Echothiophate Iodide (BioDeep_00000792987)
代谢物信息卡片
Echothiophate Iodide
化学式: C9H23INO3PS (383.0180968)
中文名称: 碘依可酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOP(=O)(OCC)SCC[N+](C)(C)C.[I-]
InChI: /p-1
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:59849
- KEGGdrug: D02193
- PubChem: 10547
- ChEMBL: CHEMBL1200367
- MeSH: Echothiophate Iodide
- CAS: 513-10-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kirstin P Hester, Krishna Bhattarai, Haobo Jiang, Pratul K Agarwal, Carey Pope. Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis.
Chemical research in toxicology.
2019 09; 32(9):1801-1810. doi:
10.1021/acs.chemrestox.9b00146. [PMID: 31411024] - Daniel K Nomura, Kathleen A Durkin, Kyle P Chiang, Gary B Quistad, Benjamin F Cravatt, John E Casida. Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Chemical research in toxicology.
2006 Sep; 19(9):1142-50. doi:
10.1021/tx060117m. [PMID: 16978018] - Bin Li, Meghan Sedlacek, Indumathi Manoharan, Rathnam Boopathy, Ellen G Duysen, Patrick Masson, Oksana Lockridge. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.
Biochemical pharmacology.
2005 Nov; 70(11):1673-84. doi:
10.1016/j.bcp.2005.09.002. [PMID: 16213467] - Eric S Peeples, Lawrence M Schopfer, Ellen G Duysen, Reggie Spaulding, Troy Voelker, Charles M Thompson, Oksana Lockridge. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):303-12. doi:
10.1093/toxsci/kfi023. [PMID: 15525694] - Yuxia Wang, Andreea Ticu Boeck, Ellen G Duysen, Margaret Van Keuren, Thomas L Saunders, Oksana Lockridge. Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.
Toxicology and applied pharmacology.
2004 May; 196(3):356-66. doi:
10.1016/j.taap.2003.12.018. [PMID: 15094306] - Andreea Ticu Boeck, Lawrence M Schopfer, Oksana Lockridge. DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase.
Biochemical pharmacology.
2002 Jun; 63(12):2101-10. doi:
10.1016/s0006-2952(02)01029-8. [PMID: 12110369] - A Manoguerra, C Whitney, R F Clark, B Anderson, S Turchen. Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops.
Journal of toxicology. Clinical toxicology.
1995; 33(5):463-5. doi:
10.3109/15563659509013755. [PMID: 7650771] - S S Kelly, C B Ferry. The origin of the effects of an anticholinesterase on the latencies of action potentials in mouse skeletal muscles.
British journal of pharmacology.
1994 Mar; 111(3):747-52. doi:
10.1111/j.1476-5381.1994.tb14801.x. [PMID: 7912624] - C B Ferry, M J Cullen. Myopathic changes in indirectly stimulated mouse diaphragm after ecothiopate in vitro.
International journal of experimental pathology.
1991 Jun; 72(3):329-43. doi:
. [PMID: 1843260] - L C Streichert, P B Sargent. Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens.
Journal of neurobiology.
1990 Sep; 21(6):938-49. doi:
10.1002/neu.480210610. [PMID: 2077105] - K M Schegg, K J Futamachi, J H Peacock. Characterization of acetylcholinesterase isoforms in septal and hippocampal cultures and cocultures.
Brain research.
1986 Dec; 395(2):221-30. doi:
10.1016/s0006-8993(86)80200-1. [PMID: 3779439] - J A Donoso, H L Fernandez. Cellular localization of cytochemically stained acetylcholinesterase activity in adult rat skeletal muscle.
Journal of neurocytology.
1985 Oct; 14(5):795-808. doi:
10.1007/bf01170829. [PMID: 2419522] - D Goudou, M Verdiere-Sahuque, F Rieger. External and internal acetylcholinesterase in rat sympathetic neurones in vivo and in vitro.
FEBS letters.
