Cefepime hydrochloride (BioDeep_00000790266)
代谢物信息卡片
Cefepime Dihydrochloride Monohydrate
化学式: C19H28Cl2N6O6S2 (570.0888728)
中文名称: 盐酸头孢吡肟
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1(CCCC1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O.O.Cl.[Cl-]
InChI: 2*1H
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
A hydrochloride that is the monohydrate of the dihydrochloride salt of cefepime.
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:31368
- KEGGdrug: D01157
- PubChem: 9571075
- ChEMBL: CHEMBL1200962
- MeSH: Cefepime
- CAS: 123171-59-5
- MetaboLights: MTBLC31368
- PubChem: 582947
- NIKKAJI: J1.746.340C
- KEGG: C12557
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Gisele Canan-Rochenbach, Marco A B Barreiros, André O S Lima, Pascale Bauda, Eric Sanches-Simões, Wendell Pimentel-Almeida, Rafael Ariente-Neto, Cleder A Somensi, Tito C M Almeida, Rogério Corrêa, Claudemir M Radetski. Characterization of bacterial resistance in treated hospital wastewater.
Environmental technology.
2024 Jan; 45(1):120-128. doi:
10.1080/09593330.2022.2100282. [PMID: 35802062] - Jiaojiao Fu, Fangting He, Jinming Xiao, Zhengyue Liao, Liying He, Jing He, Jinlin Guo, Sijing Liu. Rapid AMR prediction in Pseudomonas aeruginosa combining MALDI-TOF MS with DNN model.
Journal of applied microbiology.
2023 Nov; 134(11):. doi:
10.1093/jambio/lxad248. [PMID: 37930836] - Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M Nau, Daniel Lafitte, Mathias Winterhalter, Jean-Marie Pagès. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane.
Communications biology.
2022 10; 5(1):1059. doi:
10.1038/s42003-022-04035-y. [PMID: 36198902] - Gwendolyn M Pais, Jack Chang, Erin F Barreto, Gideon Stitt, Kevin J Downes, Mohammad H Alshaer, Emily Lesnicki, Vaidehi Panchal, Maria Bruzzone, Argyle V Bumanglag, Sara N Burke, Marc H Scheetz. Clinical Pharmacokinetics and Pharmacodynamics of Cefepime.
Clinical pharmacokinetics.
2022 07; 61(7):929-953. doi:
10.1007/s40262-022-01137-y. [PMID: 35764774] - Khalil S Husari, Eva K Ritzl, Peter W Kaplan. Acute Toxicity and Triphasic Waves-The Example of Cefepime.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.
2022 Jul; 39(5):419-426. doi:
10.1097/wnp.0000000000000791. [PMID: 33086250] - Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients.
European journal of clinical pharmacology.
2022 Jun; 78(6):989-1001. doi:
10.1007/s00228-022-03307-0. [PMID: 35275224] - Tomoyuki Nakamura, Tomoaki Yatabe, Naohide Kuriyama, Toshihisa Hiraiwa, Kana Matsumoto, Osamu Nishida. Cefepime-induced encephalopathy in a COVID-19 patient: a case report.
Journal of anesthesia.
2022 Jun; 36(3):432-435. doi:
10.1007/s00540-022-03068-1. [PMID: 35487992] - Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem.
Journal of chemotherapy (Florence, Italy).
2022 Apr; 34(2):103-109. doi:
10.1080/1120009x.2021.1965334. [PMID: 34424136] - Taylor A Imburgia, Samantha R Engdahl, Rebecca S Pettit. Evaluation of the safety of cefepime prolonged infusions in pediatric patients with cystic fibrosis.
Pediatric pulmonology.
2022 04; 57(4):919-925. doi:
10.1002/ppul.25817. [PMID: 34989183] - Céline Thibault, Ganesh S Moorthy, Christina Vedar, Maryam Y Naim, Mary Ann DiLiberto, Athena F Zuppa. Pharmacokinetics of Cefepime in Children on Extracorporeal Membrane Oxygenation: External Model Validation, Model Improvement and Dose Optimization.
The Pediatric infectious disease journal.
2022 03; 41(3):217-223. doi:
10.1097/inf.0000000000003371. [PMID: 34817416] - Maxwell J Lasko, David P Nicolau, Tomefa E Asempa. Clinical exposure-response relationship of cefepime/taniborbactam against Gram-negative organisms in the murine complicated urinary tract infection model.
The Journal of antimicrobial chemotherapy.
2022 02; 77(2):443-447. doi:
10.1093/jac/dkab405. [PMID: 34747449] - Mitchell S Buckley, Ivan A Komerdelj, Paul A D'Alessio, Pooja Rangan, Sumit K Agarwal, Nicole C Tinta, Brandon K Martinez, Delia S Ziadat, Melanie J Yerondopoulos, Emir Kobic, Sandra L Kane-Gill. Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study.
