Amitriptyline Hydrochloride (BioDeep_00000791808)
代谢物信息卡片
Amitriptyline Hydrochloride
化学式: C20H24ClN (313.15971740000003)
中文名称: 盐酸阿米替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D049990 - Membrane Transport Modulators
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:2667
- KEGGdrug: D00809
- KEGGdrug: D81789
- PubChem: 11065
- ChEMBL: CHEMBL1200964
- MeSH: Amitriptyline
- CAS: 549-18-8
- medchemexpress: HY-B0527A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine.
2024 Mar; 103(11):e37612. doi:
10.1097/md.0000000000037612. [PMID: 38489675] - Daria A Belinskaia, Natalia N Shestakova. Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data.
Biochemistry. Biokhimiia.
2024 Mar; 89(3):507-522. doi:
10.1134/s0006297924030106. [PMID: 38648769] - Anna Detzlhofer, Christian Grechhamer, Lawrence Madikizela, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea.
Environmental science and pollution research international.
2024 Mar; 31(13):19649-19657. doi:
10.1007/s11356-024-32379-x. [PMID: 38363510] - Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung-Hsun Yu, Leo Garcia Flores, Skye Hsin-Hsien Yeh, Kuo-Hsing Ma. Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137035. [PMID: 35806049] - Tan Dai, Zhiwen Wang, Xingkai Cheng, Huige Gao, Li Liang, Pengfei Liu, Xili Liu. Uncoupler SYP-14288 inducing multidrug resistance of Phytophthora capsici through overexpression of cytochrome P450 monooxygenases and P-glycoprotein.
Pest management science.
2022 Jun; 78(6):2240-2249. doi:
10.1002/ps.6845. [PMID: 35191608] - Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S Denton, Alexander Staruschenko, Oleg Palygin. Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct.
British journal of pharmacology.
2022 06; 179(12):2953-2968. doi:
10.1111/bph.15779. [PMID: 34904226] - Cihangir Buyukgoz, Shantaveer Gangu, Faaria Gowani, Dai Kimura. Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange.
Journal of clinical apheresis.
2022 Jun; 37(3):313-315. doi:
10.1002/jca.21960. [PMID: 34953071] - I Prins-Can, I R F van Berlo-van de Laar, M Zeeman, C G Vermeij, E van 't Riet, K Taxis, F G A Jansman. Assessing the binding interaction of polystyrene sulfonate with amitriptyline in healthy volunteers: a cross-over design - The BIND study.
European journal of clinical pharmacology.
2022 May; 78(5):839-845. doi:
10.1007/s00228-022-03283-5. [PMID: 35171315] - Mitchelle Katemauswa, Ekram Hossain, Zongyuan Liu, Mahbobeh Lesani, Adwaita R Parab, Danya A Dean, Laura-Isobel McCall. Enabling Quantitative Analysis of Surface Small Molecules for Exposomics and Behavioral Studies.
Journal of the American Society for Mass Spectrometry.
2022 Mar; 33(3):412-419. doi:
10.1021/jasms.1c00263. [PMID: 35084848] - Nicklas Hasselblad Lundstrøm, Nikolaj K Holgersen, Maija Bruun Haastrup. The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review.
Acta neuropsychiatrica.
2022 Feb; 34(1):1-9. doi:
10.1017/neu.2021.28. [PMID: 34497000] - Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review.
PloS one.
2022; 17(10):e0276012. doi:
10.1371/journal.pone.0276012. [PMID: 36227855] - Wen-Cong Zhou, Lin Jia, Qi Deng, Yu-Guan Wen, De-Wei Shang, Xiao-Jia Ni, Yao-Xing Huang, Yao Liu, Han-Bing Zhao, Meng Yang, Guo-Yuan Dou. Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2021 Nov; 53(11):1422-1427. doi:
10.1016/j.dld.2021.02.020. [PMID: 33753003] - Michael Paland. Use of CytoSorb in cases of acute amitriptyline intoxication.