1985 Jul; 186(1):54-8. doi:
10.1016/0014-5793(85)81338-7. [PMID: 4007159] - R Couture, A C Cuello, J L Henry. Trigeminal antidromic vasodilatation and plasma extravasation in the rat: effects of acetylcholine antagonists and cholinesterase inhibitors.
British journal of pharmacology.
1985 Mar; 84(3):637-43. doi:
10.1111/j.1476-5381.1985.tb16144.x. [PMID: 3986430] - D Gajewski, M Katkiewicz. Activity of certain enzymes and histomorphological changes in subacute intoxication of rats with selected organophosphates.
Acta physiologica Polonica.
1981 Sep; 32(5):507-20. doi:
. [PMID: 7336985] - F Donati, D R Bevan. Controlled succinylcholine infusion in a patient receiving echothiophate eye drops.
Canadian Anaesthetists' Society journal.
1981 Sep; 28(5):488-90. doi:
10.1007/bf03010364. [PMID: 7284894] - T R Friberg, J V Thomas, T D Dressel. Serum cholinesterase, serum lipase, and serum amylase levels during long-term echothiophate iodide therapy.
American journal of ophthalmology.
1981 Apr; 91(4):530-3. doi:
10.1016/0002-9394(81)90245-2. [PMID: 6164295] - P M Packman, D A Meyer, R M Verdun. Hazards of succinylcholine administration during electrotherapy.
Archives of general psychiatry.
1978 Sep; 35(9):1137-41. doi:
10.1001/archpsyc.1978.01770330111011. [PMID: 686974] - K M Kutty, J C Jocob, C J Hutton, P J Davis, S C Peterson. Serum beta -- lipoproteins: studies in a patient and in guinea pigs after the ingestion of organophosphorus compounds.
Clinical biochemistry.
1975 Dec; 8(6):379-83. doi:
10.1016/s0009-9120(75)93953-3. [PMID: 173478] - S Kitamura, K Oguri, K Kozaki, H Yamazaki. [Effect of administration of miotics on serum cholinesterase].
Masui. The Japanese journal of anesthesiology.
1974 Nov; 23(12):1225-30. doi:
NULL. [PMID: 4156575] - D M Wilson, J H Martin, J F Niall. Raised intraocular tension in renal transplant recipients.
The Medical journal of Australia.
1973 Mar; 1(10):482-4. doi:
10.5694/j.1326-5377.1973.tb110512.x. [PMID: 4573376] - D S Friendly, R A Manson, D G Albert. Cyclic strabismus--a case study.
Documenta ophthalmologica. Advances in ophthalmology.
1973 Feb; 34(1):189-202. doi:
10.1007/bf00151807. [PMID: 4706089] - T E Eilderton, O Farmati, E K Zsigmond. Reduction in plasma cholinesterase levels after prolonged administration of echothiophate iodide eyedrops.
Canadian Anaesthetists' Society journal.
1968 May; 15(3):291-6. doi:
10.1007/bf03008742. [PMID: 5658433] - G M Berlyne. The use of low-protein diet in chronic renal failure.
British journal of urology.
1966 Dec; 38(6):613-5. doi:
10.1111/j.1464-410x.1966.tb09763.x. [PMID: 5958045] - D D MCGAVI. DEPRESSED LEVELS OF SERUM-PSEUDOCHOLINESTERASE WITH ECOTHIOPHATE-IODIDE EYEDROPS.
Lancet (London, England).
1965 Aug; 2(7406):272-3. doi:
10.1016/s0140-6736(65)92391-3. [PMID: 14330066] - F SPIERS, P JUUL. CHOLINESTERASE ACTIVITY IN PLASMA AND ERYTHROCYTES. A CLINICO-HAEMATOLOGICAL STUDY BASED ON NORMAL SUBJECTS AND ON PATIENTS WITH GLAUCOMA, OF WHOM SOME NOT TREATED WITH AND SOME TREATED WITH ANTICHOLINESTERASES.
Acta ophthalmologica.
1964; 42(?):696-712. doi:
10.1111/j.1755-3768.1964.tb00921.x. [PMID: 14186626]