Azasetron (BioDeep_00000799137)
代谢物信息卡片
化学式: C17H20ClN3O3·HCl (385.09598960000005)
中文名称: D-赤型-鞘氨醇(Brain, Porcine), 盐酸阿扎司琼, 阿扎司琼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV)[1].
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:31246
- KEGGdrug: D01613
- PubChem: 115000
- ChEMBL: CHEMBL4303332
- CAS: 123040-16-4
- CAS: 123040-96-0
- CAS: 123040-94-8
- CAS: 141922-90-9
- CAS: 477243-03-1
- CAS: 123040-93-7
- medchemexpress: HY-B0068
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Hyun Jung Kim, Guem San Lee, Hyungwoo Kim, Byung Joo Kim. Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal.
World journal of gastroenterology.
2017 Aug; 23(29):5313-5323. doi:
10.3748/wjg.v23.i29.5313
. [PMID: 28839431] - Hironori Nakamura, Haruko Yokoyama, Risa Takayanagi, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin.
European journal of drug metabolism and pharmacokinetics.
2015 Mar; 40(1):39-44. doi:
10.1007/s13318-014-0175-z
. [PMID: 24470169] - Junki Endo, Hirotoshi Iihara, Maya Yamada, Koumei Yanase, Fumihiko Kamiya, Fumitaka Ito, Norihiko Funaguchi, Yasushi Ohno, Shinya Minatoguchi, Yoshinori Itoh. A randomized controlled non-inferiority study comparing the antiemetic effect between intravenous granisetron and oral azasetron based on estimated 5-HT3 receptor occupancy.
Anticancer research.
2012 Sep; 32(9):3939-47. doi:
. [PMID: 22993341]
- Guanyang Lin, Jianshe Ma, Jiayin Zhu, Xuezhi Yang, Lufeng Hu, Xianqin Wang. Determination of azasetron hydrochloride in rabbit plasma by liquid chromatography tandem mass spectrometry and its application.
Biomedical chromatography : BMC.
2011 Oct; 25(10):1107-11. doi:
10.1002/bmc.1578
. [PMID: 21204117] - So Young Um, Song Wha Chae, Hyun Joo Park, Myeon Woo Chung, Sun Ok Choi, Hwa Jeong Lee. Simple determination of azasetron in rat plasma by column-switching high-performance liquid chromatography.
Journal of separation science.
2010 Dec; 33(23-24):3638-43. doi:
10.1002/jssc.201000401
. [PMID: 20945413] - Gui-ling Li, Yi-wu Li. [Clinical efficacy of Bannaitong Mdicinal Tea combined with azasetron in preventing and treating chemotherapy induced gastrointestinal reaction].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Oct; 27(10):934-6. doi:
. [PMID: 17990468]
- Toshiro Niwa, Sachiko Yamamoto, Miho Saito, Naoto Kobayashi, Kaoru Ikeda, Yasuo Noda, Akira Takagi. Effects of serotonin-3 receptor antagonists on cytochrome P450 activities in human liver microsomes.
Biological & pharmaceutical bulletin.
2006 Sep; 29(9):1931-5. doi:
10.1248/bpb.29.1931
. [PMID: 16946512] - S Tsukagoshi. [Pharmacokinetics of azasetron (Serotone), a selective 5-HT3 receptor antagonist].
Gan to kagaku ryoho. Cancer & chemotherapy.
1999 Jun; 26(7):1001-8. doi:
NULL
. [PMID: 10396331] - T Beppu, M Ogawa, T Yamanaka, H Egami, C Ohara, Y Masuda, S Kudo, M Kuramoto, K Doi, T Matsuda. [Clinical evaluation of Azasetron Hydrochloride: a new selective 5-HT3 receptor antagonist--antiemetic profile and plasma concentration in transcatheter arterial chemoembolization using CDDP for unresectable hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1998 Jul; 25(8):1197-202. doi:
NULL
. [PMID: 9679583] - Y Moriyama, K Arimori, M Nakano. Absorption characteristics of azasetron from rectal and oral routes in rabbits.
Biological & pharmaceutical bulletin.
1997 Jun; 20(6):701-3. doi:
10.1248/bpb.20.701
. [PMID: 9212995]