Journal of clinical pharmacy and therapeutics.
2021 Oct; 46(5):1476-1479. doi:
10.1111/jcpt.13373. [PMID: 33768556] - Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
The journal of trauma and acute care surgery.
2021 08; 91(2S Suppl 2):S89-S98. doi:
10.1097/ta.0000000000003259. [PMID: 33938511] - Rafaela F Rodrigues, Taila Kawano, Rodrigo V Placido, Lellis H Costa, Marcia H M C Podesta, Rafaela S Santos, Giovane Galdino, Carlos M Barros, Vanessa B Boralli. Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Pain physician.
2021 07; 24(4):E511-E520. doi:
NULL. [PMID: 34213877] - Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R Elghobashy. Green HPLC-DAD and HPTLC Methods for Quantitative Determination of Binary Mixture of Pregabalin and Amitriptyline Used for Neuropathic Pain Management.
Journal of chromatographic science.
2021 May; 59(6):536-547. doi:
10.1093/chromsci/bmab031. [PMID: 33778855] - Haidara Majid, Andreas Puzik, Tanja Maier, Daniel Eberhard, Anke Bartel, Hans-Christian Mueller, Bjoern B Burckhardt. Exploring the transmucosal permeability of cyclobenzaprine: A comparative preformulation by standardized and controlled ex vivo and in vitro permeation studies.
International journal of pharmaceutics.
2021 May; 601(?):120574. doi:
10.1016/j.ijpharm.2021.120574. [PMID: 33831487] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tai-Yu Chen, Nian-Sheng Tzeng, Yueh-Ming Tai. Amitriptyline-Induced Acute Kidney Injury and Acute Hepatitis: A Case Report.
American journal of therapeutics.
2021 Mar; 28(2):e256-e258. doi:
10.1097/mjt.0000000000001072. [PMID: 31567200] - Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan. Acid sphingomyelinase promotes SGK1-dependent vascular calcification.
Clinical science (London, England : 1979).
2021 02; 135(3):515-534. doi:
10.1042/cs20201122. [PMID: 33479769] - Ana P Costa, Michael H Court, Nicolas F Villarino, Neal S Burke, Katrina L Mealey. Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding.
Journal of veterinary pharmacology and therapeutics.
2021 Jan; 44(1):116-125. doi:
10.1111/jvp.12899. [PMID: 32744755] - Ehab Tousson, Ezar Hafez, Somia Zaki, Amani Gad, Rehab M Elgharabawy. Evaluation of the testicular protection conferred by damiana (Turnera diffusa Willd.) against amitriptyline-induced testicular toxicity, DNA damage and apoptosis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Dec; 132(?):110819. doi:
10.1016/j.biopha.2020.110819. [PMID: 33035829] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R El Ghobashy, Fatma F Abdallah. US FDA-validated green GC-MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids.
Bioanalysis.
2020 Nov; 12(21):1521-1533. doi:
10.4155/bio-2020-0217. [PMID: 33118848] - Rajkumar Chinnadurai, Smeeta Sinha, Aoife C Lowney, Mary Miller. Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
BMC nephrology.
2020 09; 21(1):403. doi:
10.1186/s12882-020-02067-2. [PMID: 32948131] - Mahin Hashemi Hedeshi, Omid Rezvani, Habib Bagheri. Silane-based modified papers and their extractive phase roles in a microfluidic platform.
Analytica chimica acta.
2020 Sep; 1128(?):31-41. doi:
10.1016/j.aca.2020.05.069. [PMID: 32825910] - Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine.
Journal of clinical pharmacy and therapeutics.
2020 Aug; 45(4):774-782. doi:
10.1111/jcpt.13165. [PMID: 32390248] - Hatice Aygun, Nursah Basol, Serdar Savas Gul. Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [99mTc]PYP Cardiac Scintigraphy with Electrocardiographic and Biochemical Findings.
