Rotigaptide (BioDeep_00000796041)
代谢物信息卡片
化学式: C28H39N7O9 (617.2809124)
中文名称: 罗替加肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)NCC(=O)N)NC(=O)CNC(=O)C1CC(CN1C(=O)C2CCCN2C(=O)C(CC3=CC=C(C=C3)O)NC(=O)C)O
InChI: InChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D05767
- PubChem: 9938933
- DrugBank: DB13067
- ChEMBL: CHEMBL450656
- CAS: 355151-12-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Leire Arantzamendi, Francisco Roo, Carmen María Hernández-Cruz, Hipólito Fernández-Palacios, Marisol Izquierdo. Lipid digestion capacity in gilthead seabream (Sparus aurata) from first feeding to commercial size.
Fish physiology and biochemistry.
2019 Feb; 45(1):469-484. doi:
10.1007/s10695-018-0577-y
. [PMID: 30382441] - Eric I Rossman, Kun Liu, Gwen A Morgan, Robert E Swillo, Julie A Krueger, Stephen J Gardell, John Butera, Matthew Gruver, Joel Kantrowitz, Hal S Feldman, Jørgen S Petersen, Ketil Haugan, James K Hennan. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.
The Journal of pharmacology and experimental therapeutics.
2009 Jun; 329(3):1127-33. doi:
10.1124/jpet.108.150102
. [PMID: 19252062] - Anne Louise Kjølbye, Ketil Haugan, James K Hennan, Jørgen S Petersen. Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.
Basic & clinical pharmacology & toxicology.
2007 Oct; 101(4):215-30. doi:
10.1111/j.1742-7843.2007.00123.x
. [PMID: 17845503] - Ketil Haugan, Niels Marcussen, Anne Louise Kjølbye, Morten Schak Nielsen, James K Hennan, Jørgen Søberg Petersen. Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction.
Journal of cardiovascular pharmacology.
2006 Feb; 47(2):236-42. doi:
10.1097/01.fjc.0000200990.31611.6e
. [PMID: 16495761] - Dezhi Xing, Anne Louise Kjølbye, Jørgen S Petersen, James B Martins. Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs.
American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H511-6. doi:
10.1152/ajpheart.00720.2004
. [PMID: 15650154] - Anne Louise Kjølbye, Carsten Boye Knudsen, Trine Jepsen, Bjarne Due Larsen, Jorgen Søberg Petersen. Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies.
The Journal of pharmacology and experimental therapeutics.
2003 Sep; 306(3):1191-9. doi:
10.1124/jpet.103.052258
. [PMID: 12829724] - Stefan Dhein, Bjarne D Larsen, Jørgen S Petersen, Friedrich-Wilhelm Mohr. Effects of the new antiarrhythmic peptide ZP123 on epicardial activation and repolarization pattern.
Cell communication & adhesion.
2003 Jul; 10(4-6):371-8. doi:
10.1080/cac.10.4-6.371.378
. [PMID: 14681044] - Dezhi Xing, Anne Louise Kjølbye, Morten S Nielsen, Jørgen S Petersen, Kenneth W Harlow, Niels-Henrik Holstein-Rathlou, James B Martins. ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.
Journal of cardiovascular electrophysiology.
2003 May; 14(5):510-20. doi:
10.1046/j.1540-8167.2003.02329.x
. [PMID: 12776869]