SHU9119 (BioDeep_00000794662)
代谢物信息卡片
Ac-Nle-Asp(1)-His-D-2Nal-Arg-Trp-Lys(1)-NH2
化学式: C54H71N15O9 (1073.5558916)
中文名称: SHU-9119
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
InChI: InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D009074 - Melanocyte-Stimulating Hormones
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Attilio Iemolo, Mariel Seiglie, Angelo Blasio, Pietro Cottone, Valentina Sabino. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors.
Psychopharmacology.
2016 Sep; 233(17):3269-77. doi:
10.1007/s00213-016-4366-y. [PMID: 27376948] - Benjamin Barzel, Kyungjoon Lim, Pamela J Davern, Sandra L Burke, James A Armitage, Geoffrey A Head. Central proopiomelanocortin but not neuropeptide Y mediates sympathoexcitation and hypertension in fat fed conscious rabbits.
Journal of hypertension.
2016 Mar; 34(3):464-73; discussion 473. doi:
10.1097/hjh.0000000000000811. [PMID: 26820476] - Zhigang Shi, Priscila A Cassaglia, Laura C Gotthardt, Virginia L Brooks. Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Roles of Neuropeptide Y and α-Melanocyte-Stimulating Hormone.
Hypertension (Dallas, Tex. : 1979).
2015 Dec; 66(6):1191-8. doi:
10.1161/hypertensionaha.115.06045. [PMID: 26483343] - Zhigang Shi, Virginia L Brooks. Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen.
The Journal of physiology.
2015 Apr; 593(7):1633-47. doi:
10.1113/jphysiol.2014.284638. [PMID: 25398524] - Steve M Fernandes, Yeon Sun Lee, Robert J Gillies, Victor J Hruby. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor.
Bioorganic & medicinal chemistry.
2014 Nov; 22(22):6360-5. doi:
10.1016/j.bmc.2014.09.055. [PMID: 25438759] - Thomas H Meek, Miles E Matsen, Vincent Damian, Alex Cubelo, Streamson C Chua, Gregory J Morton. Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes.
Endocrinology.
2014 Nov; 155(11):4157-67. doi:
10.1210/en.2014-1169. [PMID: 25137027] - Sander Kooijman, Mariëtte R Boon, Edwin T Parlevliet, Janine J Geerling, Vera van de Pol, Johannes A Romijn, Louis M Havekes, Illiana Meurs, Patrick C N Rensen. Inhibition of the central melanocortin system decreases brown adipose tissue activity.
Journal of lipid research.
2014 Oct; 55(10):2022-32. doi:
10.1194/jlr.m045989. [PMID: 25016380] - Rodrigo O Maranon, Roberta Lima, Mohammed Mathbout, Jussara M do Carmo, John E Hall, Richard J Roman, Jane F Reckelhoff. Postmenopausal hypertension: role of the sympathetic nervous system in an animal model.
American journal of physiology. Regulatory, integrative and comparative physiology.
2014 Feb; 306(4):R248-56. doi:
10.1152/ajpregu.00490.2013. [PMID: 24381180] - Chitoku Toda, Tetsuya Shiuchi, Haruaki Kageyama, Shiki Okamoto, Eulalia A Coutinho, Tatsuya Sato, Yuko Okamatsu-Ogura, Shigefumi Yokota, Kazuyo Takagi, Lijun Tang, Kumiko Saito, Seiji Shioda, Yasuhiko Minokoshi. Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.
Diabetes.
2013 Jul; 62(7):2295-307. doi:
10.2337/db12-1629. [PMID: 23530005] - Peng Li, Bai-Ping Cui, Ling-Li Zhang, Hai-Jian Sun, Tong-Yan Liu, Guo-Qing Zhu. Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.
Experimental physiology.
2013 Feb; 98(2):435-43. doi:
10.1113/expphysiol.2012.067256. [PMID: 22872662] - Petteri Rinne, Anna-Maija Penttinen, Wendy Nordlund, Markku Ahotupa, Eriika Savontaus. α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice.
PloS one.
2013; 8(8):e72857. doi:
10.1371/journal.pone.0072857. [PMID: 23977363] - Jussara M do Carmo, Alexandre A da Silva, John S Rushing, John E Hall. Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Mar; 302(5):R561-7. doi:
10.1152/ajpregu.00392.2011. [PMID: 22204957] - Petra Wiedmer, Nilika Chaudhary, Michaela Rath, Chun-Xia Yi, Gayathri Ananthakrishnan, Rubén Nogueiras, Eva K Wirth, Henriette Kirchner, Ulrich Schweizer, Wenke Jonas, Christelle Veyrat-Durebex, Francoise Rohner-Jeanrenaud, Annette Schürmann, Hans-Georg Joost, Matthias H Tschöp, Diego Perez-Tilve. The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism.
