Lisdexamfetamine dimesylate (BioDeep_00000793030)
代谢物信息卡片
(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide,methanesulfonic acid
化学式: C17H33N3O7S2 (455.1759828)
中文名称: 甲磺酸赖氨酸安非他命
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=CC=C1)NC(=O)C(CCCCN)N.CS(=O)(=O)O.CS(=O)(=O)O
InChI: /m0../s1
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D04747
- PubChem: 11597697
- ChEMBL: CHEMBL1201178
- MeSH: Lisdexamfetamine Dimesylate
- CAS: 608137-33-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria D Chermá, Gunnel H Nilsson, Anna Johansson, Anna K Jönsson, Johan Ahlner. Use of Lisdexamfetamine or Amphetamine? Interpretation of Chiral Amphetamine Analyses.
Journal of analytical toxicology.
2022 Feb; 46(1):10-16. doi:
10.1093/jat/bkaa170. [PMID: 33216112] - Kristine J Steffen, Afroz S Mohammad, James L Roerig, James E Mitchell, Carrie Nelson, Molly Orcutt, Wenqiu Zhang, Ann L Erickson, William F Elmquist. Lisdexamfetamine Pharmacokinetic Comparison Between Patients Who Underwent Roux-en-Y Gastric Bypass and Nonsurgical Controls.
Obesity surgery.
2021 10; 31(10):4289-4294. doi:
10.1007/s11695-020-04969-4. [PMID: 34291361] - Christopher Wohkittel, Petra Högger, Stefanie Fekete, Marcel Romanos, Manfred Gerlach. Relationship Between Amphetamine Concentrations in Saliva and Serum in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder.
Therapeutic drug monitoring.
2021 08; 43(4):564-569. doi:
10.1097/ftd.0000000000000831. [PMID: 33149054] - Marianne Haedener, Wolfgang Weinmann, Dominique Eich, Michael Liebrenz, Thomas Wuethrich, Anna Buadze. Evaluating the reliability of hair analysis in monitoring the compliance of ADHD patients under treatment with Lisdexamphetamine.
PloS one.
2021; 16(3):e0248747. doi:
10.1371/journal.pone.0248747. [PMID: 33784320] - Eloisa Comiran, Graciela Carlos, Fabiano Barreto, Flavio Pechanksy, Pedro E Fröehlich, Renata P Limberger. Lisdexamfetamine and amphetamine pharmacokinetics in oral fluid, plasma, and urine after controlled oral administration of lisdexamfetamine.
Biopharmaceutics & drug disposition.
2021 Jan; 42(1):3-11. doi:
10.1002/bdd.2254. [PMID: 33119133] - Yoshiyuki Tsuda, Yumiko Matsuo, Sayaka Matsumoto, Toshihiro Wajima. Population pharmacokinetic and exposure-response analyses of d-amphetamine after administration of lisdexamfetamine dimesylate in Japanese pediatric ADHD patients.
Drug metabolism and pharmacokinetics.
2020 Dec; 35(6):548-554. doi:
10.1016/j.dmpk.2020.08.005. [PMID: 33082099] - Vitor S Tardelli, Adam Bisaga, Felipe B Arcadepani, Gilberto Gerra, Frances R Levin, Thiago M Fidalgo. Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
Psychopharmacology.
2020 Aug; 237(8):2233-2255. doi:
10.1007/s00213-020-05563-3. [PMID: 32601988] - James Ermer, Patrick Martin, Mary Corcoran, Yumiko Matsuo. A phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects.
Neuropsychopharmacology reports.
2020 03; 40(1):16-29. doi:
10.1002/npr2.12082. [PMID: 31765110] - Petra Strajhar, Patrick Vizeli, Melanie Patt, Patrick C Dolder, Denise V Kratschmar, Matthias E Liechti, Alex Odermatt. Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study.
The Journal of steroid biochemistry and molecular biology.
2019 02; 186(?):212-225. doi:
10.1016/j.jsbmb.2018.10.016. [PMID: 30381248] - Giovana Bristot, Bruna M Ascoli, Ellen Scotton, Luiza P Géa, Bianca Pfaffenseller, Márcia Kauer-Sant'Anna. Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999).
2019; 41(5):419-427. doi:
10.1590/1516-4446-2017-0001. [PMID: 30843957] - Lenard A Adler, Samuel Alperin, Terry Leon, Stephen V Faraone. Pharmacokinetic and Pharmacodynamic Properties of Lisdexamfetamine in Adults with Attention-Deficit/Hyperactivity Disorder.
Journal of child and adolescent psychopharmacology.
