Cibinetide (BioDeep_00000802595)

   


代谢物信息卡片


Cibinetide

化学式: C51H84N16O21 (1256.5996654)
中文名称: 西比奈肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C1CCC(=O)N1
InChI: InChI=1S/C51H84N16O21/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for neurological disease treatment.

同义名列表

2 个代谢物同义名

Cibinetide; ARA290



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ming Yao, Anna Domogatskaya, Nils Ågren, Masaaki Watanabe, Kazuaki Tokodai, Michael Brines, Anthony Cerami, Bo-Göran Ericzon, Makiko Kumagai-Braesch, Torbjörn Lundgren. Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation. Cell transplantation. 2021 Jan; 30(?):9636897211039739. doi: 10.1177/09636897211039739. [PMID: 34498509]
  • Mohammad Shokrzadeh, Mahmoud Etebari, Nasrin Ghassemi-Barghi. An engineered non-erythropoietic erythropoietin-derived peptide, ARA290, attenuates doxorubicin induced genotoxicity and oxidative stress. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Aug; 66(?):104864. doi: 10.1016/j.tiv.2020.104864. [PMID: 32335150]
  • Bo Huang, Juntao Jiang, Bangwei Luo, Wen Zhu, Yuqi Liu, Zhishang Wang, Zhiren Zhang. Non-erythropoietic erythropoietin-derived peptide protects mice from systemic lupus erythematosus. Journal of cellular and molecular medicine. 2018 07; 22(7):3330-3339. doi: 10.1111/jcmm.13608. [PMID: 29570934]
  • L Yan, H Zhang, S Gao, G Zhu, Q Zhu, Y Gu, F Shao. EPO Derivative ARA290 Attenuates Early Renal Allograft Injury in Rats by Targeting NF-κB Pathway. Transplantation proceedings. 2018 06; 50(5):1575-1582. doi: 10.1016/j.transproceed.2018.03.015. [PMID: 29880388]
  • Massimo Collino, Christoph Thiemermann, Anthony Cerami, Michael Brines. Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacology & therapeutics. 2015 Jul; 151(?):32-40. doi: 10.1016/j.pharmthera.2015.02.005. [PMID: 25728128]
  • Michael Brines, Ann N Dunne, Monique van Velzen, Paolo L Proto, Claes-Goran Ostenson, Rita I Kirk, Ioannis N Petropoulos, Saad Javed, Rayaz A Malik, Anthony Cerami, Albert Dahan. ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Molecular medicine (Cambridge, Mass.). 2015 Mar; 20(?):658-66. doi: 10.2119/molmed.2014.00215. [PMID: 25387363]
  • Elena Gammella, Victor Diaz, Stefania Recalcati, Paolo Buratti, Michele Samaja, Soumyadeep Dey, Constance Tom Noguchi, Max Gassmann, Gaetano Cairo. Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly. American journal of physiology. Regulatory, integrative and comparative physiology. 2015 Feb; 308(4):R330-5. doi: 10.1152/ajpregu.00410.2014. [PMID: 25519735]
  • Masanobu Kawakami. Discovery of tumor necrosis factor (TNF) and identification of the potential of anti-TNF antibodies in Dr. Cerami's laboratory. Molecular medicine (Cambridge, Mass.). 2014 Dec; 20 Suppl 1(?):S17-9. doi: 10.2119/molmed.2014.00177. [PMID: 25549227]
  • M Collino, E Benetti, M Rogazzo, F Chiazza, R Mastrocola, D Nigro, J C Cutrin, M Aragno, R Fantozzi, M A Minetto, C Thiemermann. A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. British journal of pharmacology. 2014 Dec; 171(24):5802-15. doi: 10.1111/bph.12888. [PMID: 25164531]
  • Willem G van Rijt, Harry van Goor, Rutger J Ploeg, Henri G D Leuvenink. Erythropoietin-mediated protection in kidney transplantation: nonerythropoietic EPO derivatives improve function without increasing risk of cardiovascular events. Transplant international : official journal of the European Society for Organ Transplantation. 2014 Mar; 27(3):241-8. doi: 10.1111/tri.12174. [PMID: 23964738]
  • Willem G van Rijt, Gertrude J Nieuwenhuijs-Moeke, Harry van Goor, Petra J Ottens, Rutger J Ploeg, Henri G D Leuvenink. Renoprotective capacities of non-erythropoietic EPO derivative, ARA290, following renal ischemia/reperfusion injury. Journal of translational medicine. 2013 Nov; 11(?):286. doi: 10.1186/1479-5876-11-286. [PMID: 24225194]
  • Willem G van Rijt, Gertrude J Nieuwenhuijs-Moeke, Harry van Goor, Bente Jespersen, Petra J Ottens, Rutger J Ploeg, Henri G D Leuvenink. ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury. Journal of translational medicine. 2013 Jan; 11(?):9. doi: 10.1186/1479-5876-11-9. [PMID: 23302512]
  • Nimesh S A Patel, Hannah L Kerr-Peterson, Michael Brines, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Elizabeth G Wood, Florence L Johnson, Muhammad M Yaqoob, Anthony Cerami, Christoph Thiemermann. Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. Molecular medicine (Cambridge, Mass.). 2012 May; 18(?):719-27. doi: 10.2119/molmed.2012.00093. [PMID: 22415011]