Formoterol fumarate (BioDeep_00000794673)
代谢物信息卡片
formoterol fumarate dihydrate
化学式: C42H56N4O14 (840.3792836)
中文名称: 富马酸福莫特罗二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.C(=CC(=O)O)C(=O)O.O.O
InChI: 2-1+
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31633
- KEGGdrug: D05277
- PubChem: 45358055
- PubChem: 9919001
- ChEMBL: CHEMBL3989798
- MeSH: Formoterol Fumarate
- CAS: 183814-30-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sanna H Loppi, Marco A Tavera-Garcia, Natalie E Scholpa, Boaz K Maiyo, Danielle A Becktel, Helena W Morrison, Rick G Schnellmann, Kristian P Doyle. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316632. [PMID: 38068955] - Yiwen Gong, Zichao Sui, Yinghua Lv, Qingshan Zheng, Lujin Li. LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data.
European journal of clinical pharmacology.
2023 Jul; ?(?):. doi:
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The Journal of physiology.
2023 02; 601(4):743-761. doi:
10.1113/jp283959. [PMID: 36536512] - Piotr Kuna, Joanna Jerzynska, Matteo Martini, Andrea Vele, Irene Barneschi, Fabrizia Mariotti, George Georges, Giorgia Ciurlia. Pharmacokinetics of extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide in adolescent and adult patients with asthma.
Pharmacology research & perspectives.
2022 08; 10(4):e980. doi:
10.1002/prp2.980. [PMID: 35733414] - Zhu Luo, Germano Lucci, Luigi Santoro, Eva Topole, Fabrizia Mariotti. Pharmacokinetic profile of beclometasone dipropionate/formoterol fumarate administered through a novel dry-powder inhaler in Chinese healthy volunteers.
Pulmonary pharmacology & therapeutics.
2022 06; 73-74(?):102129. doi:
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Drug testing and analysis.
2022 Jun; 14(6):997-1003. doi:
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Drugs in R&D.
2022 Mar; 22(1):35-42. doi:
10.1007/s40268-021-00374-z. [PMID: 35133636] - Qing Kong, Yuxue Cao, Zhen Gao, Jing Sun, Hongying Zhang, Yijie Du, Yubao Lv, Sihan Zhou, Zihui Tang, Baojun Liu, Jingcheng Dong. Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD: study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial.
Trials.
2022 Feb; 23(1):143. doi:
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Therapeutic advances in respiratory disease.
2022 Jan; 16(?):17534666211066068. doi:
10.1177/17534666211066068. [PMID: 35001708] - F D Richard Hobbs, Ly-Mee Yu, Benjamin R Saville, Mona Bafadhel, Christopher C Butler. High-dose budesonide for early COVID-19 - Authors' reply.
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2021 12; 398(10317):2147-2148. doi:
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Clinical therapeutics.
2021 11; 43(11):1934-1947.e4. doi:
10.1016/j.clinthera.2021.09.001. [PMID: 34600734] - Yun Shi, Jason Pizzini, Hanzhou Wang, Falguni Das, Parveez Ahamed Abdul Azees, Goutam Ghosh Choudhury, Jeffrey L Barnes, Mengwei Zang, Susan T Weintraub, Chih-Ko Yeh, Michael S Katz, Amrita Kamat. β2-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states.
American journal of physiology. Endocrinology and metabolism.
2021 07; 321(1):E90-E104. doi:
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The Lancet. Respiratory medicine.
2021 07; 9(7):e61. doi:
10.1016/s2213-2600(21)00212-5. [PMID: 33991509] - Ernest L Vallorz, Karen Blohm-Mangone, Rick G Schnellmann, Heidi M Mansour. Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules.
The AAPS journal.
2021 06; 23(4):88. doi:
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MMW Fortschritte der Medizin.
2021 04; 163(8):27-28. doi:
10.1007/s15006-021-9864-0. [PMID: 33904080] - Kristan H Cleveland, Frank C Brosius, Rick G Schnellmann. Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β2-adrenergic receptor agonist formoterol.
American journal of physiology. Renal physiology.
2020 11; 319(5):F773-F779. doi:
10.1152/ajprenal.00427.2020. [PMID: 32954853] - Ying Huang, Pryseley Nkouibert Assam, Cong Feng, Rong Su, Paul Dorinsky, Michael Gillen. Ethnic pharmacokinetic comparison of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) between Asian and Western healthy subjects.
Pulmonary pharmacology & therapeutics.
2020 10; 64(?):101976. doi:
10.1016/j.pupt.2020.101976. [PMID: 33152467] - Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Patricia C Edwards, Javier García-Nafría, Andrew G W Leslie, Arun K Shukla, Christopher G Tate. Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor.
Nature.
2020 07; 583(7818):862-866. doi:
10.1038/s41586-020-2419-1. [PMID: 32555462] - Lisa Joy Juergens, Heinrich Worth, Uwe R Juergens. New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach.
Advances in therapy.
2020 05; 37(5):1737-1753. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Mar; 144(?):105198. doi:
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Pulmonary pharmacology & therapeutics.
2020 02; 60(?):101873. doi:
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American journal of physiology. Renal physiology.
2020 02; 318(2):F322-F328. doi:
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Journal of proteome research.
2020 01; 19(1):64-74. doi:
10.1021/acs.jproteome.9b00345. [PMID: 31621329] - Donald P Tashkin. Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.
International journal of chronic obstructive pulmonary disease.
