Pisatin (BioDeep_00000008131)

Main id: BioDeep_00000396530

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


16-methoxy-5,7,11,19-tetraoxapentacyclo[10.8.0.0²,¹⁰.0⁴,⁸.0¹³,¹⁸]icosa-2(10),3,8,13,15,17-hexaen-1-ol

化学式: C17H14O6 (314.0790344)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(ccc2c(c1)OC[C@]1([C@@H]2Oc2c1cc1c(c2)OCO1)O)OC
InChI: InChI=1S/C17H14O6/c1-19-9-2-3-10-12(4-9)20-7-17(18)11-5-14-15(22-8-21-14)6-13(11)23-16(10)17/h2-6,16,18H,7-8H2,1H3

描述信息

Stress metabolite from Pisum sativum (pea) and Trifolium pratense (red clover). Pisatin is found in many foods, some of which are pulses, tea, common pea, and herbs and spices.
Pisatin is found in common pea. Pisatin is a stress metabolite from Pisum sativum (pea) and Trifolium pratense (red clover).
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents

同义名列表

9 个代谢物同义名

16-methoxy-5,7,11,19-tetraoxapentacyclo[10.8.0.0²,¹⁰.0⁴,⁸.0¹³,¹⁸]icosa-2(10),3,8,13,15,17-hexaen-1-ol; 6a-Hydroxy-3-methoxy-8,9-methylenedioxypterocarpan; pisatin, (6aS-cis)-isomer; pisatin, (6aR-cis)-isomer; (S,S)-Pisatin; (-)-Pisatin; (+)-pisatin; pisatin; Pisatin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

