lemborexant (BioDeep_00000797681)
代谢物信息卡片
化学式: C22H20F2N4O2 (410.1554)
中文名称: 莱博雷生
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC(=NC=C1OCC2(CC2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
InChI: InChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C142786 - Orexin Receptor Antagonist
D018377 - Neurotransmitter Agents > D000068796 - Orexin Receptor Antagonists
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11022
- PubChem: 56944144
- DrugBank: DB11951
- ChEMBL: CHEMBL3545367
- CAS: 1369764-02-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ishani Landry, Nancy Hall, Jagadeesh Aluri, Gleb Filippov, Beatrice Setnik, Satish Dayal, Larisa Reyderman, Margaret Moline. Effect of alcohol coadministration on the pharmacodynamics, pharmacokinetics, and safety of lemborexant: A randomized, placebo-controlled crossover study.
Journal of psychopharmacology (Oxford, England).
2022 06; 36(6):745-755. doi:
10.1177/02698811221080459. [PMID: 35634694] - Ishani Landry, Jagadeesh Aluri, Nancy Hall, Gleb Filippov, Satish Dayal, Margaret Moline, Larisa Reyderman. Effects of Lemborexant on the Pharmacokinetics of Oral Contraceptives: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Females.
Clinical pharmacology in drug development.
2021 09; 10(9):1089-1098. doi:
10.1002/cpdd.953. [PMID: 34107159] - Ishani Landry, Jagadeesh Aluri, Nancy Hall, Gleb Filippov, Satish Dayal, Margaret Moline, Larisa Reyderman. Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant.
Pharmacology research & perspectives.
2021 04; 9(2):e00734. doi:
10.1002/prp2.734. [PMID: 33689224] - Satish Dayal, Jagadeesh Aluri, Nancy Hall, Gleb Filippov, Margaret Moline, Larisa Reyderman, Ishani Landry. Effect of hepatic impairment on pharmacokinetics, safety, and tolerability of lemborexant.
Pharmacology research & perspectives.
2021 04; 9(2):e00758. doi:
10.1002/prp2.758. [PMID: 33822479] - Ishani Landry, Kenya Nakai, Jim Ferry, Jagadeesh Aluri, Nancy Hall, Bojan Lalovic, Margaret L Moline. Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single-Dose and Multiple-Ascending-Dose Phase 1 Studies in Healthy Adults.
Clinical pharmacology in drug development.
2021 02; 10(2):153-165. doi:
10.1002/cpdd.817. [PMID: 32468649] - Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T Beuckmann, Takaaki Kameyama, Shoji Asakura, Kazutomi Kusano. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites.
Drug metabolism and disposition: the biological fate of chemicals.
2021 01; 49(1):31-38. doi:
10.1124/dmd.120.000229. [PMID: 33144331] - Carsten T Beuckmann, Hiroyuki Suzuki, Erik S Musiek, Takashi Ueno, Toshitaka Sato, Masahiro Bando, Yoshihide Osada, Margaret Moline. Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer's Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant.
Journal of Alzheimer's disease : JAD.
2021; 81(3):1151-1167. doi:
10.3233/jad-201054. [PMID: 33843668] - Yuji Mano, Takashi Ueno, Koichiro Hotta. Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study.
Journal of pharmaceutical and biomedical analysis.
2020 Aug; 187(?):113359. doi:
10.1016/j.jpba.2020.113359. [PMID: 32470691] - Carsten Theodor Beuckmann, Takashi Ueno, Makoto Nakagawa, Michiyuki Suzuki, Shigeru Akasofu. Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation.
Sleep.
2019 06; 42(6):. doi:
10.1093/sleep/zsz076. [PMID: 30923834] - Takashi Ueno, Tomomi Ishida, Kazutomi Kusano. Disposition and metabolism of [14C]lemborexant, a novel dual orexin receptor antagonist, in rats and monkeys.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Jun; 49(6):688-697. doi:
10.1080/00498254.2018.1482509. [PMID: 29806508]
