] - Abul-Fotouh Ahmed, Essam Shalaby, Mohamed El-Feky, Ayman Kotb, Ebrahim Elsotohi, Mohamed El-Kholy, Ahmed Ragab, Emad Salem. Role of Tamsulosin Therapy after Extracorporeal Shockwave Lithotripsy for Renal Stones: Randomized Controlled Trial.
Urologia internationalis.
2016; 97(3):266-272. doi:
10.1159/000445840. [PMID: 27082108] - Alain Latil, Marie-Thérèse Pétrissans, Jérôme Rouquet, Grégoire Robert, Alexandre de la Taille. Effects of hexanic extract of Serenoa repens (Permixon® 160 mg) on inflammation biomarkers in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia.
The Prostate.
2015 Dec; 75(16):1857-67. doi:
10.1002/pros.23059. [PMID: 26306400] - Jun Wang, Yang Xiao, Zhi-gang Wang, Feng-feng Wang, Xue-jiao Cui. [Combination therapy of Xipayimaizipizi Capsules and Tamsulosin for benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2015 Nov; 21(11):1005-9. doi:
NULL. [PMID: 26738328] - Blayne Welk, Eric McArthur, Lisa-Ann Fraser, Jade Hayward, Stephanie Dixon, Y Joseph Hwang, Michael Ordon. The risk of fall and fracture with the initiation of a prostate-selective α antagonist: a population based cohort study.
BMJ (Clinical research ed.).
2015 Oct; 351(?):h5398. doi:
10.1136/bmj.h5398. [PMID: 26502947] - Young Joon Moon, Hong-Wook Kim, Jin Bum Kim, Hyung Joon Kim, Young-Seop Chang. Distribution of ureteral stones and factors affecting their location and expulsion in patients with renal colic.
Korean journal of urology.
2015 Oct; 56(10):717-21. doi:
10.4111/kju.2015.56.10.717. [PMID: 26495073]