Journal of critical care.
2022 02; 67(?):134-140. doi:
10.1016/j.jcrc.2021.10.018. [PMID: 34768175] - Dorothy Dao Nguyen, Samuel Lai. Prolonged Cefepime-Induced Neurotoxicity in a Patient with End-Stage Renal Disease.
The American journal of case reports.
2022 Jan; 23(?):e934083. doi:
10.12659/ajcr.934083. [PMID: 35067669] - Mohammad H Al-Shaer, Kelly Maguigan, Jennifer Ashton, Veena Venugopalan, Molly E Droege, Carolyn D Philpott, Christopher A Droege, Daniel P Healy, Eric W Mueller, Charles A Peloquin. Applying Cefepime Population Pharmacokinetics to Critically Ill Patients Receiving Continuous Renal Replacement Therapy.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0161121. doi:
10.1128/aac.01611-21. [PMID: 34662194] - Ibtisam H Al-Azawi, Mahasin S Al-Bidiri. DISTRIBUTION OF INTEGRON III AND PHYLOGENIC CLADE AMONG MDR UROPATHOGENIC E. COLI FROM PATIENT IN AL-DIWANIYAH CITY, IRAQ.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2022; 75(5 pt 2):1254-1260. doi:
10.36740/wlek202205205. [PMID: 35758440] - Matthias Gijsen, Britt Bekkers, Johan Maertens, Katrien Lagrou, Stefanie Desmet, Erwin Dreesen, Willy E Peetermans, Yves Debaveye, Isabel Spriet. Prospective assessment of breakthrough infections and neurotoxicity and their association with cefepime trough concentrations in patients with febrile neutropenia.
International journal of antimicrobial agents.
2022 Jan; 59(1):106472. doi:
10.1016/j.ijantimicag.2021.106472. [PMID: 34757136] - Brian Pacca Elliott, Michael M Tang, Joshua Alexander Madden, Ronald James Markert, Steven Dale Burdette, Craig Matthew Pleiman, Emily Claire Speelmon. A retrospective cohort study assessing acute kidney injury and renal recovery among septic patients empirically treated with vancomycin piperacillin-tazobactam versus vancomycin cefepime.
Internal and emergency medicine.
2022 Jan; 17(1):91-99. doi:
10.1007/s11739-021-02772-2. [PMID: 34089468] - Yi-Fan Lo, Chien-Wen Chien, Yueh-Ming Tai, Shin-Chang Kuo, Shih-Hua Lin, Nian-Sheng Tzeng. Cefepime-Induced Depressive Disorder in a Patient With End-Stage Renal Disease.
American journal of therapeutics.
2022 Jan; 29(1):e111-e113. doi:
10.1097/mjt.0000000000001229. [PMID: 34994352] - Cindy Lau, Deborah Marriott, Hayley B Schultz, Michael Gould, David Andresen, Sebastian G Wicha, Jan-Willem Alffenaar, Jonathan Penm, Stephanie E Reuter. Assessment of cefepime toxicodynamics: comprehensive examination of pharmacokinetic/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines.
International journal of antimicrobial agents.
2021 Dec; 58(6):106443. doi:
10.1016/j.ijantimicag.2021.106443. [PMID: 34551358] - Mohamed Aboubakr, Afaf Abdelkader, Ola A Habotta, Nisreen Adel, Mahmoud A Emam, Ehab Y Abdelhiee, Obeid Shanab, Khaled Shoghy, Heba Elnoury, Mohamed M Soliman, Samah F Ibrahim, Ahmed Abdeen. Cefepime and diclofenac sodium combined treatment-potentiated multiple organ injury: Role of oxidative damage and disrupted lipid metabolism.
Journal of biochemical and molecular toxicology.
2021 Dec; 35(12):e22929. doi:
10.1002/jbt.22929. [PMID: 34676623] - Xiaocong Liu, Qingfan Wei, Xiaowei Yang, Xiaojie Wang, Jiamei Zhang, Rui Xu, Haoluo Zhang, Shaomin Wang, Xuemei Wan, Linhong Jiang, Yuman He, Shu Li, Rong Chen, Yonghai Wang, Yaxing Chen, Feng Qin, Yuanyuan Chen, Yanping Dai, Hongchun Li, Ying Zhao, Huaqin Zhang, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen. Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime.
ACS chemical neuroscience.
2021 12; 12(23):4449-4464. doi:
10.1021/acschemneuro.1c00608. [PMID: 34762393] - Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Amanda Corley, Arne Diehl, Stephan M Jakob, Bianca J Levkovich, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, Jason A Roberts, Kiran Shekar, John F Fraser. Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study).
International journal of antimicrobial agents.
