Spirapril hydrochloride (BioDeep_00000791602)
代谢物信息卡片
Spirapril hydrochloride
化学式: C22H31ClN2O5S2 (502.1363)
中文名称: 盐酸螺普利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3.Cl
InChI: InChI=1S/C22H30N2O5S2.ClH/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - I N Medvedev. [A comparative analysis of normodipin and spirapril effects on intravascular activity of platelets in patients with metabolic syndrome].
Terapevticheskii arkhiv.
2007; 79(10):25-7. doi:
". [PMID: 18154140] - M N Mamedov, N V Kiseleva. [Rational approach to selection of antihypertensive therapy in persons with metabolic syndrome: efficacy of monotherapy with spirapril and its combination with retard form of nifedipine].
Kardiologiia.
2006; 46(9):26-30. doi:
. [PMID: 17047619] - O L Barbarash, S A Smakotina, N V Kondrikova. [Clinical application of spirapril in patients with arterial hypertension combined with chronic obstructive pulmonary disease].
Kardiologiia.
2006; 46(8):14-7. doi:
". [PMID: 17047595] - M V Leonova, M A Demidova, A V Tarasov, Iu B Belousov. [Comparative efficacy and safety of contemporary Angiotensin converting enzyme inhibitors moexipril and spirapril in women with postmenopausal metabolic syndrome].
Kardiologiia.
2006; 46(1):43-9. doi:
. [PMID: 16474309] - Michael Schürer, Stefan Amschler, Hans-Ulrich Schulz, Harald F Schäfer. Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry.
Arzneimittel-Forschung.
2003; 53(5):307-13. doi:
10.1055/s-0031-1297114. [PMID: 12854357] - Martin Haas, Zdenka Leko-Mohr, Christoph Erler, Gert Mayer. Antiproteinuric versus antihypertensive effects of high-dose ACE inhibitor therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2002 Sep; 40(3):458-63. doi:
10.1053/ajkd.2002.34883. [PMID: 12200795] - Alexei V Muravyov, Herbert J Meiselman, Vladimir V Yakusevich, Adrei V Zamishlayev. Effects of antihypertensive therapy on hemorheological profiles in female hypertensive patients with initially low or high whole blood viscosity.
Clinical hemorheology and microcirculation.
2002; 26(2):125-35. doi:
NULL. [PMID: 12082261] - L J Petersen, J R Petersen, U Talleruphuus, M L Møller, S D Ladefoged, J Mehlsen, H A Jensen. A randomized and double-blind comparison of isradipine and spirapril as monotherapy and in combination on the decline in renal function in patients with chronic renal failure and hypertension.
Clinical nephrology.
2001 May; 55(5):375-83. doi:
NULL. [PMID: 11393383] - H L Elliot. [The ACE inhibitor spirapril in chronic renal failure, hypertension and diabetic nephropathy].
Terapevticheskii arkhiv.
2000; 72(10):78-82. doi:
NULL. [PMID: 11220886] - V V Iakusevich, M E Mozheĭko, Sh Kh Paliutin, M Iu Berezina, S Iu Martsevich, S A Shal'nova, A D Deev, N P Kutishenko, E V Alimova, I P Koniakhina, Iu E Semenova. [Spirapril - a new long-acting ACE inhibitor: efficacy and safety in patients with arterial hypertension in combination with diabetes mellitus and impaired kidney function].
Terapevticheskii arkhiv.
2000; 72(10):82-6. doi:
NULL. [PMID: 11220887] - B Fabris, R Candido, L Armini, F Fischetti, M Calci, M Bardelli, M Fazio, L Campanacci, R Carretta. Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats.
Journal of hypertension.
1999 Dec; 17(12 Pt 2):1925-31. doi:
10.1097/00004872-199917121-00023. [PMID: 10703891] - K Hayduk, H Kraul. Efficacy and safety of spirapril in mild-to-moderate hypertension.
Journal of cardiovascular pharmacology.
1999 Aug; 34 Suppl 1(?):S19-23. doi:
10.1097/00005344-199908001-00004. [PMID: 10499560] - A G Jardine, H L Elliott. ACE inhibition in chronic renal failure and in the treatment of diabetic nephropathy: focus on spirapril.
Journal of cardiovascular pharmacology.
1999 Aug; 34 Suppl 1(?):S31-4. doi:
10.1097/00005344-199908001-00006. [PMID: 10499562] - J Shohat, C Wittenberg, A Erman, J Rosenfeld, G Boner. Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension.
