(2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid (BioDeep_00000814025)
代谢物信息卡片
(2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid
化学式: C6H10O7 (194.042651)
中文名称: 甘露糖醛酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=O)C(C(C(C(C(=O)O)O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3-,4+,5+/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Soheil Najafi, Payam Saadat, Nahid Beladi Moghadam, Ali Manoucherinia, Zahra Aghazadeh, Anita Vali Mohammadi, Hossein Pashaiefar, Mostafa Hosseini, Abbas Mirshafiey. Evaluation of the Effect of Mannuronic Acid as a Novel NSAID With Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1, and TRAF6 Genes and Serum Levels of IL-6 and TNF-α in Patients With Multiple Sclerosis.
Journal of clinical pharmacology.
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Current drug discovery technologies.
2021; 18(5):e17092020186049. doi:
10.2174/1570163817999200918104333. [PMID: 32964823] - Decheng Bi, Lijun Yao, Zhijian Lin, Lianli Chi, Hui Li, Hong Xu, Xiubo Du, Qiong Liu, Zhangli Hu, Jun Lu, Xu Xu. Unsaturated mannuronate oligosaccharide ameliorates β-amyloid pathology through autophagy in Alzheimer's disease cell models.
Carbohydrate polymers.
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Immunopharmacology and immunotoxicology.
2020 Jun; 42(3):228-236. doi:
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RNA biology.
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Archives of physiology and biochemistry.
2019 Dec; 125(5):435-440. doi:
10.1080/13813455.2018.1481094. [PMID: 29882437] - Bo Pilgaard, Casper Wilkens, Florian-Alexander Herbst, Marlene Vuillemin, Nanna Rhein-Knudsen, Anne S Meyer, Lene Lange. Proteomic enzyme analysis of the marine fungus Paradendryphiella salina reveals alginate lyase as a minimal adaptation strategy for brown algae degradation.
Scientific reports.
2019 Aug; 9(1):12338. doi:
10.1038/s41598-019-48823-9. [PMID: 31451726] - Mohammad Javad Fattahi, Hossein Ahmadi, Fahimeh Jafarnezhad-Ansariha, Seyed Shahabeddin Mortazavi-Jahromi, Bernd H A Rehm, Salvatore Cuzzocrea, Hidenori Matsuo, Abbas Mirshafiey. Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Apr; 100(?):495-500. doi:
10.1016/j.biopha.2018.02.059. [PMID: 29477913] - Hossein Ahmadi, Mahdi Mahmoudi, Farhad Gharibdoost, Mahdi Vojdanian, Ahmad Reza Jamshidi, Mohammad Javad Fattahi, Zahra Aghazadeh, Anis Barati, Abbas Mirshafiey. Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis.
Inflammopharmacology.
2018 Feb; 26(1):57-65. doi:
10.1007/s10787-017-0410-8. [PMID: 29063487] - Mozhgan Jahanbakhshi, Zohreh Babaloo, Seyed Shahabeddin Mortazavi-Jahromi, Maryam Monsef Shokri, Hossein Ahmadi, Abbas Mirshafiey. Modification of Sexual Hormones in Rheumatoid Arthritis Patients by M2000 (β-D-mannuronic Acid) as a Novel NSAID with Immunosuppressive Property.
Endocrine, metabolic & immune disorders drug targets.
2018; 18(5):530-536. doi:
10.2174/1871530318666180418111354. [PMID: 29667557] - Hossein Ahmadi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Farhad Gharibdoost, Mahdi Vojdanian, Mohammad Javad Fattahi, Noushin Rastkari, Zahra Aghazadeh, Abbas Mirshafiey. Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property.
Iranian journal of allergy, asthma, and immunology.
2017 Oct; 16(5):433-442. doi:
NULL. [PMID: 29149783] - Soma Hosseini, Mohammad Abdollahi, Gholamreza Azizi, Mohammad Javad Fattahi, Noshin Rastkari, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Abbas Mirshafiey. Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model.
Journal of basic and clinical physiology and pharmacology.
2017 May; 28(3):249-255. doi:
10.1515/jbcpp-2016-0092. [PMID: 28207414] - M D Bakaeva, S P Chetverikov, T Yu Korshunova, O N Loginov. [The new bacterial strain Paenibacillus sp. IB-1: A producer of exopolysaccharide and biologically active substances with phytohormonal and antifungal activities].
Prikladnaia biokhimiia i mikrobiologiia.
2017 Mar; 53(2):204-12. doi:
. [PMID: 29509374] - S Aletaha, L Haddad, M Roozbehkia, R Bigdeli, V Asgary, M Mahmoudi, A Mirshafiey. M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway.
Scandinavian journal of immunology.
2017 Feb; 85(2):122-129. doi:
10.1111/sji.12519. [PMID: 27943385] - Hossein Ahmadi, Ahmad R Jamshidi, Mahdi Mahmoudi, Salvatore Cuzzocrea, Mohammad Javad Fattahi, Anis Barati, Bernd H A Rehm, Hidenori Matsuo, Abbas Mirshafiey. The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis.
Current drug discovery technologies.
2017; 14(3):206-214. doi:
10.2174/1570163814666170321113059. [PMID: 28325148] - Miaomiao Li, Guangsheng Li, Qingsen Shang, Xiuxia Chen, Wei Liu, Xiong'e Pi, Liying Zhu, Yeshi Yin, Guangli Yu, Xin Wang. In vitro fermentation of alginate and its derivatives by human gut microbiota.
Anaerobe.
2016 Jun; 39(?):19-25. doi:
10.1016/j.anaerobe.2016.02.003. [PMID: 26891629] - A Mirshafiey, B Rehm, M Sotoude, A Razavi, R Safari Abhari, Z Borzooy. Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis.
Immunopharmacology and immunotoxicology.
2007; 29(1):49-61. doi:
10.1080/08923970701282387. [PMID: 17464766] - Dag Vollstad, Jarl Bøgwald, Olav Gåserød, Roy A Dalmo. Influence of high-M alginate on the growth and survival of Atlantic cod (Gadus morhua L.) and spotted wolffish (Anarhichas minor Olafsen) fry.
Fish & shellfish immunology.
2006 Apr; 20(4):548-61. doi:
10.1016/j.fsi.2005.07.004. [PMID: 16219475] - A Mirshafiey, S Cuzzocrea, B Rehm, E Mazzon, F Saadat, M Sotoude. Treatment of experimental arthritis with M2000, a novel designed non-steroidal anti-inflammatory drug.
Scandinavian journal of immunology.
2005 May; 61(5):435-41. doi:
10.1111/j.1365-3083.2005.01594.x. [PMID: 15882435] - Trude H Flo, Liv Ryan, Eicke Latz, Osamu Takeuchi, Brian G Monks, Egil Lien, Øyvind Halaas, Shizuo Akira, Gudmund Skjåk-Braek, Douglas T Golenbock, Terje Espevik. Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry.
2002 Sep; 277(38):35489-95. doi:
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Biomacromolecules.
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Biotechnology and bioengineering.
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