Tetradcylthioacetic acid (BioDeep_00000794095)
代谢物信息卡片
Tetradecylthioacetic acid
化学式: C16H32O2S (288.21228920000004)
中文名称: 十四烷基硫代乙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCSCC(=O)O
InChI: InChI=1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
描述信息
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Thomas Lundåsen, Matteo Pedrelli, Bodil Bjørndal, Björn Rozell, Raoul V Kuiper, Lena Burri, Chiara Pavanello, Marta Turri, Jon Skorve, Rolf K Berge, Stefan E H Alexson, Veronika Tillander. The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL.
PloS one.
2020; 15(3):e0229322. doi:
10.1371/journal.pone.0229322. [PMID: 32176696] - Regin Arge, Jens-Erik Dessen, Tone-Kari Østbye, Bente Ruyter, Magny S Thomassen, Kjell-Arne Rørvik. Effects of tetradecylthioacetic acid (TTA) treatment on lipid metabolism in salmon hearts-in vitro and in vivo studies.
Fish physiology and biochemistry.
2018 Apr; 44(2):703-716. doi:
10.1007/s10695-018-0466-4. [PMID: 29349633] - J-E Dessen, R Arge, M S Thomassen, K-A Rørvik. Differences in fat accumulation between immature male and female Atlantic salmon Salmo salar after dietary administration of tetradecylthioacetic acid.
Journal of fish biology.
2016 Oct; 89(4):2085-2097. doi:
10.1111/jfb.13113. [PMID: 27506658] - Jenny Lund, Camilla Stensrud, Rajender, Pavol Bohov, G Hege Thoresen, Rolf K Berge, Michael Wright, Ahmed Kamal, Arild C Rustan, Andrew D Miller, Jon Skorve. The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism.
Bioorganic & medicinal chemistry.
2016 Mar; 24(6):1191-203. doi:
10.1016/j.bmc.2016.01.045. [PMID: 26874397] - Vegard Lysne, Elin Strand, Gard F T Svingen, Bodil Bjørndal, Eva R Pedersen, Øivind Midttun, Thomas Olsen, Per M Ueland, Rolf K Berge, Ottar Nygård. Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats.
Nutrients.
2016 Jan; 8(1):. doi:
10.3390/nu8010026. [PMID: 26742069] - Krzysztof Wrzesinski, Ileana R León, Katarzyna Kulej, Richard R Sprenger, Bodil Bjørndal, Bjørn J Christensen, Rolf K Berge, Ole N Jensen, Adelina Rogowska-Wrzesinska. Proteomics identifies molecular networks affected by tetradecylthioacetic acid and fish oil supplemented diets.
Journal of proteomics.
2013 Jun; 84(?):61-77. doi:
10.1016/j.jprot.2013.03.027. [PMID: 23568020] - Erik Øie, Rolf K Berge, Thor Ueland, Christen P Dahl, Thor Edvardsen, Jan Otto Beitnes, Pavol Bohov, Pål Aukrust, Arne Yndestad. Tetradecylthioacetic acid increases fat metabolism and improves cardiac function in experimental heart failure.
Lipids.
2013 Feb; 48(2):139-54. doi:
10.1007/s11745-012-3749-z. [PMID: 23266898] - Bodil Bjørndal, Trond Brattelid, Elin Strand, Natalya Filipchuk Vigerust, Gard Frodahl Tveitevåg Svingen, Asbjørn Svardal, Ottar Nygård, Rolf Kristian Berge. Fish oil and the pan-PPAR agonist tetradecylthioacetic acid affect the amino acid and carnitine metabolism in rats.
PloS one.
2013; 8(6):e66926. doi:
10.1371/journal.pone.0066926. [PMID: 23826175] - Rita Vik, Marco Busnelli, Cinzia Parolini, Bodil Bjørndal, Sverre Holm, Pavol Bohov, Bente Halvorsen, Trond Brattelid, Stefano Manzini, Giulia S Ganzetti, Federica Dellera, Ottar K Nygård, Pål Aukrust, Cesare R Sirtori, Giulia Chiesa, Rolf K Berge. An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice.
PloS one.
