arteether (BioDeep_00000806855)
代谢物信息卡片
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-
化学式: C17H28O5 (312.1936638)
中文名称: 蒿乙醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1C(C2CCC(C3C24C(O1)OC(CC3)(OO4)C)C)C
InChI: InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Patrick B Memvanga, Véronique Préat. Formulation design and in vivo antimalarial evaluation of lipid-based drug delivery systems for oral delivery of β-arteether.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Sep; 82(1):112-9. doi:
10.1016/j.ejpb.2012.05.004. [PMID: 22609572] - N P Aditya, Geetanjali Chimote, Karthigayan Gunalan, Rinti Banerjee, Swati Patankar, Basavaraj Madhusudhan. Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice.
Experimental parasitology.
2012 Jul; 131(3):292-9. doi:
10.1016/j.exppara.2012.04.010. [PMID: 22561991] - Devendra Kumar, Ashok K Khanna, Ram Pratap, Jitendra K Sexana, Rabi S Bhatta. Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone.
Indian journal of pharmacology.
2012 Jan; 44(1):57-62. doi:
10.4103/0253-7613.91868. [PMID: 22345871] - Huimin Yu, Xiuhua Zhao, Yuangang Zu, Xinjuan Zhang, Baishi Zu, Xiaonan Zhang. Preparation and characterization of micronized artemisinin via a Rapid Expansion of Supercritical Solutions (RESS) Method.
International journal of molecular sciences.
2012; 13(4):5060-5073. doi:
10.3390/ijms13045060. [PMID: 22606030] - Vidhan Jain, Naomi W Lucchi, Nana O Wilson, Anna J Blackstock, Avinash C Nagpal, Pradeep K Joel, Mrigendra P Singh, Venkatachalam Udhayakumar, Jonathan K Stiles, Neeru Singh. Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India.
Malaria journal.
2011 Dec; 10(?):383. doi:
10.1186/1475-2875-10-383. [PMID: 22192385] - Tran Tinh Hien, Warunee Hanpithakpong, Nguyen Thanh Truong, Nguyen Thi Dung, Pham Van Toi, Jeremy Farrar, Niklas Lindegardh, Joel Tarning, Michael Ashton. Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover study.
Clinical therapeutics.
2011 May; 33(5):644-54. doi:
10.1016/j.clinthera.2011.04.017. [PMID: 21665048] - Philippe Rasoanaivo, Colin W Wright, Merlin L Willcox, Ben Gilbert. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions.
Malaria journal.
2011 Mar; 10 Suppl 1(?):S4. doi:
10.1186/1475-2875-10-s1-s4. [PMID: 21411015] - Bikash Medhi, Pawan K Singh, Ajay Prakash, Pramod Avti. Effect of esomeprazole on the pharmacokinetics of carbamazepine.
Indian journal of pharmacology.
2011 Feb; 43(1):73-5. doi:
10.4103/0253-7613.75675. [PMID: 21455427] - Qigui Li, Mark Hickman. Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins.
Toxicology.
2011 Jan; 279(1-3):1-9. doi:
10.1016/j.tox.2010.09.005. [PMID: 20863871] - N Kumar, M Sharma, D S Rawat. Medicinal chemistry perspectives of trioxanes and tetraoxanes.
Current medicinal chemistry.
2011; 18(25):3889-928. doi:
10.2174/092986711803414340. [PMID: 21824099] - Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Carl Craft, Lawrence Fleckenstein. Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
Malaria journal.
2009 Dec; 8(?):304. doi:
10.1186/1475-2875-8-304. [PMID: 20021657] - Lisa H Xie, Qigui Li, Jing Zhang, Peter J Weina. Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.
Malaria journal.
2009 May; 8(?):112. doi:
10.1186/1475-2875-8-112. [PMID: 19470172] - Ying-Ying Lu, Tong-Sheng Chen, Jun-Le Qu, Wen-Liang Pan, Lei Sun, Xun-Bin Wei. Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells.
Journal of biomedical science.
2009 Feb; 16(?):16. doi:
10.1186/1423-0127-16-16. [PMID: 19272183] - Lie Li, Deepthi Pabbisetty, Paulo Carvalho, Mitchell A Avery, John S Williamson, Bonnie A Avery. Ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of Artemisinin in rat serum and its application in pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 May; 867(1):131-7. doi:
10.1016/j.jchromb.2008.01.057. [PMID: 18353736] - Cheeraratana Cheeramakara, Vasant Khachonsaksumet, Nopachai Suthisai, Wanyarat Nakosiri, Kriyaporn Songmuaeng, Channarong Saenghirun, Duangduen Phienpicharn, Apichart Nontprasert. Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection.
The Southeast Asian journal of tropical medicine and public health.
2008 Mar; 39(2):195-9. doi:
NULL. [PMID: 18564701] - Jean-Marie Kindermans, Jacques Pilloy, Piero Olliaro, Melba Gomes. Ensuring sustained ACT production and reliable artemisinin supply.
Malaria journal.
2007 Sep; 6(?):125. doi:
10.1186/1475-2875-6-125. [PMID: 17868471] - Rolf Rauh, Stefan Kahl, Herbert Boechzelt, Rudolf Bauer, Bernd Kaina, Thomas Efferth. Molecular biology of cantharidin in cancer cells.
