MK-8931 (BioDeep_00000798368)
代谢物信息卡片
化学式: C17H17F2N5O3S (409.1020116000001)
中文名称: 维罗司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F
InChI: InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1
描述信息
C26170 - Protective Agent > C1509 - Neuroprotective Agent
C471 - Enzyme Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10739
- PubChem: 51352361
- DrugBank: DB12285
- ChEMBL: CHEMBL3301601
- CAS: 1286770-55-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marissa F Dockendorf, David Jaworowicz, Rebecca Humphrey, Melanie Anderson, Sheila Breidinger, Lei Ma, Theresa Taylor, Nicole Dupre, Christopher Jones, Christine Furtek, Bhavna Kantesaria, Kevin P Bateman, Eric Woolf, Michael F Egan, Julie A Stone. A Model-Based Approach to Bridging Plasma and Dried Blood Spot Concentration Data for Phase 3 Verubecestat Trials.
The AAPS journal.
2022 04; 24(3):53. doi:
10.1208/s12248-022-00682-5. [PMID: 35384522] - Melanie Anderson, Marissa F Dockendorf, Ian McIntosh, Iris Xie, Sheila Breidinger, Dongfang Meng, Sumei Ren, Wendy Zhong, Li Zhang, Brad Roadcap, Kevin P Bateman, Julie Stone, Eric Woolf. An Investigation of Instability in Dried Blood Spot Samples for Pharmacokinetic Sampling in Phase 3 Trials of Verubecestat.
The AAPS journal.
2022 04; 24(3):52. doi:
10.1208/s12248-022-00683-4. [PMID: 35384529] - Qiong Wang, Haiyun Wang, Youyan Zhong, Yibin Mei. Quantification and pharmacokinetic property of verubecestat an BACE1 inhibitor in rat plasma.
Biomedical chromatography : BMC.
2020 Feb; 34(2):e4715. doi:
10.1002/bmc.4715. [PMID: 31633829] - Stephanie Villarreal, Fuqiang Zhao, Lynn A Hyde, Daniel Holder, Thomas Forest, Marie Sondey, Xia Chen, Cyrille Sur, Eric M Parker, Matthew E Kennedy. Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage.
Journal of Alzheimer's disease : JAD.
2017; 59(4):1393-1413. doi:
10.3233/jad-170056. [PMID: 28800329] - Matthew E Kennedy, Andrew W Stamford, Xia Chen, Kathleen Cox, Jared N Cumming, Marissa F Dockendorf, Michael Egan, Larry Ereshefsky, Robert A Hodgson, Lynn A Hyde, Stanford Jhee, Huub J Kleijn, Reshma Kuvelkar, Wei Li, Britta A Mattson, Hong Mei, John Palcza, Jack D Scott, Michael Tanen, Matthew D Troyer, Jack L Tseng, Julie A Stone, Eric M Parker, Mark S Forman. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
Science translational medicine.
2016 11; 8(363):363ra150. doi:
10.1126/scitranslmed.aad9704. [PMID: 27807285]