Physiology & behavior.
2012 Feb; 105(3):791-9. doi:
10.1016/j.physbeh.2011.10.019. [PMID: 22061427] - Mamoru Tanida, Masatomo Mori. Nesfatin-1 stimulates renal sympathetic nerve activity in rats.
Neuroreport.
2011 Apr; 22(6):309-12. doi:
10.1097/wnr.0b013e328346107f. [PMID: 21451359] - Byong Seo Park, Sung Ho Jin, Joong Jean Park, Jeong Woo Park, Il Seong Namgoong, Young Il Kim, Byung Ju Lee, Jae Geun Kim. Visfatin induces sickness responses in the brain.
PloS one.
2011 Jan; 6(1):e15981. doi:
10.1371/journal.pone.0015981. [PMID: 21283791] - Guihong Yang, Juan Su, Yuan Yao, Zhihai Lei, Guorui Zhang, Xun Li. The regulatory mechanism of neuromedin S on luteinizing hormone in pigs.
Animal reproduction science.
2010 Dec; 122(3-4):367-74. doi:
10.1016/j.anireprosci.2010.10.011. [PMID: 21071159] - Miyako Tanaka, Takayoshi Suganami, Satoshi Sugita, Yuri Shimoda, Masato Kasahara, Seiichiro Aoe, Motohiro Takeya, Shu Takeda, Yasutomi Kamei, Yoshihiro Ogawa. Role of central leptin signaling in renal macrophage infiltration.
Endocrine journal.
2010; 57(1):61-72. doi:
10.1507/endocrj.k09e-296. [PMID: 19851035] - Arnold Leckstrom, Eun Ran Kim, Davie Wong, Tooru M Mizuno. Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway.
Diabetes.
2009 Jan; 58(1):87-94. doi:
10.2337/db08-0260. [PMID: 18984739] - Lourdes Mounien, Jean-Claude Do Rego, Patrice Bizet, Isabelle Boutelet, Guillaume Gourcerol, Alain Fournier, Philippe Brabet, Jean Costentin, Hubert Vaudry, Sylvie Jégou. Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Jan; 34(2):424-35. doi:
10.1038/npp.2008.73. [PMID: 18536705] - Donald A Morgan, Daniel R Thedens, Robert Weiss, Kamal Rahmouni. Mechanisms mediating renal sympathetic activation to leptin in obesity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Dec; 295(6):R1730-6. doi:
10.1152/ajpregu.90324.2008. [PMID: 18815209] - Nicole J Poritsanos, Davie Wong, Maria E Vrontakis, Tooru M Mizuno. Regulation of hepatic PPARgamma2 and lipogenic gene expression by melanocortin.
Biochemical and biophysical research communications.
2008 Nov; 376(2):384-8. doi:
10.1016/j.bbrc.2008.08.162. [PMID: 18789887] - Ruben Nogueiras, Petra Wiedmer, Diego Perez-Tilve, Christelle Veyrat-Durebex, Julia M Keogh, Gregory M Sutton, Paul T Pfluger, Tamara R Castaneda, Susanne Neschen, Susanna M Hofmann, Philip N Howles, Donald A Morgan, Stephen C Benoit, Ildiko Szanto, Brigitte Schrott, Annette Schürmann, Hans-Georg Joost, Craig Hammond, David Y Hui, Stephen C Woods, Kamal Rahmouni, Andrew A Butler, I Sadaf Farooqi, Stephen O'Rahilly, Françoise Rohner-Jeanrenaud, Matthias H Tschöp. The central melanocortin system directly controls peripheral lipid metabolism.
The Journal of clinical investigation.
2007 Nov; 117(11):3475-88. doi:
10.1172/jci31743. [PMID: 17885689] - Ernest U Do, Eun Bae Jo, Gyu Choi, Long Zhu Piao, Jaekyoon Shin, Min-Duk Seo, Su-Jin Kang, Bong-Jin Lee, Kang Ho Kim, Jae Bum Kim, Su-il Kim. Melanocortin 4 receptors interact with antimicrobial frog peptide analogues.
Biochemical and biophysical research communications.
2006 May; 343(4):1094-100. doi:
10.1016/j.bbrc.2006.03.082. [PMID: 16579969] - C Morens, M Keijzer, K de Vries, A Scheurink, G van Dijk. Effects of high-fat diets with different carbohydrate-to-protein ratios on energy homeostasis in rats with impaired brain melanocortin receptor activity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2005 Jul; 289(1):R156-63. doi:
10.1152/ajpregu.00774.2004. [PMID: 15774764] - Sarah A Nickolls, Beth Fleck, Sam R J Hoare, Rich A Maki. Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states.