2020; 15(?):3105-3122. doi:
10.2147/copd.s273497. [PMID: 33273813] - Omar Usmani, Nicolas Roche, Jonathan Marshall, Helen Danagher, David Price. An innovative corticosteroid/long-acting β2-agonist breath-triggered inhaler: facilitating lung delivery of fluticasone propionate/formoterol fumarate for the treatment of asthma.
Expert opinion on drug delivery.
2019 12; 16(12):1367-1380. doi:
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Kidney international.
2019 09; 96(3):656-673. doi:
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Drug testing and analysis.
2019 Jul; 11(7):950-956. doi:
10.1002/dta.2587. [PMID: 30865387] - Morten Hostrup, Christian K Narkowicz, Sajad Habib, David S Nichols, Glenn A Jacobson. Beta2 -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular PKA signaling at therapeutic inhaled doses.
Drug testing and analysis.
2019 Jul; 11(7):1048-1056. doi:
10.1002/dta.2580. [PMID: 30836453] - Robert B Cameron, Whitney S Gibbs, Siennah R Miller, Tess V Dupre, Judit Megyesi, Craig C Beeson, Rick G Schnellmann. Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.
The Journal of pharmacology and experimental therapeutics.
2019 04; 369(1):173-180. doi:
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Clinical pharmacology in drug development.
2019 02; 8(2):223-233. doi:
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Pulmonary pharmacology & therapeutics.
2018 12; 53(?):33-38. doi:
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Journal of pharmacological sciences.
2018 Nov; 138(3):184-191. doi:
10.1016/j.jphs.2018.09.007. [PMID: 30322801] - Ana Isabel Martín, Ana Belén Gómez-SanMiguel, Teresa Priego, Asunción López-Calderón. Formoterol treatment prevents the effects of endotoxin on muscle TNF/NF-kB, Akt/mTOR, and proteolytic pathways in a rat model. Role of IGF-I and miRNA 29b.
American journal of physiology. Endocrinology and metabolism.
2018 10; 315(4):E705-E714. doi:
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Pulmonary pharmacology & therapeutics.
2018 08; 51(?):18-25. doi:
10.1016/j.pupt.2018.05.001. [PMID: 29763659] - Patrick Darken, Paolo DePetrillo, Colin Reisner, Earl St Rose, Paul Dorinsky. The pharmacokinetics of three doses of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler compared with active controls: A Phase I randomized, single-dose, crossover study in healthy adults.
Pulmonary pharmacology & therapeutics.
2018 06; 50(?):11-18. doi:
10.1016/j.pupt.2018.03.001. [PMID: 29544728] - Faisal Fakih, Selwyn Spangenthal, Barry Sigal, Patrick Darken, Andrea Maes, Shahid Siddiqui, Michael Gillen, Colin Reisner, Ubaldo J Martin. Randomized study of the effects of Aerochamber Plus® Flow-Vu® on the efficacy, pharmacokinetics and safety of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler in patients with chronic obstructive pulmonary disease.
Respiratory medicine.
2018 05; 138(?):74-80. doi:
10.1016/j.rmed.2018.03.033. [PMID: 29724397] - Ole D Wolthers, Sabine Mersmann, Sanjeeva Dissanayake. A Pilot Study of the Normative Range of Overnight Urinary Free Cortisol Corrected for Creatinine in Children.
Clinical drug investigation.
2018 Apr; 38(4):313-318. doi:
10.1007/s40261-017-0609-x. [PMID: 29256049] - Gary T Ferguson, Roberto Rodriguez-Roisin, Colin Reisner, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin. Pharmacokinetics of glycopyrronium/formoterol fumarate dihydrate delivered via metered dose inhaler using co-suspension delivery technology in patients with moderate-to-very severe COPD.
International journal of chronic obstructive pulmonary disease.
2018; 13(?):945-953. doi:
10.2147/copd.s154988. [PMID: 29606861] - Yong Zou, Jian Xiao, Xiao Xiao Lu, Zi An Xia, Bin Xie, Jun Li, Qiong Chen. Tiotropium plus formoterol versus tiotropium alone for stable moderate-to-severe chronic obstructive pulmonary disease: A meta-analysis.
The clinical respiratory journal.
2018 Jan; 12(1):269-278. doi:
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Scientific reports.
2017 09; 7(1):10578. doi:
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European journal of applied physiology.
2017 Sep; 117(9):1907-1915. doi:
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Journal of medicinal chemistry.
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European journal of drug metabolism and pharmacokinetics.
2017 Apr; 42(2):269-279. doi:
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Clinical and experimental obstetrics & gynecology.
2017; 44(1):122-128. doi:
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Sports medicine (Auckland, N.Z.).
2016 Dec; 46(12):1787-1795. doi:
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Therapeutic advances in respiratory disease.
2016 08; 10(4):324-37. doi:
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Diabetes care.
2015 Sep; 38(9):1736-41. doi:
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British journal of clinical pharmacology.
2015 Sep; 80(3):569-80. doi:
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The Journal of pharmacy and pharmacology.
2014 Dec; 66(12):1677-85. doi:
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2014 Oct; 113(4):404-9. doi:
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Respiratory medicine.
2014 Sep; 108(9):1327-35. doi:
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Journal of chromatographic science.
2014 Sep; 52(8):848-51. doi:
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Journal of the American Society of Nephrology : JASN.
2014 Jun; 25(6):1157-62. doi:
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2014 May; 15(?):153. doi:
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Molecular bioSystems.
2013 Dec; 9(12):3015-25. doi:
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