Relebactam (BioDeep_00000797996)
代谢物信息卡片
化学式: C12H20N4O6S (348.1104)
中文名称: 瑞来巴坦
谱图信息:
最多检出来源 () %
分子结构信息
SMILES: C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
InChI: InChI=1S/C12H20N4O6S/c17-11(14-8-3-5-13-6-4-8)10-2-1-9-7-15(10)12(18)16(9)22-23(19,20)21/h8-10,13H,1-7H2,(H,14,17)(H,19,20,21)/t9-,10+/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D065093 - beta-Lactamase Inhibitors
C2140 - Adjuvant > C183118 - Beta-lactamase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Miao He, Ernane Souza, Aleksas Matvekas, Ryan L Crass, Manjunath P Pai. Alteration in Acute Kidney Injury Potential with the Combination of Vancomycin and Imipenem-Cilastatin/Relebactam or Piperacillin/Tazobactam in a Preclinical Model.
Antimicrobial agents and chemotherapy.
2021 03; 65(4):. doi:
10.1128/aac.02141-20. [PMID: 33526494] - Iris H Chen, David P Nicolau, Joseph L Kuti. Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model.
Antimicrobial agents and chemotherapy.
2020 11; 64(12):. doi:
10.1128/aac.01764-20. [PMID: 33139283] - Pratik Bhagunde, Francheska Colon-Gonzalez, Yang Liu, Jin Wu, Shiyao Sherrie Xu, Graigory Garrett, Patricia Jumes, Kenneth Lasseter, Thomas Marbury, Matthew L Rizk, Mallika Lala, Elizabeth G Rhee, Joan R Butterton, Keith Boundy. Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin.
British journal of clinical pharmacology.
2020 05; 86(5):944-957. doi:
10.1111/bcp.14204. [PMID: 31856304] - Keith S Kaye, Helen W Boucher, Michelle L Brown, Angela Aggrey, Ireen Khan, Hee-Koung Joeng, Robert W Tipping, Jiejun Du, Katherine Young, Joan R Butterton, Amanda Paschke. Comparison of Treatment Outcomes between Analysis Populations in the RESTORE-IMI 1 Phase 3 Trial of Imipenem-Cilastatin-Relebactam versus Colistin plus Imipenem-Cilastatin in Patients with Imipenem-Nonsusceptible Bacterial Infections.
Antimicrobial agents and chemotherapy.
2020 04; 64(5):. doi:
10.1128/aac.02203-19. [PMID: 32094127] - Pratik Bhagunde, Parul Patel, Mallika Lala, Kenny Watson, William Copalu, Ming Xu, Pooja Kulkarni, Katherine Young, Matthew L Rizk. Population Pharmacokinetic Analysis for Imipenem-Relebactam in Healthy Volunteers and Patients With Bacterial Infections.
CPT: pharmacometrics & systems pharmacology.
2019 10; 8(10):748-758. doi:
10.1002/psp4.12462. [PMID: 31508899] - Grace Chan, Robert Houle, Meihong Lin, Jocelyn Yabut, Kathleen Cox, Jin Wu, Xiaoyan Chu. Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655).
The Journal of antimicrobial chemotherapy.
2019 07; 74(7):1894-1903. doi:
10.1093/jac/dkz101. [PMID: 30891606] - Elizabeth G Rhee, Matthew L Rizk, Nicole Calder, Marcela Nefliu, Steven J Warrington, Michael S Schwartz, Eric Mangin, Keith Boundy, Pratik Bhagunde, Francheska Colon-Gonzalez, Patricia Jumes, Yang Liu, Joan R Butterton. Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Relebactam, a β-Lactamase Inhibitor, in Combination with Imipenem and Cilastatin in Healthy Participants.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00280-18. [PMID: 29914955] - Matthew L Rizk, Elizabeth G Rhee, Patricia A Jumes, Mark H Gotfried, Tian Zhao, Eric Mangin, Sheng Bi, Cynthia M Chavez-Eng, Zufei Zhang, Joan R Butterton. Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2018 03; 62(3):. doi:
10.1128/aac.01411-17. [PMID: 29311084]
