Epoxomicin (BioDeep_00000791997)
代谢物信息卡片
Epoxomicin
化学式: C28H50N4O7 (554.367931)
中文名称: 环氧霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C
InChI: InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D061988 - Proteasome Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lucia Longhitano, Daniele Tibullo, Cesarina Giallongo, Giacomo Lazzarino, Nicola Tartaglia, Sara Galimberti, Giovanni Li Volti, Giuseppe Alberto Palumbo, Arcangelo Liso. Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2.
International journal of molecular sciences.
2020 May; 21(10):. doi:
10.3390/ijms21103622. [PMID: 32443911] - Aikaterini Skorda, Aimilia D Sklirou, Theodore Sakellaropoulos, Despoina D Gianniou, Efstathios Kastritis, Evangelos Terpos, Ourania E Tsitsilonis, Bogdan I Florea, Herman S Overkleeft, Meletios A Dimopoulos, Leonidas G Alexopoulos, Ioannis P Trougakos. Non-lethal proteasome inhibition activates pro-tumorigenic pathways in multiple myeloma cells.
Journal of cellular and molecular medicine.
2019 12; 23(12):8010-8018. doi:
10.1111/jcmm.14653. [PMID: 31568628] - Hu Wang, Fanny Cheung, Anna C Stoll, Patricia Rockwell, Maria E Figueiredo-Pereira. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1436-1450. doi:
10.1016/j.bbadis.2019.02.016. [PMID: 30796971] - Lisanne Luks, Marcia Y Maier, Silvia Sacchi, Loredano Pollegioni, Daniel R Dietrich. Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.
Archives of toxicology.
2017 Nov; 91(11):3599-3611. doi:
10.1007/s00204-017-1970-5. [PMID: 28451739] - Tetsuto Nakagawa, Chihiro Takahashi, Hitomi Matsuzaki, Shohei Takeyama, Shinpei Sato, Ayaka Sato, Yoshiyuki Kuroda, Hideyoshi Higashi. N-glycan-dependent cell-surface expression of the P2Y2 receptor and N-glycan-independent distribution to lipid rafts.
Biochemical and biophysical research communications.
2017 04; 485(2):427-431. doi:
10.1016/j.bbrc.2017.02.061. [PMID: 28209512] - Kapil V Ramachandran, Seth S Margolis. A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function.
Nature structural & molecular biology.
2017 04; 24(4):419-430. doi:
10.1038/nsmb.3389. [PMID: 28287632] - David J Newman. Developing natural product drugs: Supply problems and how they have been overcome.
Pharmacology & therapeutics.
2016 06; 162(?):1-9. doi:
10.1016/j.pharmthera.2015.12.002. [PMID: 26706239] - Amaia Zulet, Miriam Gil-Monreal, Joji Grace Villamor, Ana Zabalza, Renier A L van der Hoorn, Mercedes Royuela. Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis.
PloS one.
2013; 8(9):e73847. doi:
10.1371/journal.pone.0073847. [PMID: 24040092] - Matthew A Smith, Rick G Schnellmann. Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury.
Archives of biochemistry and biophysics.
2012 Jan; 517(2):144-52. doi:
10.1016/j.abb.2011.11.023. [PMID: 22179018] - Joséphine Beck, Yves Guminski, Christophe Long, Laurence Marcourt, Fadila Derguini, Fabien Plisson, Antonio Grondin, Isabelle Vandenberghe, Stéphane Vispé, Viviane Brel, Yannick Aussagues, Frédéric Ausseil, Paola B Arimondo, Georges Massiot, François Sautel, Frédéric Cantagrel. Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.
Bioorganic & medicinal chemistry.
2012 Jan; 20(2):819-31. doi:
10.1016/j.bmc.2011.11.066. [PMID: 22206869] - Susanne Karbach, Alexandra Simon, Anita Slenzka, Isabel Jaenecke, Alice Habermeier, Ursula Martiné, Ulrich Förstermann, Ellen I Closs. Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase.
Journal of molecular and cellular cardiology.
2011 Nov; 51(5):855-61. doi:
10.1016/j.yjmcc.2011.07.024. [PMID: 21839088] - Natura Myeku, Maria E Figueiredo-Pereira. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
The Journal of biological chemistry.
2011 Jun; 286(25):22426-40. doi:
10.1074/jbc.m110.149252. [PMID: 21536669] - Takamasa Inoue, Billy Tsai. A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol.
PLoS pathogens.
2011 May; 7(5):e1002037. doi:
10.1371/journal.ppat.1002037. [PMID: 21589906] - Eleanor M Gilroy, Rosalind M Taylor, Ingo Hein, Petra Boevink, Ari Sadanandom, Paul R J Birch. CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a.
The New phytologist.
