Diethylpropion Hydrochloride (BioDeep_00000790608)

   


代谢物信息卡片


Diethylpropion Hydrochloride

化学式: C13H20ClNO (241.123334)
中文名称: 盐酸安非拉酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1.Cl
InChI: 1H

描述信息

C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

1 个代谢物同义名

Diethylpropion Hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ernesto Limón-Bernal, José E Roa-Coria, Ángel Zúñiga-Romero, Juan C Huerta-Cruz, Irma R C Ruíz-Velasco, Francisco J Flores-Murrieta, Eleazar Lara-Padilla, Juan G Reyes-García, Héctor I Rocha-González. Anorectic interaction and safety of 5-hydroxytryptophan/carbidopa plus phentermine or diethylpropion in rat. Behavioural pharmacology. 2021 08; 32(5):368-381. doi: 10.1097/fbp.0000000000000625. [PMID: 33660661]
  • Magdalena Gómez-Silva, Everardo Piñeyro-Garza, Rigoberto Vargas-Zapata, María Elena Gamino-Peña, Armando León-García, Mario Bermúdez de León, Adrián Llerena, Rafael B R León-Cachón. Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial. Scientific reports. 2019 11; 9(1):17833. doi: 10.1038/s41598-019-54436-z. [PMID: 31780765]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Jolanta Opacka-Juffry, Thomas Pinnell, Nisha Patel, Melissa Bevan, Meghan Meintel, Colin Davidson. Stimulant mechanisms of cathinones - effects of mephedrone and other cathinones on basal and electrically evoked dopamine efflux in rat accumbens brain slices. Progress in neuro-psychopharmacology & biological psychiatry. 2014 Oct; 54(?):122-30. doi: 10.1016/j.pnpbp.2014.04.009. [PMID: 24795175]
  • Kristiane de Cássia Mariotti, Roselena S Schuh, Priscila Ferranti, Rafael S Ortiz, Daniele Z Souza, Flavio Pechansky, Pedro E Froehlich, Renata P Limberger. Simultaneous analysis of amphetamine-type stimulants in plasma by solid-phase microextraction and gas chromatography-mass spectrometry. Journal of analytical toxicology. 2014 Sep; 38(7):432-7. doi: 10.1093/jat/bku063. [PMID: 25038769]
  • Charles Francisco Ferreira, Juliana Rombaldi Bernardi, Rachel Krolow, Danusa Mar Arcego, Gabriel Rodrigo Fries, Bianca Wollenhaupt de Aguiar, Gabrielle Senter, Flávio Pereira Kapczinski, Patrícia Pelufo Silveira, Carla Dalmaz. Vulnerability to dietary n-3 polyunsaturated fatty acid deficiency after exposure to early stress in rats. Pharmacology, biochemistry, and behavior. 2013 Jun; 107(?):11-9. doi: 10.1016/j.pbb.2013.03.006. [PMID: 23537731]
  • Abel Santamaría, Hugo R Arias. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behavioural brain research. 2010 Jul; 211(1):132-9. doi: 10.1016/j.bbr.2010.03.023. [PMID: 20307582]
  • Sonia Galvan-Arzate, Abel Santamaria. Neurotoxicity of diethylpropion: neurochemical and behavioral findings in rats. Annals of the New York Academy of Sciences. 2002 Jun; 965(?):214-24. doi: . [PMID: 12105097]
  • H Yu, R B Rothman, C M Dersch, J S Partilla, K C Rice. Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters. Bioorganic & medicinal chemistry. 2000 Dec; 8(12):2689-92. doi: 10.1016/s0968-0896(00)00210-8. [PMID: 11131159]
  • B Mey, H Paulus, E Lamparter, G Blaschke. Kinetics of racemization of (+)- and (-)-diethylpropion: studies in aqueous solution, with and without the addition of cyclodextrins, in organic solvents and in human plasma. Chirality. 1998; 10(4):307-15. doi: 10.1002/(sici)1520-636x(1998)10:4<307::aid-chir4>3.0.co;2-4. [PMID: 9614689]
  • M Pokrajac, B Miljković, B Misailović. Mass spectrometric investigation of 2-aminopropiophenones and some of their metabolites. Rapid communications in mass spectrometry : RCM. 1991 Feb; 5(2):59-61. doi: 10.1002/rcm.1290050202. [PMID: 1804406]
  • M Popa, A M Stefănescu, L Dumitriu. Decrease of urinary levels of adrenergic metabolites including conjugated MHPG after a short term course of diethylpropion in obese children fed a mixed, low-calorie diet. Endocrinologie. 1987 Jul; 25(3):179-86. doi: . [PMID: 3685848]
  • A H Beckett, M Stanojcić. Re-evaluation of the metabolism and excretion of diethylpropion in non-sustained and sustained release formulations. The Journal of pharmacy and pharmacology. 1987 Jun; 39(6):409-15. doi: 10.1111/j.2042-7158.1987.tb03411.x. [PMID: 2886596]