2021 Dec; 58(6):106466. doi:
10.1016/j.ijantimicag.2021.106466. [PMID: 34688834] - Naoto Okada, Yuki Izumi, Aki Nakamoto, Masayuki Chuma, Mitsuhiro Goda, Kenta Yagi, Fuka Aizawa, Hirofumi Hamano, Yoshito Zamami, Momoyo Azuma, Keisuke Ishizawa. Impact of Area Under the Concentration-Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study.
Clinical therapeutics.
2021 11; 43(11):1910-1920.e3. doi:
10.1016/j.clinthera.2021.09.007. [PMID: 34642081] - Jazmin D Lee, Brett H Heintz, Hilary J Mosher, Daniel J Livorsi, Jason A Egge, Brian C Lund. Risk of Acute Kidney Injury and Clostridioides difficile Infection With Piperacillin/Tazobactam, Cefepime, and Meropenem With or Without Vancomycin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 10; 73(7):e1579-e1586. doi:
10.1093/cid/ciaa1902. [PMID: 33382398] - Kevin Doello, Víctor Amezcua. Effect of adding bemiparin and cefepime to routine treatment in cancer patients with SARS-CoV-2 infection.
Medicina clinica.
2021 09; 157(6):299-300. doi:
10.1016/j.medcli.2021.03.010. [PMID: 34083071] - Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum.
The journal of applied laboratory medicine.
2021 09; 6(5):1202-1212. doi:
10.1093/jalm/jfab036. [PMID: 34086904] - Maxwell J Lasko, Kamilia Abdelraouf, David P Nicolau. Comparative in vivo activity of human-simulated plasma and epithelial lining fluid exposures of WCK 5222 (cefepime/zidebactam) against KPC- and OXA-48-like-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model.
The Journal of antimicrobial chemotherapy.
2021 08; 76(9):2310-2316. doi:
10.1093/jac/dkab183. [PMID: 34096601] - Alexandre Meurant, François Guérin, Simon Le Hello, Guillaume Saint-Lorant, Arnaud de La Blanchardière. Cefepime use: A need for antimicrobial stewardship.
Infectious diseases now.
2021 Aug; 51(5):445-450. doi:
10.1016/j.idnow.2020.10.001. [PMID: 33960301] - Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac, Florent Wallet, Olivia Vassal, Arnaud Friggeri. Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study.
Therapeutic drug monitoring.
2021 08; 43(4):451-454. doi:
10.1097/ftd.0000000000000896. [PMID: 33883521] - Adrien Contejean, Caroline Charlier, Jean-Marc Treluyer, Solen Kernéis, Laurent Chouchana. A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem.
The Journal of antimicrobial chemotherapy.
2021 07; 76(8):2221-2223. doi:
10.1093/jac/dkab144. [PMID: 34008026] - Mohammad H Al-Shaer, Carolyn D Philpott, Christopher A Droege, Joshua D Courter, Daniel P Healy, Molly E Droege, Neil E Ernst, Eric W Mueller, Charles A Peloquin. Cefepime Population Pharmacokinetics and Target Attainment in Critically Ill Patients on Continuous Renal Replacement Therapy.
Antimicrobial agents and chemotherapy.
2021 05; 65(6):. doi:
10.1128/aac.00144-21. [PMID: 33722885] - Michael Saad-Naguib, Deborah Barbouth, Willa Thorson, Stephanie Hacker, Mustafa Tekin. COVID-19 in a child with severe propionic acidemia.
Pediatrics international : official journal of the Japan Pediatric Society.
2021 05; 63(5):606-607. doi:
10.1111/ped.14633. [PMID: 34002470] - Matthew S Sussman, Michelle B Mulder, Emily L Ryon, Eva M Urrechaga, Gabriel A Lama, Amritpal Bahga, Sarah A Eidelson, Howard M Lieberman, Carl I Schulman, Nicholas Namias, Kenneth G Proctor. Acute Kidney Injury Risk in Patients Treated with Vancomycin Combined with Meropenem or Cefepime.
Surgical infections.
2021 May; 22(4):415-420. doi:
10.1089/sur.2020.105. [PMID: 32783764] - Walaa Mohammed Noor Obeid, Iman Hassan Abdoon, Bashier Osman, Wadah J A Osman, Hayat Mohamed Suliman, Elwasila M Mohamed, Ramzi A A Mothana. Drug use evaluation of cefepime at Khartoum North Teaching Hospital in Sudan.
International journal of clinical practice.
2021 Apr; 75(4):e13882. doi:
10.1111/ijcp.13882. [PMID: 33277753] - Sonya C Tang Girdwood, Peter H Tang, Mark E Murphy, Andrea R Chamberlain, Laura A Benken, Rhonda L Jones, Erin M Stoneman, Jennifer M Kaplan, Alexander A Vinks. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children.
