Mepivacaine hydrochloride (BioDeep_00000790638)
代谢物信息卡片
Mepivacaine hydrochloride
化学式: C15H23ClN2O (282.1498818)
中文名称: 甲哌卡因盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:6760
- KEGGdrug: D00738
- PubChem: 66070
- ChEMBL: CHEMBL1200440
- MeSH: Mepivacaine
- CAS: 16452-56-5
- CAS: 1722-62-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Leanda Livesey, Fred DeGraves, Courtney Allred, Lindsey Boone, John Schumacher. The efficacy of injecting a distillate of the pitcher plant (Sarraceniaceae) adjacent to the palmar digital nerves of horses to ameliorate lameness caused by digital pain.
Journal of equine veterinary science.
2024 Feb; 133(?):104974. doi:
10.1016/j.jevs.2023.104974. [PMID: 38145776] - Catina Frydendal, Katrine B Nielsen, Lise C Berg, Gaby van Galen, Ditte M T Adler, Stine M Andreassen, Stine Jacobsen. Influence of clinical and experimental intra-articular inflammation on neutrophil gelatinase-associated lipocalin concentrations in horses.
Veterinary surgery : VS.
2021 Apr; 50(3):641-649. doi:
10.1111/vsu.13582. [PMID: 33522003] - Elizabeth Jabbour, Carsten Fütterer, Sebastian Zach, Anna-Isabelle Kälsch, Michael Keese, Nuh N Rahbari, Bernhard K Krämer, Kay G Schwenke. Implantation of a peritoneal dialysis catheter in patients with ESRD using local anesthesia and Remifentanil.
PloS one.
2021; 16(11):e0259351. doi:
10.1371/journal.pone.0259351. [PMID: 34735524] - Jose L Mendez-Angulo, Maria M Granados, Rolf Modesto, Juan M Serrano-Rodriguez, Francisco J Funes, Setefilla Quiros, Rafael J Gomez-Villamandos, Sara Zaldívar, Troy N Trumble. Systemic and local effects of lidocaine or mepivacaine when used for intravenous regional anaesthesia of the distal limb in standing sedated horses.
Equine veterinary journal.
2020 Sep; 52(5):743-751. doi:
10.1111/evj.13236. [PMID: 31972065] - Eric M Yung, Faraj W Abdallah, Carla Todaro, Emily Spence, Andrew Grant, Richard Brull. Optimal local anesthetic regimen for saddle block in ambulatory anorectal surgery: an evidence-based systematic review.
Regional anesthesia and pain medicine.
2020 09; 45(9):733-739. doi:
10.1136/rapm-2020-101603. [PMID: 32699103] - Drew W Koch, Jeremiah T Easley, Jennifer N Hatzel, Brad B Nelson, Dean A Hendrickson, Jason Bruemmer, Eileen S Hackett. Prospective randomized investigation of topical anesthesia during unilateral laparoscopic ovariectomy in horses.
Veterinary surgery : VS.
2020 Jun; 49 Suppl 1(?):O54-O59. doi:
10.1111/vsu.13264. [PMID: 31225655] - M Abass, S Picek, J F G Garzón, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release.
Equine veterinary journal.
2018 Nov; 50(6):733-738. doi:
10.1111/evj.12947. [PMID: 29660154] - J-C-A Ferreira, I-S Catunda, B-C-E Vasconcelos, K-A-A da Silva, E-F-C Nogueira, E-E Vidal. Evaluation of the plasmatic level of mepivacaine in different anatomical regions.
Medicina oral, patologia oral y cirugia bucal.
2018 Jul; 23(4):e493-e497. doi:
10.4317/medoral.22374. [PMID: 29924762] - Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler. Viscosupplementation for Hip Osteoarthritis: A Systematic Review and Meta-Analysis of the Efficacy on Pain and Disability, and the Occurrence of Adverse Events.
Archives of physical medicine and rehabilitation.
