SU 5402 (BioDeep_00000794517)

   


代谢物信息卡片


3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone

化学式: C17H16N2O3 (296.1160866)
中文名称: SU-5402(DMSO溶液)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
InChI: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

描述信息

同义名列表

2 个代谢物同义名

3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone; SU 5402



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guan-Hao Zhao, Ya-Qi Qiu, Cheng-Wei Yang, Ih-Sheng Chen, Chin-Yu Chen, Shiow-Ju Lee. The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation. Biochemical pharmacology. 2020 02; 172(?):113741. doi: 10.1016/j.bcp.2019.113741. [PMID: 31812679]
  • Jie Cheng, Min Chen, Ji-Xiao Zhu, Cheng-Fu Li, Qiu-Ping Zhang, Di Geng, Qing Liu, Li-Tao Yi. FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin. Biochemical pharmacology. 2019 10; 168(?):91-99. doi: 10.1016/j.bcp.2019.06.025. [PMID: 31251937]
  • Mhairi Laird, Kathryn J Woad, Morag G Hunter, George E Mann, Robert S Robinson. Fibroblast growth factor 2 induces the precocious development of endothelial cell networks in bovine luteinising follicular cells. Reproduction, fertility, and development. 2013; 25(2):372-86. doi: 10.1071/rd12182. [PMID: 23153420]
  • Agata M Trzcinska-Daneluti, Leo Nguyen, Chong Jiang, Christopher Fladd, David Uehling, Michael Prakesch, Rima Al-awar, Daniela Rotin. Use of kinase inhibitors to correct ΔF508-CFTR function. Molecular & cellular proteomics : MCP. 2012 Sep; 11(9):745-57. doi: 10.1074/mcp.m111.016626. [PMID: 22700489]
  • Tiziana Plati, Ilaria Visigalli, Alessia Capotondo, Mario Buono, Luigi Naldini, Maria Pia Cosma, Alessandra Biffi. Development and maturation of invariant NKT cells in the presence of lysosomal engulfment. European journal of immunology. 2009 Oct; 39(10):2748-54. doi: 10.1002/eji.200939639. [PMID: 19637231]
  • Kenta Yamauchi, Shigeki Mizushima, Atsushi Tamada, Nobuhiko Yamamoto, Seiji Takashima, Fujio Murakami. FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Apr; 29(13):4044-55. doi: 10.1523/jneurosci.4794-08.2009. [PMID: 19339600]
  • C H Widberg, F S Newell, A W Bachmann, S N Ramnoruth, M C Spelta, J P Whitehead, L J Hutley, J B Prins. Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes. American journal of physiology. Endocrinology and metabolism. 2009 Jan; 296(1):E121-31. doi: 10.1152/ajpendo.90602.2008. [PMID: 18940940]
  • Christine Bolitho, Wei Xu, Hans Zoellner. Negative feedback for endothelial apoptosis: a potential physiological role for fibroblast growth factor. Journal of vascular research. 2008; 45(3):193-204. doi: 10.1159/000111072. [PMID: 18025790]
  • Jin-Ichi Ito, Yuko Nagayasu, Kuniko Okumura-Noji, Rui Lu, Tomo Nishida, Yutaka Miura, Kiyofumi Asai, Alireza Kheirollah, Seiichi Nakaya, Shinji Yokoyama. Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. Journal of lipid research. 2007 Sep; 48(9):2020-7. doi: 10.1194/jlr.m700188-jlr200. [PMID: 17548887]
  • Hui Yu, Zhanli Wang, Liangren Zhang, Jufeng Zhang, Qian Huang. Pharmacophore modeling and in silico screening for new KDR kinase inhibitors. Bioorganic & medicinal chemistry letters. 2007 Apr; 17(8):2126-33. doi: 10.1016/j.bmcl.2007.01.089. [PMID: 17306530]
  • Anna E Urban, Xiaolan Zhou, Josette M Ungos, David W Raible, Curtis R Altmann, Peter D Vize. FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development. Developmental biology. 2006 Sep; 297(1):103-17. doi: 10.1016/j.ydbio.2006.04.469. [PMID: 16872594]
  • M Etscheid, N Beer, J Dodt. The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration. Cellular signalling. 2005 Dec; 17(12):1486-94. doi: 10.1016/j.cellsig.2005.03.007. [PMID: 16153533]
  • Jefferson Terry, Joanna M Lubieniecka, Wanda Kwan, Suzanne Liu, Torsten O Nielsen. Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Aug; 11(15):5631-8. doi: 10.1158/1078-0432.ccr-05-0398. [PMID: 16061882]
  • Hidefumi Yoshioka, Yoshiyasu Ishimaru, Noriyuki Sugiyama, Naoki Tsunekawa, Toshiaki Noce, Megumi Kasahara, Ken-ichirou Morohashi. Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. Developmental biology. 2005 Apr; 280(1):150-61. doi: 10.1016/j.ydbio.2005.01.011. [PMID: 15766755]
  • Joshua L Paterson, Zhihua Li, Xiao-Yan Wen, Esther Masih-Khan, Hong Chang, Jonathan B Pollett, Suzanne Trudel, A Keith Stewart. Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. British journal of haematology. 2004 Mar; 124(5):595-603. doi: 10.1111/j.1365-2141.2004.04814.x. [PMID: 14871245]
  • Thirupandiyur S Udayakumar, Elisabeth L Bair, Raymond B Nagle, G Timothy Bowden. Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, promatrilysin, and PSA expression. Molecular carcinogenesis. 2003 Oct; 38(2):70-7. doi: 10.1002/mc.10146. [PMID: 14502646]
  • Tetsuo Yamashita, Morichika Konishi, Ayumi Miyake, Ken-ichi Inui, Nobuyuki Itoh. Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway. The Journal of biological chemistry. 2002 Aug; 277(31):28265-70. doi: 10.1074/jbc.m202527200. [PMID: 12032146]
  • I M Wormstone, K Del Rio-Tsonis, G McMahon, S Tamiya, P D Davies, J M Marcantonio, G Duncan. FGF: an autocrine regulator of human lens cell growth independent of added stimuli. Investigative ophthalmology & visual science. 2001 May; 42(6):1305-11. doi: NULL. [PMID: 11328744]
  • S D Skaper, W J Kee, L Facci, G Macdonald, P Doherty, F S Walsh. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. Journal of neurochemistry. 2000 Oct; 75(4):1520-7. doi: 10.1046/j.1471-4159.2000.0751520.x. [PMID: 10987832]
  • L Sun, N Tran, C Liang, F Tang, A Rice, R Schreck, K Waltz, L K Shawver, G McMahon, C Tang. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. Journal of medicinal chemistry. 1999 Dec; 42(25):5120-30. doi: 10.1021/jm9904295. [PMID: 10602697]