Cardiovascular toxicology.
2020 08; 20(4):427-436. doi:
10.1007/s12012-020-09569-3. [PMID: 32219715] - Lucciana Recchi, Silvana Alvariza, Alejandro Benech, Natalie Ruiz, María José Estradé, Gonzalo Suarez, Nadia Crosignani. Pharmacokinetic study of oral amitriptyline in horses.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):381-384. doi:
10.1111/jvp.12870. [PMID: 32339314] - Hossein Salar Amoli, Yadollah Yamini, Hossein Darmani. Polyoxomolybdate368 /polyaniline nanocomposite as a novel fiber for solid-phase microextraction of antidepressant drugs in biological samples.
Journal of separation science.
2020 Jul; 43(13):2636-2645. doi:
10.1002/jssc.201901152. [PMID: 32277789] - Judith M Kampa, Mikail Sahin, Markus Slopianka, Marco Giampà, Hanna Bednarz, Rainer Ernst, Bjoern Riefke, Karsten Niehaus, Amol Fatangare. Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.
Toxicology letters.
2020 Jun; 325(?):43-50. doi:
10.1016/j.toxlet.2020.02.007. [PMID: 32092452] - Ana María Angel-Isaza, Luis Alfonso Bustamante-Cristancho, Francisco L Uribe-B. Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose.
The American journal of case reports.
2020 May; 21(?):e922206. doi:
10.12659/ajcr.922206. [PMID: 32447341] - E Kurtoglu Ozdes, B Z Altunkaynak, O G Deniz, F Ilkaya, H Guzel, A Kokcu. A stereological study of the effects of antidepressants on postmenopausal rat kidney.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2020 May; 95(4):262-267. doi:
10.1080/10520295.2019.1680865. [PMID: 31746664] - Fernanda Midori de Oliveira, Guilherme Luiz Scheel, Rodinei Augusti, César Ricardo Teixeira Tarley, Clésia Cristina Nascentes. Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine.
Analytica chimica acta.
2020 Apr; 1106(?):52-60. doi:
10.1016/j.aca.2020.01.061. [PMID: 32145855] - Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122069. doi:
10.1016/j.jchromb.2020.122069. [PMID: 32213465] - Ping-Fan Wu, Tian-You Zhou, Jiang-Shan Zhang. Severe amitriptyline poisoning treated successfully with combined hemoperfusion and hemodialysis.
Revista da Associacao Medica Brasileira (1992).
2020 Mar; 66(3):248-249. doi:
10.1590/1806-9282.66.3.248. [PMID: 32520138] - You Zhai, Lihua Wu, Yunliang Zheng, Minglan Wu, Yujie Huang, Qian Huang, Jianzhong Shentu, Qingwei Zhao, Jian Liu. Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions.
Drug design, development and therapy.
2020; 14(?):3131-3142. doi:
10.2147/dddt.s258173. [PMID: 32801649] - Maike Scherf-Clavel, Jasper Zebner, Leif Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients.
European journal of clinical pharmacology.
2020 Jan; 76(1):73-80. doi:
10.1007/s00228-019-02766-2. [PMID: 31641787] - Mackenzie C Morris, Farzaan Kassam, Aron Bercz, Nadine Beckmann, Fabian Schumacher, Erich Gulbins, Amy T Makley, Michael D Goodman. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury.
The Journal of surgical research.
2019 12; 244(?):1-8. doi:
10.1016/j.jss.2019.06.022. [PMID: 31279258] - Luana Mifsud Buhagiar, Carmel Sammut, Yana Chircop, Kersty Axisa, Nicolette Sammut Bartolo, Janis Vella Szijj, Anthony Serracino Inglott, Godfrey LaFerla. Practical liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of amitriptyline, nortriptyline and their hydroxy metabolites in human serum.
Biomedical chromatography : BMC.