2013; 8(12):e81963. doi:
10.1371/journal.pone.0081963. [PMID: 24324736] - Reidar J Pettersen, Mohamed Salem, Svein Rotevatn, Karel K J Kuiper, Terje H Larsen, Pavol Bohov, Rolf K Berge, Jan Erik Nordrehaug. Effects of local delivery of tetradecylthioacetic acid within the injured coronary vessel wall.
Scandinavian cardiovascular journal : SCJ.
2012 Dec; 46(6):366-73. doi:
10.3109/14017431.2012.725477. [PMID: 22934973] - Natalya Filipchuk Vigerust, Daniel Cacabelos, Lena Burri, Kjetil Berge, Hege Wergedahl, Bjørn Christensen, Manuel Portero-Otin, Asgaut Viste, Reinald Pamplona, Rolf Kristian Berge, Bodil Bjørndal. Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks.
The Journal of nutritional biochemistry.
2012 Nov; 23(11):1384-93. doi:
10.1016/j.jnutbio.2011.08.006. [PMID: 22221672] - Elin Strand, Bodil Bjorndal, Ottar Nygard, Lena Burri, Christ Berge, Pavol Bohov, Bjørn J Christensen, Kjetil Berge, Hege Wergedahl, Asgaut Viste, Rolf K Berge. Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat.
Lipids in health and disease.
2012 Jun; 11(?):82. doi:
10.1186/1476-511x-11-82. [PMID: 22738017] - Fabian Grammes, Kjell-Arne Rørvik, Magny S Thomassen, Rolf K Berge, Harald Takle. Genome wide response to dietary tetradecylthioacetic acid supplementation in the heart of Atlantic Salmon (Salmo salar L).
BMC genomics.
2012 May; 13(?):180. doi:
10.1186/1471-2164-13-180. [PMID: 22577878] - Silje Skrede, Johan Fernø, Bodil Bjørndal, Wenche Rødseth Brede, Pavol Bohov, Rolf Kristian Berge, Vidar Martin Steen. Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment.
PloS one.
2012; 7(11):e50853. doi:
10.1371/journal.pone.0050853. [PMID: 23226405] - Anne G Lundemo, Caroline H H Pettersen, Kjetil Berge, Rolf K Berge, Svanhild A Schønberg. Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress.
Lipids in health and disease.
2011 Oct; 10(?):190. doi:
10.1186/1476-511x-10-190. [PMID: 22027281] - Lena Burri, Bodil Bjørndal, Hege Wergedahl, Kjetil Berge, Pavol Bohov, Asbjørn Svardal, Rolf K Berge. Tetradecylthioacetic acid increases hepatic mitochondrial β-oxidation and alters fatty acid composition in a mouse model of chronic inflammation.
Lipids.
2011 Aug; 46(8):679-89. doi:
10.1007/s11745-011-3536-2. [PMID: 21479675] - Fabian Grammes, Harald Takle. Anti-inflammatory effects of tetradecylthioacetic acid (TTA) in macrophage-like cells from Atlantic salmon (Salmo salar L.).
BMC immunology.
2011 Jul; 12(?):41. doi:
10.1186/1471-2172-12-41. [PMID: 21774812] - Tore Morken, Pavol Bohov, Jon Skorve, Rune Ulvik, Pål Aukrust, Rolf K Berge, John K Livden. Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot study.
Scandinavian journal of clinical and laboratory investigation.
2011 Jul; 71(4):269-73. doi:
10.3109/00365513.2011.559552. [PMID: 21338276] - Ahmed M Khalid, Anne Dragøy Hafstad, Terje S Larsen, David L Severson, Neoma Boardman, Martin Hagve, Rolf K Berge, Ellen Aasum. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice.
American journal of physiology. Heart and circulatory physiology.
2011 Jun; 300(6):H2116-22. doi:
10.1152/ajpheart.00357.2010. [PMID: 21421822] - Monique Heald, Michael A Cawthorne. Dual acting and pan-PPAR activators as potential anti-diabetic therapies.
Handbook of experimental pharmacology.
2011; ?(203):35-51. doi:
10.1007/978-3-642-17214-4_2. [PMID: 21484566] - Yushma Bhurruth-Alcor, Therese H Rost, Michael R Jorgensen, Rajender, Melanie Müller, Jon Skorve, Rolf K Berge, Andrew D Miller. Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective.