2011 May; 190(3):653-66. doi:
10.1111/j.1469-8137.2011.03643.x. [PMID: 21348873] - Izabella Kolodziejek, Johana C Misas-Villamil, Farnusch Kaschani, Jérôme Clerc, Christian Gu, Daniel Krahn, Sherry Niessen, Martijn Verdoes, Lianne I Willems, Hermen S Overkleeft, Markus Kaiser, Renier A L van der Hoorn. Proteasome activity imaging and profiling characterizes bacterial effector syringolin A.
Plant physiology.
2011 Jan; 155(1):477-89. doi:
10.1104/pp.110.163733. [PMID: 21045122] - Todd A Baker, Qing Geng, Jacqueline Romero, Maria M Picken, Richard L Gamelli, Matthias Majetschak. Prolongation of myocardial viability by proteasome inhibition during hypothermic organ preservation.
Biochemical and biophysical research communications.
2010 Oct; 401(4):548-53. doi:
10.1016/j.bbrc.2010.09.093. [PMID: 20875792] - Amin Al-Shami, Kanchan G Jhaver, Peter Vogel, Carrie Wilkins, Juliane Humphries, John J Davis, Nianhua Xu, David G Potter, Brenda Gerhardt, Robert Mullinax, Cynthia R Shirley, Stephen J Anderson, Tamas Oravecz. Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
PloS one.
2010 Oct; 5(10):e13654. doi:
10.1371/journal.pone.0013654. [PMID: 21048919] - Sandhya Xavier, Victoria Gilbert, Maria Pia Rastaldi, Stefanie Krick, Dmitrij Kollins, Anand Reddy, Erwin Bottinger, Clemens D Cohen, Detlef Schlondorff. BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.
PloS one.
2010 Sep; 5(9):e12995. doi:
10.1371/journal.pone.0012995. [PMID: 20886049] - Valentí Gómez, Marta Sesé, Anna Santamaría, Juan D Martínez, Elisabet Castellanos, Marta Soler, Timothy M Thomson, Rosanna Paciucci. Regulation of aurora B kinase by the lipid raft protein flotillin-1.
The Journal of biological chemistry.
2010 Jul; 285(27):20683-90. doi:
10.1074/jbc.m110.130591. [PMID: 20430883] - Melanie Dyllick-Brenzinger, Cheryl A D'Souza, Burkhardt Dahlmann, Peter-Michael Kloetzel, Anurag Tandon. Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue.
Neurotoxicity research.
2010 Apr; 17(3):215-27. doi:
10.1007/s12640-009-9094-1. [PMID: 19653055] - Matthias Majetschak, Siegfried Zedler, Jacqueline Romero, Joslyn M Albright, Robert Kraft, Elizabeth J Kovacs, Eugen Faist, Richard L Gamelli. Circulating proteasomes after burn injury.
Journal of burn care & research : official publication of the American Burn Association.
2010 Mar; 31(2):243-50. doi:
10.1097/bcr.0b013e3181d0f55d. [PMID: 20182370] - Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman. Characterization of the Brain 26S Proteasome and its Interacting Proteins.
Frontiers in molecular neuroscience.
2010; 3(?):. doi:
10.3389/fnmol.2010.00012. [PMID: 20717473] - Peter D Donnellan, B Therese Kinsella. Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.
Journal of molecular signaling.
2009 Sep; 4(?):7. doi:
10.1186/1750-2187-4-7. [PMID: 19781057] - Irina V Majoul, Daria Onichtchouk, Eugenia Butkevich, Dirk Wenzel, Levon M Chailakhyan, Rainer Duden. Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway.
Histochemistry and cell biology.
2009 Sep; 132(3):263-80. doi:
10.1007/s00418-009-0617-x. [PMID: 19626334] - Bruce A Boswell, Anh-Chi N Le, Linda S Musil. Upregulation and maintenance of gap junctional communication in lens cells.
Experimental eye research.
2009 May; 88(5):919-27. doi:
10.1016/j.exer.2008.11.031. [PMID: 19103198] - Halina Ostrowska, Dominika Hempel, Malgorzata Holub, Jaroslaw Sokolowski, Janusz Kloczko. Assessment of circulating proteasome chymotrypsin-like activity in plasma of patients with acute and chronic leukemias.
Clinical biochemistry.
2008 Nov; 41(16-17):1377-83. doi:
10.1016/j.clinbiochem.2008.08.063. [PMID: 18773885] - Kyle A Rasbach, Peter T Green, Rick G Schnellmann. Oxidants and Ca+2 induce PGC-1alpha degradation through calpain.
Archives of biochemistry and biophysics.
2008 Oct; 478(2):130-5. doi:
10.1016/j.abb.2008.08.003. [PMID: 18718443] - Daniel Bouyer, Florian Geier, Friedrich Kragler, Arp Schnittger, Martina Pesch, Katja Wester, Rachappa Balkunde, Jens Timmer, Christian Fleck, Martin Hülskamp. Two-dimensional patterning by a trapping/depletion mechanism: the role of TTG1 and GL3 in Arabidopsis trichome formation.
PLoS biology.
