TNP 470 (BioDeep_00000794543)
代谢物信息卡片
化学式: C19H28ClNO6 (401.16050580000007)
中文名称: TNP-470
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)NC(=O)CCl)OC)C
InChI: InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
描述信息
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C2143 - Endothelial Cell Inhibitor
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:90748
- PubChem: 369976
- DrugBank: DB08633
- ChEMBL: CHEMBL424278
- MeSH: O-(Chloroacetylcarbamoyl)fumagillol
- CAS: 129298-91-5
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Sarah L Craig, Victor A Gault, Peter R Flatt, Nigel Irwin. The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin.
Biochemical pharmacology.
2021 01; 183(?):114355. doi:
10.1016/j.bcp.2020.114355
. [PMID: 33279496] - Paige J Monsen, Frederick A Luzzio. Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba.
Journal of natural products.
2018 08; 81(8):1905-1909. doi:
10.1021/acs.jnatprod.8b00284
. [PMID: 30028612] - Maria J C Machado, Christopher A Mitchell. Temporal changes in microvessel leakiness during wound healing discriminated by in vivo fluorescence recovery after photobleaching.
The Journal of physiology.
2011 Oct; 589(Pt 19):4681-96. doi:
10.1113/jphysiol.2011.208355
. [PMID: 21768268] - Asa Svensson, Ulrika Bäckman, Dieter Fuchs, Rolf Christofferson, Faranak Azarbayjani. Angiogenesis can be reduced without significant reduction of tumor growth.
Anticancer research.
2007 Nov; 27(6B):3883-9. doi:
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Translational research : the journal of laboratory and clinical medicine.
2007 Sep; 150(3):189-96. doi:
10.1016/j.trsl.2007.04.006
. [PMID: 17761372] - Grigore Cernaianu, Sibylle Frank, Katrin Erbstösser, Sandy Leonhardt, Michael Cross, Zoe McIvor, Gabriele Scholz, Temuujin Dansranjavin, Ilhan Celik, Andrea Tannapfel, Christian Wittekind, Ralf-Bodo Troebs, Karin Rothe, Joachim Bennek, Johann Hauss, Helmut Witzigmann. TNP-470 fails to block the onset of angiogenesis and early tumor establishment in an intravital minimal disease model.
International journal of colorectal disease.
2006 Mar; 21(2):143-54. doi:
10.1007/s00384-005-0751-4
. [PMID: 15937694] - Katsumi Amikura, Seiki Matsuno, Shinichi Egawa. Synergistic antitumor effect of an angiogenesis inhibitor (TNP-470) and tumor necrosis factor in mice.
Surgery today.
2006; 36(12):1069-74. doi:
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Experimental biology and medicine (Maywood, N.J.).
2005 Nov; 230(10):742-8. doi:
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. [PMID: 16246901] - Marcin Okrój, Wojciech Kamysz, Ewa M Slominska, Andrzej Mysliwski, Jacek Bigda. A novel mechanism of action of the fumagillin analog, TNP-470, in the B16F10 murine melanoma cell line.
Anti-cancer drugs.
2005 Sep; 16(8):817-23. doi:
10.1097/01.cad.0000172835.60142.a5
. [PMID: 16096429] - Shinichi Ueno, Dai Aoki, Fumitake Kubo, Kiyokazu Hiwatashi, Kenji Matsushita, Tohru Oyama, Ikuro Maruyama, Takashi Aikou. Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Aug; 11(15):5645-50. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Dec; 10(23):8048-58. doi:
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. [PMID: 15585640] - Arin K Greene, Mark Puder, Roopali Roy, Susan Kilroy, Gwendolyn Louis, Judah Folkman, Marsha A Moses. Urinary matrix metalloproteinases and their endogenous inhibitors predict hepatic regeneration after murine partial hepatectomy.
Transplantation.
2004 Oct; 78(8):1139-44. doi:
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Kidney international.
2004 Oct; 66(4):1677-85. doi:
10.1111/j.1523-1755.2004.00935.x
. [PMID: 15458466] - Ebba Bråkenhielm, Renhai Cao, Bihu Gao, Bo Angelin, Barbara Cannon, Paolo Parini, Yihai Cao. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.
Circulation research.
2004 Jun; 94(12):1579-88. doi:
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Archives of pharmacal research.