13 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(10)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Catherine C Wasmann, Jeffrey J Coleman. Screening and Assessment of Pisatin Demethylase Activity (PDA ). Methods in molecular biology (Clifton, N.J.). 2022; 2391(?):185-190. doi: 10.1007/978-1-0716-1795-3_15. [PMID: 34686986]
  • Lee A Hadwiger. Nonhost Disease Resistance in Pea: Chitosan's Suggested Role in DNA Minor Groove Actions Relative to Phytoalexin-Eliciting Anti-Cancer Compounds. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245913. [PMID: 33327391]
  • Agnieszka Woźniak, Kinga Drzewiecka, Jacek Kęsy, Łukasz Marczak, Dorota Narożna, Marcin Grobela, Rafał Motała, Jan Bocianowski, Iwona Morkunas. The Influence of Lead on Generation of Signalling Molecules and Accumulation of Flavonoids in Pea Seedlings in Response to Pea Aphid Infestation. Molecules (Basel, Switzerland). 2017 Aug; 22(9):. doi: 10.3390/molecules22091404. [PMID: 28837107]
  • Agnieszka Woźniak, Magda Formela, Piotr Bilman, Katarzyna Grześkiewicz, Waldemar Bednarski, Łukasz Marczak, Dorota Narożna, Katarzyna Dancewicz, Van Chung Mai, Beata Borowiak-Sobkowiak, Jolanta Floryszak-Wieczorek, Beata Gabryś, Iwona Morkunas. The Dynamics of the Defense Strategy of Pea Induced by Exogenous Nitric Oxide in Response to Aphid Infestation. International journal of molecular sciences. 2017 Feb; 18(2):. doi: 10.3390/ijms18020329. [PMID: 28165429]
  • Iwona Morkunas, Agnieszka Woźniak, Magda Formela, Van Chung Mai, Łukasz Marczak, Dorota Narożna, Beata Borowiak-Sobkowiak, Christina Kühn, Bernhard Grimm. Pea aphid infestation induces changes in flavonoids, antioxidative defence, soluble sugars and sugar transporter expression in leaves of pea seedlings. Protoplasma. 2016 Jul; 253(4):1063-79. doi: 10.1007/s00709-015-0865-7. [PMID: 26239447]
  • G Desalegn, R Turetschek, H-P Kaul, S Wienkoop. Microbial symbionts affect Pisum sativum proteome and metabolome under Didymella pinodes infection. Journal of proteomics. 2016 06; 143(?):173-187. doi: 10.1016/j.jprot.2016.03.018. [PMID: 27016040]
  • Herana Kamal Seneviratne, Doralyn S Dalisay, Kye-Won Kim, Syed G A Moinuddin, Hong Yang, Christopher M Hartshorn, Laurence B Davin, Norman G Lewis. Non-host disease resistance response in pea (Pisum sativum) pods: Biochemical function of DRR206 and phytoalexin pathway localization. Phytochemistry. 2015 May; 113(?):140-8. doi: 10.1016/j.phytochem.2014.10.013. [PMID: 25457488]
  • Lee A Hadwiger, Kiwamu Tanaka. EDTA a novel inducer of pisatin, a phytoalexin indicator of the non-host resistance in peas. Molecules (Basel, Switzerland). 2014 Dec; 20(1):24-34. doi: 10.3390/molecules20010024. [PMID: 25546618]
  • Lee A Hadwiger, Keri Druffel, Jodi L Humann, Brenda K Schroeder. Nuclease released by Verticillium dahliae is a signal for non-host resistance. Plant science : an international journal of experimental plant biology. 2013 Mar; 201-202(?):98-107. doi: 10.1016/j.plantsci.2012.11.011. [PMID: 23352407]
  • Lee A Hadwiger, James Polashock. Fungal mitochondrial DNases: effectors with the potential to activate plant defenses in nonhost resistance. Phytopathology. 2013 Jan; 103(1):81-90. doi: 10.1094/phyto-04-12-0085-r. [PMID: 23228145]
  • Nicholas A Milani, Daniel P Lawrence, A Elizabeth Arnold, Hans D VanEtten. Origin of pisatin demethylase (PDA) in the genus Fusarium. Fungal genetics and biology : FG & B. 2012 Nov; 49(11):933-42. doi: 10.1016/j.fgb.2012.08.007. [PMID: 22985693]
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  • Jeffrey J Coleman, Gerard J White, Marianela Rodriguez-Carres, Hans D Vanetten. An ABC transporter and a cytochrome P450 of Nectria haematococca MPVI are virulence factors on pea and are the major tolerance mechanisms to the phytoalexin pisatin. Molecular plant-microbe interactions : MPMI. 2011 Mar; 24(3):368-76. doi: 10.1094/mpmi-09-10-0198. [PMID: 21077772]
  • Klaas Bouwmeester, Mara de Sain, Rob Weide, Anne Gouget, Sofieke Klamer, Herve Canut, Francine Govers. The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector. PLoS pathogens. 2011 Mar; 7(3):e1001327. doi: 10.1371/journal.ppat.1001327. [PMID: 21483488]