2008 Jun; 6(6):e141. doi:
10.1371/journal.pbio.0060141. [PMID: 18547143] - Fernanda Ledda, Oliver Bieraugel, Shahrzad Shirazi Fard, Marçal Vilar, Gustavo Paratcha. Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Jan; 28(1):39-49. doi:
10.1523/jneurosci.2196-07.2008. [PMID: 18171921] - Jason L DeHart, Erik S Zimmerman, Orly Ardon, Carlos M R Monteiro-Filho, Enrique R Argañaraz, Vicente Planelles. HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.
Virology journal.
2007 Jun; 4(?):57. doi:
10.1186/1743-422x-4-57. [PMID: 17559673] - Frederic Ausseil, Arnaud Samson, Yannick Aussagues, Isabelle Vandenberghe, Laurent Creancier, Isabelle Pouny, Anna Kruczynski, Georges Massiot, Christian Bailly. High-throughput bioluminescence screening of ubiquitin-proteasome pathway inhibitors from chemical and natural sources.
Journal of biomolecular screening.
2007 Feb; 12(1):106-16. doi:
10.1177/1087057106296494. [PMID: 17175525] - Xianyong Sheng, Zhenghai Hu, Hongfei Lü, Xiaohua Wang, Frantisek Baluska, Jozef Samaj, Jinxing Lin. Roles of the ubiquitin/proteasome pathway in pollen tube growth with emphasis on MG132-induced alterations in ultrastructure, cytoskeleton, and cell wall components.
Plant physiology.
2006 Aug; 141(4):1578-90. doi:
10.1104/pp.106.081703. [PMID: 16778013] - Robert M Rydzewski, Leland Burrill, Rohan Mendonca, James T Palmer, Mark Rice, Ram Tahilramani, Kathryn E Bass, Ling Leung, Erik Gjerstad, James W Janc, Lin Pan. Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.
Journal of medicinal chemistry.
2006 May; 49(10):2953-68. doi:
10.1021/jm058289o. [PMID: 16686537] - Brian A Pierchala, Jeffrey Milbrandt, Eugene M Johnson. Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Mar; 26(10):2777-87. doi:
10.1523/jneurosci.3420-05.2006. [PMID: 16525057] - Min Lu, Lena Staszewski, Fernando Echeverri, Hong Xu, Bryan D Moyer. Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression.
BMC cell biology.
2004 Sep; 5(?):34. doi:
10.1186/1471-2121-5-34. [PMID: 15369603] - Carla Marques, Paulo Pereira, Allen Taylor, Jack N Liang, Venkat N Reddy, Luke I Szweda, Fu Shang. Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 Sep; 18(12):1424-6. doi:
10.1096/fj.04-1743fje. [PMID: 15247152] - Patricio Morales, Eduardo Pizarro, Milene Kong, Marcos Jara. Extracellular localization of proteasomes in human sperm.
Molecular reproduction and development.
2004 May; 68(1):115-24. doi:
10.1002/mrd.20052. [PMID: 15039955] - Peizhen Yang, Hongyong Fu, Joseph Walker, Charles M Papa, Jan Smalle, Yu-Ming Ju, Richard D Vierstra. Purification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms.
The Journal of biological chemistry.
2004 Feb; 279(8):6401-13. doi:
10.1074/jbc.m311977200. [PMID: 14623884] - Francesco Fornai, Paola Lenzi, Marco Gesi, Michela Ferrucci, Gloria Lazzeri, Carla L Busceti, Riccardo Ruffoli, Paola Soldani, Stefano Ruggieri, Maria G Alessandri, Antonio Paparelli. Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Oct; 23(26):8955-66. doi:
10.1523/jneurosci.23-26-08955.2003. [PMID: 14523098] - Viviana M Berthoud, Peter J Minogue, Jun Guo, Edward K Williamson, Xiaorong Xu, Lisa Ebihara, Eric C Beyer. Loss of function and impaired degradation of a cataract-associated mutant connexin50.
European journal of cell biology.
2003 May; 82(5):209-21. doi:
10.1078/0171-9335-00316. [PMID: 12800976] - A Speranza, V Scoccianti, R Crinelli, G L Calzoni, M Magnani. Inhibition of proteasome activity strongly affects kiwifruit pollen germination. Involvement of the ubiquitin/proteasome pathway as a major regulator.
Plant physiology.
2001 Jul; 126(3):1150-61. doi:
10.1104/pp.126.3.1150. [PMID: 11457965] - M H Lee, D H Hyun, P Jenner, B Halliwell. Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production.
Journal of neurochemistry.
2001 Jul; 78(1):32-41. doi:
10.1046/j.1471-4159.2001.00416.x. [PMID: 11432971] - A Patnaik, V Chau, J W Wills. Ubiquitin is part of the retrovirus budding machinery.
Proceedings of the National Academy of Sciences of the United States of America.
2000 Nov; 97(24):13069-74. doi:
10.1073/pnas.97.24.13069. [PMID: 11087861]