5-Bromouridine (BioDeep_00000798420)

   

Antitumor activity


代谢物信息卡片


5-Bromouridine

化学式: C9H11BrN2O6 (321.9800446)
中文名称: 5-溴尿苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)Br
InChI: InChI=1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents
5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

同义名列表

1 个代谢物同义名

5-Bromouridine



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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Killeen S Kirkconnell, Brian Magnuson, Michelle T Paulsen, Brian Lu, Karan Bedi, Mats Ljungman. Gene length as a biological timer to establish temporal transcriptional regulation. Cell cycle (Georgetown, Tex.). 2017 Feb; 16(3):259-270. doi: 10.1080/15384101.2016.1234550. [PMID: 28055303]
  • A Fraschini, M G Bottone, A I Scovassi, M Denegri, M C Risueño, P S Testillano, T E Martin, M Biggiogera, C Pellicciari. Changes in extranucleolar transcription during actinomycin D-induced apoptosis. Histology and histopathology. 2005 01; 20(1):107-17. doi: 10.14670/hh-20.107. [PMID: 15578429]
  • A R Van Rompay, A Norda, K Lindén, M Johansson, A Karlsson. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Molecular pharmacology. 2001 May; 59(5):1181-6. doi: 10.1124/mol.59.5.1181. [PMID: 11306702]
  • K Koberna, D Stanĕk, J Malínský, V Ctrnáctá, S Cermanová, J Novotná, V Kopský, I Raska. In situ fluorescence visualization of bromouridine incorporated into newly transcribed nucleolar RNA. Acta histochemica. 2000 Feb; 102(1):15-20. doi: 10.1078/0065-1281-00535. [PMID: 10726161]
  • I Melcák, M C Risueño, I Raska. Ultrastructural nonisotopic mapping of nucleolar transcription sites in onion protoplasts. Journal of structural biology. 1996 Mar; 116(2):253-63. doi: 10.1006/jsbi.1996.0040. [PMID: 8812981]
  • D E Bergstrom, J K Abrahamson, M Y Chan. Nucleoside and nucleotide transport through a model liquid membrane. Periodic-catastrophic transport of a novel amantadine phosphoramidate conjugate of 5'-AMP. Biochimica et biophysica acta. 1991 Jan; 1061(1):95-105. doi: 10.1016/0005-2736(91)90273-b. [PMID: 1995060]
  • R I Bikbulatov, E I Papilova, D M Braginskiĭ, G V Podgornaia, S A Demidova. [Toxicological study of the new antiviral agent, 5-bromuridine]. Farmakologiia i toksikologiia. 1980 Mar; 43(2):205-8. doi: NULL. [PMID: 7002600]