Bioorganic & medicinal chemistry letters.
2010 Feb; 20(3):1252-5. doi:
10.1016/j.bmcl.2009.11.115. [PMID: 20036122] - A J Wensaas, A C Rustan, M H Rokling-Andersen, R Caesar, J Jensen, O Kaalhus, B A Graff, O A Gudbrandsen, R K Berge, C A Drevon. Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets.
Diabetes, obesity & metabolism.
2009 Nov; 11(11):1034-49. doi:
10.1111/j.1463-1326.2009.01092.x. [PMID: 19740081] - H Alne, M S Thomassen, H Takle, B F Terjesen, F Grammes, M Oehme, S Refstie, T Sigholt, R K Berge, K-A Rørvik. Increased survival by feeding tetradecylthioacetic acid during a natural outbreak of heart and skeletal muscle inflammation in S0 Atlantic salmon, Salmo salar L.
Journal of fish diseases.
2009 Nov; 32(11):953-61. doi:
10.1111/j.1365-2761.2009.01078.x. [PMID: 19602091] - Anne D Hafstad, Ahmed M Khalid, Martin Hagve, Trine Lund, Terje S Larsen, David L Severson, Kieran Clarke, Rolf K Berge, Ellen Aasum. Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss.
Cardiovascular research.
2009 Aug; 83(3):519-26. doi:
10.1093/cvr/cvp132. [PMID: 19398469] - Oddrun Anita Gudbrandsen, Hege Wergedahl, Pavol Bohov, Rolf Kristian Berge. The absorption, distribution and biological effects of a modified fatty acid in its free form and as an ethyl ester in rats.
Chemico-biological interactions.
2009 May; 179(2-3):227-32. doi:
10.1016/j.cbi.2008.10.004. [PMID: 18992229] - K Løvås, T H Røst, J Skorve, R J Ulvik, O A Gudbrandsen, P Bohov, A J Wensaas, A C Rustan, R K Berge, E S Husebye. Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation.
Diabetes, obesity & metabolism.
2009 Apr; 11(4):304-14. doi:
10.1111/j.1463-1326.2008.00958.x. [PMID: 19267708] - Andreas J Wensaas, Arild C Rustan, Marlene Just, Rolf K Berge, Christian A Drevon, Michael Gaster. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid.
Diabetes.
2009 Mar; 58(3):527-35. doi:
10.2337/db08-1043. [PMID: 19066312] - Michael R Jorgensen, Yushma Bhurruth-Alcor, Therese Røst, Pavol Bohov, Melanie Müller, Cristina Guisado, Kostas Kostarelos, Endre Dyrøy, Rolf K Berge, Andrew D Miller, Jon Skorve. Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome.
Journal of medicinal chemistry.
2009 Feb; 52(4):1172-9. doi:
10.1021/jm801019s. [PMID: 19175322] - Liliana Monica Bivol, Michael Hultström, Oddrun A Gudbrandsen, Rolf K Berge, Bjarne M Iversen. Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Dec; 295(6):R1866-73. doi:
10.1152/ajpregu.00850.2007. [PMID: 18843091] - Reidar J Pettersen, Mohamed Salem, Jon Skorve, Rune J Ulvik, Rolf K Berge, Jan Erik Nordrehaug. Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 study.
Journal of cardiovascular pharmacology.
2008 Apr; 51(4):410-7. doi:
10.1097/fjc.0b013e3181673be0. [PMID: 18427285] - Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen, Rolf K Berge. Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats.
Drug metabolism letters.
2008 Apr; 2(2):138-45. doi:
10.2174/187231208784041013. [PMID: 19356083] - Liliana M Bivol, Rolf K Berge, Bjarne M Iversen. Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Feb; 294(2):R438-47. doi:
10.1152/ajpregu.00590.2007. [PMID: 18032469] - K-A Rørvik, H Alne, M Gaarder, B Ruyter, N P Måseide, J V Jakobsen, R K Berge, T Sigholt, M S Thomassen. Does the capacity for energy utilization affect the survival of post-smolt Atlantic salmon, Salmo salar L., during natural outbreaks of infectious pancreatic necrosis?.
Journal of fish diseases.