2018 03; 99(3):574-583.e1. doi:
10.1016/j.apmr.2017.07.010. [PMID: 28803906] - Ruo-Wang Duan, Jiong Song, Yu-Ping Li, Chun-Gen Xing. A novel LC-MS/MS method for mepivacaine determination and pharmacokinetic study in a single-dose two-period crossover in healthy subjects.
Artificial cells, nanomedicine, and biotechnology.
2017 Dec; 45(8):1605-1611. doi:
10.1080/21691401.2016.1267013. [PMID: 27976931] - Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt. Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity.
Clinical toxicology (Philadelphia, Pa.).
2017 Jul; 55(6):603-607. doi:
10.1080/15563650.2017.1294693. [PMID: 28489457] - V Mojica, D Nieuwveld, A E Herrera, G Mestres, A M López, X Sala-Blanch. Axillary brachial plexus block duration with mepivacaine in patients with chronic renal failure. Case-control study.
Revista espanola de anestesiologia y reanimacion.
2017 Apr; 64(4):192-197. doi:
10.1016/j.redar.2016.09.011. [PMID: 28017345] - H C Scarparo, R N Maia, Ea Dos Santos Filho, Ecs Soares, Fwg Costa, Csr Fonteles, T P Bezerra, T R Ribeiro, N R Romero. Plasma mepivacaine concentrations in patients undergoing third molar surgery.
Australian dental journal.
2016 12; 61(4):446-454. doi:
10.1111/adj.12410. [PMID: 26780408] - Ali Mokhtari. Chemiluminescence Determination of Local Anaesthetic Mepivacaine in Human Plasma and Pharmaceuticals.
Acta chimica Slovenica.
2016 12; 63(4):920-928. doi:
10.17344/acsi.2015.2161. [PMID: 28004094] - C Aumeier, B Kasdorf, M Gruber, H Busse, C H Wiese, W Zink, B M Graf, Y A Zausig. Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.
British journal of anaesthesia.
2014 Apr; 112(4):735-41. doi:
10.1093/bja/aet353. [PMID: 24169820] - M Harvey, G Cave. Lipid rescue: does the sink hold water? And other controversies.
British journal of anaesthesia.
2014 Apr; 112(4):622-5. doi:
10.1093/bja/aeu010. [PMID: 24535605] - Seyed Mosayeb Daryanavard, Amin Jeppsson-Dadoun, Lars I Andersson, Mahdi Hashemi, Anders Colmsjö, Mohamed Abdel-Rehim. Molecularly imprinted polymer in microextraction by packed sorbent for the simultaneous determination of local anesthetics: lidocaine, ropivacaine, mepivacaine and bupivacaine in plasma and urine samples.
Biomedical chromatography : BMC.
2013 Nov; 27(11):1481-8. doi:
10.1002/bmc.2946. [PMID: 23832864] - Soo Hee Lee, Hui-Jin Sung, Seong-Ho Ok, Jongsun Yu, Mun-Jeoung Choi, Jin Soo Lim, Ju-Tae Sohn. Lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic doses.
Yonsei medical journal.
2013 Nov; 54(6):1524-32. doi:
10.3349/ymj.2013.54.6.1524. [PMID: 24142661] - D Soto Mesa, M A Bermejo Álvarez, M J García Menéndez, M Fayad Fayad. [Axillary brachial plexus block in a patient with Bardet-Biedl syndrome].
Revista espanola de anestesiologia y reanimacion.
2012 Nov; 59(9):518-9. doi:
10.1016/j.redar.2012.05.017. [PMID: 22749304] - Erik S Litonius, Tomohisa Niiya, Pertti J Neuvonen, Per H Rosenberg. Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs.
Anesthesia and analgesia.
2012 Apr; 114(4):901-6. doi:
10.1213/ane.0b013e3182367a37. [PMID: 22025489] - Guy Weinberg, Lisa Warren. Lipid resuscitation: listening to our patients and learning from our models.
Anesthesia and analgesia.