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  • Sumanti Gupta, Dipankar Chakraborti, Anindita Sengupta, Debabrata Basu, Sampa Das. Primary metabolism of chickpea is the initial target of wound inducing early sensed Fusarium oxysporum f. sp. ciceri race I. PloS one. 2010 Feb; 5(2):e9030. doi: 10.1371/journal.pone.0009030. [PMID: 20140256]
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  • Jeffrey J Coleman, Steve D Rounsley, Marianela Rodriguez-Carres, Alan Kuo, Catherine C Wasmann, Jane Grimwood, Jeremy Schmutz, Masatoki Taga, Gerard J White, Shiguo Zhou, David C Schwartz, Michael Freitag, Li-Jun Ma, Etienne G J Danchin, Bernard Henrissat, Pedro M Coutinho, David R Nelson, Dave Straney, Carolyn A Napoli, Bridget M Barker, Michael Gribskov, Martijn Rep, Scott Kroken, István Molnár, Christopher Rensing, John C Kennell, Jorge Zamora, Mark L Farman, Eric U Selker, Asaf Salamov, Harris Shapiro, Jasmyn Pangilinan, Erika Lindquist, Casey Lamers, Igor V Grigoriev, David M Geiser, Sarah F Covert, Esteban Temporini, Hans D Vanetten. The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion. PLoS genetics. 2009 Aug; 5(8):e1000618. doi: 10.1371/journal.pgen.1000618. [PMID: 19714214]
  • Marcello Iriti, Franco Faoro. Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. International journal of molecular sciences. 2009 Jul; 10(8):3371-3399. doi: 10.3390/ijms10083371. [PMID: 20111684]
  • Jeffrey J Coleman, Eleftherios Mylonakis. Efflux in fungi: la pièce de résistance. PLoS pathogens. 2009 Jun; 5(6):e1000486. doi: 10.1371/journal.ppat.1000486. [PMID: 19557154]
  • Giovanni Del Sorbo, Michelina Ruocco, Henk-Jan Schoonbeek, Felice Scala, Catello Pane, Francesco Vinale, Marteen A De Waard. Cloning and functional characterization of BcatrA, a gene encoding an ABC transporter of the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea). Mycological research. 2008 Jun; 112(Pt 6):737-46. doi: 10.1016/j.mycres.2008.01.005. [PMID: 18515055]
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  • Evans Kaimoyo, Mohamed A Farag, Lloyd W Sumner, Catherine Wasmann, Joel L Cuello, Hans VanEtten. Sub-lethal levels of electric current elicit the biosynthesis of plant secondary metabolites. Biotechnology progress. 2008 Mar; 24(2):377-84. doi: 10.1021/bp0703329. [PMID: 18331050]
  • Evans Kaimoyo, Hans D VanEtten. Inactivation of pea genes by RNAi supports the involvement of two similar O-methyltransferases in the biosynthesis of (+)-pisatin and of chiral intermediates with a configuration opposite that found in (+)-pisatin. Phytochemistry. 2008 Jan; 69(1):76-87. doi: 10.1016/j.phytochem.2007.06.013. [PMID: 17707445]
  • Nicola J Patron, Ross F Waller, Anton J Cozijnsen, David C Straney, Donald M Gardiner, William C Nierman, Barbara J Howlett. Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. BMC evolutionary biology. 2007 Sep; 7(?):174. doi: 10.1186/1471-2148-7-174. [PMID: 17897469]
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  • Tomoyoshi Akashi, Hans D VanEtten, Yuji Sawada, Catherine C Wasmann, Hiroshi Uchiyama, Shin-ichi Ayabe. Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis. Phytochemistry. 2006 Dec; 67(23):2525-30. doi: 10.1016/j.phytochem.2006.09.010. [PMID: 17067644]
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  • Qindong Wu, Hans D VanEtten. Introduction of plant and fungal genes into pea (Pisum sativum L.) hairy roots reduces their ability to produce pisatin and affects their response to a fungal pathogen. Molecular plant-microbe interactions : MPMI. 2004 Jul; 17(7):798-804. doi: 10.1094/mpmi.2004.17.7.798. [PMID: 15242174]
  • Xiaoguang Liu, Mark Inlow, Hans D VanEtten. Expression profiles of pea pathogenicity ( PEP) genes in vivo and in vitro, characterization of the flanking regions of the PEP cluster and evidence that the PEP cluster region resulted from horizontal gene transfer in the fungal pathogen Nectria haematococca. Current genetics. 2003 Nov; 44(2):95-103. doi: 10.1007/s00294-003-0428-x. [PMID: 12925899]
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  • Deanna L Funnell, Hans D VanEtten. Pisatin demethylase genes are on dispensable chromosomes while genes for pathogenicity on carrot and ripe tomato are on other chromosomes in Nectria haematococca. Molecular plant-microbe interactions : MPMI. 2002 Aug; 15(8):840-6. doi: 10.1094/mpmi.2002.15.8.840. [PMID: 12182342]
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