2007 Jul; 30(7):399-409. doi:
10.1111/j.1365-2761.2007.00823.x. [PMID: 17584437] - Oddrun Anita Gudbrandsen, Therese Halvorsen Rost, Rolf Kristian Berge. Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver.
Journal of lipid research.
2006 Oct; 47(10):2223-32. doi:
10.1194/jlr.m600148-jlr200. [PMID: 16864897] - Ellen Johanne Kleveland, Bente Ruyter, Anne Vegusdal, Hilde Sundvold, Rolf K Berge, Tor Gjøen. Effects of 3-thia fatty acids on expression of some lipid related genes in Atlantic salmon (Salmo salar L.).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2006 Oct; 145(2):239-48. doi:
10.1016/j.cbpb.2006.07.012. [PMID: 16971150] - Oddrun Anita Gudbrandsen, Michael Hultstrøm, Sabine Leh, Liliana Monica Bivol, Øyvind Vågnes, Rolf K Berge, Bjarne M Iversen. Prevention of hypertension and organ damage in 2-kidney, 1-clip rats by tetradecylthioacetic acid.
Hypertension (Dallas, Tex. : 1979).
2006 Sep; 48(3):460-6. doi:
10.1161/01.hyp.0000233018.60736.70. [PMID: 16847149] - Per O Iversen, Dag R Sørensen, Karl J Tronstad, Oddrun A Gudbrandsen, Arild C Rustan, Rolf K Berge, Christian A Drevon. A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Jun; 12(11 Pt 1):3525-31. doi:
10.1158/1078-0432.ccr-05-2802. [PMID: 16740779] - Knut Tomas Dalen, Stine M Ulven, Borghild M Arntsen, Karianne Solaas, Hilde I Nebb. PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.
Journal of lipid research.
2006 May; 47(5):931-43. doi:
10.1194/jlr.m500459-jlr200. [PMID: 16489205] - Endre Dyroy, Hege Wergedahl, Jon Skorve, Oddrun A Gudbrandsen, Jon Songstad, Rolf K Berge. Thia fatty acids with the sulfur atom in even or odd positions have opposite effects on fatty acid catabolism.
Lipids.
2006 Feb; 41(2):169-77. doi:
10.1007/s11745-006-5085-7. [PMID: 17707983] - Endre Dyrøy, Arne Yndestad, Thor Ueland, Bente Halvorsen, Jan Kristian Damås, Pål Aukrust, Rolf K Berge. Antiinflammatory effects of tetradecylthioacetic acid involve both peroxisome proliferator-activated receptor alpha-dependent and -independent pathways.
Arteriosclerosis, thrombosis, and vascular biology.
2005 Jul; 25(7):1364-9. doi:
10.1161/01.atv.0000171982.57713.96. [PMID: 15920037] - Oddrun Anita Gudbrandsen, Endre Dyrøy, Pavol Bohov, Jon Skorve, Rolf K Berge. The metabolic effects of thia fatty acids in rat liver depend on the position of the sulfur atom.
Chemico-biological interactions.
2005 Jun; 155(1-2):71-81. doi:
10.1016/j.cbi.2005.04.007. [PMID: 15949791] - A Vegusdal, T Gjøen, R K Berge, M S Thomassen, B Ruyter. Effect of 18:1n-9, 20:5n-3, and 22:6n-3 on lipid accumulation and secretion by Atlantic salmon hepatocytes.
Lipids.
2005 May; 40(5):477-86. doi:
10.1007/s11745-005-1407-z. [PMID: 16094857] - R K Berge, K J Tronstad, K Berge, T H Rost, H Wergedahl, O A Gudbrandsen, J Skorve. The metabolic syndrome and the hepatic fatty acid drainage hypothesis.
Biochimie.
2005 Jan; 87(1):15-20. doi:
10.1016/j.biochi.2004.11.011. [PMID: 15733731] - Corina Moya-Falcón, Erlend Hvattum, Endre Dyrøy, Jon Skorve, Sigurd O Stefansson, Magny S Thomassen, Jan V Jakobsen, Rolf K Berge, Bente Ruyter. Effects of 3-thia fatty acids on feed intake, growth, tissue fatty acid composition, beta-oxidation and Na+,K+-ATPase activity in Atlantic salmon.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2004 Dec; 139(4):657-68. doi:
10.1016/j.cbpc.2004.08.009. [PMID: 15581798] - Ralf Mueller, Jing Yang, Caiming Duan, Emil Pop, Otto J Geoffroy, Lian Hao Zhang, Tian-Bao Huang, Sergey Denisenko, Bruce H McCosar, Daniela C Oniciu, Charles L Bisgaier, Michael E Pape, Catherine Delaney Freiman, Brian Goetz, Clay T Cramer, Krista L Hopson, Jean-Louis H Dasseux. Long hydrocarbon chain keto diols and diacids that favorably alter lipid disorders in vivo.