  • C M Dangor, A H Beckett, A M Veltman. Bioavailability of amfepramone hydrochloride sustained release pellets formulation in healthy subjects. Arzneimittel-Forschung. 1987 Jun; 37(6):736-9. doi: NULL. [PMID: 3663274]
  • C M Dangor, A H Beckett, A M Veltman. Simultaneous determination of amfepramon and its two major metabolites in biological fluids by gas liquid chromatography. Arzneimittel-Forschung. 1986 Sep; 36(9):1307-10. doi: NULL. [PMID: 3790180]
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  • G J Wright, J F Lang, R E Lemieux, M J Goodfriend. The objective and timing of drug disposition studies, appendix III. Diethylpropion and its metabolites in the blood plasma of the human after subcutaneous and oral administration. Drug metabolism reviews. 1975; 4(2):267-76. doi: 10.3109/03602537508993760. [PMID: 1222683]
  • D Mihailova, A Rosen, B Testa, A H Beckett. A pharmacokinetic investigation of the distribution and elimination of diethylpropion and its metabolites in man. The Journal of pharmacy and pharmacology. 1974 Sep; 26(9):711-21. doi: 10.1111/j.2042-7158.1974.tb09355.x. [PMID: 4155748]
  • J F Bridgman, J M Buckler. Letter: Drug-induced gynaecomastia. British medical journal. 1974 Aug; 3(5929):520-1. doi: 10.1136/bmj.3.5929.520-b. [PMID: 4414195]
  • B Testa, A H Beckett. The metabolism of diethylpropion in man; influence of changes in drug formulation and urinary pH. Pharmaceutica acta Helvetiae. 1974 Jan; 49(1):21-7. doi: NULL. [PMID: 4854957]
  • B Testa. Some chemical and stereochemical aspects of diethylpropion metabolism in man. Acta pharmaceutica Suecica. 1973 Dec; 10(6):441-54. doi: NULL. [PMID: 4773113]
  • B Testa, A H Beckett. Metabolism and excretion of diethylpropion in man under acidic urine conditions. The Journal of pharmacy and pharmacology. 1973 Feb; 25(2):119-24. doi: 10.1111/j.2042-7158.1973.tb10604.x. [PMID: 4146542]
  • F Banci, G P Cartoni, A Cavalli, A Monai. Effect of sustained-release on the excretion of some metabolites of diethylopropion. Arzneimittel-Forschung. 1972 Oct; 22(10):1724-6. doi: NULL. [PMID: 4677065]
  • B Testa, A H Beckett. Studies on the metabolism of diethylpropion. I. Analytical procedure. Journal of chromatography. 1972 Aug; 71(1):39-54. doi: 10.1016/s0021-9673(01)85688-0. [PMID: 5056248]
  • P M Mace, A D Malcolm, K P Outar, G L Pawan. Comparative effects of four antiobesity agents on blood plasma lipids in man. The Proceedings of the Nutrition Society. 1972 May; 31(1):14A-15A. doi: NULL. [PMID: 5048465]
  • F Banci, G P Cartoni, A Cavalli, A Monai. Excretion of some basic metabolites of diethylpropion in man and rabbit. Arzneimittel-Forschung. 1971 Oct; 21(10):1616-8. doi: NULL. [PMID: 5171897]
  • E C Schreiber. The metabolic alteration of drugs. Annual review of pharmacology. 1970; 10(?):77-98. doi: 10.1146/annurev.pa.10.040170.000453. [PMID: 4392814]
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  • J C De Groot. A survey of the usage of amphetamines in parts of the Sidney community. The Medical journal of Australia. 1968 May; 1(19):826. doi: 10.5694/j.1326-5377.1968.tb28934.x. [PMID: 5656962]
  • E C Schreiber, B H Min, A V Zeiger, J F Lang. Metabolism of diethylpropion-1-C14 hydrochloride by the human. The Journal of pharmacology and experimental therapeutics. 1968 Feb; 159(2):372-8. doi: NULL. [PMID: 4295618]
  • A H Beckett, G T Tucker, A C Moffat. Routine detection and identification in urine of stimulants and other drugs, some of which may be used to modify performance in sport. The Journal of pharmacy and pharmacology. 1967 May; 19(5):273-94. doi: 10.1111/j.2042-7158.1967.tb08089.x. [PMID: 4382400]
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  • G KAMM. [STUDIES ON AN ALMOST SPECIFIC TEST FOR REGENON, REGENON A AND PRELUDIN IN THE URINE]. Beitrage zur gerichtlichen Medizin. 1965; 23(?):119-24. doi: NULL. [PMID: 14346685]