Vinflunine (BioDeep_00000810053)
Chemicals and Drugs
代谢物信息卡片
化学式: C45H54F2N4O8 (816.391)
中文名称: 长春氟宁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)C6(CC7CC(CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C
InChI: InChI=1S/C45H54F2N4O8/c1-8-42-14-11-16-51-17-15-43(36(42)51)30-19-31(34(56-5)20-33(30)49(4)37(43)45(55,40(54)58-7)38(42)59-25(2)52)44(39(53)57-6)21-26-18-27(41(3,46)47)23-50(22-26)24-29-28-12-9-10-13-32(28)48-35(29)44/h9-14,19-20,26-27,36-38,48,55H,8,15-18,21-24H2,1-7H3
描述信息
An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethyl group attached to this ring has been replaced by a 1,1-difluoroethyl group.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CA - Vinca alkaloids and analogues
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C1907 - Drug, Natural Product
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:90241
- PubChem: 10629256
- PubChem: 21874242
- DrugBank: DB11641
- ChEMBL: CHEMBL2110725
- CAS: 162652-95-1
- MetaboLights: MTBLC90241
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Alessandro Gamboni, Claudia Casanova, Vincenzo Salerno, Claudio Dazzi. [Activity and efficacy of vinflunine in third line in patients with advanced urothelial carcinoma of the renal pelvis, progressing to immunotherapy.].
Recenti progressi in medicina.
2018 Nov; 109(11):547-550. doi:
10.1701/3031.30292. [PMID: 30565574] - Paola Bordi, Marcello Tiseo, Giorgio Baldari, Sebastiano Buti. Metabolic complete response with vinflunine as second-line therapy in a kidney-transplanted patient with advanced urothelial carcinoma: a case report.
BMC cancer.
2016 08; 16(?):626. doi:
10.1186/s12885-016-2666-6. [PMID: 27519420] - Mircea Gabriel Stoleriu, Volker Steger, Migdat Mustafi, Martin Michaelis, Jindrich Cinatl, Wilke Schneider, Andrea Nolte, Julia Kurz, Hans Peter Wendel, Christian Schlensak, Tobias Walker. A new strategy in the treatment of chemoresistant lung adenocarcinoma via specific siRNA transfection of SRF, E2F1, Survivin, HIF and STAT3.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2014 Nov; 46(5):877-86. doi:
10.1093/ejcts/ezu087. [PMID: 24627437] - Nicolas Isambert, Jean Pierre Delord, Jean Marc Tourani, Pierre Fumoleau, Alain Ravaud, Marie Claire Pinel, Aurelie Petain, Thierry Nguyen, Laurent Nguyen. How to manage intravenous vinflunine in cancer patients with renal impairment: results of a pharmacokinetic and tolerability phase I study.
British journal of clinical pharmacology.
2014 Mar; 77(3):498-508. doi:
10.1111/bcp.12218. [PMID: 24283925] - J P Delord, A Ravaud, J Bennouna, P Fumoleau, S Favrel, M C Pinel, P Ferré, F Saliba. Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction.
Investigational new drugs.
2013 Jun; 31(3):724-33. doi:
10.1007/s10637-012-9878-7. [PMID: 22996801] - Amandine Rovini, Géraldine Gauthier, Raphaël Bergès, Anna Kruczynski, Diane Braguer, Stéphane Honoré. Anti-migratory effect of vinflunine in endothelial and glioblastoma cells is associated with changes in EB1 C-terminal detyrosinated/tyrosinated status.
PloS one.
2013; 8(6):e65694. doi:
10.1371/journal.pone.0065694. [PMID: 23750272] - Huang Pin, Lu Hong-Min, Ye Ming, Li Qin. A validated LC-MS/MS method for the determination of vinflunine in plasma and its application to pharmacokinetic studies.
Biomedical chromatography : BMC.
2012 Jul; 26(7):797-801. doi:
10.1002/bmc.1731. [PMID: 22102379] - Pamela Biondani, Giuseppe Procopio, Filippo Pietrantonio, Filippo de Braud, Elena Verzoni. New perspectives in advanced genitourinary malignancies.
Tumori.
2012 Mar; 98(2):267-9. doi:
10.1700/1088.11941. [PMID: 22677996] - Wei-Wei Zou, Dong-Hai Wang, Chun-Yan Sun, Jing-Bin Han, Qing Yin, Qing-Min Yang, Jing-Yi Wang. [Characterization of vinflunine tartrate liposomes in vitro and in vivo].
Yao xue xue bao = Acta pharmaceutica Sinica.
2011 Dec; 46(12):1515-9. doi:
". [PMID: 22375428] - John S Ng. Vinflunine: review of a new vinca alkaloid and its potential role in oncology.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2011 Sep; 17(3):209-24. doi:
10.1177/1078155210373525. [PMID: 20584744] - Claire Lopez, Bérengère Claude, Philippe Morin, Martine Pelissou, Richard Pena, Jean-Paul Max, Jean-Paul Ribet. Synthesis and study of a molecularly imprinted polymer for specific solid-phase extraction of vinflunine and its metabolite from biological fluids.
Journal of separation science.
2011 Aug; 34(15):1902-9. doi:
10.1002/jssc.201100015. [PMID: 25363354] - H Rexer. [First line therapy for local advanced or metastatic urothelial cell carcinoma: randomized phase II study to investigate the combination of vinflunine with gemcitabine and vinflunine with carboplatin in patients unfit for cisplatin therapy with advanced or metastatic urothelial cell carcinoma (JASINT-1 - AB 38/11) of AUO].
Der Urologe. Ausg. A.
2011 Aug; 50(8):974-6. doi:
10.1007/s00120-011-2667-7. [PMID: 21779884] - G Zorza, J C Van Heugen, J De Graeve, C Puozzo. Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):294-302. doi:
10.1016/j.jchromb.2007.03.030. [PMID: 17416213] - Xiaoping Zhao, Xiaoquan Liu, Yongsheng Wang, Jiao Zhong, Yan Chen, Guangji Wang. Determination of vinflunine in rat plasma by liquid chromatography-electrospray ionization mass spectrometry for a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(3):906-11. doi:
10.1016/j.jpba.2006.01.005. [PMID: 16460899] - Xiao-Ping Zhao, Xiao-Quan Liu, Yong-Sheng Wang, Huan Wang, Guang-Ji Wang. Pharmacokinetics, tissue distribution and excretion of vinflunine.
European journal of drug metabolism and pharmacokinetics.
2006 Apr; 31(2):59-64. doi:
10.1007/bf03191120. [PMID: 16898072] - B T Hill, H H Fiebig, W R Waud, M F Poupon, F Colpaert, A Kruczynski. Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts.
European journal of cancer (Oxford, England : 1990).
1999 Mar; 35(3):512-20. doi:
10.1016/s0959-8049(98)00416-x. [PMID: 10448309]