Journal of medicinal chemistry.
2004 Nov; 47(24):6082-99. doi:
10.1021/jm040006p. [PMID: 15537362] - J Fredriksen, T Ueland, E Dyrøy, B Halvorsen, K Melby, L Melbye, B S Skalhegg, P Bohov, J Skorve, R K Berge, P Aukrust, S S Frøland. Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapy.
European journal of clinical investigation.
2004 Oct; 34(10):709-15. doi:
10.1111/j.1365-2362.2004.01410.x. [PMID: 15473896] - Hans J Grav, Karl J Tronstad, Oddrun A Gudbrandsen, Kjetil Berge, Kari E Fladmark, Tom C Martinsen, Helge Waldum, Hege Wergedahl, Rolf K Berge. Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression: evidence for peroxisome proliferator-activated receptor-alpha independent induction of UCP-2 expression.
The Journal of biological chemistry.
2003 Aug; 278(33):30525-33. doi:
10.1074/jbc.m303382200. [PMID: 12756242] - P Aukrust, H Wergedahl, F Müller, T Ueland, E Dyrøy, J K Damås, S S Frøland, R K Berge. Immunomodulating effects of 3-thia fatty acids in activated peripheral blood mononuclear cells.
European journal of clinical investigation.
2003 May; 33(5):426-33. doi:
10.1046/j.1365-2362.2003.01140.x. [PMID: 12713457] - Kjetil Berge, Karl Johan Tronstad, Pavol Bohov, Lise Madsen, Rolf K Berge. Impact of mitochondrial beta-oxidation in fatty acid-mediated inhibition of glioma cell proliferation.
Journal of lipid research.
2003 Jan; 44(1):118-27. doi:
10.1194/jlr.m200312-jlr200. [PMID: 12518030] - K J Tronstad, Ø Bruserud, K Berge, R K Berge. Antiproliferative effects of a non-beta-oxidizable fatty acid, tetradecylthioacetic acid, in native human acute myelogenous leukemia blast cultures.
Leukemia.
2002 Nov; 16(11):2292-301. doi:
10.1038/sj.leu.2402698. [PMID: 12399975] - Bodil Bjørndal, Charlotte Helleland, Stig-Ove Bøe, Oddrun A Gudbrandsen, Karl-Henning Kalland, Pavol Bohov, Rolf K Berge, Johan R Lillehaug. Nuclear import of factors involved in signaling is inhibited in C3H/10T1/2 cells treated with tetradecylthioacetic acid.
Journal of lipid research.
2002 Oct; 43(10):1630-40. doi:
10.1194/jlr.m100406-jlr200. [PMID: 12364547] - Rolf K Berge, Jon Skorve, Karl Johan Tronstad, Kjetil Berge, Oddrun Anita Gudbrandsen, Hans Grav. Metabolic effects of thia fatty acids.
Current opinion in lipidology.
2002 Jun; 13(3):295-304. doi:
10.1097/00041433-200206000-00010. [PMID: 12045400] - Lise Madsen, Michéle Guerre-Millo, Esben N Flindt, Kjetil Berge, Karl Johan Tronstad, Elin Bergene, Elena Sebokova, Arild C Rustan, Jørgen Jensen, Susanne Mandrup, Karsten Kristiansen, Iwar Klimes, Bart Staels, Rolf K Berge. Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.
Journal of lipid research.
2002 May; 43(5):742-50. doi:
10.1016/s0022-2275(20)30116-4. [PMID: 11971945] - Ziad A Muna, Oddrun A Gudbrandsen, Hege Wergedahl, Pavol Bohov, Jon Skorve, Rolf K Berge. Inhibition of rat lipoprotein oxidation after tetradecylthioacetic acid feeding.