2019 Dec; 33(12):e4679. doi:
10.1002/bmc.4679. [PMID: 31415098] - Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
Clinica chimica acta; international journal of clinical chemistry.
2019 Dec; 499(?):81-86. doi:
10.1016/j.cca.2019.09.001. [PMID: 31491368] - Nursah Basol, Hatice Aygun, Serdar Savas Gul. Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 11; 392(11):1447-1453. doi:
10.1007/s00210-019-01683-6. [PMID: 31273393] - Karen Robijns, Niels W Boone, Rob T P Jansen, Aldy W H M Kuypers, Cees Neef, Daan J Touw. Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project.
Clinica chimica acta; international journal of clinical chemistry.
2019 Nov; 498(?):6-10. doi:
10.1016/j.cca.2019.07.036. [PMID: 31374190] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - M Blaess, F Wenzel, R Csuk, H-P Deigner. Topical use of amitriptyline and linoleic acid to restore ceramide rheostat in atopic dermatitis lesions - a case report.
Die Pharmazie.
2019 09; 74(9):563-565. doi:
10.1691/ph.2019.9484. [PMID: 31484598] - Eirini Zilfidou, Abuzar Kabir, Kenneth G Furton, Victoria Samanidou. An improved fabric phase sorptive extraction method for the determination of five selected antidepressant drug residues in human blood serum prior to high performance liquid chromatography with diode array detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1125(?):121720. doi:
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Annales pharmaceutiques francaises.
2019 Sep; 77(5):418-425. doi:
10.1016/j.pharma.2019.06.004. [PMID: 31296331] - Markus Blaess, Hans-Peter Deigner. Derailed Ceramide Metabolism in Atopic Dermatitis (AD): A Causal Starting Point for a Personalized (Basic) Therapy.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20163967. [PMID: 31443157] - Abdullah Al Maruf, Alexandra Greenslade, Paul D Arnold, Chad Bousman. Antidepressant pharmacogenetics in children and young adults: A systematic review.
Journal of affective disorders.
2019 07; 254(?):98-108. doi:
10.1016/j.jad.2019.05.025. [PMID: 31112844] - S N Kondratenko, M I Savelyeva, V G Kukes, E V Shikh, E T Gneushev. Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation.
Bulletin of experimental biology and medicine.
2019 Jul; 167(3):356-362. doi:
10.1007/s10517-019-04526-9. [PMID: 31346879] - Wenpeng Zhang, Yue Ren, Ziqing Lin, Zheng Ouyang. High-Precision Quantitation of Biofluid Samples Using Direct Mass Spectrometry Analysis.
Analytical chemistry.
2019 06; 91(11):6986-6990. doi:
10.1021/acs.analchem.9b01694. [PMID: 31074609] - Asmahan Abu-Arish, Elvis Pandžić, Dusik Kim, Hsin Wei Tseng, Paul W Wiseman, John W Hanrahan. Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains.
The Journal of general physiology.
2019 06; 151(6):834-849. doi:
10.1085/jgp.201812143. [PMID: 31048413] - Robin Chapman, Martyn Harvey, Paul Davies, Zimei Wu, Grant Cave. Liposome supported peritoneal dialysis in rat amitriptyline exposure with and without intravenous lipid emulsion.
Journal of liposome research.
2019 Jun; 29(2):114-120. doi:
10.1080/08982104.2017.1403445. [PMID: 29141481] - Jing Wen, Yuan Shen, Min Zhang, Chao Wang, Yalan Xiang, Hualin Cai, Pingfei Fang, Huande Li. Dexamethasone changes the pharmacokinetics of amitriptyline and reduces its accumulation in rat brain: The roles of P-gp and cyp3a2.
Journal of pharmacological sciences.