2017 03; 27(2):196-199. doi:
10.1089/cap.2016.0121. [PMID: 27935735] - Eloisa Comiran, Fabiano Barreto, Leonardo Z Meneghini, Graciela Carlos, Pedro E Fröehlich, Renata Pereira Limberger. Method validation and determination of lisdexamfetamine and amphetamine in oral fluid, plasma and urine by LC-MS/MS.
Biomedical chromatography : BMC.
2017 Mar; 31(3):. doi:
10.1002/bmc.3812. [PMID: 27518755] - Christopher L Norkus, Iain Keir, Charlotte Means. Dexmedetomidine to control signs associated with lisdexamfetamine dimesylate toxidrome in a cat.
The Canadian veterinary journal = La revue veterinaire canadienne.
2017 Mar; 58(3):261-264. doi:
". [PMID: 28246413] - James Ermer, Mary Corcoran, Kenneth Lasseter, Patrick T Martin. Relative Bioavailabilities of Lisdexamfetamine Dimesylate and D-Amphetamine in Healthy Adults in an Open-Label, Randomized, Crossover Study After Mixing Lisdexamfetamine Dimesylate With Food or Drink.
Therapeutic drug monitoring.
2016 12; 38(6):769-776. doi:
10.1097/ftd.0000000000000343. [PMID: 27661399] - Kelly E Wood, Matthew D Krasowski. An Infant with a Prolonged Sympathomimetic Toxidrome after Lisdexamfetamine Dimesylate Ingestion.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2016 12; 12(4):402-405. doi:
10.1007/s13181-016-0560-x. [PMID: 27277955] - James Ermer, Mary Corcoran, Kenneth Lasseter, Thomas Marbury, Brian Yan, Patrick T Martin. A Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Lisdexamfetamine Dimesylate in Individuals With Normal and Impaired Renal Function.
Therapeutic drug monitoring.
2016 08; 38(4):546-55. doi:
10.1097/ftd.0000000000000296. [PMID: 26926668] - James C Ermer, Michael Pennick, Glen Frick. Lisdexamfetamine Dimesylate: Prodrug Delivery, Amphetamine Exposure and Duration of Efficacy.
Clinical drug investigation.
2016 May; 36(5):341-56. doi:
10.1007/s40261-015-0354-y. [PMID: 27021968] - Guilherme A Eger, Vinícius V Ferreira, Camila R Batista, Henrique Bonde, Daniela D de Lima, Angela T S Wyse, Júlia N da Cruz, André F Rodrigues, Débora D Dal Magro, José G P da Cruz. Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate.
Anais da Academia Brasileira de Ciencias.
2016 Mar; 88(1):335-48. doi:
10.1590/0001-3765201620140490. [PMID: 26871491] - Marc E Mooney, David V Herin, Sheila Specker, David Babb, Frances R Levin, John Grabowski. Pilot study of the effects of lisdexamfetamine on cocaine use: A randomized, double-blind, placebo-controlled trial.
Drug and alcohol dependence.
2015 Aug; 153(?):94-103. doi:
10.1016/j.drugalcdep.2015.05.042. [PMID: 26116930] - Erik Sjögren, David Dahlgren, Carl Roos, Hans Lennernäs. Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
Molecular pharmaceutics.
2015 Jun; 12(6):2026-39. doi:
10.1021/mp500834v. [PMID: 25919764] - James Ermer, Mary Corcoran, Patrick Martin. Lisdexamfetamine Dimesylate Effects on the Pharmacokinetics of Cytochrome P450 Substrates in Healthy Adults in an Open-Label, Randomized, Crossover Study.
Drugs in R&D.
2015 Jun; 15(2):175-85. doi:
10.1007/s40268-015-0090-z. [PMID: 25862215] - Matthew L Banks, Blake A Hutsell, Bruce E Blough, Justin L Poklis, S Stevens Negus. Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure.
The international journal of neuropsychopharmacology.
2015 Jan; 18(8):. doi:
10.1093/ijnp/pyv009. [PMID: 25618405] - Greicy Coelho de Souza, Julia Ariana de S Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo. Preclinical Evidences for an Antimanic Effect of Carvedilol.
Neural plasticity.
2015; 2015(?):692541. doi:
10.1155/2015/692541. [PMID: 26075103] - Patrick Martin, Bryan Dirks, Lev Gertsik, David Walling, Annette Stevenson, Mary Corcoran, Aparna Raychaudhuri, James Ermer. Safety and pharmacokinetics of lisdexamfetamine dimesylate in adults with clinically stable schizophrenia: a randomized, double-blind, placebo-controlled trial of ascending multiple doses.
Journal of clinical psychopharmacology.
2014 Dec; 34(6):682-9. doi:
10.1097/jcp.0000000000000205. [PMID: 25310201] - Mario Thevis, Gerd Sigmund, Andreas Thomas, Matthias Vogel, Katja Walpurgis, Dorota Kwiatkowska, Hans Geyer, Wilhelm Schänzer. Isotope-dilution mass spectrometric quantification of the prodrug lisdexamfetamine in human urine in doping control analysis.