Biochemical pharmacology.
2002 Mar; 63(6):1127-35. doi:
10.1016/s0006-2952(01)00934-0. [PMID: 11931845] - R J Pettersen, Z A Muna, K K Kuiper, E Svendsen, F Müller, P Aukrust, R K Berge, J E Nordrehaug. Sustained retention of tetradecylthioacetic acid after local delivery reduces angioplasty-induced coronary stenosis in the minipig.
Cardiovascular research.
2001 Nov; 52(2):306-13. doi:
10.1016/s0008-6363(01)00404-7. [PMID: 11684079] - K J Tronstad, K Berge, E N Flindt, K Kristiansen, R K Berge. Optimization of methods and treatment conditions for studying effects of fatty acids on cell growth.
Lipids.
2001 Mar; 36(3):305-13. doi:
10.1007/s11745-001-0722-8. [PMID: 11337987] - R J Pettersen, K K Kuiper, L Frøyland, R K Berge, J E Nordrehaug. Long-term retention of a novel antioxidant sulphur-substituted fatty acid analogue after local delivery in porcine coronary arteries.
Scandinavian cardiovascular journal : SCJ.
2001 Mar; 35(2):101-6. doi:
10.1080/140174301750164754. [PMID: 11405484] - M Elholm, H Hollås, C Issalene, J F Barroso, R K Berge, T Flatmark. Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria.
IUBMB life.
2001 Feb; 51(2):99-104. doi:
10.1080/15216540119294. [PMID: 11463171] - K A Tobin, H H Steineger, S Alberti, O Spydevold, J Auwerx, J A Gustafsson, H I Nebb. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.
Molecular endocrinology (Baltimore, Md.).
2000 May; 14(5):741-52. doi:
10.1210/mend.14.5.0459. [PMID: 10809236] - Z A Muna, B J Bolann, X Chen, J Songstad, R K Berge. Tetradecylthioacetic acid and tetradecylselenoacetic acid inhibit lipid peroxidation and interact with superoxide radical.
Free radical biology & medicine.
2000 Apr; 28(7):1068-78. doi:
10.1016/s0891-5849(00)00196-9. [PMID: 10832068] - M Elholm, A Garras, S Neve, D Tornehave, T B Lund, J Skorve, T Flatmark, K Kristiansen, R K Berge. Long-chain acyl-CoA esters and acyl-CoA binding protein are present in the nucleus of rat liver cells.
Journal of lipid research.
2000 Apr; 41(4):538-45. doi:
10.1016/s0022-2275(20)32401-9. [PMID: 10744774] - E Raspé, L Madsen, A M Lefebvre, I Leitersdorf, L Gelman, J Peinado-Onsurbe, J Dallongeville, J C Fruchart, R Berge, B Staels. Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation.
Journal of lipid research.
1999 Nov; 40(11):2099-110. doi:
10.1016/s0022-2275(20)32433-0. [PMID: 10553013] - H Vaagenes, L Madsen, E Dyrøy, M Elholm, A Stray-Pedersen, L Frøyland, O Lie, R K Berge. Methylated eicosapentaenoic acid and tetradecylthioacetic acid: effects on fatty acid metabolism.
Biochemical pharmacology.
1999 Oct; 58(7):1133-43. doi:
10.1016/s0006-2952(99)00198-7. [PMID: 10484071] - A Gedde-Dahl, A Bakillah, M M Hussain, A C Rustan. Tetradecylthioacetic acid (a 3-thia fatty acid) impairs secretion of oleic acid-induced triacylglycerol-rich lipoproteins in CaCo-2 cells.
Biochimica et biophysica acta.
1999 Apr; 1438(1):73-84. doi:
10.1016/s1388-1981(99)00040-2. [PMID: 10216282] - E Dyrøy, L Madsen, R K Berge. The effect of beta-oxidable and non-beta-oxidable thia fatty acids on fatty acid metabolism.
Advances in experimental medicine and biology.
1999; 466(?):311-4. doi:
10.1007/0-306-46818-2_35. [PMID: 10709657] - R K Berge, L Madsen, L Frøyland. The 3-thia fatty acid, a novel bioactive compound, which changes the plasma profile from atherogenic to cardioprotective.