Chinese medicine.
2007 Jul; 2(?):8. doi:
10.1186/1749-8546-2-8. [PMID: 17610718] - Yang Jiao, Chun-min Ge, Qing-hui Meng, Jian-ping Cao, Jian Tong, Sai-jun Fan. Dihydroartemisinin is an inhibitor of ovarian cancer cell growth.
Acta pharmacologica Sinica.
2007 Jul; 28(7):1045-56. doi:
10.1111/j.1745-7254.2007.00612.x. [PMID: 17588342] - Sara Asimus, Doaa Elsherbiny, Trinh N Hai, Britt Jansson, Nguyen V Huong, Max G Petzold, Ulrika S H Simonsson, Michael Ashton. Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Fundamental & clinical pharmacology.
2007 Jun; 21(3):307-16. doi:
10.1111/j.1472-8206.2007.00471.x. [PMID: 17521300] - Michaela Vossen, Michael Sevestre, Christoph Niederalt, In-Jin Jang, Stefan Willmann, Andrea N Edginton. Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models.
Theoretical biology & medical modelling.
2007 Mar; 4(?):13. doi:
10.1186/1742-4682-4-13. [PMID: 17386084] - Joana Duarte, Prakash Deshpande, Vincent Guiyedi, Salah Mécheri, Constantin Fesel, Pierre-André Cazenave, Gyan C Mishra, Maryvonne Kombila, Sylviane Pied. Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status.
Malaria journal.
2007 Jan; 6(?):1. doi:
10.1186/1475-2875-6-1. [PMID: 17204149] - Julie A Simpson, Tsiri Agbenyega, Karen I Barnes, Gianni Di Perri, Peter Folb, Melba Gomes, Sanjeev Krishna, Srivicha Krudsood, Sornchai Looareesuwan, Sharif Mansor, Helen McIlleron, Raymond Miller, Malcolm Molyneux, James Mwenechanya, Visweswaran Navaratnam, Francois Nosten, Piero Olliaro, Lorrin Pang, Isabela Ribeiro, Madalitso Tembo, Michele van Vugt, Steve Ward, Kris Weerasuriya, Kyaw Win, Nicholas J White. Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.
PLoS medicine.
2006 Nov; 3(11):e444. doi:
10.1371/journal.pmed.0030444. [PMID: 17132053] - S Sabarinath, R P Singh, R C Gupta. Simultaneous quantification of alpha-/beta-diastereomers of arteether, sulphadoxine and pyrimethamine: a promising anti-relapse antimalarial therapeutic combination, by liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Sep; 842(1):36-42. doi:
10.1016/j.jchromb.2006.05.003. [PMID: 16725391] - M Sukhija, Bikash Medhi, P Pandhi. Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin.
Methods and findings in experimental and clinical pharmacology.
2006 Mar; 28(2):89-94. doi:
10.1358/mf.2006.28.2.977839. [PMID: 16636718] - Manpreet Sukhija, Bikash Medhi, P Pandhi. Effects of artemisinin, artemether, arteether on the pharmacokinetics of carbamazepine.
Pharmacology.
2006; 76(3):110-6. doi:
10.1159/000090434. [PMID: 16388199] - Marcy J Balunas, A Douglas Kinghorn. Drug discovery from medicinal plants.
Life sciences.
2005 Dec; 78(5):431-41. doi:
10.1016/j.lfs.2005.09.012. [PMID: 16198377] - S Sabarinath, K P Madhusudanan, R C Gupta. Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats.
Biopharmaceutics & drug disposition.
2005 Sep; 26(6):211-23. doi:
10.1002/bdd.452. [PMID: 15926191] - Sreedharan N Sabarinath, Omkar P Asthana, Sunil K Puri, Kumkum Srivastava, Kunnath P Madhusudanan, Ram C Gupta. Clinical pharmacokinetics of the diastereomers of arteether in healthy volunteers.
Clinical pharmacokinetics.
2005; 44(11):1191-203. doi:
10.2165/00003088-200544110-00006. [PMID: 16231969] - M Rajanikanth, K P Madhusudanan, R C Gupta. An HPLC-MS method for simultaneous estimation of alpha,beta-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study.
Biomedical chromatography : BMC.
2003 Oct; 17(7):440-6. doi:
10.1002/bmc.261. [PMID: 14598327] - S Sabarinath, M Rajanikanth, K P Madhusudanan, R C Gupta. A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-,beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies.
Journal of mass spectrometry : JMS.
2003 Jul; 38(7):732-42. doi:
10.1002/jms.487. [PMID: 12898653] - M Rajanikanth, K P Madhusudanan, R C Gupta. Liquid chromatographic-mass spectrometric method for the determination of alpha-,beta-arteether in rat serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jan; 783(2):391-9. doi:
10.1016/s1570-0232(02)00701-8. [PMID: 12482482] - S Looareesuwan, B Oosterhuis, B M Schilizzi, F A E Sollie, P Wilairatana, S Krudsood, Ch B Lugt, P A M Peeters, J O Peggins. Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria.
British journal of clinical pharmacology.
2002 May; 53(5):492-500. doi:
10.1046/j.1365-2125.2002.01590.x. [PMID: 11994055]