2012 Apr; 114(4):710-2. doi:
10.1213/ane.0b013e31824b7eed. [PMID: 22434892] - Giovana Radomille Tofoli, Cíntia M S Cereda, Daniele Ribeiro Araújo, Michelle Franz-Montan, Francisco Carlos Groppo, Daiane Quaglio, Jose Pedrazzoli Junior, Silvana Aparecida Calafatti, Fabio Alessandro Proença Barros, Eneida de Paula. Pharmacokinetic study of liposome-encapsulated and plain mepivacaine formulations injected intra-orally in volunteers.
The Journal of pharmacy and pharmacology.
2012 Mar; 64(3):397-403. doi:
10.1111/j.2042-7158.2011.01425.x. [PMID: 22309271] - Seong-Ho Ok, Ju-Tae Sohn, Ji-Seok Baik, Jae-Gak Kim, Sang-Seung Park, Hui-Jin Sung, Mi-Kyung Shin, Yong-Hyun Kwon, Chang-Shin Park, Il-Woo Shin, Heon-Keun Lee, Young-Kyun Chung. Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels.
Anesthesiology.
2011 Feb; 114(2):293-301. doi:
10.1097/aln.0b013e3182054d22. [PMID: 21239969] - Ruriko Konishi, Izumi Kawagoe, Masanori Kanai, Sonoko Kimura, Hiromasa Mitsuhata. [Anaphylactic reaction to epidural block in an outpatient].
Masui. The Japanese journal of anesthesiology.
2010 Oct; 59(10):1287-90. doi:
. [PMID: 20960905] - Paul A Moore, Elliot V Hersh. Local anesthetics: pharmacology and toxicity.
Dental clinics of North America.
2010 Oct; 54(4):587-99. doi:
10.1016/j.cden.2010.06.015. [PMID: 20831923] - Giovana Radomille Tofoli, Cíntia Maria Saia Cereda, Daniele Ribeiro de Araujo, Eneida de Paula, Rui Barbosa Brito, José Pedrazzoli, Eduardo Meurer, Fábio Alessandro Proença Barros, Francisco Carlos Groppo, Maria Cristina Volpato, José Ranali. Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats.
Drug delivery.
2010 Feb; 17(2):68-76. doi:
10.3109/10717540903508995. [PMID: 20070242] - York A Zausig, Wolfgang Zink, Meike Keil, Barbara Sinner, Juergen Barwing, Christoph H R Wiese, Bernhard M Graf. Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest.
Anesthesia and analgesia.
2009 Oct; 109(4):1323-6. doi:
10.1213/ane.0b013e3181af7fb3. [PMID: 19762764] - Hélène Charbonneau, Thi Aurore Pham Marcou, Jean-Xavier Mazoit, Paul J Zetlaoui, Dan Benhamou. Early use of lipid emulsion to treat incipient mepivacaine intoxication.
Regional anesthesia and pain medicine.
2009 May; 34(3):277-8. doi:
10.1097/aap.0b013e31819340be. [PMID: 19436188] - Emile Calenda, Stelian A Dinescu. Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine.
Journal of anesthesia.
2009; 23(3):472-3. doi:
10.1007/s00540-009-0755-2. [PMID: 19685142] - I Jimena, I Tasset, R López-Martos, A J Rubio, E Luque, P Montilla, J Peña, I Túnez. Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2009 Jan; 5(1):44-9. doi:
10.2174/157340609787049217. [PMID: 19149649] - Alastair T Kay, David M Bolt, Akikazu Ishihara, Paivi J Rajala-Schultz, Alicia L Bertone. Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses.
American journal of veterinary research.
2008 Dec; 69(12):1646-54. doi:
10.2460/ajvr.69.12.1646. [PMID: 19046013] - Rainer J Litz, Thomas Roessel, Axel R Heller, Sebastian N Stehr. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection.
Anesthesia and analgesia.