Scandinavian journal of urology and nephrology.
1999 Feb; 33(1):57-62. doi:
10.1080/003655999750016294. [PMID: 10100366] - A A Parulekar, Z S Hakim, D D Santani, R K Goyal. Effect of chronic treatment with spirapril on biochemical parameters in streptozotocin-diabetic and spontaneously hypertensive rats.
Indian journal of experimental biology.
1997 Nov; 35(11):1182-6. doi:
NULL. [PMID: 9567746] - S A van den Broek, P A de Graeff, D J van Veldhuisen, W H van Gilst, H Hillege, H Wesseling, K I Lie. Clinical and neurohumoral differences between spirapril and captopril in mild to moderate chronic congestive heart failure.
Journal of cardiac failure.
1997 Sep; 3(3):165-71. doi:
10.1016/s1071-9164(97)90012-9. [PMID: 9330124] - C Guitard, F W Lohmann, R Alfiero, M Ruina, V Alvisi. Comparison of efficacy of spirapril and enalapril in control of mild-to-moderate hypertension.
Cardiovascular drugs and therapy.
1997 Jul; 11(3):449-57. doi:
10.1023/a:1007797405850. [PMID: 9310273] - T Hakamäki, A Lehtonen. Metabolic effects of spirapril and atenolol: results from a randomized, long-term study.
International journal of clinical pharmacology and therapeutics.
1997 Jun; 35(6):227-30. doi:
NULL. [PMID: 9208336] - E R Maccariello, V Genelhu de Abreu Fagundes, E A Francischetti. The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy.
American journal of hypertension.
1997 May; 10(5 Pt 1):541-5. doi:
10.1016/s0895-7061(97)00029-0. [PMID: 9160765] - G Gleerup, J R Petersen, J Mehlsen, K Winther. Effect of spirapril and hydrochlorothiazide on platelet function and euglobulin clot lysis time in patients with mild hypertension.
Angiology.
1996 Oct; 47(10):951-5. doi:
10.1177/000331979604701003. [PMID: 8873580] - E Bellissant, D Annane, E Pussard, C Thuillez, J F Giudicelli. Systemic, pulmonary, brachial, renal and hepato-splanchnic hemodynamic effects of spirapril in severe congestive heart failure.
Fundamental & clinical pharmacology.
1996; 10(2):127-35. doi:
10.1111/j.1472-8206.1996.tb00155.x. [PMID: 8737955] - S A van den Broek, P A de Graeff, A J Smit, A R Girbes, Journée, W H van Gilst, H Hillege, D J van Veldhuisen, H Wesseling, K I Lie. Effects of spirapril and captopril on regional blood flow in chronic congestive heart failure: a comparison between a short- and a long-acting angiotensin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology.
1995 Jan; 25(1):105-12. doi:
10.1097/00005344-199501000-00017. [PMID: 7723338] - C C Haufe, B Sierakowski, U Jansa, G Stein. [Kidney function in hypertensive patients with chronic renal failure treated with the dual eliminated ACE-inhibitor spirapril].
Medizinische Klinik (Munich, Germany : 1983).
1994 Aug; 89(8):416-20. doi:
NULL. [PMID: 7968874] - C Sala, A Monopoli, C Casati, G Ardeleani, E Ongini, A Zanchetti, A Morganti. Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
1994 May; 23(5):703-8. doi:
10.1097/00005344-199405000-00003. [PMID: 7521451] - P Grass, C Gerbeau, K Kutz. Spirapril: pharmacokinetic properties and drug interactions.
Blood pressure. Supplement.
1994; 2(?):7-13. doi:
NULL. [PMID: 8061850] - G Stein, B Sierakowski, P Grass, C C Haufe, U Jansa, G Weidinger. Pharmacokinetics of spirapril and spiraprilat in patients with chronic renal failure.
Blood pressure. Supplement.
1994; 2(?):47-53. doi:
NULL. [PMID: 8061846] - G Stein, B Sierakowski, U Jansa, C C Haufe. Spirapril in chronic renal failure.
Blood pressure. Supplement.
1994; 2(?):54-60. doi:
NULL. [PMID: 8061847] - P A Meredith, P Grass, C Guitard, H L Elliott. Pharmacokinetics of spirapril in renal impairment.
Blood pressure. Supplement.
1994; 2(?):14-9. doi:
NULL. [PMID: 8061840] - C Wittenberg, A Erman, J Shohat, G Boner. Concomitant administration of isradipine and spirapril prevents reduction of renal function induced by acute administration of spirapril in patients with reduced renal function.
