RTA-408 (BioDeep_00000802605)

   


代谢物信息卡片


Omaveloxolone

化学式: C33H44F2N2O3 (554.3319818)
中文名称: 奥马索龙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)NC(=O)C(C)(F)F)C
InChI: InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1

描述信息

C26170 - Protective Agent > C2459 - Chemoprotective Agent > C2080 - Cytoprotective Agent

同义名列表

2 个代谢物同义名

Omaveloxolone; RTA-408



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Biying Yang, Jingrui Pan, Xiao-Ni Zhang, Hongxuan Wang, Lei He, Xiaoming Rong, Xiangpen Li, Ying Peng. NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis. Neurobiology of disease. 2023 08; 184(?):106210. doi: 10.1016/j.nbd.2023.106210. [PMID: 37352984]
  • Yuanyuan Wang, Hao Ma, Jiaxuan Huang, Zhengguang Yao, Jianqiang Yu, Wannian Zhang, Lichao Zhang, Zhibin Wang, Chunlin Zhuang. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. European journal of medicinal chemistry. 2021 Feb; 212(?):113030. doi: 10.1016/j.ejmech.2020.113030. [PMID: 33248849]
  • Scott A Reisman, Deborah A Ferguson, Chun-Yue I Lee, Joel W Proksch. Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis. Journal of biochemical and molecular toxicology. 2020 May; ?(?):e22526. doi: 10.1002/jbt.22526. [PMID: 32410268]
  • Karen L Madsen, Astrid E Buch, Bruce H Cohen, Marni J Falk, Angela Goldsberry, Amy Goldstein, Amel Karaa, Mary K Koenig, Colleen C Muraresku, Colin Meyer, Megan O'Grady, Fernando Scaglia, Perry B Shieh, Jerry Vockley, Zarazuela Zolkipli-Cunningham, Ronald G Haller, John Vissing. Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy: MOTOR trial. Neurology. 2020 02; 94(7):e687-e698. doi: 10.1212/wnl.0000000000008861. [PMID: 31896620]
  • Chien-Chung Yang, Chih-Chung Lin, Mei-Jie Jou, Li-Der Hsiao, Chuen-Mao Yang. RTA 408 Inhibits Interleukin-1β-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent NF-κB and AP-1 Activation in Rat Brain Astrocytes. International journal of molecular sciences. 2019 Jun; 20(11):. doi: 10.3390/ijms20112826. [PMID: 31185608]
  • Scott A Reisman, Sarabjit S Gahir, Chun-Yue I Lee, Joel W Proksch, Mitsumasa Sakamoto, Keith W Ward. Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates. Drug design, development and therapy. 2019; 13(?):1259-1270. doi: 10.2147/dddt.s193889. [PMID: 31118567]
  • Z Xu, C J Suo, Y S Ruan, R Y Tan, W Zhang, T L Niu. [Effect and related mechanisms of RTA-408 on rat vascular smooth muscle cell calcification induced by advanced glycation end products]. Zhonghua xin xue guan bing za zhi. 2018 Jun; 46(6):475-479. doi: 10.3760/cma.j.issn.0253-3758.2018.06.012. [PMID: 29925185]
  • Peng Han, Zhiqiang Qin, Jingyuan Tang, Zhen Xu, Ran Li, Xuping Jiang, Chengdi Yang, Qianwei Xing, Xiaokang Qi, Min Tang, Jiexiu Zhang, Baixin Shen, Wei Wang, Chao Qin, Wei Zhang. RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene. Oxidative medicine and cellular longevity. 2017; 2017(?):7612182. doi: 10.1155/2017/7612182. [PMID: 29435098]
  • Scott A Reisman, Chun-Yue I Lee, Colin J Meyer, Joel W Proksch, Keith W Ward. Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin. Archives of dermatological research. 2014 Jul; 306(5):447-54. doi: 10.1007/s00403-013-1433-7. [PMID: 24362512]