The Journal of pharmacology and experimental therapeutics.
2005 Jun; 313(3):1281-8. doi:
10.1124/jpet.105.083337. [PMID: 15743921] - Andrea Beatríz Cragnolini, Mario Perelló, Helgi Birgir Schiöth, Teresa Nieves Scimonelli. alpha-MSH and gamma-MSH inhibit IL-1beta induced activation of the hypothalamic-pituitary-adrenal axis through central melanocortin receptors.
Regulatory peptides.
2004 Nov; 122(3):185-90. doi:
10.1016/j.regpep.2004.06.011. [PMID: 15491790] - Alexandre A da Silva, Jay J Kuo, John E Hall. Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin.
Hypertension (Dallas, Tex. : 1979).
2004 Jun; 43(6):1312-7. doi:
10.1161/01.hyp.0000128421.23499.b9. [PMID: 15123576] - N Hoggard, L Hunter, J S Duncan, D V Rayner. Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system.
Journal of molecular endocrinology.
2004 Feb; 32(1):145-53. doi:
10.1677/jme.0.0320145. [PMID: 14765998] - Zhenhai Gao, Dachuan Lei, Julie Welch, Kathy Le, Jie Lin, Song Leng, David Duhl. Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells.
The Journal of pharmacology and experimental therapeutics.
2003 Dec; 307(3):870-7. doi:
10.1124/jpet.103.055525. [PMID: 14534363] - Radhika Muzumdar, Xiaohui Ma, Xiaoman Yang, Gil Atzmon, Julia Bernstein, George Karkanias, Nir Barzilai. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Jun; 17(9):1130-2. doi:
10.1096/fj.02-0991fje. [PMID: 12709405] - Yoshio Tsuruta, Hironobu Yoshimatsu, Shuji Hidaka, Seiya Kondou, Kenjiro Okamoto, Toshiie Sakata. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression.
American journal of physiology. Endocrinology and metabolism.
2002 Apr; 282(4):E967-73. doi:
10.1152/ajpendo.00292.2001. [PMID: 11882520] - T Adage, A J Scheurink, S F de Boer, K de Vries, J P Konsman, F Kuipers, R A Adan, D G Baskin, M W Schwartz, G van Dijk. Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001 May; 21(10):3639-45. doi:
10.1523/jneurosci.21-10-03639.2001. [PMID: 11331393] - P D Raposinho, E Castillo, V d'Alleves, P Broqua, F P Pralong, M L Aubert. Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes.
Endocrinology.
2000 Dec; 141(12):4419-27. doi:
10.1210/endo.141.12.7842. [PMID: 11108250] - M Aizawa-Abe, Y Ogawa, H Masuzaki, K Ebihara, N Satoh, H Iwai, N Matsuoka, T Hayashi, K Hosoda, G Inoue, Y Yoshimasa, K Nakao. Pathophysiological role of leptin in obesity-related hypertension.
The Journal of clinical investigation.
2000 May; 105(9):1243-52. doi:
10.1172/jci8341. [PMID: 10791999] - K J Claycombe, B Z Xue, R L Mynatt, M B Zemel, N Moustaid-Moussa. Regulation of leptin by agouti.
Physiological genomics.
2000 Apr; 2(3):101-5. doi:
10.1152/physiolgenomics.2000.2.3.101. [PMID: 11015588] - J G Hohmann, T H Teal, D K Clifton, J Davis, V J Hruby, G Han, R A Steiner. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction.
American journal of physiology. Regulatory, integrative and comparative physiology.
2000 Jan; 278(1):R50-9. doi:
10.1152/ajpregu.2000.278.1.r50. [PMID: 10644621] - W G Haynes, D A Morgan, A Djalali, W I Sivitz, A L Mark. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic.
Hypertension (Dallas, Tex. : 1979).
1999 Jan; 33(1 Pt 2):542-7. doi:
10.1161/01.hyp.33.1.542. [PMID: 9931162] - Q H Huang, V J Hruby, J B Tatro. Systemic alpha-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release.
The American journal of physiology.
1998 08; 275(2):R524-30. doi:
10.1152/ajpregu.1998.275.2.r524. [PMID: 9688689] - J C Von Frijtag, G Croiset, W H Gispen, R A Adan, V M Wiegant. The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal-axis and the induction of excessive grooming.
British journal of pharmacology.
1998 Apr; 123(8):1503-8. doi:
10.1038/sj.bjp.0701750. [PMID: 9605554] - X P Ni, R A Kesterson, S D Sharma, V J Hruby, R D Cone, E Wiedemann, M H Humphreys. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists.
The American journal of physiology.
1998 04; 274(4):R931-8. doi:
10.1152/ajpregu.1998.274.4.r931. [PMID: 9575953]