Rapid communications in mass spectrometry : RCM.
2014 Apr; 28(7):781-6. doi:
10.1002/rcm.6844. [PMID: 24573809] - Danielle S Macêdo, David F de Lucena, Ana Isabelle G Queiroz, Rafaela C Cordeiro, Maíra M Araújo, Francisca Cléa Sousa, Silvânia M Vasconcelos, Thomas N Hyphantis, João Quevedo, Roger S McIntyre, André F Carvalho. Effects of lithium on oxidative stress and behavioral alterations induced by lisdexamfetamine dimesylate: relevance as an animal model of mania.
Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jun; 43(?):230-7. doi:
10.1016/j.pnpbp.2013.01.007. [PMID: 23333378] - Benno Roesch, Mary E Corcoran, Jennifer Fetterolf, Mary Haffey, Patrick Martin, Peter Preston, Jaideep Purkayastha, Phillip Wang, James Ermer. Pharmacokinetics of coadministered guanfacine extended release and lisdexamfetamine dimesylate.
Drugs in R&D.
2013 Jun; 13(2):119-28. doi:
10.1007/s40268-013-0014-8. [PMID: 23615868] - James Ermer, Mary B Haffey, Cynthia Richards, Kenneth Lasseter, Benno Roesch, Jaideep Purkayastha, Mary Corcoran, Bree Harlin, Patrick Martin. An open-label investigation of the pharmacokinetic profiles of lisdexamfetamine dimesylate and venlafaxine extended-release, administered alone and in combination, in healthy adults.
Clinical drug investigation.
2013 Apr; 33(4):243-54. doi:
10.1007/s40261-013-0073-1. [PMID: 23512639] - H L Rowley, R Kulkarni, J Gosden, R Brammer, D Hackett, D J Heal. Lisdexamfetamine and immediate release d-amfetamine - differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity.
Neuropharmacology.
2012 Nov; 63(6):1064-74. doi:
10.1016/j.neuropharm.2012.07.008. [PMID: 22796358] - Jan Frölich, Tobias Banaschewski, Rainer Spanagel, Manfred Döpfner, Gerd Lehmkuhl. [The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents].
Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie.
2012 Sep; 40(5):287-99; quiz 299. doi:
10.1024/1422-4917/a000185. [PMID: 22869222] - Christopher Steer, Jan Froelich, César A Soutullo, Mats Johnson, Monica Shaw. Lisdexamfetamine dimesylate: a new therapeutic option for attention-deficit hyperactivity disorder.
CNS drugs.
2012 Aug; 26(8):691-705. doi:
10.2165/11634340-000000000-00000. [PMID: 22762726] - James C Ermer, Mary B Haffey, Walter J Doll, Patrick Martin, Erik P Sandefer, Kerry Dennis, Mary Corcoran, Laura Trespidi, Richard C Page. Pharmacokinetics of lisdexamfetamine dimesylate after targeted gastrointestinal release or oral administration in healthy adults.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Feb; 40(2):290-7. doi:
10.1124/dmd.111.040691. [PMID: 22039171] - James C Ermer, Kerry Dennis, Mary B Haffey, Walter J Doll, Erik P Sandefer, Mary Buckwalter, Richard C Page, Brian Diehl, Patrick T Martin. Intranasal versus oral administration of lisdexamfetamine dimesylate: a randomized, open-label, two-period, crossover, single-dose, single-centre pharmacokinetic study in healthy adult men.
Clinical drug investigation.
2011; 31(6):357-70. doi:
10.2165/11588190-000000000-00000. [PMID: 21539403] - James Ermer, Robert Homolka, Patrick Martin, Mary Buckwalter, Jaideep Purkayastha, Benno Roesch. Lisdexamfetamine dimesylate: linear dose-proportionality, low intersubject and intrasubject variability, and safety in an open-label single-dose pharmacokinetic study in healthy adult volunteers.
Journal of clinical pharmacology.
2010 Sep; 50(9):1001-10. doi:
10.1177/0091270009357346. [PMID: 20173084] - Michael Pennick. Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine.
Neuropsychiatric disease and treatment.
2010 Jun; 6(?):317-27. doi:
10.2147/ndt.s9749. [PMID: 20628632] - Suma M Krishnan, Michael Pennick, Jeffrey G Stark. Metabolism, distribution and elimination of lisdexamfetamine dimesylate: open-label, single-centre, phase I study in healthy adult volunteers.
Clinical drug investigation.
2008; 28(12):745-55. doi:
10.2165/0044011-200828120-00002. [PMID: 18991468]