2008 May; 106(5):1575-7, table of contents. doi:
10.1213/ane.0b013e3181683dd7. [PMID: 18420880] - Julio A Warren, R Brian Thoma, Alexandru Georgescu, Saurin J Shah. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.
Anesthesia and analgesia.
2008 May; 106(5):1578-80, table of contents. doi:
10.1213/01.ane.0000281434.80883.88. [PMID: 18420881] - Sanda Mihaela Popescu, Mihai Nechifor, Mihaela Baniceru, Octavian Croitoru, Florica Popescu. Effect of propranolol on mepivacaine serum concentrations in dental practice.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
2008 Apr; 105(4):e19-23. doi:
10.1016/j.tripleo.2007.12.010. [PMID: 18329563] - Hannes M Bergmann, Ingo Nolte, Sabine Kramer. Comparison of analgesic efficacy of preoperative or postoperative carprofen with or without preincisional mepivacaine epidural anesthesia in canine pelvic or femoral fracture repair.
Veterinary surgery : VS.
2007 Oct; 36(7):623-32. doi:
10.1111/j.1532-950x.2007.00314.x. [PMID: 17894588] - R Fuzier, O Fourcade, V Fuzier, H Gonzalez, N Albert, D Riviere, X Capdevila. [Characteristics of mepivacaine axillary brachial plexus block performed at 2800 m of altitude].
Annales francaises d'anesthesie et de reanimation.
2007 Jan; 26(1):17-22. doi:
10.1016/j.annfar.2006.06.026. [PMID: 17141465] - Christoph J Konrad, Guido K Schuepfer, Michael Neuburger, Marcus Schley, Martin Schmelz, Joachim Schmeck. Reduction of pulmonary edema by short-acting local anesthetics.
Regional anesthesia and pain medicine.
2006 May; 31(3):254-9. doi:
10.1016/j.rapm.2006.01.003. [PMID: 16701192] - Einosuke Tanaka, Takako Nakamura, Shinichi Inomata, Katsuya Honda. Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 834(1-2):213-6. doi:
10.1016/j.jchromb.2006.02.034. [PMID: 16530026] - I Tanoubi, N Vialles, P Cuvillon, J Ripart. [Systemic toxicity with mepivacaine following axillary block in a patient with terminal kidney failure].
Annales francaises d'anesthesie et de reanimation.
2006 Jan; 25(1):33-5. doi:
10.1016/j.annfar.2005.07.076. [PMID: 16253473] - Johan Knutsson, Anders Tibbelin, Magnus Von Unge. Adjuvant local anaesthetics in the epipharyngeal space in day-case adenoidectomy: a prospective, randomized, double-blind, placebo-controlled trial.
Acta oto-laryngologica.
2006 Jan; 126(1):51-5. doi:
10.1080/00016480510043459. [PMID: 16308255] - Adriana M Viana, Antonio Carlos de Campos, Mayra T Morlin, Verónica K L Chin. Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
2005 Oct; 100(4):415-9. doi:
10.1016/j.tripleo.2005.01.005. [PMID: 16182162] - A Koehler, R Oertel, W Kirch. Simultaneous determination of bupivacaine, mepivacain, prilocaine and ropivacain in human serum by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2005 Sep; 1088(1-2):126-30. doi:
10.1016/j.chroma.2005.03.071. [PMID: 16130740] - J F Lundberg, J Martner, C Raner, O Winsö, B Biber. Dopamine or norepinephrine infusion during thoracic epidural anesthesia? Differences in hemodynamic effects and plasma catecholamine levels.
Acta anaesthesiologica Scandinavica.
2005 Aug; 49(7):962-8. doi:
10.1111/j.1399-6576.2005.00732.x. [PMID: 16045657] - Daniele R de Araujo, Cíntia M S Cereda, Giovana B Brunetto, Luciana M A Pinto, Maria Helena A Santana, Eneida de Paula. Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2004 Jun; 51(6):566-72. doi:
10.1007/bf03018399. [PMID: 15197119] - D H Bremerich, R L Schlösser, N L'Allemand, R P Brandes, A Ahr, D Piorko, M Kaufmann, P Kessler. Mepivacaine for spinal anesthesia in parturients undergoing elective cesarean delivery: maternal and neonatal plasma concentrations and neonatal outcome.