Lipids.
1999; 34 Suppl(?):S201. doi:
10.1007/bf02562289. [PMID: 10419149] - H Vaagenes, L Madsen, D K Asiedu, J R Lillehaug, R K Berge. Early modulation of genes encoding peroxisomal and mitochondrial beta-oxidation enzymes by 3-thia fatty acids.
Biochemical pharmacology.
1998 Dec; 56(12):1571-82. doi:
10.1016/s0006-2952(98)00193-2. [PMID: 9973177] - N J Plant, N J Horley, R L Savory, C R Elcombe, T J Gray, D R Bell. The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis.
Carcinogenesis.
1998 May; 19(5):925-31. doi:
10.1093/carcin/19.5.925. [PMID: 9635884] - Z A Muna, K Doudin, J Songstad, R J Ulvik, R K Berge. Tetradecylthioacetic acid inhibits the oxidative modification of low density lipoprotein and 8-hydroxydeoxyguanosine formation in vitro.
Arteriosclerosis, thrombosis, and vascular biology.
1997 Nov; 17(11):3255-62. doi:
10.1161/01.atv.17.11.3255. [PMID: 9409320] - F Abdi-Dezfuli, L Frøyland, T Thorsen, A Aakvaag, R K Berge. Eicosapentaenoic acid and sulphur substituted fatty acid analogues inhibit the proliferation of human breast cancer cells in culture.
Breast cancer research and treatment.
1997 Sep; 45(3):229-39. doi:
10.1023/a:1005818917479. [PMID: 9386867] - L Madsen, L Frøyland, H J Grav, R K Berge. Up-regulated delta 9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a delta 9-desaturated metabolite of tetradecylthioacetic acid.
Journal of lipid research.
1997 Mar; 38(3):554-63. doi:
. [PMID: 9101436] - D K Asiedu, L Frøyland, H Vaagenes, O Lie, A Demoz, R K Berge. Long-term effect of tetradecylthioacetic acid: a study on plasma lipid profile and fatty acid composition and oxidation in different rat organs.
Biochimica et biophysica acta.
1996 Apr; 1300(2):86-96. doi:
10.1016/0005-2760(95)00235-9. [PMID: 8652642] - L Frøyland, K Helland, G K Totland, H Kryvi, R K Berge. A hypolipidemic peroxisome proliferating fatty acid induces polydispersity of rat liver mitochondria.
Biology of the cell.
1996; 87(1-2):105-12. doi:
10.1111/j.1768-322x.1996.tb00971.x. [PMID: 9004492] - L Frøyland, D K Asiedu, H Vaagenes, A Garras, O Lie, G K Totland, R K Berge. Tetradecylthioacetic acid incorporated into very low density lipoprotein: changes in the fatty acid composition and reduced plasma lipids in cholesterol-fed hamsters.
Journal of lipid research.
1995 Dec; 36(12):2529-40. doi:
. [PMID: 8847479] - S Hexeberg, L Frøyland, D K Asiedu, A Demoz, R K Berge. Tetradecylthioacetic acid reduces the amount of lipid droplets, induces megamitochondria formation and increases the fatty acid oxidation in rat heart.
Journal of molecular and cellular cardiology.
1995 Sep; 27(9):1851-7. doi:
10.1016/0022-2828(95)90008-x. [PMID: 8523446] - D K Asiedu, A Demoz, J Skorve, H J Grav, R K Berge. Acute modulation of rat hepatic lipid metabolism by sulphur-substituted fatty acid analogues.
Biochemical pharmacology.
1995 Mar; 49(7):1013-22. doi:
10.1016/0006-2952(94)00460-4. [PMID: 7741757] - A Gedde-Dahl, T Ranheim, C A Drevon, S Skrede, R K Berge, A C Rustan. Tetradecylthioacetic acid (a 3-thia fatty acid) decreases triacylglycerol secretion in CaCo-2 cells.
Journal of lipid research.
1995 Mar; 36(3):535-43. doi:
10.1016/s0022-2275(20)39887-4. [PMID: 7775865] - D K Asiedu, A al-Shurbaji, A C Rustan, I Björkhem, L Berglund, R K Berge. Hepatic fatty acid metabolism as a determinant of plasma and liver triacylglycerol levels. Studies on tetradecylthioacetic and tetradecylthiopropionic acids.
