Thioridazine hydrochloride (BioDeep_00000794640)
代谢物信息卡片
Thioridazine hydrochloride
化学式: C21H27ClN2S2 (406.13040920000003)
中文名称: 甲硫哒嗪盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
InChI: 1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:48566
- KEGGdrug: D00798
- KEGGdrug: D82085
- PubChem: 66062
- ChEMBL: CHEMBL1200916
- MeSH: Thioridazine
- CAS: 130-61-0
- medchemexpress: HY-B0965
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Somayeh Golbaz, Mirzaman Zamanzadeh, Kamyar Yaghmaeian, Ramin Nabizadeh, Nushin Rastkari, Hadi Esfahani. Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-23667-5. [PMID: 36374381] - Ágota Simon, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Alexandru Stoicu, Alan Dowson, Jack J W A van Loon, Mihail Lucian Pascu. Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions.
Molecules (Basel, Switzerland).
2022 Mar; 27(5):. doi:
10.3390/molecules27051728. [PMID: 35268828] - Tatiana Tozar, Mihai Boni, Ionut R Andrei, Mihail L Pascu, Angela Staicu. High performance thin layer chromatography-densitometry method based on picosecond laser-induced fluorescence for the analysis of thioridazine and its photoproducts.
Journal of chromatography. A.
2021 Oct; 1655(?):462488. doi:
10.1016/j.chroma.2021.462488. [PMID: 34474191] - Michał Otręba, Leon Kośmider, Anna Rzepecka-Stojko. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review.
European journal of pharmacology.
2020 Nov; 887(?):173553. doi:
10.1016/j.ejphar.2020.173553. [PMID: 32949606] - Tatiana Tozar, Sofia Santos Costa, Ana-Maria Udrea, Viorel Nastasa, Isabel Couto, Miguel Viveiros, Mihail Lucian Pascu, Mihaela Oana Romanitan. Anti-staphylococcal activity and mode of action of thioridazine photoproducts.
Scientific reports.
2020 10; 10(1):18043. doi:
10.1038/s41598-020-74752-z. [PMID: 33093568] - Andréa A S Mendonça, Elda Gonçalves-Santos, Thaiany G Souza-Silva, Kelly J González-Lozano, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
International immunopharmacology.
2020 Aug; 85(?):106611. doi:
10.1016/j.intimp.2020.106611. [PMID: 32447223] - Mike Marvin Ruth, Lian J Pennings, Valerie A C M Koeken, Jodie A Schildkraut, Aria Hashemi, Heiman F L Wertheim, Wouter Hoefsloot, Jakko van Ingen. Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00181-20. [PMID: 32312774] - Aziza El Harchi, Andrew S Butler, Yihong Zhang, Christopher E Dempsey, Jules C Hancox. The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.
Physiological reports.
2020 03; 8(5):e14385. doi:
10.14814/phy2.14385. [PMID: 32147975] - Wenjing Luan, Xiaolei Liu, Xuefei Wang, Yanan An, Yang Wang, Chao Wang, Keshu Shen, Hongyue Xu, Shulin Li, Mingyuan Liu, L U Yu. Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs.
Polish journal of microbiology.
2019 Dec; 68(4):477-491. doi:
10.33073/pjm-2019-047. [PMID: 31880892] - Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen, Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard. Molecular mechanisms of thioridazine resistance in Staphylococcus aureus.
PloS one.
2018; 13(8):e0201767. doi:
10.1371/journal.pone.0201767. [PMID: 30089175] - Jonathan Nzakizwanayo, Paola Scavone, Shirin Jamshidi, Joseph A Hawthorne, Harriet Pelling, Cinzia Dedi, Jonathan P Salvage, Charlotte K Hind, Fergus M Guppy, Lara M Barnes, Bhavik A Patel, Khondaker M Rahman, Mark J Sutton, Brian V Jones. Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis.
Scientific reports.
2017 09; 7(1):12222. doi:
10.1038/s41598-017-12445-w. [PMID: 28939900] - Piotr Skrobecki, Anna Chmielińska, Piotr Bonarek, Piotr Stepien, Anna Wisniewska-Becker, Marta Dziedzicka-Wasylewska, Agnieszka Polit. Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects.
ACS chemical neuroscience.
