SR 9243 (BioDeep_00000796680)
代谢物信息卡片
化学式: C31H32BrNO4S2 (625.0956012)
中文名称: SR9243
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: BrC1=CC(CCN(S(C2=C(C)C=C(C)C=C2C)(=O)=O)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)=CC=C1
InChI: InChI=1S/C31H32BrNO4S2/c1-22-17-23(2)31(24(3)18-22)39(36,37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4,34)35/h5-14,17-20H,15-16,21H2,1-4H3
描述信息
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hassan Dianat-Moghadam, Soheil Abbasspour-Ravasjani, Hamed Hamishehkar, Reza Rahbarghazi, Mahammad Nouri. LXR inhibitor SR9243-loaded immunoliposomes modulate lipid metabolism and stemness in colorectal cancer cells.
Medical oncology (Northwood, London, England).
2023 Apr; 40(6):156. doi:
10.1007/s12032-023-02027-4. [PMID: 37093287] - Bahaa Elgendy, Kristine Griffett, Lamees Hegazy, Paolo Di Fruscia, Kirby Sample, Emmalie Schoepke, Theodore M Kamenecka, Thomas P Burris. Synthesis and structure activity relationship of the first class of LXR inverse agonists.
Bioorganic chemistry.
2022 02; 119(?):105540. doi:
10.1016/j.bioorg.2021.105540. [PMID: 34902646] - Tomofumi Fujino, Kouta Sugizaki, Rei Kato, Masaki Beppu, Satoshi Murakami, Hyunjung Lee, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells.
The Journal of toxicological sciences.
2020; 45(1):25-35. doi:
10.2131/jts.45.25. [PMID: 31932555] - Guangzhen Wu, Qinglian Wang, Yingkun Xu, Jianyi Li, Hongge Zhang, Guanghui Qi, Qinghua Xia. Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?.
Cell death & disease.
2019 05; 10(6):416. doi:
10.1038/s41419-019-1654-6. [PMID: 31138790] - Ya-Xiong Pan, Mei-Qing Zhuo, Dan-Dan Li, Yi-Huan Xu, Kun Wu, Zhi Luo. SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio.
Chemosphere.
2019 Jan; 215(?):370-379. doi:
10.1016/j.chemosphere.2018.10.058. [PMID: 30336314] - Peng Huang, Benson Kaluba, Xiao-Lin Jiang, Shi Chang, Xiao-Feng Tang, Lin-Feng Mao, Zhi-Peng Zhang, Fei-Zhou Huang. Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis.
BioMed research international.
2018; 2018(?):8071093. doi:
10.1155/2018/8071093. [PMID: 29670908]