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. [PMID: 15029870] - Andrzej Myśliwski, Jolanta Kubasik-Juraniec, Patrycja Koszałka, Ewa Szmit. The effect of angiogenesis inhibitor TNP-470 on the blood vessels of the lungs, kidneys and livers of treated hamsters.
Folia morphologica.
2004 Feb; 63(1):5-9. doi:
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. [PMID: 15039893] - Shigeki Kinoshita, Ryuji Hirai, Toshihisa Yamano, Ichiro Yuasa, Kazunori Tsukuda, Nobuyoshi Shimizu. Angiogenesis inhibitor TNP-470 can suppress hepatocellular carcinoma growth without retarding liver regeneration after partial hepatectomy.
Surgery today.
2004; 34(1):40-6. doi:
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Annals of surgery.
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The Journal of pharmacology and experimental therapeutics.
2003 Feb; 304(2):669-74. doi:
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. [PMID: 12538820] - Carl T Whalen, Glenn D Hanson, Kathy J Putzer, Michael D Mayer, Darcy J Mulford. Assay of TNP-470 and its two major metabolites in human plasma by high-performance liquid chromatography-mass spectrometry.
Journal of chromatographic science.
2002 Apr; 40(4):214-8. doi:
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. [PMID: 12004941] - Timothy M Hazzard, Richard M Rohan, Theodore A Molskness, John W Fanton, Robert J D'Amato, Richard L Stouffer. Injection of antiangiogenic agents into the macaque preovulatory follicle: disruption of corpus luteum development and function.
Endocrine.
2002 Apr; 17(3):199-206. doi:
10.1385/endo:17:3:199
. [PMID: 12108520] - Jin Zeng, Wei Mei, Haipeng Huang, Xiaodong Li, Peng Kong. Inhibitory effect of angiogenesis inhibitor TNP-470 on human ACHN renal cell carcinoma.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2002; 22(4):331-3. doi:
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. [PMID: 12674772] - J Ma, S Pulfer, S Li, J Chu, K Reed, J M Gallo. Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.
Cancer research.
2001 Jul; 61(14):5491-8. doi:
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- C J Logothetis, K K Wu, L D Finn, D Daliani, W Figg, H Ghaddar, J U Gutterman. Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2001 May; 7(5):1198-203. doi:
NULL
. [PMID: 11350884] - H G Hotz, H A Reber, B Hotz, P C Sanghavi, T Yu, T Foitzik, H J Buhr, O J Hines. Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2001 Mar; 5(2):131-8. doi:
10.1016/s1091-255x(01)80024-x
. [PMID: 11331474] - J Drevs, I Hofmann, H Hugenschmidt, C Wittig, H Madjar, M Müller, J Wood, G Martiny-Baron, C Unger, D Marmé. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model.
Cancer research.
2000 Sep; 60(17):4819-24. doi:
NULL
. [PMID: 10987292] - S Matsusaka, K Nakasho, N Terada, A Sugihara, T Tsujimura, T Takanashi, K Uematsu, E Okamoto, A Toyosaka. Inhibition by an angiogenesis inhibitor, TNP-470, of the growth of a human hepatoblastoma heterotransplanted into nude mice.
Journal of pediatric surgery.
2000 Aug; 35(8):1198-204. doi:
10.1053/jpsu.2000.8726
. [PMID: 10945693] - J D Moore, B J Dezube, P Gill, X J Zhou, E P Acosta, J P Sommadossi. Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma.
Cancer chemotherapy and pharmacology.
2000; 46(3):173-9. doi:
10.1007/s002800000149
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Biochemical pharmacology.
1999 Dec; 58(12):1869-80. doi:
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Journal of pediatric surgery.
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. [PMID: 10507436] - H M Fraser, S E Dickson, K D Morris, G F Erickson, S F Lunn. The effect of the angiogenesis inhibitor TNP-470 on luteal establishment and function in the primate.
Human reproduction (Oxford, England).
1999 Aug; 14(8):2054-60. doi:
10.1093/humrep/14.8.2054
. [PMID: 10438426] - W M Stadler, T Kuzel, C Shapiro, J Sosman, J Clark, N J Vogelzang. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1999 Aug; 17(8):2541-5. doi:
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. [PMID: 10561320] - P Bhargava, J L Marshall, N Rizvi, W Dahut, J Yoe, M Figuera, K Phipps, V S Ong, A Kato, M J Hawkins. A Phase I and pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1999 Aug; 5(8):1989-95. doi:
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. [PMID: 10473076] - J Horti, S C Dixon, C J Logothetis, Y Guo, E Reed, W D Figg. Increased transcriptional activity of prostate-specific antigen in the presence of TNP-470, an angiogenesis inhibitor.