Journal of clinical pharmacology.
2021 04; 61(4):565-573. doi:
10.1002/jcph.1773. [PMID: 33111331] - Christian M Gill, Kamilia Abdelraouf, David P Nicolau. In vivo activity of WCK 4282 (high-dose cefepime/tazobactam) against serine β-lactamase-producing Enterobacterales and Pseudomonas aeruginosa in the neutropenic murine thigh infection model.
The Journal of antimicrobial chemotherapy.
2021 03; 76(4):993-1000. doi:
10.1093/jac/dkaa551. [PMID: 33438033] - Akram Al-Makki, Tim Taber. Neutropenic fever in COVID-19 in kidney transplant patient.
Reviews in medical virology.
2021 01; 31(1):1-2. doi:
10.1002/rmv.2156. [PMID: 32856324] - Shampa Das, Richard Fitzgerald, Asad Ullah, Marcin Bula, Andrea M Collins, Elena Mitsi, Jesus Reine, Helen Hill, Jamie Rylance, Daniela M Ferreira, Karen Tripp, Andrea Bertasini, Samantha Franzoni, Mameli Massimiliano, Omar Lahlou, Paola Motta, Philip Barth, Patrick Velicitat, Philipp Knechtle, William Hope. Intrapulmonary Pharmacokinetics of Cefepime and Enmetazobactam in Healthy Volunteers: Towards New Treatments for Nosocomial Pneumonia.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01468-20. [PMID: 33077666] - Kyle C Molina, Jeffrey F Barletta, Scott T Hall, Cyrus Yazdani, Vanthida Huang. The Risk of Acute Kidney Injury in Critically Ill Patients Receiving Concomitant Vancomycin With Piperacillin-Tazobactam or Cefepime.
Journal of intensive care medicine.
2020 Dec; 35(12):1434-1438. doi:
10.1177/0885066619828290. [PMID: 30741072] - Tarun D Singh, John C O'Horo, Courtney N Day, Jay Mandrekar, Alejandro A Rabinstein. Cefepime is Associated with Acute Encephalopathy in Critically Ill Patients: A Retrospective Case-Control Study.
Neurocritical care.
2020 12; 33(3):695-700. doi:
10.1007/s12028-020-01035-w. [PMID: 32613426] - Xavier Engalenc, Caroline Monchaud, Naïma Tafzi, Jean-Baptiste Woillard. Neurotoxicity Despite a Renal Function-Adjusted Cefepime Regimen: A Case Study.
Therapeutic drug monitoring.
2020 10; 42(5):655-657. doi:
10.1097/ftd.0000000000000786. [PMID: 32618881] - C Triffault-Fillit, E Mabrut, K Corbin, E Braun, A Becker, S Goutelle, P Chaudier, M H Fessy, C Dupieux, F Laurent, S Gunst, S Lustig, C Chidiac, T Ferry, F Valour. Tolerance and microbiological efficacy of cefepime or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2299-2306. doi:
10.1093/jac/dkaa166. [PMID: 32407512] - Jennifer Young, Devesh Dahale, Kathleen Demmel, Maureen O'Brien, James Geller, Josh Courter, David B Haslam, Lara Danziger-Isakov, Stuart L Goldstein. Reducing acute kidney injury in pediatric oncology patients: An improvement project targeting nephrotoxic medications.
Pediatric blood & cancer.
2020 08; 67(8):e28396. doi:
10.1002/pbc.28396. [PMID: 32495508] - Sophia Rehm, Katharina M Rentsch. HILIC LC-MS/MS method for the quantification of cefepime, imipenem and meropenem.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113289. doi:
10.1016/j.jpba.2020.113289. [PMID: 32428767] - Kevin O'Callaghan, Karen Hay, Jayshree Lavana, John F McNamara. Acute kidney injury with combination vancomycin and piperacillin-tazobactam therapy in the ICU: A retrospective cohort study.
International journal of antimicrobial agents.
2020 Jul; 56(1):106010. doi:
10.1016/j.ijantimicag.2020.106010. [PMID: 32413387] - Attiya Khan, Joshua M DeMott, Christy Varughese, Drayton A Hammond. Effect of Cefepime on Neurotoxicity Development in Critically Ill Adults With Renal Dysfunction.
Chest.
2020 07; 158(1):157-163. doi:
10.1016/j.chest.2020.01.051. [PMID: 32147247] - M Penven, A Lalieu, A Boruchowicz, M Paluch, T Diedrich, G Dewulf, C Cattoen. Bacteremia caused by Elizabethkingia miricola in a patient with acute pancreatitis and peritoneal dialysis.
Medecine et maladies infectieuses.