2019 May; 140(1):54-61. doi:
10.1016/j.jphs.2019.04.007. [PMID: 31105024] - Haizea Ziarrusta, Anton Ribbenstedt, Leire Mijangos, Sergio Picart-Armada, Alex Perera-Lluna, Ailette Prieto, Urtzi Izagirre, Jonathan P Benskin, Maitane Olivares, Olatz Zuloaga, Nestor Etxebarria. Amitriptyline at an Environmentally Relevant Concentration Alters the Profile of Metabolites Beyond Monoamines in Gilt-Head Bream.
Environmental toxicology and chemistry.
2019 05; 38(5):965-977. doi:
10.1002/etc.4381. [PMID: 30702171] - Ara Koh, Kwan Cheol Pak, Hee Youn Choi, Sunae Ryu, Seung-Eun Choi, Ki Soon Kim, Kyun-Seop Bae, Hyeong-Seok Lim. Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline.
Journal of clinical pharmacology.
2019 04; 59(4):532-540. doi:
10.1002/jcph.1344. [PMID: 30452773] - Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith. Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods.
Inflammopharmacology.
2019 Apr; 27(2):387-396. doi:
10.1007/s10787-018-00551-8. [PMID: 30600474] - Gabrielle Pastenkos, Jonathan L Miller, Suzanne M Pritchard, Anthony V Nicola. Role of Sphingomyelin in Alphaherpesvirus Entry.
Journal of virology.
2019 03; 93(5):. doi:
10.1128/jvi.01547-18. [PMID: 30541840] - Mai A Zaafan, Ahmed R Haridy, Amr M Abdelhamid. Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 03; 392(3):279-286. doi:
10.1007/s00210-018-1586-1. [PMID: 30474696] - Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
International clinical psychopharmacology.
2019 03; 34(2):93-100. doi:
10.1097/yic.0000000000000250. [PMID: 30557209] - Haijing Zhu, Guangming Huang. High-throughput paper spray mass spectrometry via induced voltage.
Rapid communications in mass spectrometry : RCM.
2019 Feb; 33(4):392-398. doi:
10.1002/rcm.8336. [PMID: 30394606] - Mohammad Hassan Baig, Safikur Rahman, Gulam Rabbani, Mohd Imran, Khurshid Ahmad, Inho Choi. Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches.
International journal of molecular sciences.
2019 Feb; 20(3):. doi:
10.3390/ijms20030662. [PMID: 30717459] - Jana Meiners, Vittoria Palmieri, Robert Klopfleisch, Jana-Fabienne Ebel, Lukasz Japtok, Fabian Schumacher, Ayan Mohamud Yusuf, Katrin A Becker, Julia Zöller, Matthias Hose, Burkhard Kleuser, Dirk M Hermann, Richard N Kolesnick, Jan Buer, Wiebke Hansen, Astrid M Westendorf. Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
Frontiers in immunology.
2019; 10(?):1386. doi:
10.3389/fimmu.2019.01386. [PMID: 31275322] - Gudrun Hefner, Martina Hahn, Matthias Hohner, Sybille C Roll, Ansgar Klimke, Christoph Hiemke. QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients.
Pharmacopsychiatry.
2019 Jan; 52(1):38-43. doi:
10.1055/s-0044-102009. [PMID: 29466824] - Saylav Bora, Mümin Alper Erdoğan, Gürkan Yiğittürk, Oytun Erbaş, İsmet Parlak. The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats.
Cardiovascular toxicology.
2018 12; 18(6):547-556. doi:
10.1007/s12012-018-9466-y. [PMID: 29873021] - Mélanie Kremer, Ipek Yalcin, Yannick Goumon, Xavier Wurtz, Laurent Nexon, Dorothée Daniel, Salim Megat, Rhian A Ceredig, Carl Ernst, Gustavo Turecki, Virginie Chavant, Jean-François Théroux, Adrien Lacaud, Lauriane-Elisabeth Joganah, Vincent Lelievre, Dominique Massotte, Pierre-Eric Lutz, Ralf Gilsbach, Eric Salvat, Michel Barrot. A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2018 11; 38(46):9934-9954. doi:
10.1523/jneurosci.1004-18.2018. [PMID: 30249798] - Peng Zhu, Zhi Ye, Dong Guo, Zongping Xiong, Shiqiong Huang, Jun Guo, Wei Zhang, James E Polli, Honghao Zhou, Qing Li, Yan Shu. Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2).
