HPPH (BioDeep_00000796869)

   


代谢物信息卡片


2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a

化学式: C39H48N4O4 (636.3675367999999)
中文名称: 光克洛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCOC(C)C1=C(C2=NC1=CC3=NC(=CC4=C(C5=C(CC(=C6C(C(C(=C2)N6)C)CCC(=O)O)C5=N4)O)C)C(=C3C)CC)C
InChI: InChI=1S/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,42,44H,8-16H2,1-7H3,(H,45,46)/t21-,24?,26-/m0/s1

描述信息

C1420 - Photosensitizing Agent

同义名列表

2 个代谢物同义名

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a; HPPH



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Joseph Zenga, Musaddiq Awan, Mir Hadi Razeghi Kondelaji, Christopher Hansen, Shayan Shafiee, Anne Frei, Jamie Foeckler, Rachel Kuehn, Jennifer Bruening, Becky Massey, Stuart Wong, Amit Joshi, Heather A Himburg. Photoactivated HPPH-Liposomal therapy for the treatment of HPV-Negative head and neck cancer. Oral oncology. 2023 Jul; 144(?):106487. doi: 10.1016/j.oraloncology.2023.106487. [PMID: 37423200]
  • Kowthavarapu Venkata Krishna, Ranendra Narayana Saha, Anu Puri, Mathias Viard, Bruce A Shapiro, Sunil Kumar Dubey. Pre-clinical compartmental pharmacokinetic modeling of 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) as a photosensitizer in rat plasma by validated HPLC method. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2019 May; 18(5):1056-1063. doi: 10.1039/c8pp00339d. [PMID: 30608096]
  • Lin Chen, Xian Zhang, Qingqing Cao, Yanqing Wu, Ting Zhang, Huan Tong, Xin Wang, Jin Yang. Development and application of a physiologically based pharmacokinetic model for HPPH in rats and extrapolate to humans. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Mar; 129(?):68-78. doi: 10.1016/j.ejps.2018.12.014. [PMID: 30597205]
  • Lin Chen, Qingqing Xiao, Xian Zhang, Jin Yang. Establishment and comparison of three novel methods for the determination of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) in human serum. Journal of pharmaceutical and biomedical analysis. 2016 Mar; 121(?):13-21. doi: 10.1016/j.jpba.2015.12.057. [PMID: 26773535]
  • Dandan Luo, Kevin A Carter, Aida Razi, Jumin Geng, Shuai Shao, Cuiyan Lin, Joaquin Ortega, Jonathan F Lovell. Porphyrin-phospholipid liposomes with tunable leakiness. Journal of controlled release : official journal of the Controlled Release Society. 2015 Dec; 220(Pt A):484-494. doi: 10.1016/j.jconrel.2015.11.011. [PMID: 26578438]
  • Jessica Sine, Cordula Urban, Derek Thayer, Heather Charron, Niksa Valim, Darrell B Tata, Rachel Schiff, Robert Blumenthal, Amit Joshi, Anu Puri. Photo activation of HPPH encapsulated in 'Pocket' liposomes triggers multiple drug release and tumor cell killing in mouse breast cancer xenografts. International journal of nanomedicine. 2015; 10(?):125-45. doi: 10.2147/ijn.s72143. [PMID: 25565809]
  • David A Bellnier, William R Greco, Gregory M Loewen, Hector Nava, Allan R Oseroff, Thomas J Dougherty. Clinical pharmacokinetics of the PDT photosensitizers porfimer sodium (Photofrin), 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (Photochlor) and 5-ALA-induced protoporphyrin IX. Lasers in surgery and medicine. 2006 Jun; 38(5):439-44. doi: 10.1002/lsm.20340. [PMID: 16634075]
  • David A Bellnier, William R Greco, Gregory M Loewen, Hector Nava, Allan R Oseroff, Ravindra K Pandey, Takaaki Tsuchida, Thomas J Dougherty. Population pharmacokinetics of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a in cancer patients. Cancer research. 2003 Apr; 63(8):1806-13. doi: . [PMID: 12702566]
  • Y Caraco, M Muszkat, A J Wood. Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo. Pharmacogenetics. 2001 Oct; 11(7):587-96. doi: 10.1097/00008571-200110000-00005. [PMID: 11668218]
  • J Lobel, I J MacDonald, M J Ciesielski, T Barone, W R Potter, J Pollina, R J Plunkett, R A Fenstermaker, T J Dougherty. 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy. Lasers in surgery and medicine. 2001; 29(5):397-405. doi: 10.1002/lsm.10001. [PMID: 11891727]
  • F Kamali, D E Ball, W S McLaughlin, R A Seymour. Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth. Journal of periodontal research. 1999 Apr; 34(3):145-53. doi: 10.1111/j.1600-0765.1999.tb02235.x. [PMID: 10384402]
  • J T Payne, D L McCaw, S W Casteel, D Frazier, K Rogers, R V Tompson. Pharmacokinetics of pyropheophorbide-a-hexyl ether in the dog. Lasers in surgery and medicine. 1996; 18(4):406-9. doi: 10.1002/(sici)1096-9101(1996)18:4<406::aid-lsm10>3.0.co;2-1. [PMID: 8732580]
  • D A Bellnier, B W Henderson, R K Pandey, W R Potter, T J Dougherty. Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a. Journal of photochemistry and photobiology. B, Biology. 1993 Sep; 20(1):55-61. doi: 10.1016/1011-1344(93)80131-r. [PMID: 8229470]