PugNAc (BioDeep_00000794641)

   


代谢物信息卡片


Gal-PUGNAc

化学式: C15H19N3O7 (353.1222944)
中文名称: (1Z)-2-(乙酰基氨基)-2-脱氧-N-[[(苯基氨基)羰基]氧基]-D-葡萄糖酸肟 DELTA-内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1=NOC(=O)NC2=CC=CC=C2)CO)O)O
InChI: InChI=1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-

描述信息

同义名列表

2 个代谢物同义名

Gal-PUGNAc; PugNAc



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiwon Park, Yunkyoung Lee, Eun-Hye Jung, Sang-Min Kim, Hyeongjin Cho, Inn-Oc Han. Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 10; 1865(10):158764. doi: 10.1016/j.bbalip.2020.158764. [PMID: 32663610]
  • Yoon Sun Chun, Yurim Park, Hyun Geun Oh, Tae-Wan Kim, Hyun Ok Yang, Myoung Kyu Park, Sungkwon Chung. O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane. Journal of Alzheimer's disease : JAD. 2015; 44(1):261-75. doi: 10.3233/jad-140096. [PMID: 25208619]
  • Min-Jung Park, Dong-Il Kim, Seul-Ki Lim, Joo-Hee Choi, Ho-Jae Han, Kyung-Chul Yoon, Soo-Hyun Park. High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy. The Journal of biological chemistry. 2014 May; 289(19):13519-30. doi: 10.1074/jbc.m113.530139. [PMID: 24616092]
  • Miguel Quiros, Lourdes Alarcón, Arturo Ponce, Thomas Giannakouros, Lorenza González-Mariscal. The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257. Molecular biology of the cell. 2013 Aug; 24(16):2528-43. doi: 10.1091/mbc.e13-04-0224. [PMID: 23804652]
  • Haruhiko Sakiyama, Noriko Fujiwara, Takahiro Noguchi, Hironobu Eguchi, Daisaku Yoshihara, Kosaku Uyeda, Keiichiro Suzuki. The role of O-linked GlcNAc modification on the glucose response of ChREBP. Biochemical and biophysical research communications. 2010 Nov; 402(4):784-9. doi: 10.1016/j.bbrc.2010.10.113. [PMID: 21036147]
  • Luyun Zou, Shaolong Yang, Shunhua Hu, Irshad H Chaudry, Richard B Marchase, John C Chatham. The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels. Shock (Augusta, Ga.). 2007 Apr; 27(4):402-8. doi: 10.1097/01.shk.0000245031.31859.29. [PMID: 17414423]
  • Eun Ju Kim, Melissa Perreira, Craig J Thomas, John A Hanover. An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety. Journal of the American Chemical Society. 2006 Apr; 128(13):4234-5. doi: 10.1021/ja0582915. [PMID: 16568991]
  • Melissa Perreira, Eun Ju Kim, Craig J Thomas, John A Hanover. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorganic & medicinal chemistry. 2006 Feb; 14(3):837-46. doi: 10.1016/j.bmc.2005.09.013. [PMID: 16214344]
  • A Hodge, G W Gooday, I J Alexander. Inhibition of chitinolytic activities from tree species and associated fungi. Phytochemistry. 1996 Jan; 41(1):77-84. doi: 10.1016/0031-9422(95)00571-4. [PMID: 8588878]
  • M Horsch, L Hoesch, A Vasella, D M Rast. N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase. European journal of biochemistry. 1991 May; 197(3):815-8. doi: 10.1111/j.1432-1033.1991.tb15976.x. [PMID: 2029909]