2020 Jun; 50(4):379-381. doi:
10.1016/j.medmal.2020.01.009. [PMID: 32046885] - Sai Disha K, Rashmi Puranik, Sudheesh N, Kavitha K, Fajeelath Fathima, Anu K R, Alex Joseph, Anitha J, G Arunkumar, Piya Paul Mudgal. Structure-based identification of small molecules against influenza A virus endonuclease: an in silico and in vitro approach.
Pathogens and disease.
2020 06; 78(4):. doi:
10.1093/femspd/ftaa032. [PMID: 32614388] - Emmanuel Novy, Julien Scala-Bertola, Claire Roger, Philippe Guerci. Preliminary therapeutic drug monitoring data of β-lactams in critically ill patients with SARS-CoV-2 infection.
Anaesthesia, critical care & pain medicine.
2020 06; 39(3):387-388. doi:
10.1016/j.accpm.2020.04.005. [PMID: 32315803] - Adam Johnson, Laura McEntee, Nicola Farrington, Ruwanthi Kolamunnage-Dona, Samantha Franzoni, Alberto Vezzelli, Mameli Massimiliano, Philipp Knechtle, Adam Belley, Aaron Dane, George Drusano, Shampa Das, William Hope. Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy.
2020 05; 64(6):. doi:
10.1128/aac.00180-20. [PMID: 32253209] - B Pilmis, A Mizrahi, G Petitjean, A Le Monnier, N El Helali. Clinical evaluation of subcutaneous administration of cefepime.
Medecine et maladies infectieuses.
2020 May; 50(3):308-310. doi:
10.1016/j.medmal.2019.12.006. [PMID: 31924455] - Kazutaka Oda, Toshikazu Miyakawa, Tomomi Katanoda, Yumi Hashiguchi, Koji Iwamura, Kisato Nosaka, Ayami Yamaguchi, Hirofumi Jono, Hideyuki Saito. A case of recovery from aphasia following dose reduction of cefepime by bayesian prediction-based therapeutic drug monitoring.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 May; 26(5):498-501. doi:
10.1016/j.jiac.2019.10.006. [PMID: 32143960] - John M Cunningham, Katherine V Sachs, Rebecca Allyn. Cefepime-Induced Neurotoxicity Presenting with Nonconvulsive Status Epilepticus Admitted as a Stroke Alert.
The American journal of case reports.
2020 Mar; 21(?):e921643. doi:
10.12659/ajcr.921643. [PMID: 32147665] - L Boschung-Pasquier, A Atkinson, L K Kastner, S Banholzer, M Haschke, N Buetti, D I Furrer, C Hauser, P Jent, Y A Que, H Furrer, B Babouee Flury. Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Mar; 26(3):333-339. doi:
10.1016/j.cmi.2019.06.028. [PMID: 31284030] - Cindy Lau, Deborah Marriott, Michael Gould, David Andresen, Stephanie E Reuter, Jonathan Penm. A retrospective study to determine the cefepime-induced neurotoxicity threshold in hospitalized patients.
The Journal of antimicrobial chemotherapy.
2020 03; 75(3):718-725. doi:
10.1093/jac/dkz476. [PMID: 31711216] - Xiaojiong Jia, Weijia Ma, Jianchun He, Xiaolang Tian, Hang Liu, Hua Zou, Si Cheng. Heteroresistance to cefepime in Pseudomonas aeruginosa bacteraemia.
International journal of antimicrobial agents.
2020 Mar; 55(3):105832. doi:
10.1016/j.ijantimicag.2019.10.013. [PMID: 31669739] - Mohammad H Al-Shaer, Wael A Alghamdi, Emily Graham, Charles A Peloquin. Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples.
Therapeutic drug monitoring.
2020 02; 42(1):129-132. doi:
10.1097/ftd.0000000000000675. [PMID: 31318843] - Stijn Jonckheere, Nikolaas De Neve, Jan Verbeke, Koen De Decker, Inger Brandt, An Boel, Jan Van Bocxlaer, Michel M R F Struys, Pieter J Colin. Target-Controlled Infusion of Cefepime in Critically Ill Patients.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
10.1128/aac.01552-19. [PMID: 31685467] - Jennifer Muradbegovic, Antonio Leidi, Jacques Serratrice. [Cefepime-induced encephalopathy].
Revue medicale suisse.
2019 Nov; 15(673):2210-2212. doi:
. [PMID: 31778052] - Thidarat Kitrungphaiboon, Pongpratch Puapatanakul, Piyatida Chuengsaman, Krittaya Tiskajornsiri, Guttiga Halue, Monchai Siribamrungwong, Saraporn Matayart, Kamonrat Chongthanakorn, Ussanee Poonvivatchaikarn, Chanchana Boonyakrai, Wanida Somboonsilp, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, David W Johnson, Talerngsak Kanjanabuch. Intraperitoneal Cefepime Monotherapy Versus Combination Therapy of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-Associated Peritonitis: A Multicenter, Open-Label, Noninferiority, Randomized, Controlled Trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2019 11; 74(5):601-609. doi:
10.1053/j.ajkd.2019.05.011. [PMID: 31331757] - Emily L Joyce, Sandra L Kane-Gill, Priyanka Priyanka, Dana Y Fuhrman, John A Kellum. Piperacillin/Tazobactam and Antibiotic-Associated Acute Kidney Injury in Critically Ill Children.