2017 07; 8(7):1543-1553. doi:
10.1021/acschemneuro.7b00057. [PMID: 28375612] - Alireza Asghari, Ebrahim Fahimi, Mohammad Bazregar, Maryam Rajabi, Leila Boutorabi. Rapid determination of some psychotropic drugs in complex matrices by tandem dispersive liquid-liquid microextraction followed by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):51-59. doi:
10.1016/j.jchromb.2017.03.012. [PMID: 28355580] - Devyani Deshpande, Shashikant Srivastava, Sandirai Musuka, Tawanda Gumbo. Thioridazine as Chemotherapy for Mycobacterium avium Complex Diseases.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):4652-8. doi:
10.1128/aac.02985-15. [PMID: 27216055] - Liang Qi, Li-Min Duan, Xiao-Huan Sun, Jing Zhang, Zhi-Qi Zhang. Simultaneous determination of three banned psychiatric drugs in pig feed and tissue using solid-phase reactor on-line oxidizing and HPLC-fluorescence detection.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1535-40. doi:
10.1002/bmc.3455. [PMID: 25810380] - Jin-Kun Liu, Ya-Juan Hao, Jia-Wei Huang, Xin Li, Hong-Bing Cai, Kang Peng. [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2015 Apr; 35(4):511-5. doi:
. [PMID: 25907934] - Kristina Melkersson, Moira Lewitt, Kerstin Hall. Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.
Neuro endocrinology letters.
2015; 36(5):465-80. doi:
NULL. [PMID: 26707048] - Szymon Dziomba, Michał Biernacki, Ilona Olędzka, Elżbieta Skrzydlewska, Tomasz Bączek, Piotr Kowalski. Repetitive injection field-amplified sample stacking for cationic compounds determination.
Talanta.
2014 Jul; 125(?):1-6. doi:
10.1016/j.talanta.2014.02.045. [PMID: 24840407] - Mandana Amiri, Shabnam Sohrabnezhad, Azad Rahimi. Nickel (II) incorporated AlPO-5 modified carbon paste electrode for determination of thioridazine in human serum.
Materials science & engineering. C, Materials for biological applications.
2014 Apr; 37(?):342-7. doi:
10.1016/j.msec.2014.01.035. [PMID: 24582258] - K-j Min, B R Seo, Y C Bae, Y H Yoo, T K Kwon. Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).
Cell death & disease.
2014 Feb; 5(?):e1063. doi:
10.1038/cddis.2014.35. [PMID: 24556678] - Wojciech Kopec, Himanshu Khandelia. Reinforcing the membrane-mediated mechanism of action of the anti-tuberculosis candidate drug thioridazine with molecular simulations.
Journal of computer-aided molecular design.
2014 Feb; 28(2):123-34. doi:
10.1007/s10822-014-9737-z. [PMID: 24577873] - Beth L Hahn, Peter G Sohnle. Effect of thioridazine on experimental cutaneous staphylococcal infections.
In vivo (Athens, Greece).
2014 Jan; 28(1):33-8. doi:
NULL. [PMID: 24425833] - Shen-Chieh Chang, Mong-Liang Lu, Yue-Chi Wang, Fang-Wei Lin, Shu-Huei Huang, Pei-Hsin Kuo, Hsiu-O Ho, Tzu-Hua Wu. Combined therapy with thioridazine decreases plasma levels of quetiapine inTaiwanese schizophrenic patients.
Therapeutic drug monitoring.
2012 Jun; 34(3):345-8. doi:
10.1097/ftd.0b013e31825479cc. [PMID: 22569350] - Heidi Kidron, Gloria Wissel, Nenad Manevski, Marika Häkli, Raimo A Ketola, Moshe Finel, Marjo Yliperttula, Henri Xhaard, Arto Urtti. Impact of probe compound in MRP2 vesicular transport assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 May; 46(1-2):100-5. doi:
10.1016/j.ejps.2012.02.016. [PMID: 22406294] - Mihail-Lucian Pascu, Viorel Nastasa, Adriana Smarandache, Andra Militaru, Ana Martins, Miguel Viveiros, Mihai Boni, Ionut Relu Andrei, Alexandru Pascu, Angela Staicu, Joseph Molnar, Seamus Fanning, Leonard Amaral. Direct modification of bioactive phenothiazines by exposure to laser radiation.
Recent patents on anti-infective drug discovery.
