Capromorelin (BioDeep_00000802832)

   


代谢物信息卡片


Capromorelin

化学式: C28H35N5O4 (505.26889100000005)
中文名称: 卡莫瑞林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3=NN(C(=O)C3(C2)CC4=CC=CC=C4)C)N
InChI: InChI=1S/C28H35N5O4/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20/h4-13,22H,14-19,29H2,1-3H3,(H,30,35)/t22-,28-/m1/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C76358 - Growth Hormone-Releasing Hormone Analogue

同义名列表

1 个代谢物同义名

Capromorelin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobias Lange, Andreas Thomas, Christian Görgens, Martin Bidlingmaier, Katharina Schilbach, Eric Fichant, Philippe Delahaut, Mario Thevis. Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes. Biomedical chromatography : BMC. 2021 Jun; 35(6):e5075. doi: 10.1002/bmc.5075. [PMID: 33458843]
  • Cristina Gardelli, Hiroki Wada, Asim Ray, Moya Caffrey, Antonio Llinas, Igor Shamovsky, Joakim Tholander, Joakim Larsson, Ulf Sivars, Leif Hultin, Ulf Andersson, Hitesh J Sanganee, Kristina Stenvall, Brith Leidvik, Karin Gedda, Lisa Jinton, Marie Rydén Landergren, Kostas Karabelas. Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists. Journal of medicinal chemistry. 2018 07; 61(14):5974-5987. doi: 10.1021/acs.jmedchem.8b00322. [PMID: 29909635]
  • B Zollers, L Rhodes, R G Smith. Capromorelin increases food consumption, body weight, growth hormone, and sustained insulin-like growth factor 1 concentrations when administered to healthy adult Beagle dogs. Journal of veterinary pharmacology and therapeutics. 2017 Apr; 40(2):140-147. doi: 10.1111/jvp.12344. [PMID: 27597271]
  • Bill Zollers, Linda Rhodes, Ernst Heinen. Capromorelin oral solution (ENTYCE®) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study. BMC veterinary research. 2017 Jan; 13(1):10. doi: 10.1186/s12917-016-0925-z. [PMID: 28056951]
  • Brid Callaghan, Billie Hunne, Haruko Hirayama, Daniela M Sartor, Trung V Nguyen, Fe C Abogadie, Dorota Ferens, Peter McIntyre, Kung Ban, Jonathan Baell, John B Furness, James A Brock. Sites of action of ghrelin receptor ligands in cardiovascular control. American journal of physiology. Heart and circulatory physiology. 2012 Oct; 303(8):H1011-21. doi: 10.1152/ajpheart.00418.2012. [PMID: 22886413]
  • S Cyrus Khojasteh-Bakht, John P O'donnell, Hassan G Fouda, Michael J Potchoiba. Metabolism, pharmacokinetics, tissue distribution, and excretion of [14C]CP-424391 in rats. Drug metabolism and disposition: the biological fate of chemicals. 2005 Jan; 33(1):190-9. doi: 10.1124/dmd.104.001065. [PMID: 15486077]
  • Philip A Carpino, Bruce A Lefker, Steven M Toler, Lydia C Pan, John R Hadcock, Ewell R Cook, Joseph N DiBrino, Anthony M Campeta, Shari L DeNinno, Kristin L Chidsey-Frink, William A Hada, John Inthavongsay, F Michael Mangano, Michelle A Mullins, David F Nickerson, Oicheng Ng, Christine M Pirie, John A Ragan, Colin R Rose, David A Tess, Ann S Wright, Li Yu, Michael P Zawistoski, Paul A DaSilva-Jardine, Theresa C Wilson, David D Thompson. Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorganic & medicinal chemistry. 2003 Feb; 11(4):581-90. doi: 10.1016/s0968-0896(02)00433-9. [PMID: 12538023]
  • Philip A Carpino, Bruce A Lefker, Steven M Toler, Lydia C Pan, John R Hadcock, Marianne C Murray, Ewell R Cook, Joseph N DiBrino, Shari L DeNinno, Kristin L Chidsey-Frink, William A Hada, John Inthavongsay, Sharon K Lewis, F Michael Mangano, Michelle A Mullins, David F Nickerson, Oicheng Ng, Christine M Pirie, John A Ragan, Colin R Rose, David A Tess, Ann S Wright, Li Yu, Michael P Zawistoski, John C Pettersen, Paul A DaSilva-Jardine, Theresa C Wilson, David D Thompson. Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorganic & medicinal chemistry letters. 2002 Nov; 12(22):3279-82. doi: 10.1016/s0960-894x(02)00734-5. [PMID: 12392732]
  • L C Pan, P A Carpino, B A Lefker, J A Ragan, S M Toler, J C Pettersen, D O Nettleton, O Ng, C M Pirie, K Chidsey-Frink, B Lu, D F Nickerson, D A Tess, M A Mullins, D B MacLean, P A DaSilva-Jardine, D D Thompson. Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue. Endocrine. 2001 Feb; 14(1):121-32. doi: 10.1385/endo:14:1:121. [PMID: 11322494]
  • J J Berberich, R V Andrews, G E Folk. Effects of cold exposure on urinary catecholamines in arctic lemmings. Comparative biochemistry and physiology. C: Comparative pharmacology. 1977; 58(2C):133-5. doi: 10.1016/0306-4492(77)90093-4. [PMID: 23926]