Selonsertib (BioDeep_00000795721)

   


代谢物信息卡片


Selonsertib(GS-4997)

化学式: C24H24FN7O (445.2026)
中文名称: 司隆色替
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F
InChI: InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors

同义名列表

2 个代谢物同义名

Selonsertib(GS-4997); Selonsertib



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yun-Jung Choi, Jeff D Johnson, Jin-Ju Lee, Jiangao Song, Marcy Matthews, Marc K Hellerstein, Charles A McWherter. Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis. American journal of physiology. Gastrointestinal and liver physiology. 2024 Feb; 326(2):G120-G132. doi: 10.1152/ajpgi.00158.2023. [PMID: 38014444]
  • Mohammad Hassan Baig, Preeti Gupta, Mohd Imran Khan, Mohamed F Alajmi, Afzal Hussain, Md Imtaiyaz Hassan, Jae-June Dong. Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches. Current topics in medicinal chemistry. 2022; 22(10):879-890. doi: 10.2174/1568026622666220330012032. [PMID: 35352662]
  • Cara H Nelson, Kim Etchevers, Saili Yi, David Breckenridge, Mischa Hepner, Uptal Patel, John Ling, Anita Mathias. Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects. Clinical pharmacokinetics. 2020 09; 59(9):1109-1117. doi: 10.1007/s40262-020-00878-y. [PMID: 32333325]
  • Glenn M Chertow, Pablo E Pergola, Fang Chen, Brian J Kirby, John S Sundy, Uptal D Patel. Effects of Selonsertib in Patients with Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN. 2019 10; 30(10):1980-1990. doi: 10.1681/asn.2018121231. [PMID: 31506292]
  • Wei-Feng Gui, Shuo Xu, Zhi-Sheng Dang, Yu-Min Zhao. In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis. The Journal of parasitology. 2019 02; 105(1):146-154. doi: 10.1645/18-121. [PMID: 30807708]