2011 May; 6(2):147-57. doi:
10.2174/157489111796064515. [PMID: 21517738] - Jakko van Ingen. The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials.
Recent patents on anti-infective drug discovery.
2011 May; 6(2):104-9. doi:
10.2174/157489111796064623. [PMID: 21517740] - Olga Wesołowska, Krystyna Michalak, Andrzej B Hendrich. Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes.
Molecular membrane biology.
2011 Feb; 28(2):103-14. doi:
10.3109/09687688.2010.533706. [PMID: 21190429] - Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.
Basic & clinical pharmacology & toxicology.
2011 Jan; 108(1):46-54. doi:
10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390] - Michael Margulis, Steve Sorota, Inhou Chu, Anthony Soares, Tony Priestley, Amin A Nomeir. Protein binding-dependent decreases in hERG channel blocker potency assessed by whole-cell voltage clamp in serum.
Journal of cardiovascular pharmacology.
2010 Apr; 55(4):368-76. doi:
10.1097/fjc.0b013e3181d2ce39. [PMID: 20125032] - Viktoria Hancock, Malin Dahl, Rebecca Munk Vejborg, Per Klemm. Dietary plant components ellagic acid and tannic acid inhibit Escherichia coli biofilm formation.
Journal of medical microbiology.
2010 Apr; 59(Pt 4):496-498. doi:
10.1099/jmm.0.013680-0. [PMID: 19959627] - Asish Dasgupta, Sayanti Mukherjee, Shaswati Chaki, Sujata G Dastidar, Oliver Hendricks, Jørn B Christensen, Jette E Kristiansen, Leonard Amaral. Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74.
International journal of antimicrobial agents.
2010 Feb; 35(2):174-6. doi:
10.1016/j.ijantimicag.2009.09.027. [PMID: 20005679] - Pedro Dorado, Eva M Peñas-LLedó, Alfredo de la Rubia, Adrián LLerena. Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.
Pharmacogenomics.
2009 Jul; 10(7):1083-9. doi:
10.2217/pgs.09.57. [PMID: 19604081] - Chaomei Xiong, Jinlan Ruan, Yaling Cai, Ying Tang. Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):572-8. doi:
10.1016/j.jpba.2008.11.036. [PMID: 19135820] - R H K Thanacoody, A K Daly, J G Reilly, I N Ferrier, S H L Thomas. Factors affecting drug concentrations and QT interval during thioridazine therapy.
Clinical pharmacology and therapeutics.
2007 Nov; 82(5):555-65. doi:
10.1038/sj.clpt.6100195. [PMID: 17460606] - I S M Salih, R H K Thanacoody, G A McKay, S H L Thomas. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses.
Clinical pharmacology and therapeutics.
2007 Nov; 82(5):548-54. doi:
10.1038/sj.clpt.6100194. [PMID: 17410120] - Pedro Dorado, Roland Berecz, Eva M Peñas-Lledó, Alfredo de la Rubia, Adrián Llerena. No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients.
European journal of clinical pharmacology.
2007 May; 63(5):527-8. doi:
10.1007/s00228-007-0284-6. [PMID: 17345072] - Leonard Amaral, Miguel Viveiros, Jette E Kristiansen. 'Non-Antibiotics': alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries.
Current drug targets.
2006 Jul; 7(7):887-91. doi:
10.2174/138945006777709539. [PMID: 16842219] - Luciana de Matos Alves Pinto, Sônia Valéria Pinheiro Malheiros, Antônio Carlos Senges Lino, Eneida de Paula, Maria Angélica Perillo. Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface.
Biophysical chemistry.
2006 Feb; 119(3):247-55. doi:
10.1016/j.bpc.2005.09.006. [PMID: 16233945] - Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation.
The Journal of toxicological sciences.
2005 Aug; 30(3):239-47. doi:
10.2131/jts.30.239. [PMID: 16141657] - Chiara Bastianon, Roberta Zanoni, Giorgia Miolo, Sergio Caffieri, Elena Reddi. Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine.
The international journal of biochemistry & cell biology.
2005 Apr; 37(4):901-8. doi:
10.1016/j.biocel.2004.11.016. [PMID: 15694848] - David N Bailey, John R Briggs. The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro.
Therapeutic drug monitoring.
