PD168393 (BioDeep_00000813508)

   


代谢物信息卡片


4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

化学式: C17H13BrN4O (368.0272668)
中文名称: PD168393
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
InChI: InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163952 - EGFR-targeting Agent
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor

同义名列表

2 个代谢物同义名

4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yukihisa Takada, Osamu Yamanaka, Yuka Okada, Takayoshi Sumioka, Peter S Reinach, Shizuya Saika. Effects of a prostaglandin F2alpha derivative glaucoma drug on EGF expression and E-cadherin expression in a corneal epithelial cell line. Cutaneous and ocular toxicology. 2020 Jun; 39(2):75-82. doi: 10.1080/15569527.2020.1722152. [PMID: 31986917]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xuegang Sun, Jiani Liang, Xueqing Yao, Chunhua Lu, Tianyu Zhong, Xiaoyang Hong, Xiaofei Wang, Wenjuan Xu, Miaoning Gu, Jing Tang. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget. 2015 Nov; 6(34):35478-95. doi: 10.18632/oncotarget.6071. [PMID: 26486084]
  • Tony N Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G Dickhout, Joan C Krepinsky. SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology : JASN. 2015 Aug; 26(8):1839-54. doi: 10.1681/asn.2013121332. [PMID: 25398788]
  • Zai-Wang Li, Ji-Jun Li, Lan Wang, Jian-Ping Zhang, Jing-Jing Wu, Xu-Qiang Mao, Guo-Feng Shi, Qian Wang, Feng Wang, Jian Zou. Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury. Journal of neuroinflammation. 2014 Apr; 11(?):71. doi: 10.1186/1742-2094-11-71. [PMID: 24708754]
  • Saveria Pastore, Daniela Lulli, Paolo Fidanza, Alla I Potapovich, Vladimir A Kostyuk, Chiara De Luca, Elena Mikhal'chik, Liudmila G Korkina. Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system. Antioxidants & redox signaling. 2012 Feb; 16(4):314-28. doi: 10.1089/ars.2011.4053. [PMID: 21967610]
  • Kelli Sharp, Kelly Matsudaira Yee, Oswald Steward. A re-assessment of the effects of treatment with an epidermal growth factor receptor (EGFR) inhibitor on recovery of bladder and locomotor function following thoracic spinal cord injury in rats. Experimental neurology. 2012 Feb; 233(2):649-59. doi: 10.1016/j.expneurol.2011.04.013. [PMID: 22078761]
  • Jeevan K Prasain, Alireza Arabshahi, Ray Moore, Stephen Barnes, Steven L Carroll. A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Dec; 876(2):219-24. doi: 10.1016/j.jchromb.2008.10.046. [PMID: 19010087]
  • Karina Zitta, Martin Albrecht, Stephan Weidinger, Artur Mayerhofer, Frank Köhn. Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility. Asian journal of andrology. 2007 Sep; 9(5):690-6. doi: 10.1111/j.1745-7262.2007.00289.x. [PMID: 17712488]
  • Yuehan Zhou, Patrice Bouyer, Walter F Boron. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. American journal of physiology. Renal physiology. 2006 Aug; 291(2):F358-67. doi: 10.1152/ajprenal.00520.2005. [PMID: 16705143]