European journal of biochemistry.
1995 Feb; 227(3):715-22. doi:
10.1111/j.1432-1033.1995.tb20193.x. [PMID: 7867630] - N Vu-Dac, K Schoonjans, B Laine, J C Fruchart, J Auwerx, B Staels. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
The Journal of biological chemistry.
1994 Dec; 269(49):31012-8. doi:
NULL. [PMID: 7983038] - P Wu, J Bremer. Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase.
Biochimica et biophysica acta.
1994 Nov; 1215(1-2):87-92. doi:
10.1016/0005-2760(94)90095-7. [PMID: 7948012] - H H Steineger, H N Sørensen, J D Tugwood, S Skrede, O Spydevold, K M Gautvik. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription.
European journal of biochemistry.
1994 Nov; 225(3):967-74. doi:
10.1111/j.1432-1033.1994.0967b.x. [PMID: 7957233] - H J Grav, D K Asiedu, R K Berge. Gas chromatographic measurement of 3- and 4-thia fatty acids incorporated into various classes of rat liver lipids during feeding experiments.
Journal of chromatography. B, Biomedical applications.
1994 Aug; 658(1):1-10. doi:
10.1016/0378-4347(94)00224-x. [PMID: 7952108] - S Skrede, J Bremer, R K Berge, A C Rustan. Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes.
Journal of lipid research.
1994 Aug; 35(8):1395-404. doi:
10.1016/s0022-2275(20)40081-1. [PMID: 7989864] - A Demoz, D K Asiedu, O Lie, R K Berge. Modulation of plasma and hepatic oxidative status and changes in plasma lipid profile by n-3 (EPA and DHA), n-6 (corn oil) and a 3-thia fatty acid in rats.
Biochimica et biophysica acta.
1994 Apr; 1199(3):238-44. doi:
10.1016/0304-4165(94)90002-7. [PMID: 8161562] - J Skorve, R K Berge. The hypocholesterolemic effect of sulfur-substituted fatty acid analogues in rats fed a high carbohydrate diet.
Biochimica et biophysica acta.
1993 Apr; 1167(2):175-81. doi:
10.1016/0005-2760(93)90159-7. [PMID: 8466946] - D K Asiedu, J Skorve, N Willumsen, A Demoz, R K Berge. Early effects on mitochondrial and peroxisomal beta-oxidation by the hypolipidemic 3-thia-fatty acids in rat livers.
Biochimica et biophysica acta.
1993 Feb; 1166(1):73-6. doi:
10.1016/0005-2760(93)90285-h. [PMID: 8431494] - A Demoz, A Svardal, R K Berge. Relationship between peroxisome-proliferating sulfur-substituted fatty acid analogs, hepatic lipid peroxidation and hydrogen peroxide metabolism.
Biochemical pharmacology.
1993 Jan; 45(1):257-9. doi:
10.1016/0006-2952(93)90400-q. [PMID: 8424818] - J Skorve, D Asiedu, M Solbakken, J Gjestdal, J Songstad, R K Berge. Comparative effects of oxygen and sulfur-substituted fatty acids on serum lipids and mitochondrial and peroxisomal fatty acid oxidation in rat.
Biochemical pharmacology.
1992 Feb; 43(4):815-22. doi:
10.1016/0006-2952(92)90248-h. [PMID: 1540235] - H Kryvi, A Aarsland, R K Berge. Morphologic effects of sulfur-substituted fatty acids on rat hepatocytes with special reference to proliferation of peroxisomes and mitochondria.
Journal of structural biology.
1990 May; 103(3):257-65. doi:
10.1016/1047-8477(90)90044-d. [PMID: 2261310] - R K Berge, A Aarsland, H Kryvi, J Bremer, N Aarsaether. Alkylthio acetic acids (3-thia fatty acids)--a new group of non-beta-oxidizable peroxisome-inducing fatty acid analogues--II. Dose-response studies on hepatic peroxisomal- and mitochondrial changes and long-chain fatty acid metabolizing enzymes in rats.
Biochemical pharmacology.
1989 Nov; 38(22):3969-79. doi:
10.1016/0006-2952(89)90676-x. [PMID: 2574577]