2005 Apr; 27(2):168-70. doi:
10.1097/01.ftd.0000151187.68593.12. [PMID: 15795647] - Cristiane Masetto de Gaitani, Alexandre Souto Martinez, Pierina Sueli Bonato. Degradation and configurational changes of thioridazine 2-sulfoxide.
Journal of pharmaceutical and biomedical analysis.
2004 Nov; 36(3):601-7. doi:
10.1016/j.jpba.2004.07.011. [PMID: 15522536] - Miroslav Ravic, Steve Warrington, Malcolm Boyce, Kate Dunn, Atholl Johnston. Repeated dosing with donepezil does not affect the safety, tolerability or pharmacokinetics of single-dose thioridazine in young volunteers.
British journal of clinical pharmacology.
2004 Nov; 58 Suppl 1(?):34-40. doi:
10.1111/j.1365-2125.2004.01800.x. [PMID: 15496221] - Javier Palacios, M Rosario Sepúlveda, Anthony G Lee, Ana M Mata. Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine.
Biochemistry.
2004 Mar; 43(8):2353-8. doi:
10.1021/bi0359473. [PMID: 14979732] - Edmund P Harrigan, Jeffrey J Miceli, Richard Anziano, Eric Watsky, Karen R Reeves, Neal R Cutler, John Sramek, Thomas Shiovitz, Michelle Middle. A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Journal of clinical psychopharmacology.
2004 Feb; 24(1):62-9. doi:
10.1097/01.jcp.0000104913.75206.62. [PMID: 14709949] - Cristiane Masetto de Gaitani, Alexandre Souto Martinez, Pierina Sueli Bonato. Study on thioridazine 5-sulfoxide epimerization and degradation by capillary electrophoresis.
Electrophoresis.
2003 Aug; 24(15):2723-30. doi:
10.1002/elps.200305480. [PMID: 12900889] - Cristiane Masetto de Gaitani, Alexandre Souto Martinez, Pierina Sueli Bonato. Racemization and degradation of thioridazine and thioridazine 2-sulfone in human plasma and aqueous solutions.
Chirality.
2003 Jun; 15(6):479-85. doi:
10.1002/chir.10240. [PMID: 12774286] - Roland Berecz, Alfredo de la Rubia, Pedro Dorado, Pedro Fernández-Salguero, Marja-Liisa Dahl, Adrián LLerena. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.
European journal of clinical pharmacology.
2003 May; 59(1):45-50. doi:
10.1007/s00228-003-0576-4. [PMID: 12682803] - Diane Ordway, Miguel Viveiros, Clara Leandro, Rosário Bettencourt, Josefina Almeida, Marta Martins, Jette E Kristiansen, Joseph Molnar, Leonard Amaral. Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2003 Mar; 47(3):917-22. doi:
10.1128/aac.47.3.917-922.2003. [PMID: 12604522] - Adrián LLerena, Roland Berecz, Alfredo de la Rubia, Pedro Dorado. QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Journal of psychopharmacology (Oxford, England).
2002 Dec; 16(4):361-4. doi:
10.1177/026988110201600411. [PMID: 12503836] - Jacek Wójcikowski, Władysława A Daniel. Thioridazine-fluoxetine interaction at the level of the distribution process in vivo.
Polish journal of pharmacology.
2002 Nov; 54(6):647-54. doi:
NULL. [PMID: 12866720] - Tiago Rodrigues, Antonio C Santos, Acácio A Pigoso, Fábio E Mingatto, Sérgio A Uyemura, Carlos Curti. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.
British journal of pharmacology.
2002 May; 136(1):136-42. doi:
10.1038/sj.bjp.0704672. [PMID: 11976278] - Steven G Potkin, Per T Thyrum, Gustavo Alva, Rimal Bera, Chiao Yeh, Lisa A Arvanitis. The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine.
Journal of clinical psychopharmacology.
2002 Apr; 22(2):121-30. doi:
10.1097/00004714-200204000-00004. [PMID: 11910256] - Andrzej B Hendrich, Katarzyna Lichacz, Anna Burek, Krystyna Michalak. Thioridazine induces erythrocyte stomatocytosis due to interactions with negatively charged lipids.
Cellular & molecular biology letters.
2002; 7(4):1081-6. doi:
". [PMID: 12511975] - A LLerena, R Berecz, A de la Rubia, P Fernández-Salguero, P Dorado. Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.