Zentralblatt fur Gynakologie.
2003 Dec; 125(12):518-21. doi:
10.1055/s-2003-44817. [PMID: 14755363] - Katherine L Chin, John A Yagiela, Christine L Quinn, Kent R Henderson, Donald F Duperon. Serum mepivacaine concentrations after intraoral injection in young children.
Journal of the California Dental Association.
2003 Oct; 31(10):757-64. doi:
NULL. [PMID: 14626871] - Tetsuo Yamada, Tetsuo Murayama, Masahiko Andoh. Adjuvant hydrodistension under epidural anesthesia for interstitial cystitis.
International journal of urology : official journal of the Japanese Urological Association.
2003 Sep; 10(9):463-8; discussion 469. doi:
10.1046/j.1442-2042.2003.00664.x. [PMID: 12941123] - Maki Mizogami, Hironori Tsuchiya, Jun Harada. Membrane effects of ropivacaine compared with those of bupivacaine and mepivacaine.
Fundamental & clinical pharmacology.
2002 Aug; 16(4):325-30. doi:
10.1046/j.1472-8206.2002.00090.x. [PMID: 12570022] - P Prieto-Alvarez, A Calas-Guerra, J Fuentes-Bellido, E Martínez-Verdera, A Benet-Català, J P Lorenzo-Foz. Comparison of mepivacaine and lidocaine for intravenous regional anaesthesia: pharmacokinetic study and clinical correlation.
British journal of anaesthesia.
2002 Apr; 88(4):516-9. doi:
10.1093/bja/88.4.516. [PMID: 12066727] - M R Gough, G Mayhew, G A Munroe. Diffusion of mepivacaine between adjacent synovial structures in the horse. Part 1: forelimb foot and carpus.
Equine veterinary journal.
2002 Jan; 34(1):80-4. doi:
10.2746/042516402776181097. [PMID: 11817556] - M R Gough, G A Munroe, G Mayhew. Diffusion of mepivacaine between adjacent synovial structures in the horse. Part 2: tarsus and stifle.
Equine veterinary journal.
2002 Jan; 34(1):85-90. doi:
10.2746/042516402776181088. [PMID: 11817557] - R Murtaza, H L Jackman, B Alexander, A Lleshi-Tali, A P Winnie, R Igic. Simultaneous determination of mepivacaine, tetracaine, and p-butylaminobenzoic acid by high-performance liquid chromatography.
Journal of pharmacological and toxicological methods.
2001 Nov; 46(3):131-6. doi:
10.1016/s1056-8719(02)00171-5. [PMID: 12183188] - H Iskandar, E Guillaume, F Dixmérias, B Binje, S Rakotondriamihary, R Thiebaut, P Maurette. The enhancement of sensory blockade by clonidine selectively added to mepivacaine after midhumeral block.
Anesthesia and analgesia.
2001 Sep; 93(3):771-5. doi:
10.1097/00000539-200109000-00043. [PMID: 11524354] - V Tagariello, A Caporuscio, O De Tommaso. Mepivacaine: update on an evergreen local anaesthetic.
Minerva anestesiologica.
2001 Sep; 67(9 Suppl 1):5-8. doi:
NULL. [PMID: 11778086] - J Rodríguez, V Rodríguez, A Naveira, O Quintela, M Bárcena, E Gallardo, F Gude, J Alvarez. Epidural washout with high volumes of saline to accelerate recovery from epidural anaesthesia.
Acta anaesthesiologica Scandinavica.
2001 Aug; 45(7):893-8. doi:
10.1034/j.1399-6576.2001.045007893.x. [PMID: 11472293] - H Kutchai, L M Geddis. Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Pharmacological research.