British journal of cancer.
1999 Mar; 79(9-10):1588-93. doi:
10.1038/sj.bjc.6690253
. [PMID: 10188911] - Y Maniwa, M Okada, N Ishii, K Kiyooka. Vascular endothelial growth factor increased by pulmonary surgery accelerates the growth of micrometastases in metastatic lung cancer.
Chest.
1998 Dec; 114(6):1668-75. doi:
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. [PMID: 9872204] - M J Higgins, M L Kent, J D Moran, L M Weiss, S C Dawe. Efficacy of the fumagillin analog TNP-470 for Nucleospora salmonis and Loma salmonae infections in chinook salmon Oncorhynchus tshawytscha.
Diseases of aquatic organisms.
1998 Sep; 34(1):45-9. doi:
10.3354/dao034045
. [PMID: 9789978] - C N Qian, H Q Min, H L Lin, M H Hong, Y L Ye. Primary study in experimental antiangiogenic therapy of nasopharyngeal carcinoma with AGM-1470 (TNP-470).
The Journal of laryngology and otology.
1998 Sep; 112(9):849-53. doi:
10.1017/s0022215100141878
. [PMID: 9876375] - V S Ong, G E Stamm, S Menacherry, S Chu. Quantitation of TNP-470 and its metabolites in human plasma: sample handling, assay performance and stability.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Jun; 710(1-2):173-82. doi:
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Pharmacology & toxicology.
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. [PMID: 9288798] - M Haraguchi, M Okamura, M Konishi, Y Konishi, N Negoro, T Inoue, Y Kanayama, J Yoshikawa. Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo.
Kidney international.
1997 Jun; 51(6):1838-46. doi:
10.1038/ki.1997.251
. [PMID: 9186873] - Y Tanaka, H Kawamata, K Fujimoto, R Oyasu. Angiogenesis inhibitor TNP-470 suppresses tumorigenesis in rat urinary bladder.
The Journal of urology.
1997 Feb; 157(2):683-8. doi:
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. [PMID: 8996398] - W D Figg, J M Pluda, R M Lush, M W Saville, K Wyvill, E Reed, R Yarchoan. The pharmacokinetics of TNP-470, a new angiogenesis inhibitor.
Pharmacotherapy.
1997 Jan; 17(1):91-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1997 Jan; 25(1):94-9. doi:
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Journal of experimental therapeutics & oncology.
1996 Nov; 1(6):390-6. doi:
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. [PMID: 9414430] - H Stepień, M Grochal, K W Zieliński, S Mucha, J Kunert-Radek, A Kulig, A Stawowy, H Pisarek. Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats.
The Journal of endocrinology.
1996 Jul; 150(1):99-106. doi:
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The Journal of urology.
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Cancer research.
1996 May; 56(9):1983-7. doi:
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Cancer chemotherapy and pharmacology.
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. [PMID: 8616900] - H Tanaka, H Taniguchi, T Mugitani, Y Koishi, M Masuyama, T Higashida, H Koyama, Y Suganuma, K Miyata, K Takeuchi. Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model.
British journal of cancer.
1995 Sep; 72(3):650-3. doi:
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. [PMID: 7545415] - L Placidi, E Cretton-Scott, G de Sousa, R Rahmani, M Placidi, J P Sommadossi. Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.
Cancer research.
1995 Jul; 55(14):3036-42. doi:
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. [PMID: 7606724] - A Hori, S Ikeyama, K Sudo. Suppression of cyclin D1 mRNA expression by the angiogenesis inhibitor TNP-470 (AGM-1470) in vascular endothelial cells.
Biochemical and biophysical research communications.
1994 Nov; 204(3):1067-73. doi:
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British journal of urology.
1994 Oct; 74(4):416-21. doi:
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. [PMID: 7529632] - W D Figg, H J Yeh, A Thibault, J M Pluda, F Itoh, R Yarchoan, M R Cooper. Assay of the antiangiogenic compound TNP-470, and one of its metabolites, AGM-1883, by reversed-phase high-performance liquid chromatography in plasma.
Journal of chromatography.
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