ZD7288 (BioDeep_00000794642)
代谢物信息卡片
化学式: C15H21ClN4 (292.1454656)
中文名称: ZD7288
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
InChI: 1H
描述信息
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Francesca Eroli, Sandra Vilotti, Arn M J M van den Maagdenberg, Andrea Nistri. Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1.
Neuroscience.
2017 05; 351(?):47-64. doi:
10.1016/j.neuroscience.2017.03.033
. [PMID: 28363781] - Alenka Guček, Jernej Jorgačevski, Urszula Górska, Boštjan Rituper, Marko Kreft, Robert Zorec. Local electrostatic interactions determine the diameter of fusion pores.
Channels (Austin, Tex.).
2015; 9(2):96-101. doi:
10.1080/19336950.2015.1007825
. [PMID: 25835258] - Keisuke Shinpo, Yoshiyuki Hirai, Hitoshi Maezawa, Yasunori Totsuka, Makoto Funahashi. The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting.
Physiology & behavior.
2012 Aug; 107(1):98-103. doi:
10.1016/j.physbeh.2012.06.002
. [PMID: 22722099] - Kristine E Kolkman, Lauren E McElvain, Sascha du Lac. Diverse precerebellar neurons share similar intrinsic excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Nov; 31(46):16665-74. doi:
10.1523/jneurosci.3314-11.2011
. [PMID: 22090493] - Jeremy F Atherton, Katsunori Kitano, Jerome Baufreton, Kai Fan, David Wokosin, Tatiana Tkatch, Ryuichi Shigemoto, D James Surmeier, Mark D Bevan. Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Nov; 30(47):16025-40. doi:
10.1523/jneurosci.3898-10.2010
. [PMID: 21106841] - Frans J Vinberg, Satu Strandman, Ari Koskelainen. Origin of the fast negative ERG component from isolated aspartate-treated mouse retina.
Journal of vision.
2009 Nov; 9(12):9.1-17. doi:
10.1167/9.12.9
. [PMID: 20053100] - Yau-Chi Chan, Kai Wang, Ka-Wing Au, Ka Wing Au, Chu-Pak Lau, Hung-Fat Tse, Ronald A Li. Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels.
Pflugers Archiv : European journal of physiology.
2009 Nov; 459(1):25-38. doi:
10.1007/s00424-009-0719-2
. [PMID: 19756722] - Justin Boyes, J Paul Bolam, Ryuichi Shigemoto, Ian M Stanford. Functional presynaptic HCN channels in the rat globus pallidus.
The European journal of neuroscience.
2007 Apr; 25(7):2081-92. doi:
10.1111/j.1460-9568.2007.05463.x
. [PMID: 17439493] - Shui-Wang Ying, Syed Y Abbas, Neil L Harrison, Peter A Goldstein. Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.
The European journal of neuroscience.
2006 Jan; 23(2):465-80. doi:
10.1111/j.1460-9568.2005.04587.x
. [PMID: 16420453] - Youngnam Kang, Takuya Notomi, Mitsuru Saito, Wei Zhang, Ryuichi Shigemoto. Bidirectional interactions between h-channels and Na+-K+ pumps in mesencephalic trigeminal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Apr; 24(14):3694-702. doi:
10.1523/jneurosci.5641-03.2004
. [PMID: 15071118] - Ricardo Felix, Alejandro Sandoval, Daniel Sánchez, Juan Carlos Gómora, José L De la Vega-Beltrán, Claudia L Treviño, Alberto Darszon. ZD7288 inhibits low-threshold Ca(2+) channel activity and regulates sperm function.
Biochemical and biophysical research communications.
2003 Nov; 311(1):187-92. doi:
10.1016/j.bbrc.2003.09.197
. [PMID: 14575712] - K S Shin, B S Rothberg, G Yellen. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.
The Journal of general physiology.
2001 Feb; 117(2):91-101. doi:
10.1085/jgp.117.2.91
. [PMID: 11158163]