Therapeutic drug monitoring.
2001 Dec; 23(6):616-20. doi:
10.1097/00007691-200112000-00004. [PMID: 11802093] - L Amaral, J E Kristiansen, M Viveiros, J Atouguia. Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy.
The Journal of antimicrobial chemotherapy.
2001 May; 47(5):505-11. doi:
10.1093/jac/47.5.505. [PMID: 11328759] - J Cohen-Mansfield, L Taylor, R Woosley, S Lipson, P Werner, N Billig. Relationships between psychotropic drug dosage, plasma drug concentration, and prolactin levels in nursing home residents.
Therapeutic drug monitoring.
2000 Dec; 22(6):688-94. doi:
10.1097/00007691-200012000-00007. [PMID: 11128236] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants.
British journal of pharmacology.
2000 Sep; 131(2):287-95. doi:
10.1038/sj.bjp.0703540. [PMID: 10991922] - M Castaing, P Brouant, A Loiseau, C Santelli-Rouvier, M Santelli, S Alibert-Franco, A Mahamoud, J Barbe. Membrane permeation by multidrug-resistance-modulators and non-modulators: effects of hydrophobicity and electric charge.
The Journal of pharmacy and pharmacology.
2000 Mar; 52(3):289-96. doi:
10.1211/0022357001773977. [PMID: 10757416] - L P James, K Abel, J Wilkinson, P M Simpson, M H Nichols. Phenothiazine, butyrophenone, and other psychotropic medication poisonings in children and adolescents.
Journal of toxicology. Clinical toxicology.
2000; 38(6):615-23. doi:
10.1081/clt-100102010. [PMID: 11185968] - S Akerman, K Akerman, J Karppi, P Koivu, A Sundell, P Paronen, K Järvinen. Adsorption of drugs onto a poly(acrylic acid) grafted cation-exchange membrane.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
1999 Dec; 9(2):137-43. doi:
10.1016/s0928-0987(99)00055-x. [PMID: 10620726] - J A Carrillo, S I Ramos, A G Herraiz, A Llerena, J A Agundez, R Berecz, M Duran, J Benítez. Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients.
Journal of clinical psychopharmacology.
1999 Dec; 19(6):494-9. doi:
10.1097/00004714-199912000-00002. [PMID: 10587283] - W A Daniel, J Wójcikowski. The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions.
Toxicology and applied pharmacology.
1999 Jul; 158(2):115-24. doi:
10.1006/taap.1999.8688. [PMID: 10406926] - J S Someren, L E Faber, J D Klein, J A Tumlin. Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms.
Biochemical and biophysical research communications.
1999 Jul; 260(3):619-25. doi:
10.1006/bbrc.1999.0800. [PMID: 10403816] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: in vivo and in vitro studies.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
1999 Jul; 51(4-5):309-14. doi:
10.1016/s0940-2993(99)80012-8. [PMID: 10445388] - R Wang, X Lu, M Wu, E Wang. Separation of promethazine and thioridazine using capillary electrophoresis with end-column amperometric detection.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Jan; 721(2):327-32. doi:
10.1016/s0378-4347(98)00485-x. [PMID: 10052707] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine.
Polish journal of pharmacology.
1998 Nov; 50(6):431-42. doi:
NULL. [PMID: 10385926] - S N Ghaemi, C K Kirkwood. Elevation of nortriptyline plasma levels after cotreatment with paroxetine and thioridazine.
Journal of clinical psychopharmacology.
1998 Aug; 18(4):342-3. doi:
10.1097/00004714-199808000-00016. [PMID: 9690702] - S Ramaprasad, V W Robbins. Lithium distribution in red blood cells and plasma: NMR studies of rat blood.
Magnetic resonance imaging.
1998; 16(2):213-8. doi:
10.1016/s0730-725x(97)00247-6. [PMID: 9508278] - W A Daniel, M Syrek, A Mach, J Wójcikowski, J Boksa. Pharmacokinetics of thioridazine and its metabolites in blood plasma and the brain of rats after acute and chronic treatment.
Polish journal of pharmacology.
1997 Nov; 49(6):439-52. doi:
NULL. [PMID: 9566048] - W Schmidt, K Lang. Life-threatening dysrhythmias in severe thioridazine poisoning treated with physostigmine and transient atrial pacing.
