Stattic (BioDeep_00000794678)
代谢物信息卡片
化学式: C8H5NO4S (210.9939)
中文名称: 6-硝基苯并[b] 噻吩-1,1-二氧化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChI: InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Anibal Méndez-Clemente, Alejandro Bravo-Cuellar, Salvador González-Ochoa, Maria Santiago-Mercado, Luis Palafox-Mariscal, Luis Jave-Suárez, Fabiola Solorzano-Ibarra, Maria Villaseñor-García, Pablo Ortiz-Lazareno, Georgina Hernández-Flores. Dual STAT‑3 and IL‑6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL‑6/IL‑6R/STAT‑3 axis.
Oncology reports.
2022 Aug; 48(2):. doi:
10.3892/or.2022.8349
. [PMID: 35703345] - Yong-Yun Zhu, Ying-Chun Zhao, Chuang Chen, Min Xie. CCL5 secreted by luminal B breast cancer cells induces polarization of M2 macrophages through activation of MEK/STAT3 signaling pathway via CCR5.
Gene.
2022 Feb; 812(?):146100. doi:
10.1016/j.gene.2021.146100
. [PMID: 34864094] - Stephanie Sally Fong, Yiing Yee Foo, Wen Shang Saw, Bey Fen Leo, Yin Yin Teo, Ivy Chung, Boon Tong Goh, Misni Misran, Toyoko Imae, Chia-Ching Chang, Lip Yong Chung, Lik Voon Kiew. Chitosan-Coated-PLGA Nanoparticles Enhance the Antitumor and Antimigration Activity of Stattic - A STAT3 Dimerization Blocker.
International journal of nanomedicine.
2022; 17(?):137-150. doi:
10.2147/ijn.s337093
. [PMID: 35046650] - Miaoyuan Zhang, Liyu He, Jingsong Liu, Lin Zhou. Luteolin Attenuates Diabetic Nephropathy through Suppressing Inflammatory Response and Oxidative Stress by Inhibiting STAT3 Pathway.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2021 Oct; 129(10):729-739. doi:
10.1055/a-0998-7985
. [PMID: 31896157] - Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li. Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors.
European journal of medicinal chemistry.
2021 Apr; 216(?):113333. doi:
10.1016/j.ejmech.2021.113333
. [PMID: 33689932] - Yanan Xu, Xiaoyu Huang, Fengzhan Li, Tan Liu, Tingting Yang, Fei Chen, Jie Zhu, Meng Pan, Yong Zhang, Yuzhong Wang, Linlin Fu, Chenghua Xiao, Deqin Geng. IL-21 enhances STAT3/Blimp-1 signaling pathway in B cells and contributes to plasma cell differentiation in newly diagnosed patients with myasthenia gravis.
Immunologic research.
2021 02; 69(1):59-70. doi:
10.1007/s12026-020-09164-2
. [PMID: 33145710] - Corinne Vanucci-Bacqué, Florence Bedos-Belval. Anti-inflammatory activity of naturally occuring diarylheptanoids - A review.
Bioorganic & medicinal chemistry.
2021 02; 31(?):115971. doi:
10.1016/j.bmc.2020.115971
. [PMID: 33422907] - Jamal Mohammadian, Shiva Mahmoudi, Pirouz Pourmohammad, Mohammad Pirouzpanah, Fatemeh Salehnia, Nazila Fathi Maroufi, Nasser Samadi, Mehdi Sabzichi. Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 12; 393(12):2315-2323. doi:
10.1007/s00210-020-01942-x
. [PMID: 32653978] - Kai-Rui Feng, Feng Wang, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li, Guo-Qiang Lin, Dingding Gao, Ping Tian. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy.
European journal of medicinal chemistry.
2020 Sep; 201(?):112428. doi:
10.1016/j.ejmech.2020.112428
. [PMID: 32603980] - N Yoshida, F He, V C Kyttaris. T cell-specific STAT3 deficiency abrogates lupus nephritis.
Lupus.
2019 Oct; 28(12):1468-1472. doi:
10.1177/0961203319877242
. [PMID: 31551033] - Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan, Xiaodong Han. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway.
Cell communication and signaling : CCS.
2019 05; 17(1):45. doi:
10.1186/s12964-019-0361-3
. [PMID: 31101053] - Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang, Yuh-Lien Chen. PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway.
Particle and fibre toxicology.
2018 01; 15(1):4. doi:
10.1186/s12989-018-0240-x
. [PMID: 29329563] - Ida Syazwani M Affandi, Wei Qi Lee, Shevin R Feroz, Saharuddin B Mohamad, Saad Tayyab. Interaction of stattic, a STAT3 inhibitor with human serum albumin: spectroscopic and computational study.
Journal of biomolecular structure & dynamics.
2017 12; 35(16):3581-3590. doi:
10.1080/07391102.2016.1264887
. [PMID: 27892818] - Raquel de la Varga Martínez, Beatriz Rodríguez-Bayona, Gustavo A Añez, Fermín Medina Varo, José J Pérez Venegas, José A Brieva, Carmen Rodríguez. Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation.
European journal of immunology.
2017 07; 47(7):1211-1219. doi:
10.1002/eji.201646872
. [PMID: 28463395] - Lindsay J Edwards, Masayuki Mizui, Vasileios Kyttaris. Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice.
Clinical immunology (Orlando, Fla.).
2015 Jun; 158(2):221-30. doi:
10.1016/j.clim.2015.04.004
. [PMID: 25869298] - Kerstin Boengler, Elvira Ungefug, Gerd Heusch, Rainer Schulz. The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.
Current pharmaceutical design.
2013; 19(39):6890-5. doi:
10.2174/138161281939131127115940
. [PMID: 23590160]