Tocladesine (BioDeep_00000791178)

   


代谢物信息卡片


Tocladesine

化学式: C10H11ClN5O6P (363.01354660000004)
中文名称: 8-氯腺苷-3,5-环状磷酸钠盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Cl)N)O)OP(=O)(O1)O
InChI: InChI=1S/C10H11ClN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1

描述信息

C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D000970 - Antineoplastic Agents
D007155 - Immunologic Factors

同义名列表

2 个代谢物同义名

Tocladesine; 8-Cl-cAMP



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Silvia Cristina Czuchlej, María Clara Volonteri, María Florencia Scaia, Nora Raquel Ceballos. Characterization of StAR protein of Rhinella arenarum (Amphibia, Anura). General and comparative endocrinology. 2020 09; 295(?):113535. doi: 10.1016/j.ygcen.2020.113535. [PMID: 32535173]
  • Jordan J S VerPlank, Sudarsanareddy Lokireddy, Jinghui Zhao, Alfred L Goldberg. 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 2019 03; 116(10):4228-4237. doi: 10.1073/pnas.1809254116. [PMID: 30782827]
  • Limin Su, Liying Liu, Yingli Jia, Lei Lei, Jiangfeng Liu, Shuai Zhu, Hong Zhou, Ruoyun Chen, Hua Ann Jenny Lu, Baoxue Yang. Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation. Kidney international. 2017 12; 92(6):1404-1418. doi: 10.1016/j.kint.2017.04.013. [PMID: 28709639]
  • Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yue Qi, Yun Fan, Zhiqiang Peng. Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms. Renal failure. 2017 Nov; 39(1):652-659. doi: 10.1080/0886022x.2017.1361839. [PMID: 28805491]
  • Yu-Feng Song, Christer Hogstrand, Chuan-Chuan Wei, Kun Wu, Ya-Xiong Pan, Zhi Luo. Endoplasmic reticulum (ER) stress and cAMP/PKA pathway mediated Zn-induced hepatic lipolysis. Environmental pollution (Barking, Essex : 1987). 2017 Sep; 228(?):256-264. doi: 10.1016/j.envpol.2017.05.046. [PMID: 28549333]
  • Cuicui Zhuang, Dawei Liu, Xu Yang, Haoran Wang, Lulu Han, Yanfei Li. The immunotoxicity of aluminum trichloride on rat peritoneal macrophages via β2-adrenoceptors/cAMP pathway acted by norepinephrine. Chemosphere. 2016 Apr; 149(?):34-40. doi: 10.1016/j.chemosphere.2016.01.084. [PMID: 26844663]
  • Me El-Mesery, Mm Al-Gayyar, Ha Salem, Mm Darweish, Am El-Mowafy. Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides. Cell division. 2009 Apr; 4(?):6. doi: 10.1186/1747-1028-4-6. [PMID: 19341447]
  • S K Robbins, S Houlbrook, J D Priddle, A L Harris. 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs. Cancer chemotherapy and pharmacology. 2001 Dec; 48(6):451-8. doi: 10.1007/s00280-001-0379-1. [PMID: 11800025]
  • V Gandhi, M Ayres, R G Halgren, N L Krett, R A Newman, S T Rosen. 8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer research. 2001 Jul; 61(14):5474-9. doi: NULL. [PMID: 11454694]
  • N N Davydova, J Glisic, I W Wainer. Determination of 8-chloroadenosine 3',5'-monophosphate in dog plasma by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis. 2001 Mar; 24(5-6):857-62. doi: 10.1016/s0731-7085(00)00553-7. [PMID: 11248478]
  • D J Propper, M P Saunders, A J Salisbury, L Long, K J O'Byrne, J P Braybrooke, M Dowsett, M Taylor, D C Talbot, T S Ganesan, A L Harris. Phase I study of the novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: toxicity, hormonal, and immunological effects. Clinical cancer research : an official journal of the American Association for Cancer Research. 1999 Jul; 5(7):1682-9. doi: NULL. [PMID: 10430069]
  • R G Halgren, A E Traynor, S Pillay, J L Zell, K F Heller, N L Krett, S T Rosen. 8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine. Blood. 1998 Oct; 92(8):2893-8. doi: NULL. [PMID: 9763575]
