Bromfenac Sodium (BioDeep_00000794011)
代谢物信息卡片
Bromfenac Sodium
化学式: C15H11BrNNaO3 (354.9819956)
中文名称: 溴芬酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].[Na+]
InChI: /q
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nabil A Shoman, Rana M Gebreel, Mohamed A El-Nabarawi, Alshaimaa Attia. Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation.
Drug delivery.
2023 Dec; 30(1):2162162. doi:
10.1080/10717544.2022.2162162. [PMID: 36587627] - Yaofeng Cheng, Xiaomin Liang, Jia Hao, Congrong Niu, Yurong Lai. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.
Clinical and translational science.
2021 09; 14(5):1924-1934. doi:
10.1111/cts.13047. [PMID: 34058067] - Claudio Bucolo, Giuseppina Marrazzo, Chiara Bianca Maria Platania, Giovanni Luca Romano, Filippo Drago, Salvatore Salomone. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation.
The Journal of pharmacy and pharmacology.
2014 Jul; 66(7):954-60. doi:
10.1111/jphp.12224. [PMID: 24697218] - Terumasa Hashimoto, Atsushi Igarashi, Futoshi Hoshina, Mie Yamada, Yoshihiro Toyoda, Yoshitada Notsu, Shigekatsu Kohno. Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2003 Dec; 19(6):569-77. doi:
10.1089/108076803322660486. [PMID: 14733714] - R J Fontana, T M McCashland, K G Benner, H D Appelman, N T Gunartanam, J L Wisecarver, J M Rabkin, W M Lee. Acute liver failure associated with prolonged use of bromfenac leading to liver transplantation. The Acute Liver Failure Study Group.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
1999 Nov; 5(6):480-4. doi:
10.1002/lt.500050607. [PMID: 10545534] - P Högger, P Rohdewald. Comparison of tilidine/naloxone, tramadol and bromfenac in experimental pain: a double-blind randomized crossover study in healthy human volunteers.
International journal of clinical pharmacology and therapeutics.
1999 Aug; 37(8):377-85. doi:
NULL. [PMID: 10475140] - N M Skjodt, N M Davies. Clinical pharmacokinetics and pharmacodynamics of bromfenac.
Clinical pharmacokinetics.
1999 Jun; 36(6):399-408. doi:
10.2165/00003088-199936060-00002. [PMID: 10427465] - M Osman, A Chandrasekaran, K Chan, J Scatina, J Ermer, W Cevallos, S F Sisenwine. Metabolic disposition of 14C-bromfenac in healthy male volunteers.
Journal of clinical pharmacology.
1998 Aug; 38(8):744-52. doi:
10.1002/j.1552-4604.1998.tb04815.x. [PMID: 9725551] - J A Forbes, R A Sandberg, L Bood-Björklund. The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery.
Pharmacotherapy.
1998 May; 18(3):492-503. doi:
NULL. [PMID: 9620100] - J P Boni, W H Cevallos, S DeCleene, J M Korth-Bradley. The influence of bromfenac on the pharmacokinetics and pharmacodynamic responses to glyburide in diabetic subjects.
Pharmacotherapy.
1997 Jul; 17(4):783-90. doi:
NULL. [PMID: 9250558] - K Gumbhir-Shah, W H Cevallos, S A DeCleene, C E Halstenson, J M Korth-Bradley. Absolute bioavailability of bromfenac in humans.
The Annals of pharmacotherapy.
1997 Apr; 31(4):395-9. doi:
10.1177/106002809703100401. [PMID: 9100997] - J C Ermer, J P Boni, W H Cevallos, S DeCleene, P Burghart, M R Rudnick, R J Fruncillo, J S Berns, R M Cohen. Bromfenac disposition in patients with impaired kidney function.
Clinical pharmacology and therapeutics.
1997 Mar; 61(3):312-8. doi:
10.1016/s0009-9236(97)90163-6. [PMID: 9084456] - K Gumbhir-Shah, W H Cevallos, S A DeCleene, J M Korth-Bradley. Evaluation of pharmacokinetic interaction between bromfenac and phenytoin in healthy males.
Journal of clinical pharmacology.
1997 Feb; 37(2):160-8. doi:
10.1002/j.1552-4604.1997.tb04775.x. [PMID: 9055143] - S T Chiang, J C Ermer, M Osman, T Chau, D Hicks, S Wheeler, I Vavra. Pharmacokinetic-pharmacodynamic relationships of bromfenac in mice and humans.
Pharmacotherapy.
1996 Nov; 16(6):1179-87. doi:
NULL. [PMID: 8947993] - K Gumbhir-Shah, W H Cevallos, S A DeCleene, J M Korth-Bradley. Lack of interaction between bromfenac and methotrexate in patients with rheumatoid arthritis.
The Journal of rheumatology.
1996 Jun; 23(6):984-9. doi:
NULL. [PMID: 8782127] - P Högger, P Rohdewald. Pharmacokinetics of bromfenac in healthy subjects after single oral administration of three different doses.
Arzneimittel-Forschung.
1993 Oct; 43(10):1114-8. doi:
NULL. [PMID: 8267679] - J C Nolan, M A Osman, L K Cheng, L F Sancilio. Bromfenac, a new nonsteroidal anti-inflammatory drug: relationship between the anti-inflammatory and analgesic activity and plasma drug levels in rodents.
The Journal of pharmacology and experimental therapeutics.
1990 Jul; 254(1):104-8. doi:
NULL. [PMID: 2366177] - I D MacDonald, G Graff, L A Anderson, H B Dunford. Optical spectra and kinetics of reactions of prostaglandin H synthase: effects of the substrates 13-hydroperoxyoctadeca-9,11-dienoic acid, arachidonic acid, N,N,N',N'-tetramethyl-p-phenylenediamine, and phenol and of the nonsteroidal anti-inflammatory drugs aspirin, indomethacin, phenylbutazone, and bromfenac.
Archives of biochemistry and biophysics.
1989 Jul; 272(1):194-202. doi:
10.1016/0003-9861(89)90210-5. [PMID: 2500061] - M A Osman, L K Dunning, L K Cheng, G J Wright. Determination of bromfenac in plasma by high-performance liquid chromatography.
Journal of chromatography.
1989 Apr; 489(2):452-8. doi:
NULL. [PMID: 2753969]