Oxyphenonium bromide (BioDeep_00000793419)

   


代谢物信息卡片


Oxyphenonium (bromide)

化学式: C21H34BrNO3 (427.1721914000001)
中文名称: 溴氧苯乙铵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC[N+](C)(CC)CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.[Br-]
InChI: /p-1

描述信息

C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
Oxyphenonium bromide is an antiacetylcholine compound. Oxyphenonium bromide is an antagonist of mAChR. Oxyphenonium bromide protects against the bronchial obstructive effects[1][2][3].

同义名列表

2 个代谢物同义名

Oxyphenonium (bromide); Oxyphenonium bromide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • G I Nezhinskaya, A L Vladykin, N S Sapronov. Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist. Bulletin of experimental biology and medicine. 2008 Jan; 145(1):55-7. doi: 10.1007/s10517-008-0008-7. [PMID: 19024002]
  • Galina I Nezhinskaya, Aleksandr L Vladykin, Nikolay S Sapronov. Cholinergic modulation of anaphylactic shock: plasma proteins influence. Life sciences. 2007 May; 80(24-25):2342-6. doi: 10.1016/j.lfs.2007.04.013. [PMID: 17499313]
  • M Kirkova, A Alexandova, M Kesiova, S Todorov. In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs. Autonomic & autacoid pharmacology. 2007 Apr; 27(2):99-104. doi: 10.1111/j.1474-8673.2007.00395.x. [PMID: 17391279]
  • J Smisterová, K Ensing, R A de Zeeuw. Effect of purification followed by solubilization of receptor material on quantitative receptor assays for anticholinergic drugs. Journal of pharmaceutical and biomedical analysis. 1996 Aug; 14(11):1425-33. doi: 10.1016/0731-7085(96)01722-0. [PMID: 8877848]
  • B A Hoener, A A Tzika, B L Englestad, D L White. Hepatic transport of the magnetic resonance imaging contrast agent Fe(III)-N-(3-phenylglutaryl)desferrioxamine B. Magnetic resonance in medicine. 1991 Feb; 17(2):509-15. doi: 10.1002/mrm.1910170221. [PMID: 1905776]
  • K G Feitsma, B F Drenth, R A De Zeeuw, R Oosting, D K Meijer. Unequal disposition of enantiomers of the organic cation oxyphenonium in the rat isolated perfused liver. The Journal of pharmacy and pharmacology. 1989 Jan; 41(1):27-31. doi: 10.1111/j.2042-7158.1989.tb06323.x. [PMID: 2565960]
  • K Ensing, F Kluivingh, T K Gerding, R A De Zeeuw. Development of a sensitive radioreceptor assay for oxyphenonium in plasma and urine. The Journal of pharmacy and pharmacology. 1984 Apr; 36(4):235-9. doi: 10.1111/j.2042-7158.1984.tb04356.x. [PMID: 6144769]
  • K Ensing, R A de Zeeuw. Radioreceptor assay for oxyphenonium. European journal of respiratory diseases. Supplement. 1984; 135(?):143-6. doi: NULL. [PMID: 6428927]
  • L E van Bork, J H Jonkman, J E Greving, N G Orie, R Peset, K de Vries, R A de Zeeuw. Relationship between plasma concentration and the pulmonary and cardiac effects of three anticholinergics. European journal of respiratory diseases. Supplement. 1984; 135(?):202-7. doi: NULL. [PMID: 6145613]
  • G H Koëter, H Meurs, J H Jonkman, J Greving, J Leferink, H J Sluiter, R A de Zeeuw, K de Vries. Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol. European journal of clinical pharmacology. 1984; 26(4):435-41. doi: 10.1007/bf00542137. [PMID: 6329769]
  • E Harvey, M Loberg, J Ryan, S Sikorski, W Faith, M Cooper. Hepatic clearance mechanism of Tc-99m-HIDA and its effect on quantitation of hepatobiliary function: Concise communication. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1979 Apr; 20(4):310-3. doi: NULL. [PMID: 119832]
  • V Gilsanz, C P Oteyza, J L Rebollar. Glucagon vs anticholinergics in the treatment of acute pancreatitis. A double-blind controlled trial. Archives of internal medicine. 1978 Apr; 138(4):535-8. doi: NULL. [PMID: 416763]
  • J E Greving, J H Jonkman, F Fiks, R A de Zeeuw, L E van Bork, N G Orie. Determination of oxyphenonium bromide in plasma and urine by means of ion-pair extraction, derivatization and gas chromatography-electron-capture detection. Journal of chromatography. 1977 Nov; 142(?):611-9. doi: 10.1016/s0021-9673(01)92072-2. [PMID: 410817]
  • S A Kenawy, A M El Masry, S F Saad, M T Khayyal, M T Abdel Aziz. Comparative study on the effect of neostigmine, trimetaphan an oxyphenonium on some aspects of 5-hydroxytryptamine metabolism in rats. The Journal of pharmacy and pharmacology. 1975 Nov; 27(11):871-3. doi: 10.1111/j.2042-7158.1975.tb10235.x. [PMID: 1501]
  • J Czarnecki. [Studies on the 24 hour urinary excretion of 5-hydroxyindoleacetic acid in patients with stomach or duodenal ulcer before, during and after treatment with Spasmophen in relation to the "basal HC1 excretion" and the clinical condition of patients]. Polskie Archiwum Medycyny Wewnetrznej. 1968 Jun; 40(6):683-9. doi: . [PMID: 4970763]
  • T N Calvey. The transport of 14C-neostigmine from plasma to bile. Biochemical pharmacology. 1967 Oct; 16(10):1989-95. doi: 10.1016/0006-2952(67)90310-3. [PMID: 4965192]
  • B V Ramachandran, G Agren. The effect of atropine, histamine liberators and antihistamines on the absorption of DF32P by mice, rats and guinea pigs. Acta pharmacologica et toxicologica. 1965; 23(2):143-52. doi: 10.1111/j.1600-0773.1965.tb03580.x. [PMID: 4380159]
  • A Z MANEVICH, O K MASLOV, V A MIKHELSON. [EXPERIENCE IN THE USE OF METACIN]. Klinicheskaia meditsina. 1963 Nov; 41(?):99-102. doi: NULL. [PMID: 14149127]