Critical care medicine.
1997 Nov; 25(11):1925-30. doi:
10.1097/00003246-199711000-00036. [PMID: 9366781] - N Yasui, G Tybring, K Otani, K Mihara, A Suzuki, J O Svensson, S Kaneko. Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients.
Pharmacogenetics.
1997 Oct; 7(5):369-74. doi:
10.1097/00008571-199710000-00005. [PMID: 9352572] - A Suzuki, K Otani, M Ishida, N Yasui, T Kondo, K Mihara, S Kaneko, Y Inoue, M Shibata, K Ikeda. Increased plasma concentrations of bromperidol and its reduced metabolite with levomepromazine, but not with thioridazine.
Therapeutic drug monitoring.
1997 Jun; 19(3):261-4. doi:
10.1097/00007691-199706000-00003. [PMID: 9200764] - M T Bunker, P A Marken, M E Schneiderhan, V L Ruehter. Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.
Journal of child and adolescent psychopharmacology.
1997; 7(1):65-9. doi:
10.1089/cap.1997.7.65. [PMID: 9192542] - C Long, J Crifasi, D Maginn. Interference of thioridazine (Mellaril) in identification of phencyclidine.
Clinical chemistry.
1996 Nov; 42(11):1885-6. doi:
10.1093/clinchem/42.11.1885. [PMID: 8906100] - K Hartigan-Go, D N Bateman, G Nyberg, E Mårtensson, S H Thomas. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans.
Clinical pharmacology and therapeutics.
1996 Nov; 60(5):543-53. doi:
10.1016/s0009-9236(96)90150-2. [PMID: 8941027] - C B Eap, T W Guentert, M Schãublin-Loidl, M Stabl, L Koeb, K Powell, P Baumann. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.
Clinical pharmacology and therapeutics.
1996 Mar; 59(3):322-31. doi:
10.1016/s0009-9236(96)80010-5. [PMID: 8653995] - A M Page, J R Lagnado. Effects of phenothiazine neuroleptic drugs on the microtubular-membrane complex in bloodstream forms of Trypanosoma brucei.
Parasitology.
1995 Nov; 111 ( Pt 4)(?):493-504. doi:
10.1017/s0031182000066002. [PMID: 11023414] - N Yasui, K Otani, S Kaneko, T Ohkubo, T Osanai, M Ishida, K Mihara, T Kondo, K Sugawara, Y Fukushima. Inhibition of trazodone metabolism by thioridazine in humans.
Therapeutic drug monitoring.
1995 Aug; 17(4):333-5. doi:
10.1097/00007691-199508000-00003. [PMID: 7482685] - C B Eap, L Koeb, K Powell, P Baumann. Determination of the enantiomers of thioridazine, thioridazine 2-sulfone, and of the isomeric pairs of thioridazine 2-sulfoxide and thioridazine 5-sulfoxide in human plasma.
Journal of chromatography. B, Biomedical applications.
1995 Jul; 669(2):271-9. doi:
10.1016/0378-4347(95)00096-2. [PMID: 7581903] - M Saito, Y Iimori, S Kamoshita, M Yanagisawa, Y Sakakihara. Effects of peroxisomal beta-oxidation antagonist on 2',3'-cyclic-nucleotide 3'-phosphohydrolase, membrane lipid compositions, and membrane fluidity in C-6 glial cells.
Biochimica et biophysica acta.
1995 May; 1235(2):178-82. doi:
10.1016/0005-2736(95)80003-x. [PMID: 7756324] - B Randall, J Butts, J F Halsey. Elevated postmortem tryptase in the absence of anaphylaxis.
Journal of forensic sciences.
1995 Mar; 40(2):208-11. doi:
NULL. [PMID: 7602279] - A J Larner. Rhabdomyolysis and potassium.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1995; 10(2):300. doi:
NULL. [PMID: 7753475] - J Tiihonen, H Vartiainen, P Hakola. Carbamazepine-induced changes in plasma levels of neuroleptics.
Pharmacopsychiatry.
1995 Jan; 28(1):26-8. doi:
10.1055/s-2007-979584. [PMID: 7746842] - N Koren-Schwartzer, M Chen-Zion, H Ben-Porat, R Beitner. Serotonin-induced decrease in brain ATP, stimulation of brain anaerobic glycolysis and elevation of plasma hemoglobin; the protective action of calmodulin antagonists.
