Seletalisib (BioDeep_00000802599)
代谢物信息卡片
化学式: C23H14ClF3N6O (482.086966)
中文名称: 司来利塞
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=CC(=C(N=C2C(=C1)Cl)C3=C[N+](=CC=C3)[O-])C(C(F)(F)F)NC4=NC=NC5=C4N=CC=C5
InChI: InChI=1S/C23H14ClF3N6O/c24-16-6-1-4-13-10-15(18(31-19(13)16)14-5-3-9-33(34)11-14)21(23(25,26)27)32-22-20-17(29-12-30-22)7-2-8-28-20/h1-12,21H,(H,29,30,32)/t21-/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Maria Juarez, Nieves Diaz, Geoffrey I Johnston, Saba Nayar, Andrew Payne, Eric Helmer, Dionne Cain, Paulette Williams, Valerie Devauchelle-Pensec, Benjamin A Fisher, Roberto Giacomelli, Jacques-Eric Gottenberg, Giuliana Guggino, Marika Kvarnström, Xavier Mariette, Wan Fai Ng, José Rosas, Juan Sánchez Bursón, Giovanni Triolo, Francesca Barone, Simon J Bowman. A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren's syndrome.
Rheumatology (Oxford, England).
2021 03; 60(3):1364-1375. doi:
10.1093/rheumatology/keaa410
. [PMID: 32949140] - Saba Nayar, Joana Campos, Charlotte G Smith, Valentina Iannizzotto, David H Gardner, Serena Colafrancesco, Elena Pipi, Florian Kollert, Kelly J Hunter, Charlotte Brewer, Christopher Dominic Buckley, Simon J Bowman, Roberta Priori, Guido Valesini, Maria Juarez, William A Fahy, Benjamin A Fisher, Andrew Payne, Rodger A Allen, Francesca Barone. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome.
Annals of the rheumatic diseases.
2019 02; 78(2):249-260. doi:
10.1136/annrheumdis-2017-212619
. [PMID: 30472652] - Eric Helmer, Jean-Marie Nicolas, Jeff Long, Ad F Roffel, Emma Jones, Hugues Chanteux, Nieves Diaz, Holly Garratt, Tjerk Bosje. A Dual-Administration Microtracer Technique to Characterize the Absorption, Distribution, Metabolism, and Excretion of [14 C]Seletalisib (UCB5857) in Healthy Subjects.
Journal of clinical pharmacology.
2017 Dec; 57(12):1582-1590. doi:
10.1002/jcph.954
. [PMID: 28650526] - Eric Helmer, Mark Watling, Emma Jones, Dominique Tytgat, Mark Jones, Rodger Allen, Andrew Payne, Annelize Koch, Eugene Healy. First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases.
European journal of clinical pharmacology.
2017 May; 73(5):581-591. doi:
10.1007/s00228-017-2205-7
. [PMID: 28160012]