Journal of the American Society of Nephrology : JASN.
2019 11; 30(11):2243-2251. doi:
10.1681/asn.2018121223. [PMID: 31501354] - Muthana Al Sahlawi, Adrian Liew, Jeffrey Perl. Cefepime as Empirical Peritoneal Dialysis-Associated Peritonitis Treatment: Something to Dwell On?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2019 11; 74(5):579-582. doi:
10.1053/j.ajkd.2019.06.008. [PMID: 31515138] - Carolyn D Philpott, Christopher A Droege, Molly E Droege, Daniel P Healy, Joshua D Courter, Neil E Ernst, Nicole J Harger, Madeline J Foertsch, Jessica B Winter, Kristen E Carter, Suzanne L Van Fleet, Krishna Athota, Eric W Mueller. Pharmacokinetics and Pharmacodynamics of Extended-Infusion Cefepime in Critically Ill Patients Receiving Continuous Renal Replacement Therapy: A Prospective, Open-Label Study.
Pharmacotherapy.
2019 11; 39(11):1066-1076. doi:
10.1002/phar.2332. [PMID: 31549737] - Richard A Preston, Grigor Mamikonyan, Mushtaque Mastim, Dyal Garg, Christopher J Kemper, Allan Xu, Ravindra Yeole, Rajesh Chavan, H David Friedland, Ashima Bhatia. Single-Center Investigation of the Pharmacokinetics of WCK 4282 (Cefepime-Tazobactam Combination) in Renal Impairment.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00873-19. [PMID: 31332068] - Han-Tao Li, Chih-Hong Lee, Tony Wu, Mei-Yun Cheng, Wei-En Johnny Tseng, Chun-Wei Chang, Hsiang-Yao Hsieh, Hsing-I Chiang, Chih-Yin Lin, Bao-Luen Chang, Wey-Ran Lin, Siew-Na Lim. Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.
Neurocritical care.
2019 10; 31(2):329-337. doi:
10.1007/s12028-019-00682-y. [PMID: 30756319] - M Mameli, A Vezzelli, S Verze', S Biondi, P Motta, A Greco, M Michi, M Breda. Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of enmetazobactam and cefepime in human plasma.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):655-662. doi:
10.1016/j.jpba.2019.06.041. [PMID: 31288188] - Herrison Fontana, Larissa Brasil Skaf, Ana Filipa Moreira Martins, Laís Lisboa Corrêa, Beatriz Meurer Moreira, Raquel Regina Bonelli. First report of a cefepime-resistant Escherichia coli clinical isolate carrying blaCMY-33 from Brazil.
Journal of global antimicrobial resistance.
2019 09; 18(?):153-154. doi:
10.1016/j.jgar.2019.07.004. [PMID: 31306815] - Henry T Quach, Adam J Esbenshade, Zhiguo Zhao, Ritu Banerjee. Incidence of acute kidney injury among pediatric hematology/oncology patients receiving vancomycin in combination with piperacillin/tazobactam or cefepime.
Pediatric blood & cancer.
2019 07; 66(7):e27750. doi:
10.1002/pbc.27750. [PMID: 30989780] - Kathryn M Cook, Jessica Gillon, Alison G Grisso, Ritu Banerjee, Natalia Jimenez-Truque, Elizabeth J Phillips, Sara L Van Driest. Incidence of Nephrotoxicity Among Pediatric Patients Receiving Vancomycin With Either Piperacillin-Tazobactam or Cefepime: A Cohort Study.
Journal of the Pediatric Infectious Diseases Society.
2019 Jul; 8(3):221-227. doi:
10.1093/jpids/piy030. [PMID: 29590376] - Aude Garin, Florent Bavozet. Myoclonic status epilepticus induced by cefepime overdose requiring haemodialysis.
BMJ case reports.
2019 Jun; 12(6):. doi:
10.1136/bcr-2018-228108. [PMID: 31175111] - Adam M Blevins, Jennifer N Lashinsky, Craig McCammon, Marin Kollef, Scott Micek, Paul Juang. Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem.
Antimicrobial agents and chemotherapy.