Blood pressure. Supplement.
1994; 1(?):48-9. doi:
NULL. [PMID: 8205299] - K Nørgaard, T Jensen, P Christensen, B Feldt-Rasmussen. A comparison of spirapril and isradipine in patients with diabetic nephropathy and hypertension.
Blood pressure.
1993 Dec; 2(4):301-8. doi:
10.3109/08037059309077172. [PMID: 8173700] - S Naito, M Ito, I Sekine, M Ito, T Hirano, K Iwasaki, M Niwa. Femoral head necrosis and osteopenia in stroke-prone spontaneously hypertensive rats (SHRSPs).
Bone.
1993 Sep; 14(5):745-53. doi:
10.1016/8756-3282(93)90206-p. [PMID: 8268049] - G P Reams, A Lau, V Knaus, J H Bauer. Short- and long-term effects of spirapril on renal hemodynamics in patients with essential hypertension.
Journal of clinical pharmacology.
1993 Apr; 33(4):348-53. doi:
10.1002/j.1552-4604.1993.tb04668.x. [PMID: 8473550] - R Morishita, J Higaki, M Nagano, F Nakamura, N Tomita, Y Zhao, H Mikami, M Miyazaki, T Ogihara. Discrepancy between renin mRNA and plasma renin level in angiotensin-converting enzyme inhibitor-treated rats.
Clinical and experimental pharmacology & physiology.
1993 Jan; 20(1):15-20. doi:
10.1111/j.1440-1681.1993.tb01497.x. [PMID: 8381736] - A H van den Meiracker, A J Man in 't Veld, P J Admiraal, H J Ritsema van Eck, F Boomsma, F H Derkx, M A Schalekamp. Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?.
Journal of hypertension.
1992 Aug; 10(8):803-12. doi:
NULL. [PMID: 1325513] - M Hossein-Nia, A H Surve, R Weglein, C Gerbeau, D W Holt. Radioimmunoassays for spirapril and its active metabolite spiraprilate: performance and application.
Therapeutic drug monitoring.
1992 Jun; 14(3):234-42. doi:
10.1097/00007691-199206000-00010. [PMID: 1384174] - S A van den Broek, A van Bruggen, P A de Graeff, H Hillege, W H van Gilst, H Wesseling, K I Lie. The acute hemodynamic, hormonal, and pharmacokinetic properties of oral spirapril in patients with moderate to severe heart failure.
Journal of cardiovascular pharmacology.
1991 Oct; 18(4):614-21. doi:
10.1097/00005344-199110000-00019. [PMID: 1724540] - R Morishita, J Higaki, H Okunishi, T Kawamoto, K Ishii, F Nakamura, K Katahira, M Nagano, H Mikami, M Miyazaki. Effect of long-term treatment with an angiotensin-converting enzyme inhibitor on the renin-angiotensin system in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology.
1991 Oct; 18(10):685-90. doi:
10.1111/j.1440-1681.1991.tb01381.x. [PMID: 1764812] - H Okunishi, T Kawamoto, Y Kurobe, Y Oka, K Ishii, T Tanaka, M Miyazaki. Pathogenetic role of vascular angiotensin-converting enzyme in the spontaneously hypertensive rat.
Clinical and experimental pharmacology & physiology.
1991 Sep; 18(9):649-59. doi:
10.1111/j.1440-1681.1991.tb01639.x. [PMID: 1659958] - B F Johnson, J Wilson, J Johnson, J Flemming. Digoxin pharmacokinetics and spirapril, a new ace inhibitor.
Journal of clinical pharmacology.
1991 Jun; 31(6):527-30. doi:
10.1002/j.1552-4604.1991.tb03732.x. [PMID: 1880218] - R P Hof, A Hof-Miyashita, J P Evenou. Hemodynamic effects of a new angiotensin converting enzyme inhibitor, spirapril, in sodium-loaded and sodium-depleted rabbits.
Journal of cardiovascular pharmacology.
1987 Nov; 10(5):599-606. doi:
10.1097/00005344-198711000-00017. [PMID: 2447412] - E J Sybertz, R W Watkins, H S Ahn, T Baum, P La Rocca, J Patrick, F Leitz. Pharmacologic, metabolic, and toxicologic profile of spirapril (SCH 33844), a new angiotensin converting inhibitor.
Journal of cardiovascular pharmacology.
1987; 10 Suppl 7(?):S105-8. doi:
10.1097/00005344-198706107-00020. [PMID: 2485040]