2001 Apr; 43(4):399-403. doi:
10.1006/phrs.2001.0803. [PMID: 11352545] - J Rodríguez, O Quintela, M López-Rivadulla, M Bárcena, C Diz, J Alvarez. High doses of mepivacaine for brachial plexus block in patients with end-stage chronic renal failure. A pilot study.
European journal of anaesthesiology.
2001 Mar; 18(3):171-6. doi:
10.1046/j.0265-0215.2000.00806.x. [PMID: 11298176] - Y Hashizume, S Yamaguchi, M Mishio, T Takiguchi, Y Okuda, T Kitajima. Pediatric caudal block with mepivacaine, bupivacaine or a mixture of both drugs: requirement for postoperative analgesia and plasma concentration of local anesthetics.
Journal of clinical anesthesia.
2001 Feb; 13(1):30-4. doi:
10.1016/s0952-8180(00)00242-7. [PMID: 11259892] - T Kitajima, Y Okuda, M Mishio, S Hamaguchi, S Yamaguchi, Y Kimura. Acute cigarette smoking reduces vasodilative effect induced by sympathetic block in dogs.
Regional anesthesia and pain medicine.
2001 Jan; 26(1):41-5. doi:
10.1053/rapm.2001.16163. [PMID: 11172510] - M E Bräu, P Branitzki, A Olschewski, W Vogel, G Hempelmann. Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics.
Anesthesia and analgesia.
2000 Dec; 91(6):1499-505. doi:
10.1097/00000539-200012000-00038. [PMID: 11094008] - M S Burgos, W Langhans, M Senn. Role of rumen fluid hypertonicity in the dehydration-induced hypophagia of cows.
Physiology & behavior.
2000 Nov; 71(3-4):423-30. doi:
10.1016/s0031-9384(00)00357-7. [PMID: 11150576] - M Lucas, M Hinojosa, A Rodríguez, R Garcia-Guasch. Anaesthesia in lipid myopathy.
European journal of anaesthesiology.
2000 Jul; 17(7):461-2. doi:
10.1046/j.1365-2346.2000.00676.x. [PMID: 10964150] - J Greisen, T Grøfte, P O Hansen, T S Jensen, H Vilstrup. Acute non-traumatic pain increases the hepatic amino- to urea-N conversion in normal man.
Journal of hepatology.
1999 Oct; 31(4):647-55. doi:
10.1016/s0168-8278(99)80344-4. [PMID: 10551388] - J Greisen, M Hokland, T Grøfte, P O Hansen, T S Jensen, H Vilstrup, E Tønnesen. Acute pain induces an instant increase in natural killer cell cytotoxicity in humans and this response is abolished by local anaesthesia.
British journal of anaesthesia.
1999 Aug; 83(2):235-40. doi:
10.1093/bja/83.2.235. [PMID: 10618935] - J D Harkins, W Karpiesiuk, W E Woods, A Lehner, G D Mundy, W A Rees, L Dirikolu, S Bass, W G Carter, J Boyles, T Tobin. Mepivacaine: its pharmacological effects and their relationship to analytical findings in the horse.
Journal of veterinary pharmacology and therapeutics.
1999 Apr; 22(2):107-21. doi:
10.1046/j.1365-2885.1999.00189.x. [PMID: 10372595] - H A Adams, D Pawlik, H Bauer, W Mautgreve. Stability of local anesthetics in heparinized blood, plasma and sulfuric acid.
Acta anaesthesiologica Scandinavica.
1998 Aug; 42(7):783-5. doi:
10.1111/j.1399-6576.1998.tb05322.x. [PMID: 9698953] - K Groen, M Mantel, P W Zeijlmans, B Zeppenfeldt, W Olieman, R Stienstra, J W van Kleef, A G Burm. Pharmacokinetics of the enantiomers of bupivacaine and mepivacaine after epidural administration of the racemates.
Anesthesia and analgesia.
1998 Feb; 86(2):361-6. doi:
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