Symadex (BioDeep_00000812970)
代谢物信息卡片
化学式: C20H22N4O2 (350.1743)
中文名称: 5-((2-(二乙基氨基)乙基)氨基)-8-羟基-6H-咪唑并[4,5,1-de]吖啶-6-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCNC1=C2C3=C(C=C1)N=CN3C4=C(C2=O)C=C(C=C4)O
InChI: InChI=1S/C20H22N4O2/c1-3-23(4-2)10-9-21-15-6-7-16-19-18(15)20(26)14-11-13(25)5-8-17(14)24(19)12-22-16/h5-8,11-12,21,25H,3-4,9-10H2,1-2H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kamila Rząd, Ewa Paluszkiewicz, Damian Neubauer, Mateusz Olszewski, Katarzyna Kozłowska-Tylingo, Wojciech Kamysz, Iwona Gabriel. The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413190. [PMID: 34947987] - Ji-Ning Chen, Xing-Kang Wu, Chun-Hua Lu, Xun Li. Structure-activity relationship of novel acridone derivatives as antiproliferative agents.
Bioorganic & medicinal chemistry.
2021 01; 29(?):115868. doi:
10.1016/j.bmc.2020.115868. [PMID: 33191085] - V V S Rajendra Prasad, G J Peters, Clara Lemos, Ietje Kathmann, Y C Mayur. Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Jul; 43(4):217-24. doi:
10.1016/j.ejps.2011.04.010. [PMID: 21565270] - Eran E Bram, Ilan Ifergan, Michal Grimberg, Krzysztof Lemke, Andrzej Skladanowski, Yehuda G Assaraf. C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Biochemical pharmacology.
2007 Jun; 74(1):41-53. doi:
10.1016/j.bcp.2007.03.028. [PMID: 17481587] - C R Calabrese, P M Loadman, L S Lim, M C Bibby, J A Double, J E Brown, J H Lamb. In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans.
Drug metabolism and disposition: the biological fate of chemicals.
1999 Feb; 27(2):240-5. doi:
NULL. [PMID: 9929509] - C R Calabrese, M C Bibby, J A Double, P M Loadman. Pharmacokinetics and tissue distribution of the imidazoacridinone C1311 in tumour-bearing mice.
Cancer chemotherapy and pharmacology.
1998; 42(5):379-85. doi:
10.1007/s002800050833. [PMID: 9771952] - C R Calabrese, P M Loadman. Analysis of the imidazoacridinone C1311 by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 690(1-2):275-81. doi:
10.1016/s0378-4347(96)00387-8. [PMID: 9106053]