Pharmaceutical research.
2018 Oct; 35(12):243. doi:
10.1007/s11095-018-2526-y. [PMID: 30361780] - Gyanesh M Tripathi, Jayantee Kalita, Usha K Misra. Role of glutamate and its receptors in migraine with reference to amitriptyline and transcranial magnetic stimulation therapy.
Brain research.
2018 10; 1696(?):31-37. doi:
10.1016/j.brainres.2018.05.046. [PMID: 29859974] - Laura L Giusto, Patricia M Zahner, Daniel A Shoskes. An evaluation of the pharmacotherapy for interstitial cystitis.
Expert opinion on pharmacotherapy.
2018 07; 19(10):1097-1108. doi:
10.1080/14656566.2018.1491968. [PMID: 29972328] - Josh J Wang, Eric Villeneuve, Sophie Gosselin, Susan C Smolinske, Lotte C G Hoegberg, Robert S Hoffman. Tsujikawa and Lipid Emulsion.
Anesthesia and analgesia.
2018 06; 126(6):2147-2148. doi:
10.1213/ane.0000000000002883. [PMID: 29762225] - Julia Ríos-Gómez, Beatriz Fresco-Cala, María Teresa García-Valverde, Rafael Lucena, Soledad Cárdenas. Carbon Nanohorn Suprastructures on a Paper Support as a Sorptive Phase.
Molecules (Basel, Switzerland).
2018 May; 23(6):. doi:
10.3390/molecules23061252. [PMID: 29794967] - S Otte, B Fischer, F Sayk. [Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication].
Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2018 05; 113(4):305-308. doi:
10.1007/s00063-017-0330-9. [PMID: 28785811] - Tejs Jansen, Lotte C G Hoegberg, Thomas Eriksen, Christian Haarmark, Kim Dalhoff, Bo Belhage. Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion.
Basic & clinical pharmacology & toxicology.
2018 Apr; 122(4):442-447. doi:
10.1111/bcpt.12931. [PMID: 29117643] - Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki Kuno, Kiyonobu Nishikawa. Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.
Anesthesia and analgesia.
2018 04; 126(4):1159-1169. doi:
10.1213/ane.0000000000002707. [PMID: 29239964] - Amanda L Maciel, Helena M Abelaira, Airam B de Moura, Thays G de Souza, Thayse Rosa, Danyela Matos, Talita Tuon, Leandro Garbossa, Ana Paula Strassi, Maria Eduarda Fileti, Mariana P Goldim, Khiany Mathias, Fabricia Petronilho, João Quevedo, Gislaine Z Réus. Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events.
Brain research bulletin.
2018 03; 137(?):204-216. doi:
10.1016/j.brainresbull.2017.12.005. [PMID: 29253605] - Nur Jaharat Lubna, Takeshi Wada, Yuji Nakamura, Koki Chiba, Xin Cao, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Yoshioki Satoh, Atsushi Sugiyama. Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.
Cardiovascular toxicology.
2018 02; 18(1):91-98. doi:
10.1007/s12012-017-9417-z. [PMID: 28616803] - J Depciuch, M Parlinska-Wojtan. Qualitative and quantitative changes in phospholipids and proteins investigated by spectroscopic techniques in olfactory bulbectomy animal depression model.
Journal of pharmaceutical and biomedical analysis.
2018 Jan; 148(?):24-31. doi:
10.1016/j.jpba.2017.09.016. [PMID: 28950213] - Yao Liu, Lin Jia, Shu-Man Jiang, Dong-Yun Chen, Jiang-Shun Song, Jian Xu. Serotonin Transporter Gene (SLC6A4) Polymorphism May Be Associated with Chinese Globus Pharyngeus and Its Antidepressant Effects.