  • Z Juranić, S Radulović, J Joksimović, I Juranić. The mechanism of 8-Cl-cAMP action. Journal of experimental & clinical cancer research : CR. 1998 Sep; 17(3):269-75. doi: NULL. [PMID: 9894761]
  • K Noguchi, T Murata, Y S Cho-Chung. 8-chloroadenosine 3',5'-monophosphate (8-Cl-cAMP) selectively eliminates protein kinase A type I to induce growth inhibition in c-ras-transformed fibroblasts. European journal of cancer (Oxford, England : 1990). 1998 Jul; 34(8):1260-7. doi: 10.1016/s0959-8049(98)00051-3. [PMID: 9849489]
  • D Cassarà, A Ginestra, V Dolo, M Miele, G Caruso, G Lucania, M L Vittorelli. Modulation of vesicle shedding in 8701 BC human breast carcinoma cells. Journal of submicroscopic cytology and pathology. 1998 Jan; 30(1):45-53. doi: NULL. [PMID: 9530851]
  • G Tortora, G di Isernia, C Sandomenico, R Bianco, G Pomatico, S Pepe, A R Bianco, F Ciardiello. Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells. Cancer research. 1997 Nov; 57(22):5107-11. doi: NULL. [PMID: 9371510]
  • N L Krett, J L Zell, R G Halgren, S Pillay, A E Traynor, S T Rosen. Cyclic adenosine-3',5'-monophosphate-mediated cytotoxicity in steroid sensitive and resistant myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research. 1997 Oct; 3(10):1781-7. doi: NULL. [PMID: 9815564]
  • K S Graebert, H Bauch, W Neumüller, K Brix, V Herzog. Epithelial folding in vitro: studies on the cellular mechanism underlying evagination of thyrocyte monolayers. Experimental cell research. 1997 Feb; 231(1):214-25. doi: 10.1006/excr.1996.3456. [PMID: 9056429]
  • J Cummings, S P Langdon, A A Ritchie, D J Burns, J Mackay, P Stockman, R C Leonard, W R Miller. Pharmacokinetics, metabolism and tumour disposition of 8-chloroadenosine 3',5'-monophosphate in breast cancer patients and xenograft bearing mice. Annals of oncology : official journal of the European Society for Medical Oncology. 1996 Mar; 7(3):291-6. doi: 10.1093/oxfordjournals.annonc.a010574. [PMID: 8740794]
  • J Cummings, R C Leonard, W R Miller. Sensitive determination of 8-chloroadenosine 3',5'-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1994 Aug; 658(1):183-8. doi: 10.1016/0378-4347(94)00200-2. [PMID: 7952122]
  • N Borsellino, M Crescimanno, V Leonardi, N D'Alessandro. Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines. Pharmacological research. 1994 Jul; 30(1):81-90. doi: 10.1016/1043-6618(94)80090-1. [PMID: 7831198]
  • Z Han, D Chatterjee, J H Wyche. Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP. The Journal of pharmacology and experimental therapeutics. 1993 May; 265(2):790-4. doi: NULL. [PMID: 8388460]
  • C A Lange-Carter, J J Vuillequez, A M Malkinson. 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer research. 1993 Jan; 53(2):393-400. doi: NULL. [PMID: 8380255]
  • C W Taylor, L C Yeoman. Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anti-cancer drugs. 1992 Oct; 3(5):485-91. doi: 10.1097/00001813-199210000-00007. [PMID: 1450443]
  • F Ciardiello, G Tortora, N Kim, T Clair, S Ally, D S Salomon, Y S Cho-Chung. 8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. The Journal of biological chemistry. 1990 Jan; 265(2):1016-20. doi: NULL. [PMID: 1688548]
  • G Tortora, F Ciardiello, S Ally, T Clair, D S Salomon, Y S Cho-Chung. Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts. FEBS letters. 1989 Jan; 242(2):363-7. doi: 10.1016/0014-5793(89)80502-2. [PMID: 2536620]
  • J P Miller, K H Boswell, R B Meyer, L F Christensen, R K Robins. Synthesis and enzymatic and inotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate. Journal of medicinal chemistry. 1980 Mar; 23(3):242-51. doi: 10.1021/jm00177a007. [PMID: 6245211]