Loreclezole (BioDeep_00000794534)

   


代谢物信息卡片


Loreclezole

化学式: C10H6Cl3N3 (272.9627)
中文名称: 盐酸洛雷唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1Cl)Cl)C(=CN2C=NC=N2)Cl
InChI: InChI=1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-

描述信息

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

同义名列表

2 个代谢物同义名

Loreclezole; R 72063



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jarogniew J Luszczki, Neville Ratnaraj, Philip N Patsalos, Stanislaw J Czuczwar. Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Naunyn-Schmiedeberg's archives of pharmacology. 2006 May; 373(2):169-81. doi: 10.1007/s00210-006-0055-4. [PMID: 16604339]
  • Shu-Huei Hsiao, Dustin W DuBois, Rajesh C Miranda, Gerald D Frye. Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro. Brain research. 2004 May; 1008(1):69-80. doi: 10.1016/j.brainres.2004.02.020. [PMID: 15081384]
  • K K Borowicz, A Sawiniec, S J Czuczwar. Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2004 May; 14(3):251-7. doi: 10.1016/j.euroneuro.2003.09.004. [PMID: 15056485]
  • N C Saxena. Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits. Pflugers Archiv : European journal of physiology. 2000 Jul; 440(3):380-92. doi: 10.1007/s004240000289. [PMID: 10954324]
  • R F Halliwell, P Thomas, D Patten, C H James, A Martinez-Torres, R Miledi, T G Smart. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. The European journal of neuroscience. 1999 Aug; 11(8):2897-905. doi: 10.1046/j.1460-9568.1999.00709.x. [PMID: 10457186]
  • S Ueno, C Zorumski, J Bracamontes, J H Steinbach. Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells. Molecular pharmacology. 1996 Oct; 50(4):931-8. doi: NULL. [PMID: 8863839]
  • T Rentmeester, A Janssen, J Hulsman, F Scholtes, B van der Kleij, J Overweg, J Meijer, F de Beukelaar. Long-term evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures: a 1-year open follow-up. Epilepsy research. 1991 May; 9(1):65-70. doi: 10.1016/0920-1211(91)90048-k. [PMID: 1909240]
  • T Rentmeester, A Janssen, J Hulsman, F Scholtes, B van der Kleij, J Overweg, J Meijer, F de Beukelaar. A double-blind, placebo-controlled evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures. Epilepsy research. 1991 May; 9(1):59-64. doi: 10.1016/0920-1211(91)90047-j. [PMID: 1909239]
  • T Rentmeester, J Hulsman. Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients. Epilepsy research. 1991 Mar; 8(2):166-9. doi: 10.1016/0920-1211(91)90085-t. [PMID: 2065645]