Digestion.
2018; 97(2):146-153. doi:
10.1159/000484202. [PMID: 29310115] - Liat Adar, William Zarycranski, Jill B Conner, Jeffrey Dragone, Lindsay Janka, Laura Rabinovich-Guilatt. Bioequivalence of cyclobenzaprine hydrochloride extended-release capsule taken intact or sprinkled over applesauce
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International journal of clinical pharmacology and therapeutics.
2017 Dec; 55(12):931-938. doi:
10.5414/cp203059. [PMID: 29092731] - Aijie He, Dehua Song, Lei Zhang, Chen Li. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis.
The journal of headache and pain.
2017 Dec; 18(1):26. doi:
10.1186/s10194-017-0720-7. [PMID: 28220376] - Sazlinda Kamaruzaman, Mohd Marsin Sanagi, Noorfatimah Yahaya, Wan Aini Wan Ibrahim, Salasiah Endud, Wan Nazihah Wan Ibrahim. Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography-mass spectrometry for the determination of antidepressant drugs in biological fluids.
Journal of separation science.
2017 Nov; 40(21):4222-4233. doi:
10.1002/jssc.201700549. [PMID: 28837263] - Takeshi Nishimura, Hayato Maruguchi, Atsunori Nakao, Shinichi Nakayama. Unusual complications from amitriptyline intoxication.
BMJ case reports.
2017 Oct; 2017(?):. doi:
10.1136/bcr-2017-219257. [PMID: 29018010] - Katia Sayyed, Marc Le Vee, Ziad Abdel-Razzak, Olivier Fardel. Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Oct; 44(?):27-35. doi:
10.1016/j.tiv.2017.06.014. [PMID: 28629854] - Weerawan Boonlert, Hattaya Benya-Aphikul, Jariya Umka Welbat, Ratchanee Rodsiri. Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels.
Nutrients.
2017 Aug; 9(9):. doi:
10.3390/nu9090931. [PMID: 28837087] - L Vrignaud, C Simon, M-S Agier, T Bejan-Angoulvant, E Bouquet, F Beau-Salinas, A-P Jonville-Béra. [Drugs news].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2017 Aug; 24(8):783-787. doi:
10.1016/j.arcped.2017.05.008. [PMID: 28668216] - Khandker Mohammad Nurus Sabah, Abdul Wadud Chowdhury, Mohammad Shahidul Islam, Bishnu Pada Saha, Syed Rezwan Kabir, Shamima Kawser. Amitriptyline-induced ventricular tachycardia: a case report.
BMC research notes.
2017 Jul; 10(1):286. doi:
10.1186/s13104-017-2615-8. [PMID: 28709467] - Yuri A Saito, G Richard Locke, Ann E Almazar, Ernest P Bouras, Colin W Howden, Brian E Lacy, John K DiBaise, Charlene M Prather, Bincy P Abraham, Hashem B El-Serag, Paul Moayyedi, Linda M Herrick, Lawrence A Szarka, Michael Camilleri, Frank A Hamilton, Cathy D Schleck, Katherine E Tilkes, Alan R Zinsmeister, Nicholas J Talley. Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.
The American journal of gastroenterology.
2017 Jun; 112(6):903-909. doi:
10.1038/ajg.2017.52. [PMID: 28291238] - Tejs Jansen, Henrik Petersen, Cecilie M Malskaer, Charlotte Gabel-Jensen, Kim Dalhoff, Thomas Eriksen, Bo Belhage, Lotte C G Hoegberg. Activated Charcoal Haemoperfusion in the Treatment of Experimental Amitriptyline Poisoning in Pigs - The Effect on Amitriptyline Plasma Concentration and Haemodynamic Parameters.
Basic & clinical pharmacology & toxicology.