General pharmacology.
1994 Oct; 25(6):1257-62. doi:
10.1016/0306-3623(94)90147-3. [PMID: 7875554] - J S Binford, W H Palm. Absorption of surfactants by membranes: erythrocytes versus synthetic vesicles.
Biophysical journal.
1994 Jun; 66(6):2024-8. doi:
10.1016/s0006-3495(94)80995-6. [PMID: 8075335] - S A Jortani, A Poklis. Determination of thioridazine enantiomers in human serum by sequential achiral and chiral high-performance liquid chromatography.
Journal of analytical toxicology.
1993 Oct; 17(6):374-7. doi:
10.1093/jat/17.6.374. [PMID: 8271785] - G Lin, E M Hawes, G McKay, E D Korchinski, K K Midha. Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1993 Oct; 23(10):1059-74. doi:
10.3109/00498259309059422. [PMID: 8259689] - C Van den Branden, R Collumbien, F Roels, G Dacremont, H Roels. Altered adrenocortical response under the influence of experimentally increased serum very long chain fatty acids in rats.
Pathology, research and practice.
1993 Jun; 189(5):558-62. doi:
10.1016/s0344-0338(11)80366-3. [PMID: 8397390] - G S Dhaunsi, B Singh, A K Singh, D A Kirschner, I Singh. Thioridazine induces lipid peroxidation in myelin of rat brain.
Neuropharmacology.
1993 Feb; 32(2):157-67. doi:
10.1016/0028-3908(93)90096-l. [PMID: 8383815] - M Vostatek. [Monitoring urinary levels of chlorpromazine and thioridazine in patients].
Ceskoslovenska psychiatrie.
1992 Mar; 88(1):51-4. doi:
NULL. [PMID: 1591804] - P Baumann, J W Meyer, M Amey, D Baettig, C Bryois, M Jonzier-Perey, L Koeb, C Monney, B Woggon. Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.
Therapeutic drug monitoring.
1992 Feb; 14(1):1-8. doi:
10.1097/00007691-199202000-00001. [PMID: 1546384] - C B Eap, A Souche, L Koeb, P Baumann. Light-induced racemization: artifacts in the analysis of the diastereoisomeric pairs of thioridazine 5-sulfoxide in the plasma and urine of patients treated with thioridazine.
Therapeutic drug monitoring.
1991 Jul; 13(4):356-62. doi:
. [PMID: 1780970] - J P Kassirer, R I Kopelman. The accuracy of clinical information. 1. The history.
Hospital practice (Office ed.).
1991 Apr; 26(4):21-4, 29. doi:
10.1080/21548331.1991.11704153. [PMID: 2010477] - C von Bahr, G Movin, C Nordin, A Lidén, M Hammarlund-Udenaes, A Hedberg, H Ring, F Sjöqvist. Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype.
Clinical pharmacology and therapeutics.
1991 Mar; 49(3):234-40. doi:
10.1038/clpt.1991.22. [PMID: 2007317] - J S Strobl, K L Kirkwood, T K Lantz, M A Lewine, V A Peterson, J F Worley. Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine.
Cancer research.
1990 Sep; 50(17):5399-405. doi:
. [PMID: 2386945] - E Spina, A M Amendola D'Agostino, M P Ioculano, G Oteri, A Fazio, F Pisani. No effect of thioridazine on plasma concentrations of carbamazepine and its active metabolite carbamazepine-10,11-epoxide.
Therapeutic drug monitoring.
1990 Sep; 12(5):511-3. doi:
10.1097/00007691-199009000-00017. [PMID: 2293416] - C Svensson, G Nyberg, M Soomägi, E Mårtensson. Determination of the serum concentrations of thioridazine and its main metabolites using a solid-phase extraction technique and high-performance liquid chromatography.
Journal of chromatography.
1990 Jul; 529(1):229-36. doi:
10.1016/s0378-4347(00)83827-x. [PMID: 2211938] - M C Villarruel, G Fernández, E C de Ferreyra, O M de Fenos, J A Castro. Modulation of the course of CCl4-induced liver injury by the anti-calmodulin drug thioridazine.
Toxicology letters.
1990 Mar; 51(1):13-21. doi:
10.1016/0378-4274(90)90219-c. [PMID: 2315954]