2019 05; 63(5):. doi:
10.1128/aac.02658-18. [PMID: 30782987] - Diana J Schreier, Kianoush B Kashani, Ankit Sakhuja, Kristin C Mara, Mohammad S Tootooni, Heather A Personett, Sarah Nelson, Andrew D Rule, James M Steckelberg, Aaron J Tande, Erin F Barreto. Incidence of Acute Kidney Injury Among Critically Ill Patients With Brief Empiric Use of Antipseudomonal β-Lactams With Vancomycin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 04; 68(9):1456-1462. doi:
10.1093/cid/ciy724. [PMID: 30165426] - Gideon Stitt, Jennifer Morris, Lindsay Schmees, Joseph Angelo, Ayse Akcan Arikan. Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02006-18. [PMID: 30718247] - Sean N Avedissian, Gwendolyn Pais, Medha D Joshi, Nathaniel J Rhodes, Marc H Scheetz. A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime.
mSphere.
2019 01; 4(1):. doi:
10.1128/msphere.00595-18. [PMID: 30700511] - Edyta Konecka, Joanna Mokracka, Sylwia Krzymińska, Adam Kaznowski. Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans.
Polish journal of microbiology.
2019; 68(2):185-191. doi:
10.21307/pjm-2019-018. [PMID: 31257791] - Mitchell S Buckley, Nicole C Hartsock, Andrew J Berry, Dale S Bikin, Emily C Richards, Melanie J Yerondopoulos, Emir Kobic, Laura M Wicks, Drayton A Hammond. Comparison of acute kidney injury risk associated with vancomycin and concomitant piperacillin/tazobactam or cefepime in the intensive care unit.
Journal of critical care.
2018 12; 48(?):32-38. doi:
10.1016/j.jcrc.2018.08.007. [PMID: 30172962] - Luke Vlismas, Hannah Coleman, Tom N Lea-Henry, Bobby Chacko. Acute kidney injury in an older patient.
The Medical journal of Australia.
2018 11; 209(10):434-435. doi:
10.5694/mja18.00045. [PMID: 30428817] - Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig, Michel-Henry Fessy, Christian Chidiac, Tristan Ferry. Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.00163-18. [PMID: 30038037] - Ronilda D'Cunha, Thanh Bach, Beth Ann Young, Peizhi Li, Demet Nalbant, Jun Zhang, Patricia Winokur, Guohua An. Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 1: Assay Development and Validation.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00859-18. [PMID: 29941654] - Lynn E Kassel, Edward T Van Matre, Charles J Foster, Douglas N Fish, Scott W Mueller, Deb S Sherman, Michael F Wempe, Robert MacLaren, Robert T Neumann, Tyree H Kiser. A Randomized Pharmacokinetic and Pharmacodynamic Evaluation of Every 8-Hour and 12-Hour Dosing Strategies of Vancomycin and Cefepime in Neurocritically ill Patients.
Pharmacotherapy.
2018 09; 38(9):921-934. doi:
10.1002/phar.2156. [PMID: 29906310] - Ronilda D'Cunha, Thanh Bach, Beth Ann Young, Peizhi Li, Demet Nalbant, Jun Zhang, Patricia Winokur, Guohua An. Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 2: Stability Evaluation.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00861-18. [PMID: 29941653] - Kiran Patil, Harshad Tambe, Vineet Zope, Rajesh Chavan, Ravindra Yeole, Mahesh Patel. Simultaneous determination of zidebactam and cefepime in dog plasma by LC-MS/MS and its application to pre-clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4249. doi:
10.1002/bmc.4249. [PMID: 29577355] - Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H David Friedland, Ashima Bhatia. Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2018 08; 62(8):. doi:
10.1128/aac.00682-18. [PMID: 29784852] - W Cliff Rutter, David S Burgess. Incidence of Acute Kidney Injury among Patients Treated with Piperacillin-Tazobactam or Meropenem in Combination with Vancomycin.
Antimicrobial agents and chemotherapy.
2018 07; 62(7):. doi:
10.1128/aac.00264-18. [PMID: 29712661] - Brandon P Mullins, C Joseph Kramer, Billie J Bartel, Jennifer S Catlin, Richard E Gilder. Comparison of the Nephrotoxicity of Vancomycin in Combination With Cefepime, Meropenem, or Piperacillin/Tazobactam: A Prospective, Multicenter Study.
The Annals of pharmacotherapy.
2018 07; 52(7):639-644. doi:
10.1177/1060028018757497. [PMID: 29442542] - Percy Guanzon Balderia, Aditya Chandorkar, Yongwoo Kim, Soumya Patnaik, Joshua Sloan, George Charles Newman. Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient With Kidney Transplant.
Journal of patient safety.
2018 06; 14(2):e33-e34. doi:
10.1097/pts.0000000000000225. [PMID: 26102002] - M Paal, M Zoller, C Schuster, M Vogeser, G Schütze. Simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin in human serum using an isotope-dilution HPLC-MS/MS method.