2017 May; 120(5):491-497. doi:
10.1111/bcpt.12704. [PMID: 27863000] - Philippe Le Fevre, Mark Gosling, Keyur Acharya, Andrew Georgiou. Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol.
BMJ case reports.
2017 Mar; 2017(?):. doi:
10.1136/bcr-2016-218281. [PMID: 28254832] - Michele A Glinn, Andrew J Lickteig, Luke Weber, Sherri Recer, Matthew Salske, Audrey Harvey, Brian Rappold, Julie Stensland, Patrick Bell. Urinary Concentrations of Topically Administered Pain Medications.
Journal of analytical toxicology.
2017 Mar; 41(2):127-133. doi:
10.1093/jat/bkw110. [PMID: 28376226] - Haizea Ziarrusta, Leire Mijangos, Urtzi Izagirre, Merle M Plassmann, Jonathan P Benskin, Eneritz Anakabe, Maitane Olivares, Olatz Zuloaga. Bioconcentration and Biotransformation of Amitriptyline in Gilt-Head Bream.
Environmental science & technology.
2017 02; 51(4):2464-2471. doi:
10.1021/acs.est.6b05831. [PMID: 28106990] - Zofia Tylutki, Sebastian Polak. A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application.
Scientific reports.
2017 01; 7(?):39494. doi:
10.1038/srep39494. [PMID: 28051093] - Akiko Mikami, Satoko Hori, Hisakazu Ohtani, Yasufumi Sawada. Analysis of the Mechanism of Prolonged Persistence of Drug Interaction between Terbinafine and Amitriptyline or Nortriptyline.
Biological & pharmaceutical bulletin.
2017; 40(7):1010-1020. doi:
10.1248/bpb.b16-01004. [PMID: 28674244] - Chun-Han Chen, Tse-Hung Huang, Ahmed O Elzoghby, Pei-Wen Wang, Chia-Wen Chang, Jia-You Fang. Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification.
International journal of nanomedicine.
2017; 12(?):8071-8083. doi:
10.2147/ijn.s143370. [PMID: 29138563] - Maryam Shamsayei, Yadollah Yamini, Hamid Asiabi. Polythiophene/graphene oxide nanostructured electrodeposited coating for on-line electrochemically controlled in-tube solid-phase microextraction.
Journal of chromatography. A.
2016 Dec; 1475(?):8-17. doi:
10.1016/j.chroma.2016.11.003. [PMID: 27836227] - Dimitri Beeckman, Nele Van Damme, Lisette Schoonhoven, Aurélie Van Lancker, Jan Kottner, Hilde Beele, Mikel Gray, Sue Woodward, Mandy Fader, Karen Van den Bussche, Ann Van Hecke, Dorien De Meyer, Sofie Verhaeghe. Interventions for preventing and treating incontinence-associated dermatitis in adults.
The Cochrane database of systematic reviews.
2016 11; 11(?):CD011627. doi:
10.1002/14651858.cd011627.pub2. [PMID: 27841440] - Kaylee R Mastrianni, L Andrew Lee, William E Brewer, Nagaraju Dongari, Michael Barna, Stephen L Morgan. Variations in enzymatic hydrolysis efficiencies for amitriptyline and cyclobenzaprine in urine.
Journal of analytical toxicology.
2016 Nov; 40(9):732-737. doi:
10.1093/jat/bkw062. [PMID: 27405366] - Ana Laura Albertoni Giraldes, Reinaldo Salomão, Plinio da Cunha Leal, Milena Karina Coló Brunialti, Rioko Kimiko Sakata. Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.
International journal of rheumatic diseases.
2016 Oct; 19(10):946-953. doi:
10.1111/1756-185x.12904. [PMID: 27309886] - Matthew J Snyder, Lawrence M Gibbs, Tammy J Lindsay. Treating Painful Diabetic Peripheral Neuropathy: An Update.
American family physician.
2016 Aug; 94(3):227-34. doi:
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