Journal of pharmaceutical and biomedical analysis.
2018 Apr; 152(?):102-110. doi:
10.1016/j.jpba.2018.01.031. [PMID: 29414000] - Amber B Clemmons, Christine F Bech, Jeremy Pantin, Imran Ahmad. Acute Kidney Injury in Hematopoietic Cell Transplantation Patients Receiving Vancomycin and Piperacillin/Tazobactam Versus Vancomycin and Cefepime.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 04; 24(4):820-826. doi:
10.1016/j.bbmt.2017.12.799. [PMID: 29292056] - Holden Hutchinson, Sarah Finney, Lohendy Muñoz-Vargas, Sydnee Feicht, Margaret Masterson, Gregory Habing. Prevalence and Transmission of Antimicrobial Resistance in a Vertically Integrated Veal Calf Production System.
Foodborne pathogens and disease.
2017 12; 14(12):711-718. doi:
10.1089/fpd.2017.2310. [PMID: 28915068] - Mariana Castanheira, Leonard R Duncan, Paul R Rhomberg, Helio S Sader. Enhanced activity of cefepime-tazobactam (WCK 4282) against KPC-producing Enterobacteriaceae when tested in media supplemented with human serum or sodium chloride.
Diagnostic microbiology and infectious disease.
2017 Dec; 89(4):305-309. doi:
10.1016/j.diagmicrobio.2017.08.011. [PMID: 28969934] - Lauren E Payne, David J Gagnon, Richard R Riker, David B Seder, Elizabeth K Glisic, Jane G Morris, Gilles L Fraser. Cefepime-induced neurotoxicity: a systematic review.
Critical care (London, England).
2017 Nov; 21(1):276. doi:
10.1186/s13054-017-1856-1. [PMID: 29137682] - Sarah E Cotner, W Cliff Rutter, Donna R Burgess, Katie L Wallace, Craig A Martin, David S Burgess. Influence of β-Lactam Infusion Strategy on Acute Kidney Injury.
Antimicrobial agents and chemotherapy.
2017 10; 61(10):. doi:
10.1128/aac.00871-17. [PMID: 28760891] - Laurie Toullec, Julien Dupouey, Coralie Vigne, Amélie Marsot, Laurent Allanioux, Olivier Blin, Marc Leone, Romain Guilhaumou. Analytical interference during cefepime therapeutic drug monitoring in intensive care patient: About a case report.
Therapie.
2017 Oct; 72(5):587-592. doi:
10.1016/j.therap.2017.02.003. [PMID: 28457572] - Cristina Miglis, Nathaniel J Rhodes, Joseph L Kuti, David P Nicolau, Scott A Van Wart, Marc H Scheetz. Defining the impact of severity of illness on time above the MIC threshold for cefepime in Gram-negative bacteraemia: a 'Goldilocks' window.
International journal of antimicrobial agents.
2017 Sep; 50(3):487-490. doi:
10.1016/j.ijantimicag.2017.04.023. [PMID: 28668683] - Lisa K LeCleir, Rebecca S Pettit. Piperacillin-tazobactam versus cefepime incidence of acute kidney injury in combination with vancomycin and tobramycin in pediatric cystic fibrosis patients.
Pediatric pulmonology.
2017 08; 52(8):1000-1005. doi:
10.1002/ppul.23718. [PMID: 28440913] - Nakyung Jeon, Ben Staley, Kenneth P Klinker, Juan Hincapie Castillo, Almut G Winterstein. Acute kidney injury risk associated with piperacillin/tazobactam compared with cefepime during vancomycin therapy in hospitalised patients: a cohort study stratified by baseline kidney function.
International journal of antimicrobial agents.
2017 Jul; 50(1):63-67. doi:
10.1016/j.ijantimicag.2017.02.023. [PMID: 28522340] - T Huwyler, L Lenggenhager, M Abbas, K Ing Lorenzini, S Hughes, B Huttner, A Karmime, I Uçkay, E von Dach, P Lescuyer, S Harbarth, A Huttner. Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2017 Jul; 23(7):454-459. doi:
10.1016/j.cmi.2017.01.005. [PMID: 28111294] - Alexander R Shaw, Bruce A Mueller. Antibiotic Dosing in Continuous Renal Replacement Therapy.
Advances in chronic kidney disease.
2017 07; 24(4):219-227. doi:
10.1053/j.ackd.2017.05.004. [PMID: 28778361] - José Marco-Del Río, Esther Domingo-Chiva, Pablo Cuesta-Montero, Ana Valladolid-Walsh, Eva María García-Martínez. Cefepime Associated With Phenytoin Induced Stevens-Johnson Syndrome.
American journal of therapeutics.
2017 Jul; 24(4):e481-e484. doi:
10.1097/mjt.0000000000000520. [PMID: 28692440]